Portal de investigación
DEVELOPMENT OF A HIGH THROUGHPUT GENOMICS-BASED TEST FOR ASSESSING GENOTOXIC AND CARCINOGENIC PROPERTIES OF CHEMICAL COMPOUNDS IN VITRO
Datos básicos
- NumeroConcesion:
- CARCINOGENOMICS
- Año inicial:
- 2006
- Año final:
- 2012
Objetivos del proyecto
FINALIZADO
Documentos
- No hay documentos
Participantes
-
Bernardo Roque Bort Martí
Investigador
-
José Vicente Castell Ripoll
Investigador Principal
Grupos
-
Hepatología experimental y Trasplante hepático
Investigador Principal
Laia Tolosa Pardo
-
Unidad Mixta de Investigación en Hepatología Experimental
Investigador Principal
Ramiro Jover Atienza
Financiadores
Resultados del Proyecto
CELL SOURCES FOR HEPATIC CELL THERAPY
EUGENIA PAREJA IBARS, MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER, LAIA TOLOSA PARDO
Capítulo de un Libro. 2017
CELL-BASED THERAPEUTIC STRATEGIES FOR TREATMENT OF LIVER DISEASES.
LAIA TOLOSA PARDO, MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER, EUGENIA PAREJA IBARS
Capítulo de un Libro. 2017
Embryonic Development of the Liver
Zaret, Kenneth S., Bort, Roque, Duncan, Stephen A.
Capítulo de un Libro. 2020
[Liver cell therapy in the treatment of inborn errors of metabolism in children].
Abstract of Published Item. 10.1016/j.anpedi.2013.05.018. 2013
In vitro personalised model based on induced pluripotent stem cells for studying idiosyncratic hepatotoxicity
Pelecha, M.; (...); Tolosa, L.
Meeting Abstract. 10.1016/j.toxlet.2024.07.291. 2024
3D HYDROGEL MICROENVIROMENTS OF GELATIN AND HYALURONIC ACID FOR LIVER TISSUE ENGINEERING
Gallego-Ferrer, Gloria; (...); Tolosa, Laia
Article. 2022
A combination of transcriptomics and metabolomics uncovers enhanced bile acid biosynthesis in HepG2 cells expressing CCAAT/enhancer-binding protein ß (C/EBPß), hepatocyte nuclear factor 4a (HNF4a), and constitutive androstane receptor (CAR).
Blazquez M; (...); Bort R
Article. 10.1021/pr400085n. 2013
A Comprehensive Untargeted Metabonomic Analysis of Human Steatotic Liver Tissue by RP and HILIC Chromatography Coupled to Mass Spectrometry Reveals Important Metabolic Alterations
Garcia-Canaveras, Juan C.; (...); Lahoz, Agustin
Article. 10.1021/pr200629p. 2011
A dietary intervention with Akkermansia muciniphila and quercetin supplementation reshapes gut microbiota composition in an in vivo model of early obesity related non-alcoholic fatty liver disease
Juarez-Fernandez, M; (...); Sanchez-Campos, S
Meeting Abstract. 10.1017/S002966512100063X. 2021
A lipidomic cell-based assay for studying drug-induced phospholipidosis and steatosis
Garcia-Canaveras, JC; (...); Lahoz, A
Article. 10.1002/elps.201700079. 2017
A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury
García-Cañaveras JC; (...); Lahoz A
Article. 10.1038/srep27239. 2016
A microRNA signature for valproate-induced steatosis in human hepatocytes and its application to predict fatty liver in paediatric epileptic patients on valproate therapy.
Soluyanova P; (...); Jover R
Article. 10.1016/j.tox.2024.153974. 2024
A Multi-Parametric Fluorescent Assay for the Screening and Mechanistic Study of Drug-Induced Steatosis in Liver Cells in Culture.
Tolosa, Laia, Gomez-Lechon, M Jose, Donato, M Teresa
Article. 10.1002/cptx.20. 2017
A Network Involving Gut Microbiota, Circulating Bile Acids, and Hepatic Metabolism Genes That Protects Against Non-Alcoholic Fatty Liver Disease.
Article. 10.1002/mnfr.201900487. 2019
A New Score System To Classify Liver Graft Functionality after Transplantation
Cortes, Miriam; (...); Lahoz, Agustin
Article. 2011
A novel microRNA signature for cholestatic drugs in human hepatocytes and its translation into novel circulating biomarkers for drug-induced liver injury patients.
López-Riera M; (...); Jover R
Article. 10.1093/toxsci/kfz138. 2020
A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes.
Moreno-Torres, Marta; (...); Castell, V, Jose
Article. 10.1021/acs.jproteome.1c00779. 2022
A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: a case study on chemical-induced liver steatosis.
Verhoeven, Anouk; (...); Vanhaecke, Tamara
Article. 10.1016/j.tox.2024.153814. 2024
A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies.
Garcia-Llorens, Guillem; (...); Bort, Roque
Article. 10.1186/s13287-023-03311-w. 2023
A Score Model for the Continuous Assessment of Early Allograft Function after Liver Transplantation
Cortes, Miriam; (...); Lahoz, Agustin
Article. 2014
A Score Model for the Continuous Grading of Early Allograft Dysfunction Severity
Article. 10.1002/lt.23990. 2015
A simple transcriptomic signature able to predict drug-induced hepatic steatosis
Article. 10.1007/s00204-014-1197-7. 2014
Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems
Fernandez-Murga, ML; (...); Jover, R
Review. 10.1016/j.fct.2018.07.017. 2018
Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis
Article. 10.1016/j.taap.2016.04.007. 2016
Akkermansia spp. mediates protection from obesity-associated NAFLD development in germ free mice following intestinal microbiota transplantation from high fat diet and quercetin treated donors
Porras, D; (...); Sanchez-Campos, S
Meeting Abstract. 10.1016/S0168-8278(18)30894-8. 2018
Alternative Cell Sources to Adult Hepatocytes for Hepatic Cell Therapy.
Pareja, E, Gomez-Lechon, MJ, Tolosa, L
Article. 10.1007/978-1-4939-6506-9_2. 2017
An in vitro tool to assess cytochrome P450 drug biotransformation-dependent cytotoxicity in engineered HepG2 cells generated by using adenoviral vectors.
Lahoz A; (...); Gómez-Lechón MJ
Article. 10.1016/j.tiv.2012.08.001. 2013
An updated adverse outcome pathway network on chemical- induced liver steatosis
Verhoeven, A.; (...); Vanhaecke, T.
Meeting Abstract. 2023
Angiopoietin-Like Protein 8 Is a Novel Vitamin D Receptor Target Gene Involved in Nonalcoholic Fatty Liver Pathogenesis
Garcia-Monzon, C; (...); Jover, R
Article. 10.1016/j.ajpath.2018.07.028. 2018
Angiopoietin-like protein 8 is a novel vitamin D receptor-targeted lipogenic gene associated with non-alcoholic fatty liver
Gonzalez-Rodriguez, A; (...); Garcia-Monzon, C
Meeting Abstract. 10.1016/S0168-8278(18)30948-6. 2018
Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1
Rodriguez-Agudo, Ruben; (...); Martinez-Chantar, Maria L.
Article. 10.1016/jjhepr.2023.100918. 2024
Apicobasal Polarity Controls Lymphocyte Adhesion to Hepatic Epithelial Cells
Reglero-Real N; (...); Millán J
Article. 10.1016/j.celrep.2014.08.007. 2014
Application of high-content screening for the study of hepatotoxicity: Focus on food toxicology.
Review. 10.1016/j.fct.2020.111872. 2021
Assessing ATR-FTIR spectroscopy for steatosis quantification in liver biopsies in a long-duration cross-sectional study
Rienda, Ivan; (...); Quintas, Guillermo
Article. 10.1016/j.microc.2024.110135. 2024
Assessment of cytochrome P450 induction in human hepatocytes using the cocktail strategy plus liquid chromatography tandem mass spectrometry.
Lahoz, Agustin; (...); Gomez-Lechon, Maria Jose
Article. 10.2174/187231208785425845. 2008
Assessment of the cytotoxic potential of an aqueous-ethanolic extract from Thalassia testudinum angiosperm marine grown in the Caribbean Sea.
Rodeiro, I; (...); Lopes, M
Article. 10.1111/jphp.13001. 2018
Automated generation of hiPSC-derived hepatic progeny by cost-efficient compounds.
Vanmarcke G; (...); Verfaillie CM
Article. 10.1093/stmcls/sxad065. 2023
Bladder cancer recurrence surveillance by urine metabolomics analysis
Loras, A; (...); Ruiz-Cerda, JL
Article. 10.1038/s41598-018-27538-3. 2018
Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development
Article. 10.1016/j.toxlet.2016.10.008. 2016
CCAAT/Enhancer-binding Protein alpha (C/EBP alpha) and Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha) Synergistically Cooperate with Constitutive Androstane Receptor to Transactivate the Human Cytochrome P450 2B6 (CYP2B6) Gene APPLICATION TO THE DEVELOPMENT OF A METABOLICALLY COMPETENT HUMAN HEPATIC CELL MODEL
Benet, Marta; (...); Jover, Ramiro
Article. 10.1074/jbc.M110.118364. 2010
Cell Models and Omics Techniques for the Study of Nonalcoholic Fatty Liver Disease: Focusing on Stem Cell-Derived Cell Models.
Article. 10.3390/antiox11010086. 2021
Clinical Application of Pluripotent Stem Cells: An Alternative Cell-Based Therapy for Treating Liver Diseases?
Tolosa L, Pareja E, Gomez-Lechon MJ
Review. 10.1097/TP.0000000000001426. 2016
Clinical outcome of hepatocyte transplantation in four pediatric patients with inherited metabolic diseases.
Ribes-Koninckx C; (...); Castell JV
Article. 10.3727/096368912X637505. 2012
Cluster-Partial Least Squares (c-PLS) regression analysis: Application to miRNA and metabolomic data.
Kuligowski, Julia; (...); Quintas, Guillermo
Article. 10.1016/j.aca.2023.342052. 2024
Comparative analysis of eight cytotoxicity assays evaluated within the ACuteTox Project.
Clothier R; (...); Stanzel S
Article. 10.1016/j.tiv.2012.08.015. 2013
Comparing in vitro human liver models to in vivo human liver using RNA-Seq.
Gupta R; (...); Caiment F
Article. 10.1007/s00204-020-02937-6. 2020
Comparing Targeted vs. Untargeted MS2 Data-Dependent Acquisition for Peak Annotation in LC-MS Metabolomics
Ten-Domenech, I; (...); Kuligowski, J
Article. 10.3390/metabo10040126. 2020
Comparing the direct assessment of steatosis in liver explants with mid- and near-infrared vibrational spectroscopy, prior to organ transplantation.
Rienda, Ivan; (...); Quintas, Guillermo
Article. 10.1039/d3an01184d. 2023
Competency of different cell models to predict human hepatotoxic drugs
Gómez-Lechón MJ; (...); Donato MT
Review. 10.1517/17425255.2014.967680. 2014
Culture and Functional Characterization of Human Hepatoma HepG2 Cells.
Donato, MT, Tolosa, L, Gomez-Lechon, MJ
Article. 10.1007/978-1-4939-2074-7_5. 2015
Current status and future perspectives of hepatocyte transplantation
Review. 10.1016/j.ciresp.2013.04.010. 2014
Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury
Tolosa, L; (...); Teresa Donato, M.
Article. 10.1007/s00204-017-2036-4. 2018
Challenges and perspectives of liver tissue engineering: From cell therapy to bioprinting
Rodriguez-Fernandez, Julio; (...); Tolosa, Laia
Review. 10.36922/ijb.2706. 2024
Characterization of Proliferating Human Hepatocytes As a Model System for Drug Interaction Studies and Toxicity Screenings
Noerenberg, A; (...); Jover, R
Meeting Abstract. 2017
Chemometric approaches to improve PLSDA model outcome for predicting human non-alcoholic fatty liver disease using UPLC-MS as a metabolic profiling tool
Quintas, Guillermo; (...); Lahoz, Agustin
Article. 10.1007/s11306-011-0292-5. 2012
Delayed diagnosis of inflammatory bowel disease in women: Characterization and use of health resources
Sempere Robles, L.; (...); Ruiz, M. T.
Article. 2022
Derivation of healthy hepatocyte-like cells from a female patient with ornithine transcarbamylase deficiency through X-inactivation selection.
Santamaria R; (...); Bort R
Article. 10.1038/s41598-022-06184-w. 2022
Determination of major human cytochrome P450s activities in 96-well plates using liquid chromatography tandem mass spectrometry
Lahoz, A.; (...); Castell, J. V.
Article. 10.1016/j.tiv.2007.03.022. 2007
Development and optimization of hepatic cell models for pharmaco-toxicology and cell therapy research
Bonora-Centelles, A.; (...); Gomez-Lechon, M. J.
Article. 2008
Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.1093/toxsci/kfs083. 2012
Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress assessment of nanoparticle-treated cells.
Aranda A; (...); Gombau L
Article. 10.1016/j.tiv.2013.01.016. 2013
Direct conversion of human fibroblast to hepatocytes using a single inducible polycistronic vector.
Ballester M; (...); Bort R
Article. 10.1186/s13287-019-1416-5. 2019
Drug-Induced Fatty Liver Disease (DIFLD): A Comprehensive Analysis of Clinical, Biochemical, and Histopathological Data for Mechanisms Identification and Consistency with Current Adverse Outcome Pathways.
Lopez-Pascual, Ernesto; (...); Castell, Jose V.
Article. 10.3390/ijms25105203. 2024
Drug-induced liver steatosis and phospholipidosis: cell-based assays for early screening of drug candidates.
Article. 2012
Dysfunctional mitochondrial fission impairs cell reprogramming.
Prieto J; (...); Torres J
Article. 10.1080/15384101.2016.1241930. 2016
Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming
Prieto J; (...); Torres J
Article. 10.1038/ncomms11124. 2016
Effects of Mangifera indica L. aqueous extract (Vimang) on primary culture of rat hepatocytes
Rodeiro, I.; (...); Gomez-Lechon, M. J.
Article. 10.1016/j.fct.2007.05.027. 2007
Elimination of Vitamin D Signaling Causes Increased Mortality in a Model of Overactivation of the Insulin Receptor: Role of Lipid Metabolism
Crespo-Masip, Maria; (...); Manuel Valdivielso, Jose
Article. 10.3390/nu14071516. 2022
Enhancing the accuracy of mid-infrared spectroscopy-based liver steatosis quantification using digital image analysis as a reference.
Rienda, Ivan; (...); Quintas, Guillermo
Article. 10.1039/d3an00324h. 2023
Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes.
Article. 10.1007/s00204-019-02643-y. 2020
Evaluation of cytochrome P450 activities in human hepatocytes in vitro.
Gómez-Lechón MJ; (...); Donato MT
Article. 10.1007/978-1-61779-367-7_7. 2012
Evaluation of Drug-Metabolizing and Functional Competence of Human Hepatocytes Incubated Under Hypothermia in Different Media for Clinical Infusion
Jose Gomez-Lechon, Maria; (...); Teresa Donato, Maria
Article. 10.3727/096368908786576534. 2008
Evaluation of genotoxicity and DNA protective effects of mangiferin, a glucosylxanthone isolated from Mangifera indica L. stem bark extract.
Rodeiro I; (...); Espinosa-Aguirre JJ
Article. 10.1016/j.fct.2012.06.032. 2012
Exploring Individual Variability in Drug-Induced Liver Injury (DILI) Responses through Metabolomic Analysis.
Moreno-Torres M; (...); Castell JV
Article. 10.3390/ijms25053003. 2024
Exploring Mass Spectrometry Suitability to Examine Human Liver Graft Metabonomic Profiles
Cortes, M.; (...); Lahoz, A.
Article. 10.1016/j.transproceed.2010.07.049. 2010
Extending metabolome coverage for untargeted metabolite profiling of adherent cultured hepatic cells
García-Cañaveras JC; (...); Lahoz A
Article. 10.1007/s00216-015-9227-8. 2016
Extracting consistent biological information from functional results of metabolomic pathway analysis using the Mantel's test.
Ten-Doménech I; (...); Kuligowski J
Article. 10.1016/j.aca.2021.339173. 2021
FACTORS RELATED TO INADEQUATE COLON CLEANSING
Mangas-Sanjuan, C; (...); Jover, R
Meeting Abstract. 2018
Factors that influence the quality of metabolomics data in in vitro cell toxicity studies: a systematic survey.
Moreno-Torres, Marta; (...); Castell, Jose Vicente
Article. 10.1038/s41598-021-01652-1. 2021
FALSE-POSITIVE FECAL IMMUNOCHEMICAL TEST RESULT INFLUENCED BY SEX
Mangas-Sanjuan, C; (...); Jover, R
Meeting Abstract. 2018
Foxa1 reduces lipid accumulation in human hepatocytes and is down-regulated in nonalcoholic fatty liver.
Moya M; (...); Jover R
Article. 10.1371/journal.pone.0030014. 2012
Functional Assessment of the Quality of Human Hepatocyte Preparations for Cell Transplantation
Donato, Maria Teresa; (...); Gomez-Lechon, Maria Jose
Article. 10.3727/096368908787236620. 2008
Functional Characterization of Hepatocytes for Cell Transplantation: Customized Cell Preparation for Each Receptor
Bonora-Centelles, A.; (...); Gomez-Lechon, M. J.
Article. 10.3727/096368909X474267. 2010
Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High-Fat Diet Determine Non-Alcoholic Fatty Liver Disease Development in Germ-Free Mice
Porras, D; (...); Sanchez-Campos, S
Article. 10.1002/mnfr.201800930. 2019
Gata4 blocks somatic cell reprogramming by directly repressing Nanog.
Serrano F; (...); Bort R
Article. 10.1002/stem.1272. 2013
General Cytotoxicity Assessment by Means of the MTT Assay.
Tolosa, L, Donato, MT, Gomez-Lechon, MJ
Article. 10.1007/978-1-4939-2074-7_26. 2015
Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4a upregulation in primary human hepatocytes.
Rulcova A; (...); Pavek P
Article. 10.1016/S1734-1140(13)71491-9. 2013
Glutamine/glutamate metabolism rewiring in reprogrammed human hepatocyte-like cells
Ballester, M; (...); Bort, R
Article. 10.1038/s41598-019-54357-x. 2019
Growth-promoting and tumourigenic activity of c-Myc is suppressed by Hhex
Marfil V; (...); Bort R
Article. 10.1038/onc.2014.240. 2015
Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients.
Perez-Rubio, Alvaro; (...); Jover, Ramiro
Article. 10.3390/nu15143187. 2023
Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering.
Donato MT, Jover R, Gómez-Lechón MJ
Article. 2013
Hepatocyte transplantation program: Lessons learned and future strategies
Review. 10.3748/wjg.v22.i2.874. 2016
Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis
Bozic M; (...); Jover R
Article. 10.1016/j.jhep.2016.05.031. 2016
HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved.
Article. 10.1007/s00204-013-1012-x. 2013
High-content imaging technology for the evaluation of drug-induced steatosis using a multiparametric cell-based assay.
Donato MT; (...); Gómez-Lechón MJ
Article. 10.1177/1087057111427586. 2012
High-Content Screening for the Detection of Drug-Induced Oxidative Stress in Liver Cells.
Review. 10.3390/antiox10010106. 2021
High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins
Article. 10.1007/s00204-014-1334-3. 2015
High-content screening technology for studying drug-induced hepatotoxicity in cell models
Tolosa L, Gómez-Lechón MJ, Donato MT
Review. 10.1007/s00204-015-1503-z. 2015
Hnf4 alpha is a key gene that can generate columnar metaplasia in oesophageal epithelium
Colleypriest, Benjamin J.; (...); Tosh, David
Article. 10.1016/j.diff.2016.11.001. 2017
Human Embryonic Stem Cell Derived Hepatocyte-Like Cells as a Tool for In Vitro Hazard Assessment of Chemical Carcinogenicity
Yildirimman, Reha; (...); Herwig, Ralf
Article. 10.1093/toxsci/kfr225. 2011
Human hepatocyte transplantation in patients with hepatic failure awaiting a graft.
Article. 10.1159/000351332. 2013
Human hepatocytes derived from pluripotent stem cells: a promising cell model for drug hepatotoxicity screening
Review. 10.1007/s00204-016-1756-1. 2016
Human hepatocytes encapsulated in injectable hydrogels for their use in liver cell therapy
Rodriguez-Fernandez, J.; (...); Tolosa, L.
Meeting Abstract. 2019
Human neonatal hepatocyte transplantation induces long-term rescue of unconjugated hyperbilirubinemia in the Gunn rat
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.1002/lt.24121. 2015
Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing
Article. 10.1093/toxsci/kfw078. 2016
Idiosyncratic Drug-Induced Liver Injury and Amoxicillin-Clavulanate: Spotlight on Gut Microbiota, Fecal Metabolome and Bile Acid Profile in Patients.
Roman-Saguillo, Sara; (...); Sanchez-Campos, Sonia
Article. 10.3390/ijms25136863. 2024
Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure
Bolonio, M.; (...); Tolosa, L.
Meeting Abstract. 2019
Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure.
Article. 10.1016/j.jcyt.2019.12.005. 2020
Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London.
Puppi J; (...); Dhawan A
Article. 10.3727/096368911X566208. 2012
In vitro ADME medium/high-throughput screening in drug preclinical development
Lahoz, A; (...); Gomez-Lechon, MJ
Review. 10.2174/138955706778195153. 2006
In Vitro Evaluation of Potential Hepatotoxicity Induced by Drugs
Gomez-Lechon, M. J.; (...); Donato, M. T.
Article. 10.2174/138161210791208910. 2010
In vitro modulation of the cytochrome P450 and ABCB1/P-glycoprotein activities of the aqueous extract of Allophylus cominia (L) Sw. leaves.
Pérez CL; (...); Rodeiro I
Article. 10.1515/dmpt-2017-0020. 2017
In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4 alpha, expression
Sangan CB; (...); Tosh D
Article. 10.1016/j.mce.2014.09.009. 2015
In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay
Brecklinghaus, Tim; (...); Hengstler, Jan G.
Article. 10.1016/j.toxlet.2022.08.006. 2022
In vitro/in vivo screening of oxidative homeostasis and damage to DNA, protein, and lipids using UPLC/MS-MS
Carretero, A; (...); Lahoz, A
Article. 10.1007/s00216-014-7983-5. 2014
Induced pluripotent stem cells for the treatment of liver diseases: challenges and perspectives from a clinical viewpoint
Pareja, E, Gomez-Lechon, MJ, Tolosa, L
Review. 10.21037/atm.2020.02.164. 2020
Influence of peritoneal fluid on the expression of angiogenic and proteolytic factors in cultures of endometrial cells from women with endometriosis.
Cosín R; (...); Estelles A
Article. 10.1093/humrep/dep419. 2010
Inhibition of VEGF expression through blockade of Hif1a and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.
Carbajo-Pescador S; (...); González-Gallego J
Article. 10.1038/bjc.2013.285. 2013
Interaction between Hhex and SOX13 modulates Wnt/TCF activity.
Marfil V; (...); Bort R
Article. 10.1074/jbc.M109.046649. 2010
Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices
Jetten MJ; (...); Kleinjans JC
Article. 10.1016/j.tox.2014.06.007. 2014
Intestinal Microbiota Transplantation From HFD-fed and Quercetin Treated Donors Results in a Complex Metabolic Phenotype Transfer that Modulates Obesity-Related NAFLD in Germ Free Mice
Porras, D; (...); Sanchez-Campos, S
Meeting Abstract. 2017
LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells
García-Cañaveras JC; (...); Lahoz A
Article. 10.1002/elps.201500095. 2015
Lifestyle changes after Inflamatory Bowel Disease diagnosis
Galipienso, O. Belen; (...); Sempere, L.
Article. 2022
Liver cell culture techniques.
Castell, Jose V, Gomez-Lechon, Maria Jose
Article. 10.1007/978-1-59745-201-4_4. 2009
Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes.
Tolosa, L; (...); Donato, MT
Article. 10.1007/s00204-018-2349-y. 2019
Low density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial Hypercholesterolemia modelling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection
Caron, J; (...); Dubart-Kupperschmitt, A
Meeting Abstract. 10.1016/S0168-8278(18)30382-9. 2018
Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection.
Caron J; (...); Dubart-Kupperschmitt A
Article. 10.1186/s13287-019-1342-6. 2019
Mammalian cell metabolomics: experimental design and sample preparation.
León Z; (...); Lahoz A
Article. 10.1002/elps.201200605. 2013
Mangifera indica L. extract and mangiferin modulate cytochrome P450 and UDP-glucuronosyltransferase enzymes in primary cultures of human hepatocytes.
Rodeiro I; (...); Teresa Donato M
Article. 10.1002/ptr.4782. 2013
Mapping physiology: A systems biology approach for the development of alternative methods in toxicology.
Staumont, Bernard; (...); Geris, Liesbet
Article. 10.14573/altex.2412241. 2025
Maturation of Induced Pluripotent Stem Cell Derived Hepatocytes by 3D-Culture
Gieseck RL; (...); Vallier L
Article. 10.1371/journal.pone.0086372. 2014
Mechanistic Understanding of Idiosyncratic Drug-Induced Hepatotoxicity Using Co-Cultures of Hepatocytes and Macrophages.
Villanueva-Badenas, Estela, Donato, M. Teresa, Tolosa, Laia
Article. 10.3390/antiox12071315. 2023
Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs
Gomez-Lechon, MJ, Tolosa, L, Donato, MT
Review. 10.1002/jat.3277. 2016
Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo
Teresa Donato, M.; (...); Lahoz, Agustin
Article. 10.1124/dmd.110.033605. 2010
Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes
Quintas, G; (...); Castell, JV
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Alteracion De La Inducción A La Pluripotencialidad Por Los Factores De Transcripcion Gata4 Y Foxa2
Proyecto Fin de Carrera
Director/es: BERNARDO ROQUE BORT MARTÍ
Characterization Of Novel Hhex Partners: Sox13 And C-Myc
Tesis Doctoral
Director/es: BERNARDO ROQUE BORT MARTÍ
Ensayo Multiparamétrico In Vitro Para La Evaluación De La Hepatotoxicidad Mitocondrial De Fármacos
Autor/es: Antonio Carmona Serrano
Proyecto Fin de Carrera
Director/es: LAIA TOLOSA PARDO; MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER
Transdiferenciación De Fibroblastos A Hepatocitos Mediante Reprogramación Celular - Papel De Gata4 En El Bloqueo De La Reprogramación De Células Somáticas-
Tesis Doctoral
Director/es: BERNARDO ROQUE BORT MARTÍ
Campos de Estudio
Cita
DEVELOPMENT OF A HIGH THROUGHPUT GENOMICS-BASED TEST FOR ASSESSING GENOTOXIC AND CARCINOGENIC PROPERTIES OF CHEMICAL COMPOUNDS IN VITRO. (CARCINOGENOMICS). COMISION EUROPEA. 2006-2012. IP:JOSÉ VICENTE CASTELL RIPOLL.