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In vitro ADME medium/high-throughput screening in drug preclinical development

Fecha de publicación:

Autores de IIS La Fe

Abstract

The study of the ADME features of the huge number of new chemical entities (NCEs) produced mainly by combinatorial chemistry has become a bottleneck in the drug development process. In response the pharmaceutical industry is involved in the development of new medium/high-throughput screening capabilities. The aim of this paper is to review some of the available in vitro ADME systems adapted to screening requirements together with the technological approaches which can be linked to medium/high-throughput molecular screening.

Datos de la publicación

ISSN/ISSNe:
1389-5575, 1875-5607

MINI-REVIEWS IN MEDICINAL CHEMISTRY  BENTHAM SCIENCE PUBL LTD

Tipo:
Review
Páginas:
1053-1062
PubMed:
17018004
Factor de Impacto:
0,975 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 24

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Keywords

  • ADME; metabolism; screening; HTS; mass spectrometry

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