Portal de investigación
In vitro ADME medium/high-throughput screening in drug preclinical development
Autores de IIS La Fe
Abstract
The study of the ADME features of the huge number of new chemical entities (NCEs) produced mainly by combinatorial chemistry has become a bottleneck in the drug development process. In response the pharmaceutical industry is involved in the development of new medium/high-throughput screening capabilities. The aim of this paper is to review some of the available in vitro ADME systems adapted to screening requirements together with the technological approaches which can be linked to medium/high-throughput molecular screening.
Datos de la publicación
- ISSN/ISSNe:
- 1389-5575, 1875-5607
- Tipo:
- Review
- Páginas:
- 1053-1062
- PubMed:
- 17018004
- Factor de Impacto:
- 0,975 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
MINI-REVIEWS IN MEDICINAL CHEMISTRY Bentham Science Publishers
Citas Recibidas en Web of Science: 23
Documentos
- No hay documentos
Filiaciones
Filiaciones no disponibles
Keywords
- ADME; metabolism; screening; HTS; mass spectrometry
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Cita
Lahoz A,Gombau L,Donato MT,Castell JV,Gomez MJ. In vitro ADME medium/high-throughput screening in drug preclinical development. Mini-Rev. Med. Chem. 2006. 6(9):p. 1053-1062. IF:3,000. (1).