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Alternative Cell Sources to Adult Hepatocytes for Hepatic Cell Therapy.

Fecha de publicación:

Autores de IIS La Fe

Grupos

Abstract

Adult hepatocyte transplantation is limited by scarce availability of suitable donor liver tissue for hepatocyte isolation. New cell-based therapies are being developed to supplement whole-organ liver transplantation, to reduce the waiting-list mortality rate, and to obtain more sustained and significant metabolic correction. Fetal livers and unsuitable neonatal livers for organ transplantation have been proposed as potential useful sources of hepatic cells for cell therapy. However, the major challenge is to use alternative cell sources for transplantation that can be derived from reproducible methods. Different types of stem cells with hepatic differentiation potential are eligible for generating large numbers of functional hepatocytes for liver cell therapy to treat degenerative disorders, inborn hepatic metabolic diseases, and organ failure. Clinical trials are designed to fully establish the safety profile of such therapies and to define target patient groups and standardized protocols.

Datos de la publicación

ISSN/ISSNe:
1064-3745, 1940-6029

Methods in molecular biology (Clifton, N.J.)  HUMANA PRESS INC

Tipo:
Article
Páginas:
17-42
PubMed:
27830543
Factor de Impacto:
0,616 SCImago ℠
Cuartil:
Q3 SCImago ℠

Citas Recibidas en Web of Science: 2

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Keywords

  • *Clinical trials; *Fetal hepatocytes; *Hepatocyte transplantation; *Inborn metabolic errors; *Induced pluripotent stem cells; *Liver transplantation; *Neonatal hepatocytes; *Pluripotent stem cells

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