Comparing the direct assessment of steatosis in liver explants with mid- and near-infrared vibrational spectroscopy, prior to organ transplantation.

Autores de IIS La Fe

• Iván Rienda Martínez

  Autor

• Erika Moro Castaño

  Autor

• Julia Kuligowski

  Autor

• José Vicente Castell Ripoll

  Autor

• Judith Pérez Rojas

  Autor

• Eugenia Pareja Ibars

  Autor

• Guillermo Quintas Soriano

  Autor

Participantes ajenos a IIS La Fe

• Perez-Rubio, Alvaro
• Trullenque-Juan, Ramon
• Perez-Guaita, David
• Lendl, Bernhard

Grupos

• Hepatología experimental y Trasplante hepático

• Hepatología, Cirugia Hepatobiliopancreática y Trasplantes

• Perinatología

• Unidad Mixta de Investigación en Hepatología Experimental

Abstract

A fast and accurate assessment of liver steatosis is crucial during liver transplantation surgery as it can negatively impact its success. Recent research has shown that near-infrared (NIR) and attenuated total reflectance-Fourier transform mid-infrared (ATR-FTIR) spectroscopy could be used as real-time quantitative tools to assess steatosis during abdominal surgery. Here, in the frame of a clinical study, we explore the performance of NIR and ATR-FTIR spectroscopy for the direct assessment of steatosis in liver tissues. Results show that both NIR and ATR-FTIR spectroscopy are able to quantify the % of steatosis with cross-validation errors of 1.4 and 1.6%, respectively. Furthermore, the two portable instruments used both provided results within seconds and can be placed inside an operating room evidencing the potential of IR spectroscopy for initial characterization of grafts in liver transplantation surgery. We also evaluated the complementarity of the spectral ranges through correlation spectroscopy.

Keywords

• REGRESSION