Outcomes of elective liver surgery worldwide: a global, prospective, multicenter, cross-sectional study

Data de publicació: 01/12/2023

Autors de IIS La Fe

• José Vicente Castell Ripoll

  Autor

• Eva María Montalvá Orón

  Autor

• Rafael López Andújar

  Autor

Autors aliens a IIS La Fe

• Malago, Massimo
• Serrablo, Alejandro
• Raptis, Dimitri Aristotle
• Dervenis, Christos
• Oldhafer, Karl Jurgen
• Machado, Marcel Autran
• Kokudo, Norihiro
• Line, Pal-Dag
• Hernandez-Alejandro, Roberto
• Breitenstein, Stefan
• van Gulik, Thomas
• Tokat, Yaman
• Neumann, Ulf Peter
• Borakati, Aditya
• Monaco, Andrea
• Schnitzbauer, Andreas A.
• Elfrink, Arthur
• Buis, Carlijn
• Salinas, Camila Hidalgo
• Imber, Charles
• Ferraro, Daniele
• Balci, Deniz
• Schadde, Erik
• Soggiu, Fiammetta
• Lurje, Georg
• Stavrou, Gregor A.
• Passas, Ioannis
• Pape, James
• Bemelmans, Marc
• de Boer, Marieke
• Madadi-Sanjani, Omid
• Olthof, Pim
• Koti, Rahul
• Gilg, Stefen
• Damink, Steven Olde
• Lang, Sven
• Pissanou, Theodora
• Hanna, Thomas
• Ardiles, Victoria
• Mostefa, Ahmed Belhadj
• Goransky, Jeremias
• McCormack, Lucas
• Resio, Nicolas
• Petrou, George
• Hugh, Thomas
• Lam, Vincent
• Gruenberger, Thomas
• Shcherba, Aliaksei
• Bertrand, Claude
• D'Hondt, Mathieu
• Junior, Claudemiro Quireze
• Pereira, Lucio Lucas
• Coimbra, Felipe Jose Fernandez
• Kostov, Daniel
• Vladov, Nikola
• Belev, Nikolay
• Sapisochin, Gonzalo
• Hidalgo, Camila
• Jarufe, Nicolas
• Gong, An
• Liu, Chao
• Chen, Yiming
• Zhang, Fei
• Wen, Zhang
• Kopljar, Mario
• Petrou, Athanasios
• Treska, Vladislav
• Sherif, Ahmed
• El-Meteini, Mahmoud
• Fuks, David
• Sgarbura, Olivia
• Buchholz, Bettina M.
• Li, Jun
• Heinrich, Stefan
• Tzimas, George
• Tsoulfas, Georgios
• Petras, Panagiotis
• Vyas, Soumil
• Irwan, Budi
• Prabowo, Erik
• Gallagher, Tom
• Haddad, Riad
• Antonucci, Adelmo
• Jovine, Elio
• Ratti, Francesca
• Papadia, Francesco Saverio
• Maestri, Marcello
• Ozolins, Arturs
• Khalife, Mohamad
• Elhadi, Muhammed
• Dulskas, Audrius
• Paskonis, Marius
• Vanagas, Tomas
• Koh, Peng Soon
• Ghani, Shahi
• Ramirez Del Val, Alejandro
• Padilla Rosciano, Alejandro Eduardo
• Florez Zorrilla, Carlos
• Melchor-Ruan, Javier
• Koea, Jonathan
• Ojo-Williams, Bose
• Alatise, Olusegun
• Yaqub, Sheraz
• Castillo, Eduardo Anchante
• Cuevs, Victor Hugo Torres
• Teh, Catherine
• Komorowski, Andrzej
• Jeziorski, Krzysztof
• Zieniewicz, Krzysztof
• Kornasiewicz, Oskar
• Nunes, Vitor
• Khalaf, Hatem
• Schipor, Anamaria
• Negoi, Ionut
• Bratu, Matei
• Ginghina, Octav
• Bedzhanyan, Arkady
• Kozyrin, Ivan
• Chardarov, Nikita
• Bagmet, Nikolay
• Zagainov, Vladimir
• Zidan, Ahmed
• Karamarkovic, Aleksandar
• Galun, Daniel
• Protic, Mladjan
• Ferko, Alexander
• Trotovsek, Blaz
• Pipan, Peter
• Ielpo, Benedetto
• Ortega, Irene
• Asencio, J. M.
• Suarez-Munoz, Miguel-Angel
• Brusadin, Roberto
• Artigas, Vicenc
• Bulathsinhala, Bulathsinhalage
• Siriwardana, Rohan
• Sparrelid, Ernesto
• Sandstrom, Per
• Peloso, Andrea
• Coker, Ahmet
• Dulundu, Ender
• Kerem, Mustafa
• Robertson, Francis
• Abu Hilal, Moh
• Lahiri, Rajiv
• Ravikumar, Reena
• Hutchins, Robert
• Iype, Satheesh
• Pericleous, Stephanos
• Dasari, V. M. Bobby
• Koffron, Alan
• Giorgakis, Emmanouil
• Samant, Hrishikesh
• Curley, Steven
• Genyk, Yuri
• Czarnevicz, Daniel
• Delvalle, Gabriela
• Balmer, Matias
• Ramich, Diego
• Gondolesi, Gabriel
• Barros Schelotto, Pablo
• Abaca, Dario
• Lazarte, Julio
• Yuen, Lawrence
• Pang, Tony
• Bhimani, Nazim
• Hauer, Andreas
• Kirbes, Klaus
• Klug, Reinhold
• Braunwarth, Eva
• Primavesi, Florian
• Stattner, Stefan
• Fedaruk, Dmitry
• Korotkov, Sergey
• Strypstein, Sebastien
• Smet, Bart
• Biglari, Mehrdad
• Dili, Alexandra
• Vanlander, Aude
• Van Loo, Betsy
• de Carvalho, Luis Filipe Abreu
• Hendrikx, Bart
• Tomassini, Federico
• Rogiers, Xavier
• De Meyere, Celine
• Vansteenkiste, Franky
• Barreto Garcia, Fernanda Oliveira
• Romero Garcia, Rafael Jose
• Kleinubing, Diego
• Linhares, Marcelo Moura
• Cezar, Leandro Dias
• Shiraiwa, Daniel Kitayama
• Riera, Rachel
• Lukanova, Tsonka
• Kostov, Vasil
• Krastev, Panche
• Penkov, Radoslav
• Dib, Martin
• Marino, Carlo
• Zhou, Dachen
• Gu, Jiong
• Zhang, Bin
• Xu, Lei-bo
• Zhang, Rui
• Tan, Yunbo
• Su, Ziting
• Xu, Banghao
• Wang, Jilong
• Miao, Ke
• Luo, Xuhang
• Chen, Haimin
• Zhao, Jiafeng
• Zovak, Mario
• Fichtl, Jakub
• Dabbous, Hany
• Bahaa, Mohamed
• Ayoub, Islam
• Osman, Maher
• Soplepmann, Jaan
• Kivisild, Margus
• Tammik, Olav
• Quenet, Francois
• Truant, Stephanie
• Boleslawski, Emmanuel
• Lupinacci, Renato M.
• Peschaud, Frederique S.
• Ekmekcigil, Ela
• Triantafyllidis, Ioannis
• Makridis, Georgios
• Kantas, Alexandros
• Reese, Tim
• Lehwald-Tywuschik, Nadja
• Shabes, Paulina
• Knoefel, Wolfram
• Menzel, Magdalena
• Kardassis, Dimitrios
• Stoss, Christian
• Hartmann, Daniel
• Novotny, Alexander
• Friess, Helmut
• Mehrabi, Arianeb
• Lang, Hauke
• Tripke, Verena
• Schlitt, Hans Jurgen
• Werner, Jens M.
• Diehl-Bein, Monika
• Brunner, Stefan M.
• Lurje, Isabella
• Czigany, Zoltan
• Bramis, Konstantinos
• Konstadoulakis, Manousos
• Alexakis, Nikolaos
• Giakoustidis, Dimitrios
• Papadopoulos, Vasileios
• Paspala, Anna
• Pikoulis, Emmanuel
• Arkadopoulos, Nikolaos
• Kokoropoulos, Panagiotis
• Patapis, Paul
• Sidiropoulos, Theodoros
• Machairas, Nikolaos
• Stamopoulos, Paraskevas
• Pangratis, Spiridon
• Kambaroudis, Apostolos
• Kanteres, Thomas
• Dimitroulis, Dimitrios
• Sotiropoulos, Georgios
• Vailas, Michail
• Garoufalia, Zoe
• Papalampros, Alexandros
• Griniatsos, John
• Zacharakis, Emmanuil
• Tsirlis, Theo
• Sideris, Ioannis
• Syllaios, Athanasios
• Schizas, Dimitrios
• Toutouzas, Konstantinos
• Hasemaki, Natasha
• Zygomalas, Apollon
• Karavias, Dionissios
• Katsiakis, Nikolaos
• Balalis, Dimitrios
• Korkolis, Dimitrios
• Manatakis, Dimitrios
• Kyrochristos, Ioannis
• Glantzounis, Georgios
• Diamantis, Alexandros
• Perivoliotis, Konstantinos
• Tepetes, Konstantinos
• Felekouras, Evangelos
• Moris, Dimitrios
• Chandran, Biju
• Varghese, Christi
• Sudhindran, Surendran
• Kumar, Arun
• Appukuttan, Murali
• Nair, Vinitha
• Ramamurthy, Anand
• Vasavada, Bhavin
• Patel, Hardik
• Rachman, Irwan
• Tendean, Michael
• O'Dowling, Aidan
• Hoti, Emir
• Kambakamba, Patrick
• Swaed, Moneer
• Sadot, Eran
• Kashtan, Hanoch
• Ben-Ishay, Offir
• Khouri, Safi
• Bortolasi, Luca
• Rubicondo, Carolina
• Giovanelli, Mara
• Zanello, Matteo
• Masetti, Michele
• Lombardi, Raffaele
• Spampinato, Marcello
• Garritano, Stefano
• Saladino, Edoardo
• Cuticone, Giuseppe
• Gulla, Nino
• Recordare, Alfonso
• Cimino, Fabrizio
• Germini, Alessandro
• Mazzaferro, Vincenzo
• Piscitelli, Claudia
• Dominioni, Tommaso
• Guglielmi, Alfredo
• Ruzzenente, Andrea
• Campagnaro, Tommaso
• Parrino, Chiara
• Grazi, Gian Luca
• De Peppo, Valerio
• Paci, Marco
• Mandala, Lucio
• Mezzatesta, Pietro
• Ferrero, Alessandro
• Forchino, Fabio
• Russolillo, Nadia
• Belli, Andrea
• Granata, Vincenza
• Izzo, Francesco
• Frena, Antonio
• Patauner, Stefan
• Scotton, Giovanni
• Notte, Francesca
• Massobrio, Andrea
• Pertile, Davide
• De Cian, Franco
• Di Domenico, Stefano
• Scabini, Stefano
• Mattioli, Marco
• Gonta, Ana
• Ivano, Sciannamea
• Serenari, Matteo
• Pinotti, Enrico
• Montuori, Mauro
• Zago, Mauro
• Cipriani, Federica
• Aldrighetti, Luca
• Binetti, Margherita
• Cervellera, Maurizio
• Tonini, Valeria
• Mocchegiani, Federico
• Conte, Grazia
• Vivarelli, Marco
• Giani, Alessandro
• Romano, Fabrizio
• Famularo, Simone
• Porcu, Alberto
• Feo, Claudio F.
• Cherchi, Giuseppe
• Faraj, Walid
• Almiqlash, Bushray
• Ahmed, Hazem
• Alzedam, Ahmad
• Stratilatovas, Eugenijus
• Bausys, Rimantas
• Strupas, Kestutis
• Rackauskas, Rokas
• Barauskas, Giedrius
• Riauka, Romualdas
• Yoong, Boon Koon
• Koong, Jun Kit
• Basave, Horacio Lopez
• Saldivar, Alan Contreras
• Rosado, Ismael Dominguez
• Vilatoba Chapa, Mario
• Mercado, Miguel
• Belt, Eric
• Musters, Gijs
• Van der Hoeven, Joost
• Rijken, Arjen
• Wijsman, Jan
• Gobardhan, Paul
• Erdmann, Joris
• Besselink, Marc
• Swijnenburg, Rutger-Jan
• Kuhlmann, Koert
• Kok, Niels
• Ruers, Theo
• Talsma, A.
• Torrenga, Hans
• Vanlaarhoven, Stijn
• Grunhagen, Dirk
• Verhoef, C.
• Rothbarth, Michiel
• van Duijvendijk, Peter
• de Wijkerslooth, Elisabeth
• Vermaas, Maarten
• Doornebosch, Pascal
• Patijn, Gijs
• Nieuwenhuis, V
• den Dulk, Marcel
• Dejong, Kees
• Coolsen, Marielle
• Slooter, Gerrit
• Leclerq, Wouter
• Sijmons, Julie
• Hoff, Christiaan
• Manusama, Eric
• Eker, Hasan
• Lips, Daan
• Nijhuis, Jorieke
• Liem, Mike
• Rassam, Fadi
• Marsman, Hendrik
• Gerhards, Michael
• van den Boezem, Peter
• de Wilt, Johannes
• Stommel, Martijn
• Hagendoorn, Jeroen
• te Riele, Wouter
• Vuylsteke, Ronald
• Oosterling, Steven
• Hoogwater, Frederik
• Poelmann, Floris
• Torrenga, H.
• Talsma, K.
• Rodgers, Michael
• Leung, Universe
• Johnston, Peter
• McCall, John
• Welch, Fraser
• Connor, Saxon
• Hore, Todd
• Audeau, Andrew
• Silva, Lilian Rebecs Mantilla
• Jordan-Casupang, Amornetta
• Cieslak, Bartosz
• Maczkowski, Bartosz
• Wasiak, Dariusz
• Kosieradzki, Maciej
• Krasnodebski, Maciej
• Kotulski, Marcin
• Grat, Michal
• Kalinowski, Piotr
• Malkowski, Piotr
• Smoter, Piotr
• Paluszkiewicz, Rafal
• Holowko, Waclaw
• Patkowski, Waldemar
• de Melo, Renato
• Gomes, Antonio
• Marinho, Rui
• Elaffandi, Ahmed
• El-Moghazy, Walid
• Lee, Boram
• Cho, Jai Young
• Han, Ho-Seong
• Fagot, Herve
• Zemour, Johanna
• Diaconescu, Bogdan
• Stoica, Bogdan
• Beuran, Mircea
• Negoita, Valentina Madalina
• Ciubotaru, Cezar
• Spanu, Andrada
• Mardare, Mara
• Shatverian, Garnik
• Petrenko, Konstantin
• Polishchuk, Lilia
• Gorochov, Gleb
• Bobrov, Nikolay
• Sturdevant, Mark
• Juloski, Jovan
• Milic, Ljiljana
• Cuk, Vladica
• Bogdanovic, Aleksandar
• Zivanovic, Marko
• Laca, Ludovit
• Vojtko, Martin
• Petric, Miha
• Djokic, Mihajlo
• Teresa Albiol, Maria
• Castro, Ernest
• Lopez-Ben, Santiago
• del Mar Rico, Maria
• Vargas, Miguel
• Porcel, Orlando
• Molina Romero, Francesc Xavier
• Moron Canis, Jose Miguel
• Pujol Cano, Natalia
• Miyar de Leon, Alberto
• Garcia Bernardo, Carmen
• Solar-Garcia, Lorena
• Rojas Holguin, Adela
• Lopez Guerra, Diego
• Blanco Fernandez, Gerardo
• Pallares, Angel
• Martin Malagon, Antonio
• Pezzetta Hernandez, Liliana
• Manuel, Alba
• Ramia, Jose
• Latorre, Raquel
• Esteban Agusti, Enrique
• Gutierrez Samaniego, Maria
• Hernandez Bartolome, Miguel-Angel
• Martinez-Baena, Dario
• Lorente-Herce, Jose
• Parra-Memrbives, Pablo
• Uriarte, Angel
• Ayora, Santiago
• Lopez Fernandez, Jose
• Garcia Plaza, Gabriel
• Alcala Serrano, Javier
• Castro Santiago, Maria Jesus
• Cuadrado, Angel
• Fernandez, Rocio
• Bonar, Nuria
• Sabbagh, Rula
• Serradilla, Mario
• Paterna, Sandra
• Gimenez-Maurel, Teresa
• Burdio, Fernando
• Sanchez-Velazquez, Patricia
• Rodriguez Blanco, Manuel
• Roldan de la Rua, Jorge
• Hinojosa-Arco, Luis
• Martin-Perez, Elena
• Di Martino, Marcello
• de la Hoz Rodriguez, Angela
• Compan Rosique, Antonio F.
• Rumenova Smilevska, Rumyana
• Padillo Ruiz, Francisco Javier
• Gomez Bravo, Miguel-Angel
• Beltran Miranda, Pablo
• Robles Campos, Ricardo
• Lopez-Lopez, Victor
• Pavel, Mihai Calin
• Estalella, Laia
• Memba, Robert
• Jorba, Rosa
• Ranaweera, Nattashi
• Harshani, Nisansala
• Bjornsson, Bergthor
• Lundgren, Linda
• Hemmingsson, Oskar
• Colucci, Nicola
• Toso, Christian
• Loosen, Antonia
• Abbassi, Fariba
• Steffen, Thomas
• Heid, Franziska
• Melloul, Emmanuel
• Labgaa, Ismail
• Demartines, Nicolas
• Cristaudi, Alessandra
• Roesel, Raffaello
• Majno, Pietro
• Yang, Po-Chih
• Kirimker, Elvan
• Karayalcin, Kaan
• Uguz, Alper
• Unalp, Omer
• Emek, Ertan
• Yazici, Pinar
• Yalcinkaya, Ali
• Bostanci, Hasan
• Dikmen, Kursat
• Kvasivka, Oleksandr
• Kopchak, Kostiantyn
• Sumarokova, Valeriya
• Cheverdiuk, Dmitry
• Vasilev, Oleg
• Sikachov, Sergei
• Boumpoureka, Christina
• Bogatu, Diana
• Intzepogazoglou, Dimitra
• Srinivasan, Parthi
• Siriwardena, Ajith K.
• Liova, Eirini
• Donigiewicz, Urszula
• Woodrow, Lisa
• Schlegel, Andrea
• Dassanayake, Buddhika
• Kausar, Ambareen
• Tufo, Andrea
• Framptonl, Adam
• Del Var, Alejandro Ramirez
• Raptis, Dimitri A.
• Davidson, Brian R.
• Nasralla, David
• Ferraro, Danielle
• Sharma, Dinesh
• Fusai, Giuseppe Kito
• Tzerbinis, Helen
• Kostakis, Ioannis D.
• de Costa, Joao Mestre
• Pollok, Joerg-Matthias
• Dimitrokallis, Nikolaos
• Tinguely, Pascale
• Owen, Timothy
• Harrison, Ewen
• Primrose, John
• Armstrong, Thomas
• Kuemmerli, Christoph
• Tschuor, Christoph
• Aljarrah, Raed
• Lodge, Peter
• Kron, Philipp
• Akhtar, Daniel
• Policastro, Tania
• Bhogal, Ricky H.
• Vrochides, Dionisios
• Martinie, John
• Klein, J. J.
• Hertl, Martin
• Keutgen, Xavier
• Kalil, Jennifer
• Burdine, Lyle
• Helbig, Katie
• Andreoli, Gustavo

Grups d'Investigació

• Hepatología experimental y Trasplante hepático

  Investigador Principal

  Laia Tolosa Pardo

• Hepatología, Cirugia Hepatobiliopancreática y Trasplantes

  

  Leader

  Marina Berenguer Haym

• Unidad Mixta de Investigación en Hepatología Experimental

  

  Investigador Principal

  Ramiro Jover Atienza

Abstract

Background:The outcomes of liver surgery worldwide remain unknown. The true population-based outcomes are likely different to those vastly reported that reflect the activity of highly specialized academic centers. The aim of this study was to measure the true worldwide practice of liver surgery and associated outcomes by recruiting from centers across the globe. The geographic distribution of liver surgery activity and complexity was also evaluated to further understand variations in outcomes.Methods:LiverGroup.org was an international, prospective, multicenter, cross-sectional study following the Global Surgery Collaborative Snapshot Research approach with a 3-month prospective, consecutive patient enrollment within January-December 2019. Each patient was followed up for 90 days postoperatively. All patients undergoing liver surgery at their respective centers were eligible for study inclusion. Basic demographics, patient and operation characteristics were collected. Morbidity was recorded according to the Clavien-Dindo Classification of Surgical Complications. Country-based and hospital-based data were collected, including the Human Development Index (HDI). (NCT03768141).Results:A total of 2159 patients were included from six continents. Surgery was performed for cancer in 1785 (83%) patients. Of all patients, 912 (42%) experienced a postoperative complication of any severity, while the major complication rate was 16% (341/2159). The overall 90-day mortality rate after liver surgery was 3.8% (82/2,159). The overall failure to rescue rate was 11% (82/ 722) ranging from 5 to 35% among the higher and lower HDI groups, respectively.Conclusions:This is the first to our knowledge global surgery study specifically designed and conducted for specialized liver surgery. The authors identified failure to rescue as a significant potentially modifiable factor for mortality after liver surgery, mostly related to lower Human Development Index countries. Members of the LiverGroup.org network could now work together to develop quality improvement collaboratives.

Keywords

• failure to rescue; global surgery; human development index; liver surgery; morbidity; mortality; outcomes