Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4a upregulation in primary human hepatocytes.

Autores de IIS La Fe

• 

  Ramiro Jover Atienza

  Autor

Participantes ajenos a IIS La Fe

• Rulcova A
• Krausova L
• Smutny T
• Vrzal R
• Dvorak Z
• Pavek P

Grupos

• Hepatología experimental y Trasplante hepático

• Unidad Mixta de Investigación en Hepatología Experimental

Abstract

Organic cation transporter 1 (OCT1, SLC22A1) is a membrane transporter that is important for therapeutic effect of the antidiabetic drug metformin. Its liver-specific expression in hepatocytes is strongly controlled by hepatocyte nuclear factor-4a (HNF4a). HNF4a expression and transcriptional activity have been demonstrated to be augmented by glucocorticoid receptor (GR) in human hepatocytes and rodent livers.