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  3. The Synbiotic Combination of Akkermansia muciniphila and Quercetin Ameliorates Early Obesity and NAFLD through Gut Microbiota Reshaping and Bile Acid Metabolism Modulation.

The Synbiotic Combination of Akkermansia muciniphila and Quercetin Ameliorates Early Obesity and NAFLD through Gut Microbiota Reshaping and Bile Acid Metabolism Modulation.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Juárez-Fernández M
  • Porras D
  • Román-Sagüillo S
  • García-Mediavilla MV
  • Martínez-Flórez S
  • González-Gallego J
  • Nistal E
  • Sánchez-Campos S

Grupos

Abstract

Gut microbiota plays a key role in obesity and non-alcoholic fatty liver disease (NAFLD), so synbiotics could be a therapeutic alternative. We aim to evaluate a nutritional intervention together with the administration of the bacteria Akkermansia muciniphila and the antioxidant quercetin in an in vivo model of early obesity and NAFLD. 21-day-old rats were fed with control or high-fat diet for six weeks. Then, all animals received control diet supplemented with/without quercetin and/or A. muciniphila for three weeks. Gut microbiota, NAFLD-related parameters, circulating bile acids (BAs) and liver gene expression were analyzed. The colonization with A. muciniphila was associated with less body fat, while synbiotic treatment caused a steatosis remission, linked to hepatic lipogenesis modulation. The synbiotic promoted higher abundance of Cyanobacteria and Oscillospira, and lower levels of Actinobacteria, Lactococcus, Lactobacillus and Roseburia. Moreover, it favored elevated unconjugated hydrophilic BAs plasma levels and enhanced hepatic expression of BA synthesis and transport genes. A. muciniphila correlated with circulating BAs and liver lipid and BA metabolism genes, suggesting a role of this bacterium in BA signaling. Beneficial effects of A. muciniphila and quercetin combination are driven by gut microbiota modulation, the shift in BAs and the gut-liver bile flow enhancement.

Datos de la publicación

ISSN/ISSNe:
2076-3921, 2076-3921

ANTIOXIDANTS  MDPI

Tipo:
Article
Páginas:
-
Factor de Impacto:
1,008 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 66

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Keywords

  • Akkermansia muciniphila; childhood obesity; gut microbiota; quercetin; synbiotic

Financiación

European Regional Development Fund "A way to achieve Europe"
Instituto de Salud Carlos III - European Social Fundation (CD18/00158)
Instituto de Salud Carlos III, SpainInstituto de Salud Carlos III
Instituto de Salud Carlos IIIInstituto de Salud Carlos IIIEuropean Commission (PI17/01089)
Instituto de Salud Carlos IIIInstituto de Salud Carlos IIIEuropean Commission (PI20/00690)
Junta de Castilla y Leon
Junta de Castilla y Leon - European Social Fund
Ministerio de Ciencia, Innovacion y UniversidadesSpanish Government
Ministerio de Economia y Competitividad/FEDERSpanish Government

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