Portal de recerca
MECANISMOS TRANSCRIPCIONALES IMPLICADOS EN EL HIGADO GRASO NO ALCOHOLICO DE ORIGEN METABOLICO E IATROGENICO: INFLUENCIA DE LA RESISTENCIA A LA INSULINA
Dades bàsiques
- Protocol:
- PI10/00194
- EURDRACT:
- NO PROCEDE
- NCT:
- Centre:
- Any inici:
- 2010
- Any de finalització:
- 2014
Objectius del projecte
FINALIZADO
Documents
- No hi ha documents
Participants
-
Ramiro Jover Atienza
Investigador Principal
Grups d'Investigació
-
Hepatología experimental y Trasplante hepático
Investigador Principal
Laia Tolosa Pardo
-
Unidad Mixta de Investigación en Hepatología Experimental
Investigador Principal
Ramiro Jover Atienza
Finançadors - Promotors
Resultats de l'Assaig Clínic
CELL SOURCES FOR HEPATIC CELL THERAPY
EUGENIA PAREJA IBARS, MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER, LAIA TOLOSA PARDO
Capítulo de un Libro. 2017
CELL-BASED THERAPEUTIC STRATEGIES FOR TREATMENT OF LIVER DISEASES.
LAIA TOLOSA PARDO, MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER, EUGENIA PAREJA IBARS
Capítulo de un Libro. 2017
In vitro personalised model based on induced pluripotent stem cells for studying idiosyncratic hepatotoxicity
Pelecha, M.; (...); Tolosa, L.
Meeting Abstract. 10.1016/j.toxlet.2024.07.291. 2024
3D HYDROGEL MICROENVIROMENTS OF GELATIN AND HYALURONIC ACID FOR LIVER TISSUE ENGINEERING
Gallego-Ferrer, Gloria; (...); Tolosa, Laia
Article. 2022
A dietary intervention with Akkermansia muciniphila and quercetin supplementation reshapes gut microbiota composition in an in vivo model of early obesity related non-alcoholic fatty liver disease
Juarez-Fernandez, M; (...); Sanchez-Campos, S
Meeting Abstract. 10.1017/S002966512100063X. 2021
A microRNA signature for valproate-induced steatosis in human hepatocytes and its application to predict fatty liver in paediatric epileptic patients on valproate therapy.
Soluyanova P; (...); Jover R
Article. 10.1016/j.tox.2024.153974. 2024
A Multi-Parametric Fluorescent Assay for the Screening and Mechanistic Study of Drug-Induced Steatosis in Liver Cells in Culture.
Tolosa, Laia, Gomez-Lechon, M Jose, Donato, M Teresa
Article. 10.1002/cptx.20. 2017
A Network Involving Gut Microbiota, Circulating Bile Acids, and Hepatic Metabolism Genes That Protects Against Non-Alcoholic Fatty Liver Disease.
Article. 10.1002/mnfr.201900487. 2019
A novel microRNA signature for cholestatic drugs in human hepatocytes and its translation into novel circulating biomarkers for drug-induced liver injury patients.
López-Riera M; (...); Jover R
Article. 10.1093/toxsci/kfz138. 2020
A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes.
Moreno-Torres, Marta; (...); Castell, V, Jose
Article. 10.1021/acs.jproteome.1c00779. 2022
A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: a case study on chemical-induced liver steatosis.
Verhoeven, Anouk; (...); Vanhaecke, Tamara
Article. 10.1016/j.tox.2024.153814. 2024
A Question Seeking for an Answer: Use of T-tube in the Era of Liver Transplantation With Grafts From Extended Criteria Donors and Donors After Cardiac Death Reply
López-Andújar R, Montalvá EM, Vergara FA
Letter. 10.1097/SLA.0000000000000722. 2015
A read-across case study on chronic toxicity of branched carboxylic acids (1): Integration of mechanistic evidence from new approach methodologies (NAMs) to explore a common mode of action.
Escher, Sylvia E.; (...); Fisher, Ciaran
Art Exhibit Review. 10.1016/j.tiv.2021.105269. 2022
A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies.
Garcia-Llorens, Guillem; (...); Bort, Roque
Article. 10.1186/s13287-023-03311-w. 2023
A simple transcriptomic signature able to predict drug-induced hepatic steatosis
Article. 10.1007/s00204-014-1197-7. 2014
A surgical model for isolating the pig liver in vivo for gene therapy.
Carreño O; (...); Lopez-Andujar R
Article. 10.1159/000351339. 2013
Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems
Fernandez-Murga, ML; (...); Jover, R
Review. 10.1016/j.fct.2018.07.017. 2018
Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis
Article. 10.1016/j.taap.2016.04.007. 2016
Akkermansia spp. mediates protection from obesity-associated NAFLD development in germ free mice following intestinal microbiota transplantation from high fat diet and quercetin treated donors
Porras, D; (...); Sanchez-Campos, S
Meeting Abstract. 10.1016/S0168-8278(18)30894-8. 2018
Alternative Cell Sources to Adult Hepatocytes for Hepatic Cell Therapy.
Pareja, E, Gomez-Lechon, MJ, Tolosa, L
Article. 10.1007/978-1-4939-6506-9_2. 2017
An updated adverse outcome pathway network on chemical- induced liver steatosis
Verhoeven, A.; (...); Vanhaecke, T.
Meeting Abstract. 2023
Angiopoietin-Like Protein 8 Is a Novel Vitamin D Receptor Target Gene Involved in Nonalcoholic Fatty Liver Pathogenesis
Garcia-Monzon, C; (...); Jover, R
Article. 10.1016/j.ajpath.2018.07.028. 2018
Angiopoietin-like protein 8 is a novel vitamin D receptor-targeted lipogenic gene associated with non-alcoholic fatty liver
Gonzalez-Rodriguez, A; (...); Garcia-Monzon, C
Meeting Abstract. 10.1016/S0168-8278(18)30948-6. 2018
Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1
Rodriguez-Agudo, Ruben; (...); Martinez-Chantar, Maria L.
Article. 10.1016/jjhepr.2023.100918. 2024
Application of high-content screening for the study of hepatotoxicity: Focus on food toxicology.
Review. 10.1016/j.fct.2020.111872. 2021
Assessing ATR-FTIR spectroscopy for steatosis quantification in liver biopsies in a long-duration cross-sectional study
Rienda, Ivan; (...); Quintas, Guillermo
Article. 10.1016/j.microc.2024.110135. 2024
Assessment of the cytotoxic potential of an aqueous-ethanolic extract from Thalassia testudinum angiosperm marine grown in the Caribbean Sea.
Rodeiro, I; (...); Lopes, M
Article. 10.1111/jphp.13001. 2018
Baseline circulating myeloid-derived suppressor cells correlate with neutrophil-to-lymphocyte ratio and overall survival in advanced non-small cell lung cancer patients treated with immune checkpoint inhibitors
Garcia-Sanchez, J.; (...); Lahoz, A.
Meeting Abstract. 2021
Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development
Article. 10.1016/j.toxlet.2016.10.008. 2016
CCAAT/Enhancer-binding Protein alpha (C/EBP alpha) and Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha) Synergistically Cooperate with Constitutive Androstane Receptor to Transactivate the Human Cytochrome P450 2B6 (CYP2B6) Gene APPLICATION TO THE DEVELOPMENT OF A METABOLICALLY COMPETENT HUMAN HEPATIC CELL MODEL
Benet, Marta; (...); Jover, Ramiro
Article. 10.1074/jbc.M110.118364. 2010
Cell Models and Omics Techniques for the Study of Nonalcoholic Fatty Liver Disease: Focusing on Stem Cell-Derived Cell Models.
Article. 10.3390/antiox11010086. 2021
Cellular and molecular mechanisms involved in the neuroprotective effects of VEGF on motoneurons.
Lladó J, Tolosa L, Olmos G
Article. 10.3389/fncel.2013.00181. 2013
Clinical Application of Pluripotent Stem Cells: An Alternative Cell-Based Therapy for Treating Liver Diseases?
Tolosa L, Pareja E, Gomez-Lechon MJ
Review. 10.1097/TP.0000000000001426. 2016
Cluster-Partial Least Squares (c-PLS) regression analysis: Application to miRNA and metabolomic data.
Kuligowski, Julia; (...); Quintas, Guillermo
Article. 10.1016/j.aca.2023.342052. 2024
CMV reactivation (rCMV) is associated with lower hepatocellular carcinoma (HCC) recurrence after liver transplatatoin (LT)
Aguilera, V.; (...); Berenguer, M.
Meeting Abstract. 2023
Co-culture of multiple myeloma cell lines and bone marrow mesenchymal stem cells in a 3D microgel environment.
Garcia-Briega, M Inmaculada; (...); Ribelles, Jose Luis Gomez
Article. 10.1016/j.bioadv.2025.214243. 2025
Comparing in vitro human liver models to in vivo human liver using RNA-Seq.
Gupta R; (...); Caiment F
Article. 10.1007/s00204-020-02937-6. 2020
Compassionate use of cannabidiol in spray form for the treatment of spastic paraparesis in a patient with adrenomyeloneuropathy
Roda-Alcayde, Cristina; (...); Manez-Anon, Inmaculada
Letter. 10.33588/rn.6411.2017090. 2017
Competency of different cell models to predict human hepatotoxic drugs
Gómez-Lechón MJ; (...); Donato MT
Review. 10.1517/17425255.2014.967680. 2014
Computational Strategies for Assessing Adverse Outcome Pathways: Hepatic Steatosis as a Case Study.
Ortega-Vallbona R; (...); Serrano-Candelas E
Article. 10.3390/ijms252011154. 2024
Consensus document from the Spanish Society for Liver Transplantation: Enhanced recovery after liver transplantation
Llado, Laura; (...); Soc Espanola Trasplante Hepatico S
Article. 10.1016/j.ciresp.2023.07.001. 2024
Consensus document from the Spanish Society for Liver Transplantation: enhanced recovery after liver transplantation.
Llado, Laura; (...); Rodriguez-Laiz, Gonzalo
Article. 10.1016/j.cireng.2023.07.004. 2024
Consensus document from the Spanish Society for Liver Transplantation: Enhanced recovery after liver transplantation.
Lladó L; (...); en representación de la Sociedad Española de Trasplante Hepático (SETH)
Practice Guideline. 10.1016/j.gastrohep.2023.06.009. 2024
Consensus Statement on Hemostatic Management, Anticoagulation, and Antiplatelet Therapy in Liver Transplantation.
Montalvá E; (...); Colmenero J
Article. 10.1097/TP.0000000000004014. 2022
Culture and Functional Characterization of Human Hepatoma HepG2 Cells.
Donato, MT, Tolosa, L, Gomez-Lechon, MJ
Article. 10.1007/978-1-4939-2074-7_5. 2015
Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury
Tolosa, L; (...); Teresa Donato, M.
Article. 10.1007/s00204-017-2036-4. 2018
Challenges and perspectives of liver tissue engineering: From cell therapy to bioprinting
Rodriguez-Fernandez, Julio; (...); Tolosa, Laia
Review. 10.36922/ijb.2706. 2024
Characterization of Proliferating Human Hepatocytes As a Model System for Drug Interaction Studies and Toxicity Screenings
Noerenberg, A; (...); Jover, R
Meeting Abstract. 2017
Delayed diagnosis of inflammatory bowel disease in women: Characterization and use of health resources
Sempere Robles, L.; (...); Ruiz, M. T.
Article. 2022
Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.1093/toxsci/kfs083. 2012
Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress assessment of nanoparticle-treated cells.
Aranda A; (...); Gombau L
Article. 10.1016/j.tiv.2013.01.016. 2013
Drug-Induced Fatty Liver Disease (DIFLD): A Comprehensive Analysis of Clinical, Biochemical, and Histopathological Data for Mechanisms Identification and Consistency with Current Adverse Outcome Pathways.
Lopez-Pascual, Ernesto; (...); Castell, Jose V.
Article. 10.3390/ijms25105203. 2024
Effect of Calcineurin Inhibitors in the Outcome of Liver Transplantation in Hepatitis C Virus-Positive Recipients
Berenguer, Marina; (...); Prieto, Martin
Article. 10.1097/TP.0b013e3181fa93fa. 2010
Efficacy of gene transfer to "in vivo'' whole isolated pig liver
Sendra, L.; (...); Alino, S. F.
Article. 2012
Efficacy of human interleukin-10 gene transfer to human liver segments "ex vivo'' by hydrodynamic injection
Sendra, L.; (...); Alino, S. F.
Article. 2015
Efficacy of Hydrodynamic Interleukin 10 Gene Transfer in Human Liver Segments With Interest in Transplantation
Sendra Gisbert L; (...); Aliño Pellicer SF
Article. 10.1002/lt.24667. 2017
Efficacy of interleukin 10 gene hydrofection in pig liver vascular isolated 'in vivo' by surgical procedure with interest in liver transplantation.
Sendra L; (...); Aliño SF
Article. 10.1371/journal.pone.0224568. 2019
Elimination of Vitamin D Signaling Causes Increased Mortality in a Model of Overactivation of the Insulin Receptor: Role of Lipid Metabolism
Crespo-Masip, Maria; (...); Manuel Valdivielso, Jose
Article. 10.3390/nu14071516. 2022
Endothelin-1-Mediated Drug Resistance in EGFR-Mutant Non-Small Cell Lung Carcinoma
Pulido, I; (...); Shimamura, T
Article. 10.1158/0008-5472.CAN-20-0141. 2020
Enhancing the accuracy of mid-infrared spectroscopy-based liver steatosis quantification using digital image analysis as a reference.
Rienda, Ivan; (...); Quintas, Guillermo
Article. 10.1039/d3an00324h. 2023
Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes.
Article. 10.1007/s00204-019-02643-y. 2020
Exploring Individual Variability in Drug-Induced Liver Injury (DILI) Responses through Metabolomic Analysis.
Moreno-Torres M; (...); Castell JV
Article. 10.3390/ijms25053003. 2024
Extended distal pancreatectomy with thoracic wall resection after neoadjuvant FOLFIRINOX: Is there a limit of resection for pancreatic cancer after downstaging?
Giuliani T; (...); Lopez Andujar R
Case Reports. 10.14701/ahbps.2020.24.1.90. 2020
FACTORS RELATED TO INADEQUATE COLON CLEANSING
Mangas-Sanjuan, C; (...); Jover, R
Meeting Abstract. 2018
FALSE-POSITIVE FECAL IMMUNOCHEMICAL TEST RESULT INFLUENCED BY SEX
Mangas-Sanjuan, C; (...); Jover, R
Meeting Abstract. 2018
FAMetA: a mass isotopologue-based tool for the comprehensive analysis of fatty acid metabolism.
Alcoriza-Balaguer MI; (...); Lahoz A
Article. 10.1093/bib/bbad064. 2023
Feasibility and Short-Term Outcomes in Liver-First Approach: A Spanish Snapshot Study (the RENACI Project).
Serradilla-Martín M; (...); Ramia JM
Article. 10.3390/cancers16091676. 2024
FibroScan compared to liver biopsy for accurately detecting recurrent hepatic steatosis and fibrosis after liver transplantation for metabolic dysfunction-associated steatohepatitis
Martinez-Arenas, Laura; (...); Berenguer, Marina
Meeting Abstract. 2024
FibroScan compared to liver biopsy for accurately detecting recurrent hepatic steatosis and fibrosis after liver transplantation for metabolic dysfunction-associated steatohepatitis
Martinez-Arenas, L.; (...); Berenguer, M.
Meeting Abstract. 2024
FibroScan compared to liver biopsy for accurately staging recurrent hepatic steatosis and fibrosis after transplantation for MASH.
Martinez-Arenas, Laura; (...); Berenguer, Marina
Article. 10.1111/liv.16085. 2024
Foxa1 reduces lipid accumulation in human hepatocytes and is down-regulated in nonalcoholic fatty liver.
Moya M; (...); Jover R
Article. 10.1371/journal.pone.0030014. 2012
Frailty changes after liver transplantation in the Spanish setting. Results from a Spanish multicentre prospective cohort study
Puchades, L.; (...); Berenguer, M.
Meeting Abstract. 2023
Frailty Changes After Liver Transplantation. Results From a Spanish Multicenter Prospective Cohort Study
Puchades, Lorena; (...); Berenguer, Marina
Article. 10.1097/TXD.0000000000001599. 2024
Framingham score, renal dysfunction, and cardiovascular risk in liver transplant patients
Di Maira, Tommaso; (...); Berenguer, Marina
Article. 10.1002/lt.24128. 2015
From conventional two-stage hepatectomy to ALPPS: Fifteen years of experience in a hepatobiliary surgery unit
Maupoey Ibanez, Javier; (...); Lopez-Andujar, Rafael
Article. 10.1016/j.hbpd.2021.08.0011499-3872. 2021
Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High-Fat Diet Determine Non-Alcoholic Fatty Liver Disease Development in Germ-Free Mice
Porras, D; (...); Sanchez-Campos, S
Article. 10.1002/mnfr.201800930. 2019
General Cytotoxicity Assessment by Means of the MTT Assay.
Tolosa, L, Donato, MT, Gomez-Lechon, MJ
Article. 10.1007/978-1-4939-2074-7_26. 2015
Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4a upregulation in primary human hepatocytes.
Rulcova A; (...); Pavek P
Article. 10.1016/S1734-1140(13)71491-9. 2013
Good posttransplant outcome using donors after cardiac death (DCD) when applying strict selection criteria
de la Varga, MF; (...); Castillo, MP
Meeting Abstract. 2021
Good post-transplant outcomes using liver donors after circulatory death when applying strict selection criteria: A propensity-score matched-cohort study.
Fernandez-de la Varga, Margarita; (...); Aguilera, Victoria
Article. 10.1016/j.aohep.2022.100724. 2022
Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients.
Perez-Rubio, Alvaro; (...); Jover, Ramiro
Article. 10.3390/nu15143187. 2023
Has Laparoscopic Kasai Portoenterostomy Got Any Advantage in Pediatric Liver Transplant Patients?
Vila Carbo, Juan Jose; (...); Dejuan, Manolo
Article. 2011
Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering.
Donato MT, Jover R, Gómez-Lechón MJ
Article. 2013
Hepatic endometrioma. An update and new approaches
Cantos Pallarés M; (...); Rayón Martín M
Letter. 10.1016/j.ciresp.2012.01.014. 2014
Hepatocyte transplantation program: Lessons learned and future strategies
Review. 10.3748/wjg.v22.i2.874. 2016
Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis
Bozic M; (...); Jover R
Article. 10.1016/j.jhep.2016.05.031. 2016
Hepatolitiasis simulando un colangiocarcinoma hiliar.
Vergara Suárez F; (...); Pérez Rojas J
Letter. 10.1016/j.ciresp.2013.03.003. 2013
HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved.
Article. 10.1007/s00204-013-1012-x. 2013
High-content imaging technology for the evaluation of drug-induced steatosis using a multiparametric cell-based assay.
Donato MT; (...); Gómez-Lechón MJ
Article. 10.1177/1087057111427586. 2012
High-Content Screening for the Detection of Drug-Induced Oxidative Stress in Liver Cells.
Review. 10.3390/antiox10010106. 2021
High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins
Article. 10.1007/s00204-014-1334-3. 2015
High-content screening technology for studying drug-induced hepatotoxicity in cell models
Tolosa L, Gómez-Lechón MJ, Donato MT
Review. 10.1007/s00204-015-1503-z. 2015
Hnf4 alpha is a key gene that can generate columnar metaplasia in oesophageal epithelium
Colleypriest, Benjamin J.; (...); Tosh, David
Article. 10.1016/j.diff.2016.11.001. 2017
Human hepatocytes derived from pluripotent stem cells: a promising cell model for drug hepatotoxicity screening
Review. 10.1007/s00204-016-1756-1. 2016
Human hepatocytes encapsulated in injectable hydrogels for their use in liver cell therapy
Rodriguez-Fernandez, J.; (...); Tolosa, L.
Meeting Abstract. 2019
Human neonatal hepatocyte transplantation induces long-term rescue of unconjugated hyperbilirubinemia in the Gunn rat
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.1002/lt.24121. 2015
Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing
Article. 10.1093/toxsci/kfw078. 2016
Hydrodynamic IL10 Gene Transfer in Human Colon: Results from an "EX VIVO" Study with Potential Clinical Application in Crohn's Disease
Frasson, M; (...); Aliño S
Article. 10.1097/MIB.0000000000001197. 2017
Hydrodynamic IL10 gene transfer in human colon: Results from an ex-vivo study with potential application in Crohn's disease
Sendra, L; (...); Alino, SF
Meeting Abstract. 2017
Idiosyncratic Drug-Induced Liver Injury and Amoxicillin-Clavulanate: Spotlight on Gut Microbiota, Fecal Metabolome and Bile Acid Profile in Patients.
Roman-Saguillo, Sara; (...); Sanchez-Campos, Sonia
Article. 10.3390/ijms25136863. 2024
Importance of Technical Aspects in the Beginnings of a Pancreas Transplantation Program
Moya Herraiz, A.; (...); Mir Pallardo, J.
Article. 10.1016/j.transproceed.2009.12.001. 2010
Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure
Bolonio, M.; (...); Tolosa, L.
Meeting Abstract. 2019
Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure.
Article. 10.1016/j.jcyt.2019.12.005. 2020
In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4 alpha, expression
Sangan CB; (...); Tosh D
Article. 10.1016/j.mce.2014.09.009. 2015
In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay
Brecklinghaus, Tim; (...); Hengstler, Jan G.
Article. 10.1016/j.toxlet.2022.08.006. 2022
Indications and results of liver retransplantation: experience with 1181 patients in the hospital universitario La Fe
Torres-Queuedo, Rodrigo; (...); Mir, Jose
Article. 10.1016/j.ciresp.2009.10.012. 2010
Induced pluripotent stem cells for the treatment of liver diseases: challenges and perspectives from a clinical viewpoint
Pareja, E, Gomez-Lechon, MJ, Tolosa, L
Review. 10.21037/atm.2020.02.164. 2020
Inefficient RNA translation limits the efficacy of hydrodynamic gene transfer to pig liver "in vivo"
Sendra, L.; (...); Alino, S. F.
Article. 2013
Inhibition of VEGF expression through blockade of Hif1a and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.
Carbajo-Pescador S; (...); González-Gallego J
Article. 10.1038/bjc.2013.285. 2013
Injectable cell-laden gelatin-chondroitin sulphate hydrogels for liver in vitro models.
Sanchez-Gonzalez, E; (...); Gallego-Ferrer, G
Article. 10.1016/j.ijbiomac.2024.138693. 2024
Intestinal Microbiota Transplantation From HFD-fed and Quercetin Treated Donors Results in a Complex Metabolic Phenotype Transfer that Modulates Obesity-Related NAFLD in Germ Free Mice
Porras, D; (...); Sanchez-Campos, S
Meeting Abstract. 2017
Lifestyle changes after Inflamatory Bowel Disease diagnosis
Galipienso, O. Belen; (...); Sempere, L.
Article. 2022
Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes.
Tolosa, L; (...); Donato, MT
Article. 10.1007/s00204-018-2349-y. 2019
Long-term outcome of 'long-term liver transplant survivors'.
Rubín A; (...); Berenguer M
Article. 10.1111/tri.12118. 2013
Long-term outcomes after breast cancer liver metastasis surgery: A European, retrospective, snapshot study (LIBREAST STUDY).
Cantalejo-Diaz, Miguel; (...); Serradilla-Martin, Mario
Article. 10.1016/j.suronc.2024.102129. 2024
Low density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial Hypercholesterolemia modelling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection
Caron, J; (...); Dubart-Kupperschmitt, A
Meeting Abstract. 10.1016/S0168-8278(18)30382-9. 2018
Low RNA translation activit limits the efficacy of hydrodynamic gene transfer to pig liver in vivo
Sendra L; (...); Aliño SF
Article. 10.1002/jgm.2777. 2014
Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection.
Caron J; (...); Dubart-Kupperschmitt A
Article. 10.1186/s13287-019-1342-6. 2019
Magnetically Activated Piezoelectric 3D Platform Based on Poly(Vinylidene) Fluoride Microspheres for Osteogenic Differentiation of Mesenchymal Stem Cells
Guillot-Ferriols, Maria; (...); Gallego Ferrer, Gloria
Article. 10.3390/gels8100680. 2022
Malignization of a choledocal cyst in the adult: A rare entity
Aguilar Martí MD; (...); López Andújar R
Editorial Material. 10.1016/j.ciresp.2014.11.008. 2016
Management of the pancreatic gastrinoma associated with Von Hippel-Lindau disease. About a case
Sala-Hernandez, A; (...); Lopez-Andujar, R
Article. 10.17235/reed.2016.4224/2016. 2017
Mapping physiology: A systems biology approach for the development of alternative methods in toxicology.
Staumont, Bernard; (...); Geris, Liesbet
Article. 10.14573/altex.2412241. 2025
Mechanistic Understanding of Idiosyncratic Drug-Induced Hepatotoxicity Using Co-Cultures of Hepatocytes and Macrophages.
Villanueva-Badenas, Estela, Donato, M. Teresa, Tolosa, Laia
Article. 10.3390/antiox12071315. 2023
Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs
Gomez-Lechon, MJ, Tolosa, L, Donato, MT
Review. 10.1002/jat.3277. 2016
Metastasis of the gallbladder in clear cell renal carcinoma
Bosca Robledo, Andrea; (...); De Juan Burgueno, Manuel
Article. 10.3892/ol.2012.616. 2012
Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen.
Rodríguez-Agudo R; (...); Martínez-Chantar ML
Article. 10.3390/antiox11050897. 2022
Mimicking cell-matrix crosstalk: bioinspired gelatin hydrogels functionalized with monomeric fibronectin as a liver in vitro model
Sanchez Gonzalez, Estela; (...); Gallego Ferrer, Gloria
Meeting Abstract. 2023
Modulation of biotransformation and elimination systems by BM-21, an aqueous ethanolic extract from Thalassia testudinum, and thalassiolin B on human hepatocytes
Rodeiro, Idania; (...); Teresa Donato, Maria
Article. 10.1016/j.jff.2011.10.002. 2012
Modulation of PI3K-LXR alpha-dependent lipogenesis mediated by oxidative/nitrosative stress contributes to inhibition of HCV replication by quercetin
Pisonero-Vaquero S; (...); Sánchez-Campos S
Article. 10.1038/labinvest.2013.156. 2014
Modulation of protein synthesis and degradation maintains proteostasis during yeast growth at different temperatures
Benet, M; (...); Perez-Ortin, JE
Article. 10.1016/j.bbagrm.2017.04.003. 2017
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PIEZOELECTRIC 3D PLATFORM BASED ON HYDROGEL-POLY(VINYLIDENE FLUORIDE) MICROSPHERES FOR MESENCHYMAL STEM CELL OSTEOGENIC DIFFERENTIATION
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Silva, Silvia Gomes; (...); Cardoso, Joana
Meeting Abstract. 2024
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Validation of MELD3.0 in two centres from different continents
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Validation of MELD3.0 in two centres from different continents
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Which scope of NAM testing is sufficient for hazard characterisation? - An investigation based on transcriptomics data
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Caracterización Funcional De Hepatocitos Neonatales Criopreservados Para Su Uso En Terapia Celular Hepática
Autor/es: Rita Ortega Vallbona
Proyecto Fin de Carrera
Director/s: LAIA TOLOSA PARDO
Ensayo Multiparamétrico In Vitro Para La Evaluación De La Hepatotoxicidad Mitocondrial De Fármacos
Autor/es: Antonio Carmona Serrano
Proyecto Fin de Carrera
Director/s: LAIA TOLOSA PARDO; MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER