Efficacy of interleukin 10 gene hydrofection in pig liver vascular isolated 'in vivo' by surgical procedure with interest in liver transplantation.

Fecha de publicación: 05/11/2019

Autores de IIS La Fe

• Luis Sendra Gisbert

  Autor

• María José Herrero Cervera

  Autor

• Eva María Montalvá Orón

  Autor

• Inmaculada Noguera Salva

  Autor

• Francisco Orbis Castellanos

  Autor

• Rafael López Andújar

  Autor

• Salvador F Aliño Pellicer

  Autor

Participantes ajenos a IIS La Fe

• Díaz A
• Fernández-Delgado R

Grupos

• Farmacogenética

  Investigador Principal

  María José Herrero Cervera

• Hepatología, Cirugia Hepatobiliopancreática y Trasplantes

  

  Leader

  Marina Berenguer Haym

Abstract

Liver transplantation is the only curative strategy for final stage liver diseases. Despite the great advances achieved during the last 20 years, the recipient immune response after transplantation is not entirely controlled. This results in high rates of acute cell rejection and, approximately, 10% of early mortality. Therapeutic treatment could be improved by efficiently transfecting genes that encode natural immunosuppressant proteins, employing safe procedures that could be transferred to clinical setting. In this sense, interleukin 10 plays a central role in immune tolerance response by acting at different levels.