Portal de investigación
Susceptibility factors and non-invasive biomarkers for liver steatosis induced by valproate in pediatric epileptic patients.
Datos básicos
- Código:
- PI20/00690
- Protocolo:
- PI20/00690
- EUDRACT:
- NCT:
- Centro:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Dotación:
- 171.820,00 €
- Año de incio:
- 2021
- Año de finalización:
- 2024
Documentos
- No hay documentos
Participantes
Grupos
Financiadores - Promotores
Resultados del Ensayo Clínico
A dietary intervention with Akkermansia muciniphila and quercetin supplementation reshapes gut microbiota composition in an in vivo model of early obesity related non-alcoholic fatty liver disease
Juarez-Fernandez, M; (...); Sanchez-Campos, S
Meeting Abstract. 10.1017/S002966512100063X. 2021
A microRNA signature for valproate-induced steatosis in human hepatocytes and its application to predict fatty liver in paediatric epileptic patients on valproate therapy.
Soluyanova P; (...); Jover R
Article. 10.1016/j.tox.2024.153974. 2024
A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes.
Moreno-Torres, Marta; (...); Castell, V, Jose
Article. 10.1021/acs.jproteome.1c00779. 2022
A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: a case study on chemical-induced liver steatosis.
Verhoeven, Anouk; (...); Vanhaecke, Tamara
Article. 10.1016/j.tox.2024.153814. 2024
A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies.
Garcia-Llorens, Guillem; (...); Bort, Roque
Article. 10.1186/s13287-023-03311-w. 2023
An updated adverse outcome pathway network on chemical- induced liver steatosis
Verhoeven, A.; (...); Vanhaecke, T.
Meeting Abstract. 2023
Analysis of longitudinal metabolomic data using multivariate curve resolution-alternating least squares and pathway analysis
Ten-Domenech, Isabel; (...); Kuligowski, Julia
Article. 10.1016/j.chemolab.2022.104720. 2023
Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1
Rodriguez-Agudo, Ruben; (...); Martinez-Chantar, Maria L.
Article. 10.1016/jjhepr.2023.100918. 2024
Assessing ATR-FTIR spectroscopy for steatosis quantification in liver biopsies in a long-duration cross-sectional study
Rienda, Ivan; (...); Quintas, Guillermo
Article. 10.1016/j.microc.2024.110135. 2024
Automated generation of hiPSC-derived hepatic progeny by cost-efficient compounds.
Vanmarcke G; (...); Verfaillie CM
Article. 10.1093/stmcls/sxad065. 2023
Case Report: Novel Homozygous Likely Pathogenic SCN1A Variant With Autosomal Recessive Inheritance and Review of the Literature.
Marco Hernández AV; (...); Martinez F
Case Reports. 10.3389/fneur.2021.784892. 2021
Cluster-Partial Least Squares (c-PLS) regression analysis: Application to miRNA and metabolomic data.
Kuligowski, Julia; (...); Quintas, Guillermo
Article. 10.1016/j.aca.2023.342052. 2024
Comparing the direct assessment of steatosis in liver explants with mid- and near-infrared vibrational spectroscopy, prior to organ transplantation.
Rienda, Ivan; (...); Quintas, Guillermo
Article. 10.1039/d3an01184d. 2023
Delayed diagnosis of inflammatory bowel disease in women: Characterization and use of health resources
Sempere Robles, L.; (...); Ruiz, M. T.
Article. 2022
Derivation of healthy hepatocyte-like cells from a female patient with ornithine transcarbamylase deficiency through X-inactivation selection.
Santamaria R; (...); Bort R
Article. 10.1038/s41598-022-06184-w. 2022
Drug-Induced Fatty Liver Disease (DIFLD): A Comprehensive Analysis of Clinical, Biochemical, and Histopathological Data for Mechanisms Identification and Consistency with Current Adverse Outcome Pathways.
Lopez-Pascual, Ernesto; (...); Castell, Jose V.
Article. 10.3390/ijms25105203. 2024
Elimination of Vitamin D Signaling Causes Increased Mortality in a Model of Overactivation of the Insulin Receptor: Role of Lipid Metabolism
Crespo-Masip, Maria; (...); Manuel Valdivielso, Jose
Article. 10.3390/nu14071516. 2022
Enhancing the accuracy of mid-infrared spectroscopy-based liver steatosis quantification using digital image analysis as a reference.
Rienda, Ivan; (...); Quintas, Guillermo
Article. 10.1039/d3an00324h. 2023
Exploring Individual Variability in Drug-Induced Liver Injury (DILI) Responses through Metabolomic Analysis.
Moreno-Torres M; (...); Castell JV
Article. 10.3390/ijms25053003. 2024
Extending the Phenotype Related to SCN1A Gene: Arthrogryposis, Movement Disorders, and Malformations of Cortical Development.
Marco-Hernandez, Ana Victoria; (...); Martinez, Francisco
Article. 10.1177/08830738211072694. 2022
Extracting consistent biological information from functional results of metabolomic pathway analysis using the Mantel's test.
Ten-Doménech I; (...); Kuligowski J
Article. 10.1016/j.aca.2021.339173. 2021
Factors that influence the quality of metabolomics data in in vitro cell toxicity studies: a systematic survey.
Moreno-Torres, Marta; (...); Castell, Jose Vicente
Article. 10.1038/s41598-021-01652-1. 2021
Genetic Heterogeneity Underlying Phenotypes with Early-Onset Cerebellar Atrophy
Martinez-Rubio, Dolores; (...); Espinos, Carmen
Article. 10.3390/ijms242216400. 2023
Genetics of Paroxysmal Dyskinesia: Novel Variants Corroborate the Role of KCNA1 in Paroxysmal Dyskinesia and Highlight the Diverse Phenotypic Spectrum of KCNA1- and SLC2A1-Related Disorders
Kegele J; (...); Lauxmann S
Article. 10.3389/fneur.2021.701351. 2021
Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients.
Perez-Rubio, Alvaro; (...); Jover, Ramiro
Article. 10.3390/nu15143187. 2023
Idiosyncratic Drug-Induced Liver Injury and Amoxicillin-Clavulanate: Spotlight on Gut Microbiota, Fecal Metabolome and Bile Acid Profile in Patients.
Roman-Saguillo, Sara; (...); Sanchez-Campos, Sonia
Article. 10.3390/ijms25136863. 2024
Improving insights from metabolomic functional analysis combining multivariate tools.
Kuligowski J, Moreno-Torres M, Quintás G
Article. 10.1016/j.aca.2024.343062. 2024
In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay
Brecklinghaus, Tim; (...); Hengstler, Jan G.
Article. 10.1016/j.toxlet.2022.08.006. 2022
Lifestyle changes after Inflamatory Bowel Disease diagnosis
Galipienso, O. Belen; (...); Sempere, L.
Article. 2022
Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes
Quintas, G; (...); Castell, JV
Article. 10.1007/s00204-021-03114-z. 2021
Metabolomic Diversity of Human Milk Cells over the Course of Lactation-A Preliminary Study.
Ten-Domenech, Isabel; (...); Kuligowski, Julia
Article. 10.3390/nu15051100. 2023
Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved.
Martínez-Sena T; (...); Castell JV
Article. 10.1007/s00204-023-03474-8. 2023
Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen.
Rodríguez-Agudo R; (...); Martínez-Chantar ML
Article. 10.3390/antiox11050897. 2022
Mitochondrial developmental encephalopathy with bilateral optic neuropathy related to homozygous variants in IMMT gene.
Marco-Hernández AV; (...); Martínez-Castellano F
Article. 10.1111/cge.14093. 2022
Modeling a Novel Variant of Glycogenosis IXa Using a Clonal Inducible Reprogramming System to Generate "Diseased" Hepatocytes for Accurate Diagnosis.
Garcia-Llorens, Guillem; (...); Bort, Roque
Article. 10.3390/jpm12071111. 2022
Modulatory effects of CNNM4 on protein- l -isoaspartyl- O -methyltransferase repair function during alcohol-induced hepatic damage.
Gonzalez-Recio, Irene; (...); Martinez-Chantar, Maria Luz
Article. 10.1097/HEP.0000000000001156. 2024
Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid in human hepatocytes
Petrov, P. D.; (...); Jover, R.
Meeting Abstract. 2021
Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways.
Article. 10.1016/j.fct.2021.112664. 2021
New variants expand the neurological phenotype of COQ7 deficiency.
Fabra, Maria Alcazar; (...); Santos-Ocana, Carlos
Article. 10.1002/jimd.12776. 2024
Newserum miRNA biomarkers to predict liver steatosis by valproic acid in paediatric epileptic patients
Jover, R.; (...); Castell, J. V.
Meeting Abstract. 10.1016/j.toxlet.2022.07.200. 2022
Novel clinical phenotypes and chemical classifications in drug-induced cholestasis: analysis of a database of 390 patients developed by collaborative literature review and machine learning support
Moreno Torres, M.; (...); Jover, R.
Meeting Abstract. 2023
Novel clinical phenotypes, drug categorization, and outcome prediction in drug-induced cholestasis: Analysis of a database of 432 patients developed by literature review and machine learning support (vol 174, 116560, 2024)
Moreno-Torres, Marta; (...); Jover, Ramiro
Correction. 10.1016/j.biopha.2024.116813. 2024
Novel clinical phenotypes, drug categorization, and outcome prediction in drug-induced cholestasis: Analysis of a database of 432 patients developed by literature review and machine learning support.
Moreno-Torres M; (...); Jover R
Article. 10.1016/j.biopha.2024.116530. 2024
N-Type Ca Channel in Epileptic Syndromes and Epilepsy: A Systematic Review of Its Genetic Variants
Mayo, Sonia; (...); Martinez, Francisco
Review. 10.3390/ijms24076100. 2023
Ontology maps: data integration tools for applications in toxicology
Staumont, B.; (...); Geris, L.
Meeting Abstract. 10.1016/j.toxlet.2024.07.380. 2024
Optimization of an adverse outcome pathway network on chemical-induced cholestasis using an artificial intelligence-assisted data collection and confidence level quantification approach.
Ertvelde, Jonas van; (...); Vinken, Mathieu
Article. 10.1016/j.jbi.2023.104465. 2023
Outcomes of elective liver surgery worldwide: a global, prospective, multicenter, cross-sectional study
Malago, Massimo; (...); Andreoli, Gustavo
Article. 10.1097/JS9.0000000000000711. 2023
Physiological maps: a benchmark tool for adverse outcome pathways and a cornerstone for the development of disease ontologies
Staumont, B.; (...); Geris, L.
Meeting Abstract. 10.1016/j.toxlet.2022.07.228. 2022
Progress and challenges of mid-infrared spectroscopy for liver characterization focusing on steatosis, fibrosis and cancer
Ten-Domenech, Isabel; (...); Quintas, Guillermo
Review. 10.1080/05704928.2023.2215858. 2024
Protectiveness of NAM-based hazard assessment - which testing scope is required?
Zobl, Walter; (...); Escher, Sylvia E.
Article. 10.14573/altex.2309081. 2023
Psychological burden and quality of life in newly diagnosed inflammatory bowel disease patients.
Bernabeu P; (...); Sempere L
Article. 10.3389/fpsyg.2024.1334308. 2024
PTEN Deletion in Adult Mice Induces Hypoinsulinemia With Concomitant Low Glucose Levels.
Crespo-Masip, Maria; (...); Valdivielso, Jose Manuel
Article. 10.3389/fendo.2022.850214. 2022
Quantitative Prediction of Steatosis in Patients with Non-Alcoholic Fatty Liver by Means of Hepatic MicroRNAs Present in Serum and Correlating with Hepatic Fat
Quintas, Guillermo; (...); Jover, Ramiro
Article. 10.3390/ijms23169298. 2022
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
Gonzalez-Recio, Irene; (...); Martinez-Chantar, Maria L.
Article. 10.1038/s41467-022-34262-0. 2022
Safer chemicals using less animals: kick-off of the European ONTOX project
Vinken, M; (...); Piersma, AH
Review. 10.1016/j.tox.2021.152846. 2021
Specific metabolomic and bile acid profiles and their relationship with gut microbiota composition in patients with drug-induced liver injury
Roman-Saguillo, Sara; (...); Sanchez-Campos, Sonia
Meeting Abstract. 10.1016/S0168-8278(24)00508-7. 2024
The assessment of the potential hepatotoxicity of new drugs by in vitro metabolomics.
Quintas, Guillermo, Castell, Jose V., Moreno-Torres, Marta
Article. 10.3389/fphar.2023.1155271. 2023
The Development of a Non-Invasive Screening Method Based on Serum microRNAs to Quantify the Percentage of Liver Steatosis
Soluyanova, Polina; (...); Jover, Ramiro
Article. 10.3390/biom14111423. 2024
The effect of Holder pasteurization on the lipid and metabolite composition of human milk.
Ten-Domenech, Isabel; (...); Quintas, Guillermo
Article. 10.1016/j.foodchem.2022.132581. 2022
The in vitro assessment of the toxicity of volatile, oxidisable, redox-cycling compounds: phenols as an example
Tolosa, L; (...); Castell, JV
Article. 10.1007/s00204-021-03036-w. 2021
The LINCE Project: A Pathway for Diagnosing NCL2 Disease.
Rodrigues, Daniel; (...); Colon, Cristobal
Article. 10.3389/fped.2022.876688. 2022
The Potential Role of Metabolomics in Drug-Induced Liver Injury (DILI) Assessment.
Moreno-Torres, Marta, Quintas, Guillermo, Castell, V, Jose
Article. 10.3390/metabo12060564. 2022
The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes
Mercado-Gomez, Maria; (...); Martinez-Chantar, Maria L.
Article. 10.1038/s42003-022-03789-9. 2022
The Synbiotic Combination of Akkermansia muciniphila and Quercetin Ameliorates Early Obesity and NAFLD through Gut Microbiota Reshaping and Bile Acid Metabolism Modulation.
Juárez-Fernández M; (...); Sánchez-Campos S
Article. 10.3390/antiox10122001. 2021
Uncovering the toxicity mechanisms of a series of carboxylic acids in liver cells through computational and experimental approaches.
Ortega-Vallbona, Rita; (...); Serrano-Candelas, Eva
Article. 10.1016/j.tox.2024.153764. 2024
Using Metabolomics to Uncover Ontogeny of Drug-Induced Hepatotoxicity and Underlying AOP Mechanisms
Martinez-Sena, T.; (...); Castell Ripoll, J. V.
Meeting Abstract. 2023
Valproate and Short-Chain Fatty Acids Activate Transcription of the Human Vitamin D Receptor Gene through a Proximal GC-Rich DNA Region Containing Two Putative Sp1 Binding Sites
Moreno-Torres, Marta; (...); Jover, Ramiro
Article. 10.3390/nu14132673. 2022
Variant in CACNA1G as a Possible Genetic Modifier of Neonatal Epilepsy in an Infant with a De Novo SCN2A Mutation
Nieto-Barcelo, Juan Jose; (...); Tomas Vila, Miguel
Article. 10.1055/s-0041-1723958. 2021
Venous sinus thrombosis in pediatrics. Case series of a tertiary hospital.
Rubio Atienza Y; (...); Tomás Vila M
Article. 10.32641/andespediatr.v92i3.3344. 2021