RED DE TERAPIA CELULAR (TERCEL)
Dades bàsiques
- Codi Financador:
- RD12/0019/0025
- Any inicial:
- 2013
- Any final:
- 2017
Objectius del projecte
FAVORABLE
Documents
- No hi ha documents
Participants
-
Pilar Sepúlveda Sanchis
Investigador Principal
-
Marina Piquer Gil
Licenciado
Grups d'Investigació
Finançadors
Resultats del Projecte
Polymer Therapeutics as nano-sized medicines for Tissue Regeneration and Repair
Armiñán, Ana, PILAR SEPÚLVEDA SANCHIS, Vicent, María Jesús
Libro Completo. 2014
Conductive polycaprolactone/gelatin/polyaniline nanofibres as functional scaffolds for cardiac tissue regeneration
Gil-Castell, O.; (...); Ribes-Greus, A.
Article. 10.1016/j.reactfunctpolym.2021.105064. 2022
A Comparison of Electrospun Polymers Reveals Poly(3-Hydroxybutyrate) Fiber as a Superior Scaffold for Cardiac Repair
Castellano D; (...); Sepúlveda P
Article. 10.1089/scd.2013.0578. 2014
A Fibrosis Biomarker Early Predicts Cardiotoxicity Due to Anthracycline-Based Breast Cancer Chemotherapy
de la Fuente, Ana; (...); Ravassa, Susana
Article. 10.3390/cancers14122941. 2022
Activation of mesenchymal stem cells migration and spreading is mediated by crosslink of HIF, NOTCH and SUMO pathways
Ciria, M.; (...); Sepulveda, P.
Meeting Abstract. 2016
Allogenicity of human cardiac stem/progenitor cells orchestrated by programmed death ligand 1.
Lauden L; (...); Al-Daccak R
Article. 10.1161/CIRCRESAHA.112.276501. 2013
Analysis of Exosome Transfer in Mammalian Cells by Fluorescence Recovery after Photobleaching
Gonzalez-King, H; (...); Sepulveda, P
Article. 10.21769/BioProtoc.2692. 2018
Anthracycline mediated cardiotoxicity: Detection of miRNA based early biomarkers for the prediction of myocardial injury. Hecatos study
Coloma, C. Salvador; (...); Santaballa, A.
Meeting Abstract. 10.1093/annonc/mdw365.69. 2016
Aortic arch dilation in bicuspid aortic valve disease: Predictive factors and medium-term follow-up
Berbel, A; (...); Montero, JA
Article. 10.1016/j.circv.2016.11.056. 2017
ATR-FTIR spectroscopy for the routine quality control of exosome isolations
Ramos-Garcia, V; (...); Kuligowski, J
Article. 10.1016/j.chemolab.2021.104401. 2021
Atypical presentation of a giant atrial myxoma
Dominguez-Massa, C, Bel-Minguez, AM, Montero-Argudo, JA
Article. 10.1016/j.circv.2017.07.003. 2018
Balance of Active, Passive, and Anatomical Cardiac Properties in Doxorubicin-Induced Heart Failure.
Lewalle A; (...); Niederer SA
Article. 10.1016/j.bpj.2019.07.033. 2019
Cardiac Cell Therapy: Boosting Mesenchymal Stem Cells Effects
Samper, E; (...); PILAR SEPÚLVEDA SANCHIS
Article. 2013
Cardiac cell therapy: boosting mesenchymal stem cells effects.
Samper E; (...); Sepúlveda P
Article. 10.1007/s12015-012-9353-z. 2013
Cardiomyocyte exosomes regulate glycolytic flux in endothelium by direct transfer of GLUT transporters and glycolytic enzymes
Garcia NA; (...); Diez-Juan A
Article. 10.1093/cvr/cvv260. 2016
Cardiopulmonary Rehabilitation Improves Respiratory Muscle Function and Functional Capacity in Children with Congenital Heart Disease. A Prospective Cohort Study
Ferrer-Sargues FJ; (...); Iranzo, MACI
Article. 10.3390/ijerph17124328. 2020
CFD analysis of the HVAD's hemodynamic performance and blood damage with insight into gap clearance
Gil A; (...); Montero JA
Article. 10.1007/s10237-022-01585-2. 2022
Circulating exosomes deliver free fatty acids from the bloodstream to cardiac cells: Possible role of CD36
Garcia, NA; (...); Sepulveda, P
Article. 10.1371/journal.pone.0217546. 2019
Clonal Hematopoiesis Landscape in Patients with De Novo Acute Myeloid Leukemia By Deep Sequencing
Ibanez, Mariam; (...); Cervera, Jose
Meeting Abstract. 10.1182/blood.V128.22.598.598. 2016
Co-administration of human MSC overexpressing HIF-1a increases human CD34(+) cell engraftment in vivo.
Preciado S; (...); Sánchez-Guijo F
Article. 10.1186/s13287-021-02669-z. 2021
Corrigendum to "Plasmatic Membrane Expression of Adhesion Molecules in Human Cardiac Progenitor/Stem Cells Might Explain Their Superior Cell Engraftment after Cell Transplantation".
Ontoria-Oviedo I; (...); Sepúlveda P
Correction. 10.1155/2022/9786160. 2022
Changes in human skin composition due to intrinsic aging: a histologic and morphometric study.
Arnal-Forne, Marta; (...); Ruiz-Sauri, Amparo
Article. 10.1007/s00418-024-02305-w. 2024
Characterisation of iPSCs from a patient with transposition of the great arteries
Ontoria-Oviedo, I; (...); Sepulveda, P
Meeting Abstract. 2017
Characterization of hiPSC-CMs derived from pediatric cancer patients treated with anthracyclines that suffered cardiotoxicity
Reinal, I.; (...); Sepulveda, P.
Meeting Abstract. 2021
Diagnostic preformance of mass spectometry metabolomics for assessment of early myocardial ischemia
Munoz, B. Igual; (...); Sepulveda-Sanchis, P. S. S.
Meeting Abstract. 2016
Differential Gene Expression of Cardiac Ion Channels in Human Dilated Cardiomyopathy
Micaela Molina-Navarro, Maria; (...); Rivera, Miguel
Article. 2013
Differential gene expression of cardiac ion channels in human dilated cardiomyopathy.
Molina-Navarro MM; (...); Rivera M
Article. 10.1371/journal.pone.0079792. 2013
Dissected aberrant right subclavian artery with Kommerell diverticulum.
Domínguez-Massa C; (...); Montero-Argudo JA
Article. 10.1016/j.repc.2017.07.023. 2019
Early detection of chemotherapy-induced cardiotoxicity in breast cancer patients
Salvador-Coloma, C; (...); Santaballa, A
Meeting Abstract. 2018
Electrospun poly(hydroxybutyrate) scaffolds promote engraftment of human skin equivalents via macrophage M2 polarization and angiogenesis
Castellano, D; (...); Ontoria-Oviedo, I
Article. 10.1002/term.2420. 2018
Estudio comparativo de los cambios funcionales y estructurales producidos en un modelo porcino de infarto de miocardio agudo y cronico.
Hernándiz A; (...); Sepúlveda P
Article. 10.1016/j.acmx.2015.09.009. 2016
Evaluation of the efficacy and safety of lanreotide in combination with targeted therapies in patients with neuroendocrine tumours in clinical practice: a retrospective cross-sectional analysis
Capdevila J; (...); García Alfonso P
Article. 10.1186/s12885-015-1512-6. 2015
EVs derived from HIF-overexpressing MSC primed with a pro-inflammatory cocktail promote M2 macrophage polarization and reduce fibrosis and endothelium activation in vitro and in a mouse ulcerous colitis model.
Gomez-Ferrer, M.; (...); Sepulveda, P.
Meeting Abstract. 2021
Experience, outcomes and impact of delayed indication for video-assisted wide septal myectomy in 69 consecutive patients with hypertrophic cardiomyopathy.
Heredia Cambra T; (...); Montero Argudo JA
Article. 10.1093/ejcts/ezt050. 2013
Extracellular vesicles from dental pulp mesenchymal stem cells modulate macrophage phenotype during acute and chronic cardiac inflammation in athymic nude rats with myocardial infarction.
Amaro-Prellezo, Elena; (...); Sepulveda, Pilar
Article. 10.1186/s41232-024-00340-7. 2024
Extracellular Vesicles Secreted by Hypoxic AC10 Cardiomyocytes Modulate Fibroblast Cell Motility.
Ontoria-Oviedo, I; (...); Sepulveda, P
Article. 10.3389/fcvm.2018.00152. 2018
Extrathoracic Aneurysms in Marfan Syndrome: A Systematic Review of the Literature.
Requejo-Garcia, Lucia; (...); Miralles-Hernandez, Manuel
Article. 10.1016/j.avsg.2022.08.005. 2022
Genotype FBN1/Phenotype relationship in a cohort of patients with Marfan syndrome.
Hernándiz A; (...); Sepúlveda P
Article. 10.1111/cge.13879. 2020
Giant Circumflex Aneurysm with Arteriovenous Fistula Surgery Guided by Three-dimensional Printing.
Blanco-Herrera OR; (...); Montero-Argudo JA
Editorial Material. 10.1016/j.athoracsur.2019.11.051. 2020
Glucose Starvation in Cardiomyocytes Enhances Exosome Secretion and Promotes Angiogenesis in Endothelial Cells
Garcia NA; (...); Sepúlveda P
Article. 10.1371/journal.pone.0138849. 2015
GMP manufacturing process for allogeneic cell therapy treatment of acute myocardial infarction
Palacios, I.; (...); Rodriguez-Borlado, L.
Article. 2013
Heart failure entails significant changes in human nucleocytoplasmic transport gene expression.
Molina-Navarro MM; (...); Rivera M
Article. 10.1016/j.ijcard.2013.03.192. 2013
HIF-1 alpha and Pro-Inflammatory Signaling Improves the Immunomodulatory Activity of MSC-Derived Extracellular Vesicles
Gomez-Ferrer, M; (...); Dorronsoro, A
Article. 10.3390/ijms22073416. 2021
HIF-Overexpression and Pro-Inflammatory Priming in Human Mesenchymal Stromal Cells Improves the Healing Properties of Extracellular Vesicles in Experimental Crohn's Disease.
Gómez-Ferrer M; (...); Sepúlveda P
Article. 10.3390/ijms222011269. 2021
Histological Differentiation Provides Useful, Additive and Independent Prognostic Information to Proliferation Index in G2 and G3 Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs)
Canovas, MS; (...); Garcia-Carbonero, R
Meeting Abstract. 2017
Hydrogen Sulfide Improves Cardiomyocyte Function in a Cardiac Arrest Model
Garcia, NA; (...); Sepulveda, P
Article. 10.12659/AOT.901410. 2017
Hypoxia Inducible Factor-1 alpha Potentiates Jagged 1-Mediated Angiogenesis by Mesenchymal Stem Cell-Derived Exosomes
Gonzalez-King, H; (...); Sepulveda, P
Article. 10.1002/stem.2618. 2017
Hypoxia-inducible factor 1 alpha contributes to cardiac healing in mesenchymal stem cells-mediated cardiac repair.
Cerrada I; (...); Sepúlveda P
Article. 10.1089/scd.2012.0340. 2013
Identification of omega-3 oxylipins in human milk-derived extracellular vesicles with pro-resolutive actions in gastrointestinal inflammation.
Gómez-Ferrer M; (...); Sepúlveda P
Article. 10.3389/fimmu.2023.1293737. 2023
IFN gamma Regulates Activated V delta 2+T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells
Fechter, K; (...); Trigueros, C
Article. 10.1371/journal.pone.0169362. 2017
In vitro model of atrial fibrillation: investigating the initiation and maintenance mechanisms of atrial remodeling using hiPSC-derived atrial cardiomyocytes
Casini, M.; (...); Sepulveda, P.
Meeting Abstract. 2023
In vitro validation of biomedical polyester-based scaffolds: Poly(lactide-co-glycolide) as model-case
Gil-Castell, O; (...); Ribes-Greus, A
Article. 10.1016/j.polymertesting.2018.01.027. 2018
Incidence of Development of Obesity After Heart Transplantation According to the Calcineurin Inhibitor
López-Vilella R; (...); Montero-Argudo A
Article. 10.1016/j.transproceed.2014.11.025. 2015
Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans - joint RENEB and EURADOS inter-laboratory comparisons
Ainsbury, E; (...); Woda, C
Article. 10.1080/09553002.2016.1206233. 2017
Intracellular role of IL - 6 in mesenchymal stromal cell immunosuppression and proliferation
Dorronsoro, Akaitz; (...); Trigueros C
Article. 2020
Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation.
Dorronsoro, Akaitz; (...); Trigueros, Cesar
Article. 10.1038/s41598-020-78864-4. 2020
Involvement of the-420C > G RETN polymorphism in myocardial fibrosis in patients with hypertrophic cardiomyopathy
Hernández-Romero D; (...); Marín F
Article. 10.1111/joim.12334. 2015
Isolation and Lipidomic Screening of Human Milk Extracellular Vesicles.
Ramos-Garcia, Victoria; (...); Kuligowski, Julia
Article. 10.1007/978-1-0716-2699-3_18. 2023
Isolation of extracellular vesicles derived from mesenchymal stem cells by ultracentrifugation and tangential flow filtration followed by size-exclusion chromatography: a functional comparison
Amaro-Prellezo, E.; (...); Sepulveda, P.
Meeting Abstract. 2021
Mesenchymal Stem Cell Migration and Proliferation Are Mediated by Hypoxia-Inducible Factor-1 alpha Upstream of Notch and SUMO Pathways
Ciria, M; (...); Sepulveda, P
Article. 10.1089/scd.2016.0331. 2017
Metabolic syndrome in heart transplantation: impact on survival and renal function.
Martínez-Dolz L; (...); Montero JA
Article. 10.1111/tri.12149. 2013
Metabolomic changes in the rat retina after optic nerve crush.
Agudo-Barriuso M; (...); Mullor JL
Article. 10.1167/iovs.12-11451. 2013
MICRORNA EXPRESSION PROFILE IN EPICARDIAL FAT IN SUDDEN CARDIAC DEATH FROM CORONARY ARTERY DISEASE
Braza-Boils, A.; (...); Zorio, E.
Article. 2014
miR-133a Enhances the Protective Capacity of Cardiac Progenitors Cells after Myocardial Infarction
Izarra A; (...); Bernad A
Article. 10.1016/j.stemcr.2014.10.010. 2014
miR-4732-3p in Extracellular Vesicles From Mesenchymal Stromal Cells Is Cardioprotective During Myocardial Ischemia
Sánchez-Sánchez R; (...); Sepúlveda P
Article. 10.3389/fcell.2021.734143. 2021
miRNA-4732-3p as a possible therapeutic tool for the treatment of myocardial ischemia
Sanchez-Sanchez, R.; (...); Sepulveda, P.
Meeting Abstract. 2021
Mitral repair results in endocarditis
Dominguez-Massa, C; (...); Montero-Argudo, JA
Article. 10.1016/j.circv.2020.08.005. 2020
Modeling Cardiotoxicity in Pediatric Oncology Patients Using Patient-Specific iPSC-Derived Cardiomyocytes Reveals Downregulation of Cardioprotective microRNAs.
Reinal, Ignacio; (...); Sepulveda, Pilar
Article. 10.3390/antiox12071378. 2023
Modeling Transposition of the Great Arteries with Patient-Specific Induced Pluripotent Stem Cells.
Ontoria-Oviedo, Imelda; (...); Sepulveda, Pilar
Article. 10.3390/ijms222413270. 2021
Mortality risk score in aortic surgery. Initial experience with the implementation of a new predictive model
Berbel, A; (...); Montero, JA
Article. 10.1016/j.circv.2014.10.009. 2015
Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds.
Verheijen, Marcha; (...); HeCaToS Consortium
Article. 10.1038/s41597-022-01825-1. 2022
New Cell Adhesion Molecules in Human Ischemic Cardiomyopathy. PCDHGA3 Implications in Decreased Stroke Volume and Ventricular Dysfunction
Ortega, Ana; (...); Rosello-Lleti, Esther
Article. 10.1371/journal.pone.0160168. 2016
Non-classical Notch signaling by MDA-MB-231 breast cancer cell-derived small extracellular vesicles promotes malignancy in poorly invasive MCF-7 cells.
Gonzalez-King, Hernan; (...); Garcia, Nahuel A.
Article. 10.1038/s41417-021-00411-8. 2022
Normalization approaches for extracellular vesicle-derived lipidomic fingerprints - A human milk case study
Ten-Domenech, Isabel; (...); Kuligowski, Julia
Article. 10.1016/j.chemolab.2024.105070. 2024
Notch ligand Jagged 1 in MSC-HIF exosomes and its angiogenic potential
Gonzalez-King, H.; (...); Sepulveda, P.
Meeting Abstract. 2016
Oncostatin M-Enriched Small Extracellular Vesicles Derived from Mesenchymal Stem Cells Prevent Isoproterenol-Induced Fibrosis and Enhance Angiogenesis.
Tejedor, Sandra; (...); Sepulveda, Pilar
Article. 10.3390/ijms24076467. 2023
Optimization of Mesenchymal Stromal Cell (MSC) Manufacturing Processes for a Better Therapeutic Outcome
Fernandez-Santos, Maria Eugenia; (...); Zapata, Agustin G.
Article. 10.3389/fimmu.2022.918565. 2022
Over-Expression of HIF-1A In Mesenchymal Stromal Cells Increases Human CD34+Cells Clonogenic Capacity in Vitro And Engraftment Ability in A Xenotransplantation Model
Preciado, S; (...); Sanchez-Guijo, F
Meeting Abstract. 2021
Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells
Martinez, VG; (...); Vicente, A
Article. 10.1186/s13287-017-0659-2. 2017
Oxylipin profile of human milk and human milk-derived extracellular vesicles.
Albiach-Delgado, Abel; (...); Quintas, Guillermo
Article. 10.1016/j.aca.2024.342759. 2024
Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice.
Lerida-Viso, Araceli; (...); Martinez-Manez, Ramon
Article. 10.1016/j.phrs.2022.106356. 2022
Plasmatic Membrane Expression of Adhesion Molecules in Human Cardiac Progenitor/Stem Cells Might Explain Their Superior Cell Engraftment after Cell Transplantation.
Ontoria-Oviedo I; (...); Sepúlveda P
Article. 10.1155/2020/8872009. 2020
Platelet rich plasma and plasma rich in growth factors for split-thickness skin graft donor site treatment in the burn patient setting: A randomized clinical trial.
García-Sánchez JM; (...); Pérez-Del-Caz MD
Article. 10.1016/j.burns.2021.10.001. 2021
Podocalyxin-like protein 1 is a relevant marker for human c-kit(pos) cardiac stem cells
Moscoso I; (...); Bernad A
Article. 10.1002/term.1795. 2016
Polycaprolactone/gelatin-based scaffolds with tailored performance: in vitro and in vivo validation
Gil-Castell, O; (...); Ribes-Greus, A
Article. 10.1016/j.msec.2019.110296. 2020
Polymer Conjugation of Docosahexaenoic Acid Potentiates Cardioprotective Therapy in Preclinical Models of Myocardial Ischemia/Reperfusion Injury.
Tejedor S; (...); Vicent MJ
Article. 10.1002/adhm.202002121. 2021
Postoperative prognostic impact of replacement fibrosis in patients with aortic valve stenosis
Munoz, BI; (...); Serrano, RP
Meeting Abstract. 2020
Potency of Human Cardiosphere-Derived Cells from Patients with Ischemic Heart Disease Is Associated with Robust Vascular Supportive Ability
Harvey, E; (...); Martin-Rendon, E
Article. 10.1002/sctm.16-0229. 2017
Priorities in Cardio-Oncology Basic and Translational Science: GCOS 2023 Symposium Proceedings: JACC: CardioOncology State-of-the-Art Review.
Salloum FN; (...); López-Fernández T
Article. 10.1016/j.jaccao.2023.08.003. 2023
Prognostic Significance of Venous Thromboembolic Events in Disseminated Germ Cell Cancer Patients
Gonzalez-Billalabeitia, E; (...); Spanish Germ Cell Cancer Group
Article. 10.1093/jnci/djw265. 2017
Prognostic value and clinical predictors of intramyocardial hemorrhage measured by CMR T2* sequences in STEMI.
Ferré-Vallverdú M; (...); Igual-Muñoz B
Article. 10.1007/s10554-020-02142-7. 2021
Reliable assessment of carbon black nanomaterial of a variety of cell culture media for in vitro toxicity assays by asymmetrical flow field-flow fractionation.
Boughbina-Portoles, Aaron; (...); Campins-Falco, Pilar
Article. 10.1007/s00216-023-04597-8. 2023
RNA Sequencing Analysis and Atrial Natriuretic Peptide Production in Patients with Dilated and Ischemic Cardiomyopathy
Tarazón E; (...); Portolés M
Article. 10.1371/journal.pone.0090157. 2014
RNA-sequencing analysis reveals new alterations in cardiomyocyte cytoskeletal genes in patients with heart failure
Herrer I; (...); Portolés M
Article. 10.1038/labinvest.2014.54. 2014
SERCA2a as non-invasive biomarker of heart transplant rejection
Rosello-Lleti, EE; (...); Rivera, M
Meeting Abstract. 2017
Short-term mechanical circulatory support
Bertolin, LD, Puerta, ST, Argudo, JAM
Article. 10.1016/j.circv.2016.06.007. 2016
Subtype-specific differentiation of atrial and ventricular cardiomyocytes from human iPSCs
Casini, M.; (...); Sepulveda, P.
Meeting Abstract. 2021
Sum of effects of myocardial ischemia followed by electrically induced tachycardia on myocardial function.
Díez JL; (...); Portolés M
Article. 10.12659/MSMBR.889115. 2013
Takeuchi technique in the anomalous origin of the left coronary artery from the pulmonary artery.
Domínguez-Massa C; (...); Hornero-Sos F
Article. 10.24875/ACME.M19000044. 2019
Targeted Disruption of the SUCNR1 Metabolic Receptor Leads to Dichotomous Effects on Obesity
McCreath KJ; (...); Cervera AM
Article. 10.2337/db14-0346. 2015
Tecnica de Takeuchi en el origen anmalo de la arteria coronaria izquierda de la arteria pulmonar.
Domínguez-Massa C; (...); Hornero-Sos F
Article. 10.24875/ACM.M19000033. 2019
The combination of cell and gene therapy as new generation tool to boost MSCs immunosuppressive and tissue regeneration properties
Dorronsoro, A; (...); Sepulveda, P
Meeting Abstract. 2017
The morphology and primary lesion of the bicuspid aortic valve determines the aortic disease pattern
Hernandez, CE; (...); Montero, JA
Article. 10.1016/j.circv.2011.11.002. 2015
The Vascular Niche for Adult Cardiac Progenitor Cells.
Herrero, Diego; (...); Bernad, Antonio
Article. 10.3390/antiox11050882. 2022
Time evolution of in vivo articular cartilage repair induced by bone marrow stimulation and scaffold implantation in rabbits
Sancho-Tello M; (...); Carda C
Article. 10.5301/ijao.5000404. 2015
Topical Administration of a Marine Oil Rich in Pro-Resolving Lipid Mediators Accelerates Wound Healing in Diabetic db/db Mice through Angiogenesis and Macrophage Polarization.
Ontoria-Oviedo, Imelda; (...); Sepulveda, Pilar
Article. 10.3390/ijms23179918. 2022
Treatment of Hepatic Embryonal Undifferentiated Sarcoma With Cardiothoracic Involvement.
Domínguez-Massa C; (...); Montero-Argudo JA
Article. 10.1177/2150135118775411. 2020
TWEAK and NT-proBNP levels predict exercise capacity in hypertrophic cardiomyopathy
Hernández-Romero D; (...); Marín F
Article. 10.1111/eci.12394. 2015
Two-component Peptidic Molecular Gels for Topical Drug Delivery of Naproxen
Martí-Centelles, Rosa; (...); Escuder, Beatriu
Article. 10.1021/acsabm.0c01422. 2021
Use of a "CNI holidays" strategy in acute renal dysfunction late after heart transplant. Report of two cases.
Article. 2014
Use of an electrospun bioveil is safe and does not decrease skin graft take on burn wounds: A randomised, controlled clinical trial.
Perez-Del-Caz, Maria Dolores; (...); Perez-Plaza, Aranzazu
Article. 10.1016/j.burns.2025.107427. 2025