Portal de investigación
IFN gamma Regulates Activated V delta 2+T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Fechter, K
- Jakobsson, E
- Ferrin, I
- Lang, V
- Pennington, DJ
- Trigueros, C
Grupos
Abstract
gamma delta T cells play a role in a wide range of diseases such as autoimmunity and cancer. The majority of circulating human gamma delta T lymphocytes express a V gamma 9V delta 2+ (V delta 2+) T cell receptor (TCR) and following activation release pro-inflammatory cytokines. In this study, we show that IFN gamma, produced by V delta 2+ cells, activates mesenchymal stem cell (MSC)-mediated immunosupression, which in turn exerts a negative feedback mechanism on gamma delta T cell function ranging from cytokine production to proliferation. Importantly, this modulatory effect is limited to a short period of time (<24 hours) post-T cell activation, after which MSCs can no longer exert their immunoregulatory capacity. Using genetically modified MSCs with the IFNy receptor 1 constitutively silenced, we demonstrate that IFN gamma is essential to this process. Activated gamma delta T cells induce expression of several factors by MSCs that participate in the depletion of amino acids. In particular, we show that indolamine 2,3-dioxygenase (IDO), an enzyme involved in L-tryptophan degradation, is responsible for MSC -mediated immunosuppression of V delta 2+ T cells. Thus, our data demonstrate that gamma delta T cell responses can be immuno-modulated by different signals derived from MSC.
Datos de la publicación
- ISSN/ISSNe:
- 1932-6203, 1932-6203
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 28076364
- Factor de Impacto:
- 1,164 SCImago ℠
PLoS One PUBLIC LIBRARY SCIENCE
Citas Recibidas en Web of Science: 8
Documentos
- No hay documentos
Filiaciones
Keywords
- DELTA T-CELLS; INTERFERON-GAMMA; STROMAL CELLS; INDOLEAMINE 2,3-DIOXYGENASE; LYMPHOCYTE-PROLIFERATION; CYTOKINE ANALYSIS; DENDRITIC CELLS; RESPONSES; ENCEPHALOMYELITIS; CYTOTOXICITY
Campos de Estudio
Cita
Fechter K,DORRONSORO A,Jakobsson E,Ferrin I,Lang V,SEPULVEDA P,Pennington DJ,Trigueros C. IFN gamma Regulates Activated V delta 2+T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells. PLoS One. 2017. 12. (1):e0169362. IF:2,766. (1).