CFD analysis of the HVAD's hemodynamic performance and blood damage with insight into gap clearance

Data de publicació: 01/05/2022 Data Ahead of Print: 01/05/2022

Autors de IIS La Fe

José Anastasio Montero Argudo

Autor

Autors aliens a IIS La Fe

Gil A
Navarro R
Quintero P
Mares A
Pérez M

Grups d'Investigació

Regeneración y Trasplante Cardíaco

Leader

Pilar Sepúlveda Sanchis

Abstract

Mechanical circulatory support using ventricular assist devices has become commonplace in the treatment of patients suffering from advanced stages of heart failure. While blood damage generated by these devices has been evaluated in depth, their hemodynamic performance has been investigated much less. This work presents the analysis of the complete operating map of a left ventricular assist device, in terms of pressure head, power and efficiency. Further investigation into its hemocompatibility is included as well. To achieve these objectives, computational fluid dynamics simulations of a centrifugal blood pump with a wide-blade impeller were performed. Several conditions were considered by varying the rotational speed and volumetric flow rate. Regarding the device's hemocompatibility, blood damage was evaluated by means of the hemolysis index. By relating the hemocompatibility of the device to its hemodynamic performance, the results have demonstrated that the highest hemolysis occurs at low flow rates, corresponding to operating conditions of low efficiency. Both performance and hemocompatibility are affected by the gap clearance. An innovative investigation into the influence of this design parameter has yielded decreased efficiencies and increased hemolysis as the gap clearance is reduced. As a further novelty, pump operating maps were non-dimensionalized to highlight the influence of Reynolds number, which allows their application to any working condition. The pump's operating range places it in the transitional regime between laminar and turbulent, leading to enhanced efficiency for the highest Reynolds number.

Dades de la publicació

ISSN/ISSNe:: 1617-7959, 1617-7940
Tipus:: Article
Pàgines:: 1201-1215
DOI:: 10.1007/s10237-022-01585-2
PubMed:: 35546646
Factor d'Impacte:: 0,761 SCImago ℠
Quartil:: Q1 SCImago ℠

Documents

No hi ha documents

Mètriques

Filiacions

Gil A:: 1CMT-Motores Térmicos, Universitat Politècnica de València, Camí de Vera, s/n, 46022, Valencia, Spain.
Navarro R:: 1CMT-Motores Térmicos, Universitat Politècnica de València, Camí de Vera, s/n, 46022, Valencia, Spain.
Quintero P:: 1CMT-Motores Térmicos, Universitat Politècnica de València, Camí de Vera, s/n, 46022, Valencia, Spain.
Mares A:: 2CMT-Motores Térmicos, Universitat Politècnica de València, Camí de Vera, s/n, 46022, Valencia, Spain.
Pérez M:: 3Servicio de Cirugía Cardíaca, Hospital Universitario La Fe, Avinguda de Fernando Abril Martorell, 106, 46026, Valencia, Spain.
Montero JA:: 3Servicio de Cirugía Cardíaca, Hospital Universitario La Fe, Avinguda de Fernando Abril Martorell, 106, 46026, Valencia, Spain.