CARACTERIZACIÓN FARMACOCINÉTICA DE LA POBLACIÓN CON HEMOFILIA A EN ESPAÑA, UTILIZANDO UNA APLICACIÓN MÉDICA ONLINE BASADA EN UN MODELO POBLACIONAL PUBLICADO Y UN ALGORITMO BAYESIANO.

Datos básicos

Código:
STH-OCT-2016-01
Protocolo:
STH-OCT-2016-01
EUDRACT:
NCT:
Centro:
HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
Dotación:
Año de incio:
2019
Año de finalización:
2020
ESTUDIO OBSERVACIONAL NACIONAL

Documentos

  • No hay documentos

Participantes

Grupos

Financiadores - Promotores

FUNDACIÓN ESPAÑOLA DE TROMBOSIS Y HEMOSTASIA

Resultados del Ensayo Clínico


"In Vitro" Evaluation of Energy-Based Sealing of Graft Side Branches in Bypass Surgery.

Miralles, Manuel; (...); Clara, Albert

Article. 10.1007/s00268-023-07107-0. 2023


[Translated article] New challenges in advanced therapies.

Megías-Vericat JE; (...); Poveda Andrés JL

Article. 10.1016/j.farma.2024.05.001. 2024

  • Open Access.

[Translated article] Pharmacokinetic-guided switching from standard half-life factor VIII to extended half-life pegylated factor VIII in haemophilia A therapy in clinical practice.

Chovi-Trull, Maria; (...); Andres, Jose Luis Poveda

Article. 10.1016/j.farma.2024.12.007. 2025


A phase I trial of selinexor plus FLAG-Ida for the treatment of refractory/relapsed adult acute myeloid leukemia patients

Sanchez, MPM; (...); Montesinos, P

Article. 10.1007/s00277-021-04542-8. 2021


A post hoc comparative real-world analysis of HEAD-US score for joint health assessment of patients with severe haemophilia A and B in Spain

Alvarez-Roman, Maria Teresa; (...); Kim, Hae Kyung

Article. 10.1111/hae.14924. 2024


A predictive model for prostate cancer incorporating PSA molecular forms and age.

Oto J; (...); Navarro S

Article. 10.1038/s41598-020-58836-4. 2020

  • Open Access.

A Series of 14 Polish Patients with Thrombotic Events and PC Deficiency-Novel c.401-1G>A PROC Gene Splice Site Mutation in a Patient with Aneurysms.

Weronska A; (...); Wypasek E

Article. 10.3390/genes13050733. 2022

  • Open Access.

Activated protein C assays: a review.

Oto J; (...); Medina P

Review. 10.1016/j.cca.2019.11.005. 2020


Adherence to prophylaxis in adult patients with severe haemophilia A

Bonanad, S; (...); Alvarez, M

Meeting Abstract. 2019


Adherence to prophylaxis in adult patients with severe haemophilia A

Bonanad, S; (...); Alvarez, MP

Article. 10.1111/hae.14039. 2020


alpha(2)-Macroglobulin Is a Significant In Vivo Inhibitor of Activated Protein C and Low APC: alpha M-2 Levels Are Associated with Venous Thromboembolism

Martos, L; (...); Medina, P

Article. 10.1055/s-0038-1629902. 2018

  • Open Access.

ANALYSIS OF THE USE OF MOBILE APPLICATIONS IN PATIENTS WITH HAEMOPHILIA AFTER TWO YEARS OF FOLLOW-UP

Megias Vericat, J. E.; (...); Bonanad Boix, S.

Meeting Abstract. 2019

  • Open Access.

Applicability of the Thrombin Generation Test to Evaluate the Hemostatic Status of Hemophilia A Patients in Daily Clinical Practice

Bernardo, Angel; (...); Medina, Pilar

Article. 10.3390/jcm11123345. 2022

  • Open Access.

Assessment of haemophilic arthropathy through balance analysis: a promising tool

Garcia-Masso, X; (...); Gonzalez, LM

Article. 10.1080/10255842.2018.1561877. 2019

  • Open Access.

Assessment of Kinect V2 for elbow range of motion estimation in people with haemophilia using an angle correction model

Mateo, F; (...); Perez-Alenda, S

Article. 10.1111/hae.13744. 2019


Association of Vitamin K and Non-Vitamin K Oral Anticoagulant Use and Cancer Incidence in Atrial Fibrillation Patients

Iftimi AA; (...); Sanfélix-Gimeno G

Article. 10.1002/cpt.2362. 2021

  • Open Access.

Baricitinib against severe COVID-19: effectiveness and safety in hospitalised pretreated patients.

Iglesias Gómez R; (...); Poveda Andrés JL

Article. 10.1136/ejhpharm-2021-002741. 2021

  • Open Access.

Bayesian pharmacokinetic individualization of prophylaxis with recombinant factor VIII in severe or moderate hemophilia A

Megias-Vericat, JE; (...); Bonanad, S

Meeting Abstract. 2018


Bayesian pharmacokinetic-guided prophylaxis with recombinant factor VIII in severe or moderate haemophilia A

Megias-Vericat, JE; (...); Poveda, JL

Article. 10.1016/j.thromres.2018.12.027. 2019


Benefits of Ehl Factor VIII Replacement Therapy in Hemophilia: Observations on Coverage, Physical Activity and Phisiotherapy

Querol, Felipe; (...); Bonanad Boix, Santiago

Meeting Abstract. 10.1182/blood-2019-125651. 2019


Benefits of physical activity self-monitoring in patients with haemophilia: a prospective study with one-year follow-up.

Pérez-Alenda S; (...); Núñez-Cortés R

Article. 10.1111/hae.14988. 2024

  • Open Access.

Biomarkers of venous thromboembolism recurrence after discontinuation of anticoagulation for cancer-associated thrombosis (HISPALIS study)

Candelera, RO; (...); Badenes, PM

Meeting Abstract. 2021


Biomarkers of Venous Thromboembolism Recurrence after Discontinuation of Low Molecular Weight Heparin Treatment for Cancer-Associated Thrombosis (HISPALIS-Study).

Otero, Remedios; (...); Medina, Pilar

Article. 10.3390/cancers14112771. 2022

  • Open Access.

Bladder cancer patients have increased NETosis and impaired DNaseI-mediated NET degradation that can be therapeutically restored in vitro.

Herranz R; (...); Medina P

Article. 10.3389/fimmu.2023.1171065. 2023

  • Open Access.

Calprotectin as a new inflammatory marker of abdominal aortic aneurysm: A pilot study.

Plana E; (...); Miralles M

Article. 10.1177/1358863X241231494. 2024


Cerebral calcium embolism.

Asensi Canto, Pedro; (...); Bonanad Boix, Santiago

Article. 10.1002/ccr3.4962. 2022

  • Open Access.

Circulating Cell-Free DNA in Liquid Biopsies as Potential Biomarker for Bladder Cancer: A Systematic Review

Herranz, R; (...); Medina, P

Review. 10.3390/cancers13061448. 2021

  • Open Access.

Clinical and molecular characterization by next generation sequencing of Spanish patients affected by congenital deficiencies of fibrinogen.

Moret, A; (...); Bonanad, S

Letter. 10.1016/j.thromres.2019.06.015. 2019


CLINICAL AND MOLECULAR CHARACTERIZATION BY SEQUENCING OF NEW GENERATION OF PATIENTS AFFECTED BY FIBRINOGEN CONGENITAL DEFICIENCIES

Moret, A.; (...); Bonanad, S.

Meeting Abstract. 2019

  • Open Access.

Clinical benefits of a Bayesian model for plasma-derived factor VIII/VWF after one year of pharmacokinetic-guided prophylaxis in severe/moderate hemophilia A patients

Megias-Vericat, JE; (...); Poveda, JL

Article. 10.1016/j.thromres.2021.07.009. 2021


CLINICAL VALIDATION OF THE SPECIFIC POPULATION MODEL OF FACTOR VIII/FVW PLASMA USING WAPPS-HEMO

Megias Vericat, J. E.; (...); Poveda, A. J. L.

Meeting Abstract. 2019

  • Open Access.

Clinical, pharmacokinetic and economic analysis of the first switch to an extended half-life factor IX (albutrepenonacog alfa, rFIX-FP) in Spain.

Rodríguez López M; (...); Bonanad S

Article. 10.1136/bcr-2019-234142. 2020


Collaborative model of home delivery program in haemophilia through an association of patients

Megias-Vericat, JE; (...); Bonanad, S

Meeting Abstract. 2018


Common Genetic Variants in ABO and CLEC4M Modulate the Pharmacokinetics of Recombinant FVIII in Severe Hemophilia A Patients.

Garcia-Martínez I; (...); Vidal F

Article. 10.1055/s-0040-1714214. 2020


Comparative analysis of Hemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) scores in persons with nonsevere hemophilia A and B reveals a high degree of joint damage in both disease types

Jimenez-Yuste, Victor; (...); Kim, Hae Kyung

Letter. 10.1016/j.rpth.2023.102207. 2023

  • Open Access.

Comparison of pharmacokinetic estimates using generic and specific population pharmacokinetic models of plasma-derived factor VIII/VWF using WAPPS-Hemo

Megias-Vericat, JE; (...); Poveda, JL

Meeting Abstract. 2020


Comprehensive Screening of Genetic Variants in the Coding Region of F8 in Severe Hemophilia A Reveals a Relationship with Disease Severity in a Colombian Cohort.

Sarmiento Doncel, Samuel; (...); Lopez Guerrero, Jose A

Article. 10.3390/life14081041. 2024

  • Open Access.

Consensus Statement on Hemostatic Management, Anticoagulation, and Antiplatelet Therapy in Liver Transplantation.

Montalvá E; (...); Colmenero J

Article. 10.1097/TP.0000000000004014. 2022

  • Open Access.

CONTRIBUTION OF NETOSIS IN ADVANCED STAGES OF HIGH-GRADE SEROUS OVARIAN CANCER: DIAGNOSTIC IMPLICATIONS

Alexandre, J. Mari; (...); Gilabert-Estelles, J.

Meeting Abstract. 10.1136/ijgc-2021-ESGO.604. 2021

  • Open Access.

Correction to: Routine clinical care data for population pharmacokinetic modeling: the case for Fanhdi/Alphanate in hemophilia A patients.

Chelle P; (...); Edginton A

Article. 10.1007/s10928-019-09647-2. 2019

  • Open Access.

Cost-effectiveness and cost-utility analysis of haemate-P versus other von willebrand disease treatments in Spain.

Megias-Vericat, Juan E; (...); Yan, Songkai

Article. 10.1080/13696998.2025.2474886. 2025


Costs of the management of hemophilia A with inhibitors in Spain

Bonanad, S; (...); Gonzalez-Dominguez, A

Article. 10.33393/grhta.2021.2234. 2021

  • Open Access.

Creating a Population Model for PK-Tailored Dosing Using Real-World Data from the Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) Platform

Chelle, P; (...); Edginton, AN

Meeting Abstract. 10.1182/blood-2018-99-115308. 2018

  • Open Access.

Cross-sectional comparative study of pharmacokinetics and efficacy between sucrose-formulated recombinant factor VIII (Kogenate (R)) and BAY 81-8973 (KovaltryA (R)) in patients with severe or moderate haemophilia A in prophylaxis

Megias-Vericat, JE; (...); Poveda, JL

Letter. 10.1111/hae.13733. 2019


Cross-Sectional Comparative Study of PK-Guided Switch between Standard Half-Life and Extended Half-Life Factor VIII Products

Eduardo Megias, Juan; (...); Iorio, Alfonso

Meeting Abstract. 10.1182/blood-2019-127946. 2019

  • Open Access.

Characteristics, clinical outcomes, and risk factors of SARS-COV-2 infection in adult acute myeloid leukemia patients: experience of the PETHEMA group

Palanques-Pastor, Tomas; (...); Montesinos, Pau

Article. 10.1080/10428194.2021.1948031. 2021


Daunorubicin and cytarabine for certain types of poor-prognosis acute myeloid leukemia: a systematic literature review

Megias-Vericat, JE; (...); Montesinos, P

Review. 10.1080/17512433.2019.1573668. 2019


Delving into the clinical impact of NETs in pediatric cancer.

Benavent N; (...); Medina P

Article. 10.1038/s41390-024-03437-4. 2024


Development and testing of a mobile app for systematic collection of patient-reported outcomes (PROs) in patients with hemophilia.

Megias-Vericat, J E; (...); Poveda Andres, J L

Letter. 10.1016/j.thromres.2024.109122. 2024


Development and Validation of a Population-Pharmacokinetic Model for Rurioctacog Alfa Pegol (Adynovate ): A Report on Behalf of the WAPPS-Hemo Investigators Ad Hoc Subgroup.

Chelle P; (...); Iorio A

Article. 10.1007/s40262-019-00809-6. 2020


DIAGNOSIS AND MANAGEMENT OF HEMARTHROSIS AND HAEMOPHILIC ARTHROPATHY USING UNIFIED CLINICAL AND ULTRASOUND CRITERIA: PRELIMINARY RESULTS

Chimeno-Hernandez, A; (...); Querol, F

Meeting Abstract. 2021


DIAGNOSIS OF JOINT BLEEDS: PREDICTIVE MODELING BASED ON PATIENT-REPORTED SYMPTOMS

Goldmann, G.; (...); Tiede, A.

Meeting Abstract. 2023


Differences in ex-vivo Chemosensitivity to Anthracyclines in First Line Acute Myeloid Leukemia

Megias-Vericat, JE; (...); Spanish PETHEMA Grp

Article. 10.4084/MJHID.2019.016. 2019

  • Open Access.

Differences in the expression of microRNAs 16-5p and 451a after acute exercise in patients with thrombosis versus healthy subjects

Lopez, Veronica Sanchez; (...); Candelera, Remedios Otero

Meeting Abstract. 10.1183/13993003.congress-2024.PA535. 2024

  • Open Access.

Differential expression of miRNAs present in plasma and contained within circulating microparticles in precapillary pulmonary hypertension

Oto, Julia; (...); Albert Barbera, Joan

Meeting Abstract. 10.1183/13993003.congress-2019.PA5050. 2019


Differential expression of plasma microRNAs in chronic thromboembolic pulmonary hypertension and pulmonary embolism related to occult cancer

Oto, Julia; (...); Otero, Remedios

Meeting Abstract. 10.1183/13993003.congress-2021.PA593. 2021


Drug-drug interactions associated with FLT3 inhibitors for acute myeloblastic leukemia: current landscape.

Solana-Altabella, Antonio; (...); Montesinos, Pau

Article. 10.1080/17512433.2023.2174523. 2023


Drug-drug interactions of newly approved small molecule inhibitors for acute myeloid leukemia

Megías-Vericat JE; (...); Montesinos P

Review. 10.1007/s00277-020-04186-0. 2020


Dysregulated neutrophil extracellular traps and haemostatic biomarkers as diagnostic tools and therapeutic targets in periprosthetic joint infection.

Oto, Julia; (...); Medina, Pilar

Article. 10.1302/0301-620X.106B9.BJJ-2024-0187.R1. 2024


Effect of monitoring daily physical activity on quality of life in adult patients with haemophilic arthropathy

Perez-Alenda, Sofia; (...); Carrasco, Juan J.

Meeting Abstract. 2018


Effectiveness of Caplacizumab Nanobody in Acquired Thrombotic Thrombocytopenic Purpura Refractory to Conventional Treatment

Palanques-Pastor T; (...); Poveda Andrés JL

Article. 10.1159/000517813. 2021


Effectiveness of progressive moderate-vigorous intensity elastic resistance training on quality of life and perceived functional abilities in people with haemophilia: secondary analysis of a randomized controlled trial.

Cruz-Montecinos C; (...); Calatayud J

Article. 10.1111/ejh.13900. 2022

  • Open Access.

Effects of a non-pharmacological approach for chronic pain management in patients with haemophilia: efficacy of cognitive-behavioural therapy associated with physiotherapy.

García-Dasí M; (...); Bonanad S

Article. 10.1111/hae.14284. 2021


EFFECTS OF MULTIMODAL EXERCISES PROGRAM ON BALANCE, FUNCTIONALITY, RISK OF FALLS AND STRENGTH IN PEOPLE WITH HAEMOPHILIA

Chimeno-Hernandez, A.; (...); Querol, F.

Article. 2022


Effects of performing dual tasks on postural sway and postural control complexity in people with haemophilic arthropathy

Cruz-Montecinos, C; (...); Perez-Alenda, S

Article. 10.1111/hae.13955. 2020


EFFICACY AND SAFETY OF EPTACOG BETA (RECOMBINANT HUMAN FVIIA) ACCORDING TO AGE IN PERSONS WITH HAEMOPHILIA A/B WITH INHIBITORS UNDERGOING SURGICAL PROCEDURES

Miesbach, W.; (...); Mahlangu, J.

Meeting Abstract. 2023


eLearning of pharmacokinetic monitoring in hemophilia with application in the clinical practice

Bonanad, S; (...); Megias-Vericat, JE

Meeting Abstract. 2018


Electromyographic and Safety Comparisons of Common Lower Limb Rehabilitation Exercises for People With Hemophilia.

Calatayud J; (...); Casaña J

Article. 10.1093/ptj/pzz146. 2020


Emerging FLT3 inhibitors for the treatment of acute myeloid leukemia.

Solana-Altabella, Antonio; (...); Montesinos, Pau

Article. 10.1080/14728214.2021.2009800. 2022


Emicizumab-induced photosensitivity.

Asensi Canto, Pedro; (...); Haya Guaita, Saturnino

Article. 10.1055/s-0042-1749092. 2022


EPTACOG BETA EFFICACY AT 24 HOURS POSTINFUSION FOR MILD OR MODERATE BLEEDS IN INDIVIDUALS WITH HEMOPHILIA A OR B AND INHIBITORS

Boggio, Lisa; (...); Escobar, Miguel

Meeting Abstract. 2023


Evolving patterns of care and outcomes in relapsed/refractory FLT3 mutated acute myeloid leukemia adult patients.

Boluda B; (...); Montesinos P

Article. 10.1080/10428194.2021.1938031. 2021


Experience of basic course of physical therapy in haemophilia in South America

Cruz-Montecinos, C; (...); Perez-Alenda, S

Meeting Abstract. 2018


Extracorporeal photopheresis vs standard therapies for steroid-refractory chronic graft-vs-host disease: Pharmacoeconomic assessment of hospital resource use in Spain.

Boluda, Blanca; (...); Montesinos, Pau

Article. 10.1002/jca.21901. 2021

  • Open Access.

Extrathoracic Aneurysms in Marfan Syndrome: A Systematic Review of the Literature.

Requejo-Garcia, Lucia; (...); Miralles-Hernandez, Manuel

Article. 10.1016/j.avsg.2022.08.005. 2022


Factor XIII deficiency in two Spanish families with a novel variant in gene F13A1 detected by next-generation sequencing; symptoms and clinical management.

Moret A; (...); Bonanad S

Article. 10.1007/s11239-020-02065-z. 2020


Feasibility, safety and muscle activity during flywheel vs traditional strength training in adult patients with severe haemophilia.

Calatayud J; (...); Casaña J

Article. 10.1111/hae.14170. 2020


Geriatric assessment in hematology scale predicts treatment tolerability in older patients diagnosed with hematological malignancies: The RETROGAH study.

de la Rubia J; (...); Bonanad, Santiago

Article. 10.1016/j.jgo.2022.10.016. 2022

  • Open Access.

Gilteritinib use in the treatment of relapsed or refractory acute myeloid leukemia with a FLT3 mutation.

Ballesta-López O; (...); Montesinos P

Review. 10.2217/fon-2020-0700. 2020


Haemophilic arthropathy: basic protocols for clinical examination and imaging.

Querol, F.; (...); Perez-Alenda, S.

Article. 10.1097/MBC.0000000000001215. 2023


Haemotrack: Musculoskeletal management in haemophilia with physiotherapist-driven digital solutions

Perez-Alenda, Sofia; (...); Aguilar-Rodriguez, Marta

Meeting Abstract. 2024


Healthcare Resource Utilization among Patients between 60-75 Years with Secondary Acute Myeloid Leukemia Receiving Intensive Chemotherapy Induction: A Spanish Retrospective Observational Study

Solana-Altabella, Antonio; (...); Martinez-Cuadron, David

Article. 10.3390/cancers14081921. 2022

  • Open Access.

Healthcare resource utilization in adult patients with relapsed/refractory FLT3 mutated acute myeloid leukemia: A retrospective chart review from Spain.

Solana-Altabella A; (...); Montesinos P

Article. 10.1111/ejh.13604. 2021


HemoKinect: A Microsoft Kinect V2 Based Exergaming Software to Supervise Physical Exercise of Patients with Hemophilia

Mateo, F; (...); Perez-Alenda, S

Article. 10.3390/s18082439. 2018

  • Open Access.

IDENTIFICATION OF 58 MUTATIONS (26 NEW) IN 94 OF 109 BEING TESTED WITH PROTEIN DEFICIENCY C. SETH WORKING GROUP

Fernandez-Pardo, A.; (...); Navarro, S.

Meeting Abstract. 2019

  • Open Access.

Identification of 58 Mutations (26 Novel) in 94 of 109 Symptomatic Spanish Probands with Protein C Deficiency

Martos, L; (...); Spanish Soc Thrombosis Haemostasis

Article. 10.1055/s-0039-1692440. 2019


IDENTIFICATION OF A PROFILE OF CLASSES OF CIRCULATING LIPIDS ASSOCIATED WITH THE VENOUS THROMBOEMBOLISM

Fernandez-Pardo, A.; (...); Navarro, S.

Meeting Abstract. 2019

  • Open Access.

Identification of miR-20a-5p as Robust Normalizer for Urine microRNA Studies in Renal Cell Carcinoma and a Profile of Dysregulated microRNAs

Oto J; (...); Medina P

Article. 10.3390/ijms22157913. 2021

  • Open Access.

Identification of miR-29c-3p as a Robust Normalizer for Urine microRNA Studies in Bladder Cancer.

Oto J; (...); Medina P

Article. 10.3390/biomedicines8110447. 2020

  • Open Access.

Identification of Novel microRNA Profiles Dysregulated in Plasma and Tissue of Abdominal Aortic Aneurysm Patients

Plana E; (...); Miralles M

Article. 10.3390/ijms21134600. 2020

  • Open Access.

IDH1-mutated relapsed or refractory AML: current challenges and future prospects

Megias-Vericat, JE; (...); Montesinos, P

Review. 10.2147/BLCTT.S177913. 2019

  • Open Access.

Impact of combinations of single-nucleotide polymorphisms of anthracycline transporter genes upon the efficacy and toxicity of induction chemotherapy in acute myeloid leukemia.

Megías-Vericat JE; (...); Montesinos P

Article. 10.1080/10428194.2020.1839650. 2020


IMPACT OF INITIATION OF PROPHYLAXIS, SYNOVITIS AND FUNCTIONALITY ON JOINT HEALTH IN PATIENTS WITH HEMOPHILIA

Chimeno, A.; (...); Bonanad Boix, S.

Meeting Abstract. 2023


Incidence and Risk Factors for Development of Cardiac Toxicity in Adult Patients with Newly Diagnosed Acute Myeloid Leukemia

Boluda, Blanca; (...); Montesinos, Pau

Article. 10.3390/cancers15082267. 2023

  • Open Access.

Increase of Neutrophil Activation Markers in Venous Thrombosis-Contribution of Circulating Activated Protein C

Martos L; (...); Medina P

Article. 10.3390/ijms21165651. 2020

  • Open Access.

INCREASED LEVELS OF FREE CIRCULATING DNA AND DNASE 1 ACTIVITY IN PLASMA IS ASSOCIATED WITH AN INCREASED RISK OF VENOUS THROMBOEMBOLISM

Oto, J.; (...); Medina, P.

Meeting Abstract. 2019

  • Open Access.

Increased levels of NETosis biomarkers in high-grade serous ovarian cancer patients' biofluids: Potential role in disease diagnosis and management.

Tomás-Pérez S; (...); Gilabert-Estellés J

Article. 10.3389/fimmu.2023.1111344. 2023

  • Open Access.

Influence of polymorphisms in anthracyclines metabolism genes in the standard induction chemotherapy of acute myeloid leukemia.

Megías-Vericat JE; (...); Montesinos P

Article. 10.1097/FPC.0000000000000431. 2021


Interaction of dual task in haemophiliac and non-haemophiliac subjects in postural control during quiet stance

Cruz-Montecinos, C; (...); Perez-Alenda, S

Meeting Abstract. 2018


Intra-plaque calcium and its relation with the progression of carotid atheromatous disease.

Miralles, Manuel; (...); Plana, Emma

Article. 10.23736/S0392-9590.22.04872-6. 2022


Joint status in Spanish haemophilia B patients assessed using the Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) score.

Jiménez-Yuste V; (...); Kim HK

Article. 10.1111/hae.13628. 2019


LC-MS metabolomics of urine reveals distinct profiles for non-muscle-invasive and muscle-invasive bladder cancer

Oto, Julia; (...); Medina, Pilar

Article. 10.1007/s00345-022-04136-7. 2022


Management of flexible cavovarus foot in patients with Charcot-Marie-Tooth disease: midterm results.

Megías-Vericat JE; (...); Poveda-Andrés JL

Article. 2021

  • Open Access.

Management of Urgent Bleeding in Patients with Hemophilia A: Focus on the Use of Emicizumab.

Jiménez-Yuste V; (...); Rodríguez-López M

Article. 10.1055/s-0044-1785525. 2024

  • Open Access.

Matching-Adjusted Indirect Comparison of Efficacy and Consumption of rVIII-SingleChain Versus Two Recombinant FVIII Products Used for Prophylactic Treatment of Adults/Adolescents with Severe Haemophilia A

Bonanad, S; (...); Santos, S

Article. 10.1007/s12325-021-01853-0. 2021

  • Open Access.

Mental, emotional and social dimensions of quality of life and their relationship with physical and functional status in adults with haemophilia.

Rodríguez MA; (...); Chimeno-Hernández A

Article. 10.1016/j.thromres.2024.109181. 2024

  • Open Access.

Metabolomic study for the identification of symptomatic carotid plaque biomarkers

Botello-Marabotto, Marina; (...); Miralles, Manuel

Article. 10.1016/j.talanta.2024.127211. 2025

  • Open Access.

microRNAs and Markers of Neutrophil Activation as Predictors of Early Incidental Post-Surgical Pulmonary Embolism in Patients with Intracranial Tumors

Oto, J; (...); Medina, P

Article. 10.3390/cancers12061536. 2020

  • Open Access.

MicroRNAs and Neutrophil Activation Markers Predict Venous Thrombosis in Pancreatic Ductal Adenocarcinoma and Distal Extrahepatic Cholangiocarcinoma.

Oto J; (...); Medina P

Article. 10.3390/ijms21030840. 2020

  • Open Access.

MicroRNAs as predictors of chronic thromboembolic pulmonary hypertension

Otero Candelera, Remedios; (...); Sanchez Lopez, Veronica

Meeting Abstract. 10.1183/13993003.congress-2023.OA4831. 2023


Moderate and severe haemophilia in Spain: An epidemiological update

Aznar, JA; (...); Lopez, MF

Letter. 10.1111/hae.13462. 2018


Moderate haemophilia A: Recommendations from a Spanish panel of experts.

Álvarez Román MT; (...); López-Jaime FJ

Article. 10.1111/hae.15110. 2024

  • Open Access.

Monitoring coagulation factors during surgery. A systematic review

Eduardo Megias-Vericat, Juan; (...); Luis Poveda-Andres, Jose

Review. 10.7399/fh.11766. 2021


MONITORING OF THE JOINT HEALTH OF PATIENTS WITH HEMOPHILIA IN SPAIN. INITIAL ANALYSIS OF THE JOINT US PROJECT

Alvarez-Roman, MT; (...); Querol, F

Meeting Abstract. 2021


Multimodal exercises program to improve balance in patients with haemophilia: preliminary results

Chimeno-Hernandez, A; (...); Quero, F

Meeting Abstract. 2021


Musculoskeletal ultrasound in hemophilia: Results and recommendations from a global survey and consensus meeting.

Bakeer, Nihal; (...); Blanchette, Victor S

Article. 10.1002/rth2.12531. 2021

  • Open Access.

National Survey on the Use of Mobile Applications in Patients with Hemophilia and Other Coagulopathies

Eduardo Megias, Juan; (...); Poveda Andres, Jose Luis

Meeting Abstract. 10.1182/blood-2022-169938. 2022

  • Open Access.

Neutrophil extracellular traps (NETs) in patients with STEMI. Association with percutaneous coronary intervention and antithrombotic treatments.

Ferre-Vallverdu, Mari; (...); Moscardo, Antonio

Article. 10.1016/j.thromres.2022.03.002. 2022


Neutrophil Extracellular Traps and Cancer: Trapping Our Attention with Their Involvement in Ovarian Cancer.

Castano, Maria; (...); Gilabert-Estelles, Juan

Article. 10.3390/ijms24065995. 2023

  • Open Access.

New challenges of advanced therapies.

Megías-Vericat JE; (...); Poveda Andrés JL

Article. 10.1016/j.farma.2023.11.008. 2024

  • Open Access.

New Roles for Old Friends: Involvement of the Innate Immune System in Tumor Progression.

Castano, Maria; (...); Gilabert-Estelles, Juan

Editorial Material. 10.3390/ijms24087604. 2023

  • Open Access.

Next generation sequencing in bleeding disorders: two novel variants in the F5 gene (Valencia-1 and Valencia-2) associated with mild factor V deficiency.

Moret, A; (...); Bonanad, S

Article. 10.1007/s11239-019-01911-z. 2019


Novel contributions of neutrophils in the pathogenesis of abdominal aortic aneurysm, the role of neutrophil extracellular traps: A systematic review

Plana, E; (...); Miralles, M

Review. 10.1016/j.thromres.2020.07.039. 2020


Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Treated with Pegcetacoplan: Real Life Experience

Vallejo, Carlos; (...); Vara, Miriam

Meeting Abstract. 10.1182/blood-2023-185570. 2023


Pharmacogenetics in Response to Biological Agents in Inflammatory Bowel Disease: A Systematic Review.

Ballesta-Lopez, Octavio; (...); Poveda-Andres, Jose Luis

Article. 10.3390/ijms26041760. 2025

  • Open Access.

Pharmacotherapeutic management of advanced therapy medicinal products

Luis Poveda-Andres, Jose; (...); Valero-Garcia, Silvia

Article. 10.7399/fh.13036. 2022


Physical Activity Monitoring and Acceptance of a Commercial Activity Tracker in Adult Patients with Haemophilia.

Carrasco JJ; (...); Querol F

Article. 10.3390/ijerph16203851. 2019

  • Open Access.

Pilot evaluation of home delivery programme in haemophilia

Megias-Vericat, JE; (...); Poveda-Andres, JL

Article. 10.1111/jcpt.12718. 2018


PK-GUIDED SWITCH BETWEEN STANDARD HALF-LIFE AND EXTENDED HALF-LIFE FACTOR VIII PRODUCTS

Vericat, JEM; (...); Iorio, A

Meeting Abstract. 2020


PK-guided switch from standard half-life to extended half-life factor VIII products

Megias-Vericat, JE; (...); Iorio, Alfonso

Meeting Abstract. 2020


PLASMATIC DNA STIMULATES THE GENERATION OF IN VITRO THROMBIN EVEN IN THE ABSENCE OF EXTRINSIC TISSUE FACTOR AND CAN BE REVERSED WITH DNA'S

Fernandez-Pardo, A.; (...); Medina, P.

Meeting Abstract. 2019

  • Open Access.

Practical guide to emergency treatment of thrombotic microangiopathy

Romero S; (...); Grupo de Microangiopatía Trombótica del Hospital Universitario y Politécnico La

Editorial Material. 10.1016/j.medcli.2018.01.013. 2018


Precision medicine in acute myeloid leukemia: where are we now and what does the future hold?

Megías-Vericat JE; (...); Montesinos P

Review. 10.1080/17474086.2020.1818559. 2020


Predictive factors of immune tolerance treatment response in severe haemophilia A patients with inhibitors: A real-world report from a single centre, mixed retrospective-prospective long-term study

Haya, S; (...); Casana, P

Letter. 10.1111/hae.13660. 2019

  • Open Access.

Proactive therapeutic drug monitoring and pharmacogenetic analysis in inflammatory bowel disease: A systematic review

Ballesta-Lopez, Octavio; (...); Luis Poveda-Andres, Jose

Review. 10.7399/fh.11780. 2021

  • Open Access.

PROPOSAL FOR A MULTIMODAL BALANCE EXERCISE PROGRAM FOR PEOPLE WITH HAEMOPHILIA

Chimeno-Hernandez, A; (...); Bonanad, S

Meeting Abstract. 2020


Quality of electronic treatment records and adherence to prophylaxis in haemophilia and von Willebrand disease: Systematic assessments from an electronic diary.

Tiede A; (...); Oldenburg J

Article. 10.1111/hae.14178. 2020

  • Open Access.

Real-world analysis of the PK-guided switch from standard half-life factor VIII to efmoroctocog alfa.

Megias-Vericata, J. E.; (...); Poveda Andres, J L

Letter. 10.1016/j.thromres.2023.11.023. 2023


Risk Factors for One-Year Mortality in Hospitalized Adults with Severe COVID-19 Comment

Nunez-Cortes, Rodrigo; (...); Calatayud, Joaquin

Editorial Material. 10.14336/AD.2022.0424. 2022

  • Open Access.

Role of multimeric analysis of von Willebrand factor (VWF) in von Willebrand disease (VWD) diagnosis: Lessons from the PCM-EVW-ES Spanish project

Perez-Rodriguez, A; (...); Lopez-Fernandez, MF

Article. 10.1371/journal.pone.0197876. 2018

  • Open Access.

Role of Syndecans in Ovarian Cancer: New Diagnostic and Prognostic Biomarkers and Potential Therapeutic Targets.

Oto, Julia; (...); Gotte, Martin

Article. 10.3390/cancers15123125. 2023

  • Open Access.

Routine clinical care data for population pharmacokinetic modeling: the case for Fanhdi/Alphanate in hemophilia A patients

Chelle, P; (...); Edginton, A

Meeting Abstract. 2018


Routine clinical care data for population pharmacokinetic modeling: the case for Fanhdi/Alphanate in hemophilia A patients.

Chelle P; (...); Edginton A

Article. 10.1007/s10928-019-09637-4. 2019

  • Open Access.

Safety and Effectiveness of Progressive Moderate-to-Vigorous Intensity Elastic Resistance Training on Physical Function and Pain in People With Hemophilia.

Calatayud J; (...); Casaña J

Article. 10.1093/ptj/pzaa106. 2020


Salvage regimens using conventional chemotherapy agents for relapsed/refractory adult AML patients: a systematic literature review

Megias-Vericat, JE; (...); Montesinos, P

Review. 10.1007/s00277-018-3304-y. 2018


Sequelae of repeated lesions in persons with hemophilia.

Querol F

Article. 10.1097/MBC.0000000000000820. 2019


Signal transducer and activator of transcription 3 (STAT3) phosphorylation regulates thromboxane A 2 receptor activity in human platelets.

Latorre AM; (...); Moscardó A

Letter. 10.1111/bjh.16309. 2020

  • Open Access.

Spanish Society of Hematology and Hemotherapy expert consensus opinion for SARS-CoV-2 vaccination in onco-hematological patients.

Pinana, JL; (...); Bosch F

Article. 10.1080/10428194.2021.1992619. 2021

  • Open Access.

Suitability and readiness assessment of organizational resources for the implementation of gene therapy in hemophilia in Spain and Portugal: A survey-based study.

Villas JMC; (...); Álvarez-Román MT

Letter. 10.1016/j.thromres.2024.109180. 2024


SWITCH ANALYSIS GUIDED BY PHARMACOKINETICS FROM FACTORS VIII OF STANDARD HALF LIFE TO EXTENDED HALF LIFE FACTORS

Megias Vericat, J. E.; (...); Poveda, A. J. L.

Meeting Abstract. 2019

  • Open Access.

Systematic Review of Pharmacogenetics of ABC and SLC Transporter Genes in Acute Myeloid Leukemia

Megías-Vericat JE; (...); Montesinos P

Review. 10.3390/pharmaceutics14040878. 2022

  • Open Access.

The factor VIII treatment history of non-severe hemophilia A: COMMENT. Joint damage in adult patients with mild or moderate hemophilia A evaluated with the HEAD-US system

Roman, MTA; (...); Mosteirin, NF

Letter. 10.1111/jth.15475. 2021

  • Open Access.

The impact of progressive resistance training on physical function and quality of life in patients with haemophilia

Carrasco, JJ; (...); Querol-Fuentes, F

Meeting Abstract. 2019


The Limitations and Unmet Needs of the Five Cornerstones to Guarantee Lifelong Optimization of Prophylaxis in Hemophilia Patients.

Nunez, Ramiro; (...); Jimenez-Yuste, Victor

Article. 10.1055/s-0042-1757745. 2022

  • Open Access.

The Potential of Extracellular Microvesicle-microRNAs in Precapillary Pulmonary Hypertension.

Tura-Ceide, Olga; (...); Barbera, Joan Albert

Article. 10.1165/rcmb.2024-0282LE. 2025


The safety of activated eptacog beta in the management of bleeding episodes and perioperative haemostasis in adult and paediatric haemophilia patients with inhibitors.

Escobar, M; (...); Kessler, C

Article. 10.1111/hae.14419. 2021

  • Open Access.

Thromboembolic hazard in hereditary hemorrhagic telangiectasia.

Asensi Canto, Pedro; (...); Bonanad Boix, Santiago

Article. 10.1002/jha2.471. 2022


Thrombospondins in human aortic aneurysms.

Plana, Emma; (...); Miralles, Manuel

Article. 10.1002/iub.2610. 2022


Thrombotic risk and features of patients with inferior vena cava agenesis: a multicentre, retrospective, observational study.

Bravo-Perez, Carlos; (...); Corral, Javier

Article. 10.1016/S2352-3026(24)00138-8. 2024


Treatment patterns and outcomes of 2310 patients with secondary acute myeloid leukemia: a PETHEMA registry study.

Martínez-Cuadrón D; (...); Montesinos P

Article. 10.1182/bloodadvances.2021005335. 2022

  • Open Access.

Type 2N VWD: Conclusions from the Spanish PCM-EVW-ES project

Perez-Rodriguez, Almudena; (...); Lopez-Fernandez, Maria Fernanda

Article. 10.1111/hae.14405. 2021


Tyrosine kinase inhibitors for acute myeloid leukemia: A step toward disease control?

Megías-Vericat JE; (...); Montesinos P

Review. 10.1016/j.blre.2020.100675. 2020


Ultrasound evaluation of joint damage and disease activity in adult patients with severe haemophilia A using the HEAD-US system.

Jiménez-Yuste V; (...); Kim HK

Article. 10.1111/hae.14280. 2021


Unraveling the effect of silent, intronic and missense mutations on VWF splicing: contribution of next generation sequencing in the study of mRNA

Borras, N; (...); Corrales, I

Article. 10.3324/haematol.2018.203166. 2019

  • Open Access.

Unraveling the Influence of Common von Willebrand factor variants on von Willebrand Disease Phenotype: An Exploratory Study on the Molecular and Clinical Profile of von Willebrand Disease in Spain Cohort

Borras, N; (...); Vidal, F

Article. 10.1055/s-0040-1702227. 2020


Update on Molecular Testing in von Willebrand Disease

Batlle, J; (...); PCM-EVW-ES Investigators Team

Review. 10.1055/s-0039-1679922. 2019


Upper-Body Exercises With External Resistance Are Well Tolerated and Enhance Muscle Activity in People With Hemophilia

Calatayud, J; (...); Casana, J

Article. 10.1093/ptj/pzy136. 2019

  • Open Access.

Urinary microRNAs: Looking for a New Tool in Diagnosis, Prognosis, and Monitoring of Renal Cancer

Oto, J; (...); Medina, P

Article. 10.1007/s11934-020-0962-9. 2020


Urine metabolomic analysis in clear cell and papillary renal cell carcinoma: A pilot study

Oto J; (...); Medina P

Article. 10.1016/j.jprot.2020.103723. 2020


Use of ultrasound for assessment of musculoskeletal disease in persons with haemophilia: Results of an International Prophylaxis Study Group global survey.

Ignas DM; (...); Babyn P

Article. 10.1111/hae.14006. 2020


Use of ultrasound for assessment of musculoskeletal disease in persons with hemophilia: Results of an International Prophylaxis Study Group (IPSG) survey

Doria, A; (...); Querol, F

Meeting Abstract. 2018


VALIDATION OF A MODEL WITH COAGULATION-RELATED MARKERS FOR THE DIAGNOSIS OF PROSTHETIC JOINT INFECTION

Oto, J.; (...); Medina, P.

Meeting Abstract. 2019

  • Open Access.

Validation of urine p-cresol glucuronide as renal cell carcinoma non-invasive biomarker

Oto, Julia; (...); Medina, Pilar

Article. 10.1016/j.jprot.2024.105357. 2025


Validity of a depth camera for elbow range of motion measurement in haemophilic patients: The first step for a telemedicine approach

Mateo, F; (...); Querol-Fuentes, F

Meeting Abstract. 2018


Identificación De Nuevas Moléculas Con Actividad Anticoagulante Y/O Citoprotectora En La Vía De La Proteína C: Explorando Su Utilidad Clínica.

Autor/es: Álvaro Fernández Pardo

Tesis Doctoral

Director/es: PILAR MEDINA BADENES; Silvia Navarro Rosales; Luís Andrés Ramón Núñez


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