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Risk Factors for One-Year Mortality in Hospitalized Adults with Severe COVID-19 Comment

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Nunez-Cortes, Rodrigo
  • Lopez-Bueno, Ruben
  • Torres-Castro, Rodrigo
  • Soto-Carmona, Camilo
  • Ortega-Palavecinos, Maritza
  • Solis-Navarro, Lilian
  • Martinez-Arnau, Francisco M.
  • Calatayud, Joaquin

Grupos

Abstract

As the body's immunity declines with age, elderly-hospitalized patients due to COVID-19 might be at higher mortality risk. Therefore, the aim of this prospective study was to examine the possible risk factors (demographic, social or comorbidities) most associated with mortality one-year after diagnosis of COVID-19. Routine data were collected from a cohort of hospitalized adults with severe COVID-19. The primary endpoint was mortality at one-year after diagnosis of COVID-19. We used a Cox proportional hazard model to estimate the hazard ratios (HRs) for both all-cause and specific cardiorespiratory mortality. A fully adjusted model included sex, socioeconomic status, institutionalization status, disability, smoking habit, and comorbidities as confounders. A total of 368 severe cases hospitalized on average 67.3 +/- 15.9 years old were included. Participants aged >= 71 years had significantly higher HRs for all-cause mortality (adjusted HRs = 2.86, 95%CI: 2.01-4.07) and cardiorespiratory mortality (adjusted HRs = 2.86, 95%CI: 1.99-4.12). The association between age and mortality after diagnosis of COVID-19 due to both all-causes and cardiorespiratory mortality showed a consistent dose-response fashion. Institutionalization, disability, and socioeconomic status also showed a significant association with mortality. In conclusion, aging itself was the most important risk factor associated with mortality one year after diagnosis of COVID-19. People with disabilities, institutionalized or low socioeconomic status are significantly more likely to die after COVID-19.

copyright: © 2022 Nunez-Cortes et al.

Datos de la publicación

ISSN/ISSNe:
2152-5250, 2152-5250

Aging and Disease  INT SOC AGING & DISEASE

Tipo:
Editorial Material
Páginas:
14-20
PubMed:
36818568
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
1,720 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 8

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Keywords

  • aging; SARS-CoV-2; coronavirus; mortality; infectious diseases

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