Neutrophil extracellular traps (NETs) in patients with STEMI. Association with percutaneous coronary intervention and antithrombotic treatments.

Autores de IIS La Fe

• Maria Ferre Vallverdú

  Autor

• Ana María Latorre Campos

  Autor

• María Paz Fuset Cabanes

  Autor

• María Elena Sánchez Lacuesta

  Autor

• Maria Isabel Madrid López

  Autor

• Francisco Ten Morro

  Autor

• Juana Valles Giner

  Autor

• Maria Teresa Santos Diaz

  Autor

• Santiago Bonanad Boix

  Autor

• Antonio Moscardó Martínez

  Autor

Grupos

• Hemostasia, Trombosis, Arteriosclerosis y Biología vascular

• Infecciones Respiratorias

• Medicina Intensiva

• Regeneración y Trasplante Cardíaco

Abstract

Neutrophil extracellular traps (NETs) are formed by DNA, histones and proteolytic enzymes, and are produced by activated neutrophils through different mechanisms. In turn, NETs can activate platelets and coagulation cascade favoring thrombotic processes. The aims of this study were to analyze levels and kinetics of NETs in ST-segment elevation myocardial infarction (STEMI) patients and correlate them with antithrombotic therapy and cardiovascular outcomes at follow-up.

Copyright © 2022 Elsevier Ltd. All rights reserved.

Keywords

• Citrullinated histone 3 (citH3), Neutrophil extracellular traps (NETs), Primary percutaneous coronary intervention (pPCI), ST-segment elevation myocardial infarction (STEMI)