Portal de investigación
NUEVAS ESTRATEGIAS DE PREVENCIÓN Y DIAGNÓSTICO DE LAS INFECCIONES RELACIONADAS CON DISPOSITIVOS BIOMÉDICOS CAUSADOS POR STAPHYLOCOCCUS SPP.
Datos básicos
- Protocolo:
- SAF2017-82251-R
- EUDRACT:
- NCT:
- Centro:
- Año de incio:
- 2018
- Año de finalización:
- 2021
Objetivos del proyecto
NO FAVORABLE
Documentos
- No hay documentos
Participantes
Grupos
Financiadores - Promotores
Resultados del Ensayo Clínico
A Cutting-Edge Bioinformatics Tool for Neoantigen Identification in Unpaired RNA-Seq Samples of AML
Perez Miguez, Carlos; (...); Montesinos, Pau
Meeting Abstract. 10.1182/blood-2024-201407. 2024
A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species
Bacigalupe, R; (...); Fitzgerald, JR
Article. 10.1126/sciadv.aax0063. 2019
A predictive model for prostate cancer incorporating PSA molecular forms and age.
Oto J; (...); Navarro S
Article. 10.1038/s41598-020-58836-4. 2020
a2-Macroglobulin is a significant in vivo inhibitor of activated protein C and low levels of APC:a2M are associated with venous thromboembolism
Navarro S; (...); Medina P
Article. 2018
Activated protein C assays: a review.
Review. 10.1016/j.cca.2019.11.005. 2020
alpha(2)-Macroglobulin Is a Significant In Vivo Inhibitor of Activated Protein C and Low APC: alpha M-2 Levels Are Associated with Venous Thromboembolism
Martos, L; (...); Medina, P
Article. 10.1055/s-0038-1629902. 2018
An ex vivo cystic fibrosis model recapitulates key clinical aspects of chronic Staphylococcus aureus infection.
Sweeney E; (...); Harrison F
Article. 10.1099/mic.0.000987. 2021
Angioedema in patients with urticaria is associated with an increase in thrombin generation peak
Valle, DGK; (...); Rosales, SN
Meeting Abstract. 2018
Antibacterial Activity of Linezolid against Gram-Negative Bacteria: Utilization of e-Poly-l-Lysine Capped Silica Xerogel as an Activating Carrier.
Guzel Kaya G; (...); Martínez-Máñez R
Article. 10.3390/pharmaceutics12111126. 2020
Aptamer-Capped nanoporous anodic alumina for Staphylococcus aureus detection
Pla, L; (...); Martinez-Manez, R
Article. 10.1016/j.snb.2020.128281. 2020
Autologous or allogeneic hematopoietic stem cell transplantation as front-line treatment for adult secondary acute myeloid leukemia patients: the PETHEMA registry experience.
Serrano, Josefina; (...); Montesinos, Pau
Article. 10.1016/j.jtct.2025.02.011. 2025
Climate change, animals, and Candida auris: insights into the ecological niche of a new species from a one health approach.
Garcia-Bustos, Victor; (...); Peman, Javier
Article. 10.1016/j.cmi.2023.03.016. 2023
Clonal Evolution Analysis Using Next Generation Sequencing (NGS) Panel in a Cohort of 3,025 Patients With Acute Myeloid Leukemia (AML)
Colmenares, Rafael; (...); Montesinos, Pau
Meeting Abstract. 2023
Comparison of the 2022 and 2017 European LeukemiaNet risk classifications in a real-life cohort of the PETHEMA group
Sargas, Claudia; (...); Montesinos, Pau
Article. 10.1038/s41408-023-00835-5. 2023
Conventional PCR Versus Next Generation Sequencing for Diagnosis of FLT3, IDH and NPM1 Mutations in Acute Myeloid Leukemia: Interim Analysis of the PCR-LMA Protocol of the Pethema Group
Boluda, Blanca; (...); Montesinos, Pau
Meeting Abstract. 10.1182/blood-2022-160136. 2022
Changes in sleep-disordered breathing from the acute to the stable phase of pulmonary embolism and impact of right ventricular dysfunction: preliminary findings of ESAET study
Ortega, AG; (...); Martinez-Garcia, MA
Meeting Abstract. 10.1183/13993003.congress-2020.4974. 2020
Characteristics and outcome of adult patients with acute promyelocytic leukemia and increased body mass index treated with the PETHEMA Protocols.
Sobas M; (...); PETHEMA, HOVON, PALG, GATLA cooperative groups
Article. 10.1111/ejh.13346. 2020
Characterization of the Differential Pathogenicity of Candida auris in a Galleria mellonella Infection Model.
Garcia-Bustos V; (...); Pemán J
Article. 10.1128/Spectrum.00013-21. 2021
Data-Driven Multiparameter Flow Cytometry (MFC) Classification of Blast Differentiation in Elderly Patients with Acute Myeloid Leukemia (AML)
Gonzalez, Carmen; (...); Paiva, Bruno
Meeting Abstract. 10.1182/blood-2023-180646. 2023
Early-Onset Myelodysplastic Syndromes (MDS) with Ring Sideroblasts (RS) without SF3B1 Mutations in Adults: Enrichment with Germline Variants in Genes Responsible for Congenital Sideroblastic Anemias
Jauregui, Sandra Novoa; (...); Jerez, Andres
Meeting Abstract. 10.1182/blood-2023-185836. 2023
Enhanced Antibacterial Activity through Silver Nanoparticles Deposited onto Carboxylated Graphene Oxide Surface
Barjola, Arturo; (...); Gimenez, Enrique
Article. 10.3390/nano12121949. 2022
Essential Topics for the Regulatory Consideration of Phages as Clinically Valuable Therapeutic Agents: A Perspective from Spain
Vazquez, Roberto; (...); Garcia, Pilar
Review. 10.3390/microorganisms10040717. 2022
Evolution of the Genetic and Biological Studies Performed at Diagnosis in Patients with Acute Myeloid Leukemia Included in the Pethema Epidemiological Registry (REALMOL Study)
Labrador, Jorge; (...); Manuel Alonso-Dominguez, Juan
Meeting Abstract. 10.1182/blood-2022-163016. 2022
Evolving patterns and clinical outcome of genetic studies performed at diagnosis in acute myeloid leukemia patients: Real life data from the PETHEMA Registry.
Labrador, Jorge; (...); Montesinos, Pau
Article. 10.1002/cncr.35431. 2024
Exploring Potential Molecular Mechanisms of Drug Response in FLT3-ITD Negative AML Patients Treated with Quizartinib Vs Placebo Plus Standard Chemotherapy in the Quiwi Trial
Mosquera Orgueira, Adrian; (...); Montesinos, Pau
Meeting Abstract. 10.1182/blood-2023-180710. 2023
Genomics improves risk stratification of adults with T-cell acute lymphoblastic leukemia patients enrolled in measurable residual disease-oriented trials.
Gonzalez-Gil, Celia; (...); Genesca, Eulalia
Article. 10.3324/haematol.2022.281196. 2023
Host-pathogen interactions upon Candida auris infection: fungal behaviour and immune response in Galleria mellonella
Garcia-Bustos, Victor; (...); Ruiz-Sauri, Amparo
Article. 10.1080/22221751.2021.2017756. 2022
Human papilloma virus DNA detection in clinical samples using fluorogenic probes based on oligonucleotide gated nanoporous anodic alumina films.
Hernández-Montoto A; (...); Martínez-Máñez R
Article. 10.1002/adhm.202203326. 2023
IDENTIFICATION OF 58 MUTATIONS (26 NEW) IN 94 OF 109 BEING TESTED WITH PROTEIN DEFICIENCY C. SETH WORKING GROUP
Fernandez-Pardo, A.; (...); Navarro, S.
Meeting Abstract. 2019
Identification of 58 Mutations (26 Novel) in 94 of 109 Symptomatic Spanish Probands with Protein C Deficiency
Martos, L; (...); Spanish Soc Thrombosis Haemostasis
Article. 10.1055/s-0039-1692440. 2019
IDENTIFICATION OF A PROFILE OF CLASSES OF CIRCULATING LIPIDS ASSOCIATED WITH THE VENOUS THROMBOEMBOLISM
Fernandez-Pardo, A.; (...); Navarro, S.
Meeting Abstract. 2019
Identification of Novel microRNA Profiles Dysregulated in Plasma and Tissue of Abdominal Aortic Aneurysm Patients
Plana E; (...); Miralles M
Article. 10.3390/ijms21134600. 2020
Impact of Center-related Characteristics and Macroeconomic Factors on the Outcome of Adult Patients With Acute Lymphoblastic Leukemia Treated With Pediatric-inspired Protocols.
Barba P; (...); Ribera JM
Article. 10.1097/HS9.0000000000000810. 2023
IMPACT OF CYTOGENETIC ABNORMALITIES DEFINING AML MYELODYSPLASIA-RELATED (WHO AND ICC 2022) IN FIRST LINE DECITABINE IN UNFIT AML PATIENTS
de la Fuente, Adolfo; (...); Tormo, Mar
Meeting Abstract. 2023
Impact of FLT3-ITD Mutation Status and Its Ratio in a Cohort of 2901 Patients Undergoing Upfront Intensive Chemotherapy: A PETHEMA Registry Study.
Ayala, Rosa; (...); Montesinos, Pau
Article. 10.3390/cancers14235799. 2022
Impact of trisomy 19 on outcome according to genetic makeup in patients with acute myeloid leukemia.
Kayser, Sabine; (...); Schlenk, Richard F.
Article. 10.3324/haematol.2022.282127. 2023
Increase of Neutrophil Activation Markers in Venous Thrombosis-Contribution of Circulating Activated Protein C
Martos L; (...); Medina P
Article. 10.3390/ijms21165651. 2020
Indolent Acute Myeloid Leukemia with Long Survival in Patients Treated with Best Supportive Care Only: A Pethema Registry Study
Labrador, Jorge; (...); Montesinos, Pau
Meeting Abstract. 10.1182/blood-2022-162591. 2022
INSM1 immunohistochemical expression in a large cohort of Ewing sarcoma family of tumours
Llombart-Bosch, A; (...); Picci, P
Meeting Abstract. 2019
INTENSIVE CHEMOTHERAPY VERSUS DECITABINE FIRST LINE LAM OVER 60 YEARS OLD
De la Fuente, A.; (...); Montesinos, P.
Meeting Abstract. 2019
Invasive scedosporiosis in lung transplant recipients: A nine-year retrospective study in a tertiary care hospital.
Ibáñez-Martínez E; (...); Pemán J
Case Reports. 10.1016/j.riam.2021.06.002. 2021
Involvement of the coagulation system in hereditary angioedema
Echevarria, EI; (...); De Rojas, DHF
Meeting Abstract. 2018
Long-term antibacterial Ag plus -release biomaterials based on anodized Ti6Al4V and silver nanoparticles
Molina, J.; (...); Tormo-Mas, M. A.
Article. 10.1016/j.colsurfa.2023.132243. 2023
Machine Learning Improves Risk Stratification in Myelodysplastic Neoplasms: An Analysis of the Spanish Group of Myelodysplastic Syndromes.
Mosquera Orgueira, Adrian; (...); Valcarcel, David
Article. 10.1097/HS9.0000000000000961. 2023
microRNAs and Markers of Neutrophil Activation as Predictors of Early Incidental Post-Surgical Pulmonary Embolism in Patients with Intracranial Tumors
Article. 10.3390/cancers12061536. 2020
MicroRNAs and Neutrophil Activation Markers Predict Venous Thrombosis in Pancreatic Ductal Adenocarcinoma and Distal Extrahepatic Cholangiocarcinoma.
Article. 10.3390/ijms21030840. 2020
Microstructural, mechanical, electrochemical, and biological studies of an electron beam melted Ti-6Al-4V alloy
Romero-Resendiz, L.; (...); Amigo-Borras, V
Article. 10.1016/j.mtcomm.2022.103337. 2022
Mobilisation Mechanism of Pathogenicity Islands by Endogenous Phages in Staphylococcus aureus clinical strains.
Cervera-Alamar, M; (...); Tormo-Mas, MA
Article. 10.1038/s41598-018-34918-2. 2018
Molecular identification of Candida auris by PCR amplification of species-specific GPI protein-encoding genes
Ruiz-Gaitan, AC; (...); de Groot PWJ
Article. 10.1016/j.ijmm.2018.06.014. 2018
Molecular Landscape and Validation of New Genomic Classification in 2668 Adult AML Patients: Real Life Data from the PETHEMA Registry.
Sargas, Claudia; (...); On Behalf Of Pethema Group
Article. 10.3390/cancers15020438. 2023
Molecular profiling refines minimal residual disease-based prognostic assessment in adults with Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia.
Ribera J; (...); Ribera JM
Article. 10.1002/gcc.22788. 2019
MUTATIONAL PROFILE IN PATIENTS DIAGNOSED WITH LOW-RISK SMD WITHOUT THE RINGED SIDEROBLASTS
Abaigar, M; (...); Campelo, MD
Meeting Abstract. 2018
Nanoemulsion Increases the Antifungal Activity of Amphotericin B against Four Candida auris Clades: In Vitro and In Vivo Assays.
Marena, Gabriel Davi; (...); Peman, Javier
Article. 10.3390/microorganisms11071626. 2023
NATIONAL EXPERIENCE WITH THE USE OF VENETOCLAX IN PATIENTS WITH RELAPSED OR REFRACTORY ACUTE MYELOID LEUKEMIA
Labrador, J.; (...); Montesinos, P.
Meeting Abstract. 2020
Novel Chromogenic Medium CHROMagar TM Candida Plus for Detection of Candida auris and Other Candida Species from Surveillance and Environmental Samples: A Multicenter Study.
Mulet Bayona, Juan Vicente; (...); Gimeno Cardona, Concepcion
Article. 10.3390/jof8030281. 2022
Oligonucleotide-capped nanoporous anodic alumina biosensor as diagnostic tool for rapid and accurate detection of Candida auris in clinical samples.
Pla, Luis; (...); Santiago-Felipe, Sara
Article. 10.1080/22221751.2020.1870411. 2020
Onychomycosis of rare etiology
Valentin-Martin, Amparo; (...); Miguel Molina-Moreno, Jose
Editorial Material. 10.1016/j.eimc.2021.07.015. 2022
Outcomes after intensive chemotherapy for secondary and myeloid-related changes acute myeloid leukemia patients aged 60 to 75 years old: a retrospective analysis from the PETHEMA registry
Martinez-Cuadron, David; (...); Montesinos, Pau
Article. 10.3324/haematol.2022.282506. 2024
Pethema NGS-AML Project. Final Analysis and Clinical Validation of New Genomic Classifications
Sargas, Claudia; (...); Montesinos, Pau
Meeting Abstract. 10.1182/blood-2022-166639. 2022
PLASMATIC DNA STIMULATES THE GENERATION OF IN VITRO THROMBIN EVEN IN THE ABSENCE OF EXTRINSIC TISSUE FACTOR AND CAN BE REVERSED WITH DNA'S
Fernandez-Pardo, A.; (...); Medina, P.
Meeting Abstract. 2019
Prognostic Impact of NPM1 and FLT3-ITD Mutations in Patients Treated with Non-Intensive Regimens: A Pethema Registry Study
Uriel Suarez, Edwin; (...); Montesinos, Pau
Meeting Abstract. 10.1182/blood-2022-167365. 2022
Radical genome remodelling accompanied the emergence of a novel host-restricted bacterial pathogen
Yebra, G; (...); Penades, JR
Article. 10.1371/journal.ppat.1009606. 2021
Real-World Outcomes Using Front-Line Midostaurine in Combination with Intensive Chemotherapy for Patients Aged = 60 Years Old with FLT3 Mutated Acute Myeloid Leukemia
Requena, Gaspar Aspas; (...); Matinez-Cuadron, David
Meeting Abstract. 10.1182/blood-2023-190128. 2023
RESULTS OF THE TREATMENT OF LYMPHOBLASTIC LYMPHOMA WITH PROTOCOLS OF LYMPHOBLASTIC ACUTE LEUKEMIA OF PETHEMA GROUP
Sagues, M.; (...); Ribera, J. M.
Meeting Abstract. 2019
Risk assessment of arterial allograft contamination from tissue donors colonized by Candida auris.
Mirabet V; (...); Pemán J
Article. 10.1016/j.jhin.2021.03.003. 2021
Salvage Therapy with Second-Generation Inhibitors for FLT3 Mutated Acute Myeloid Leukemia: A Real-World Study by the CETLAM and PETHEMA Groups
Vives, Susana; (...); PETHEMA Grp
Article. 10.3390/cancers16234028. 2024
SARS-CoV-2 N protein IgG antibody detection employing nanoporous anodized alumina: A rapid and selective alternative for identifying naturally infected individuals in populations vaccinated with spike protein (S)-based vaccines
Esteve-Sanchez, Yoel; (...); Climent, Estela
Article. 10.1016/j.snb.2024.136378. 2024
SARS-CoV-2-reactive antibody waning, booster effect and breakthrough SARS-CoV-2 infection in hematopoietic stem cell transplant and cell therapy recipients at one year after vaccination.
Pinana, Jose Luis; (...); Solano, Carlos
Article. 10.1038/s41409-023-01946-0. 2023
Screening of microRNAs as possible biomarkers in abdominal aortic aneurysm
Plana, E; (...); Miralles, M
Article. 10.1016/j.angio.2017.09.001. 2018
Selective and Sensitive Probe Based in Oligonucleotide-Capped Nanoporous Alumina for the Rapid Screening of Infection Produced by Candida albicans.
Ribes À; (...); Martinez-Manez, R
Article. 10.1021/acssensors.9b00169. 2019
Supervised Machine Learning Improves Risk Stratification in Newly Diagnosed Myelodysplastic Syndromes: An Analysis of the Spanish Group of Myelodysplastic Syndromes
Mosquera Orgueira, Adrian; (...); Valcarcel, David
Meeting Abstract. 10.1182/blood-2022-159429. 2022
The FLT3-like Gene Expression Signature Predicts Response to Quizartinib in Wild-Type FLT3 Acute Myeloid Leukemia: An Analysis of the Pethema Quiwi Trial
Mosquera Orgueira, Adrian; (...); Montesinos, Pau
Meeting Abstract. 10.1182/blood-2023-180482. 2023
The Optimization of the Synthesis of Antibacterial Coatings on Ti6Al4V Coupons Obtained by Electron Beam Melting
Molina, Javier; (...); Bosch, Francisco
Article. 10.3390/met14080855. 2024
The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients
Ribera, J; (...); Ribera, JM
Article. 10.1111/bjh.15887. 2019
The transcriptomic landscape of elderly acute myeloid leukemia identifies B7H3 and BANP as a favorable signature in high-risk patients.
Villar, Sara; (...); Montesinos, Pau
Article. 10.3389/fonc.2022.1054458. 2022
Transcriptional and Genomic Characterization of Measurable Residual Disease (MRD) Cells in Acute Myeloid Leukemia (AML)
Patricia Simoes, Catia; (...); Paiva, Bruno
Meeting Abstract. 10.1182/blood-2022-163159. 2022
Transcriptional and genomic characterization of measurable residual disease in acute myeloid leukaemia.
Simoes, Catia; (...); Montesinos, Pau
Letter. 10.1111/bjh.18815. 2023
Treatment Outcomes in Unfit Patients with Newly Acute Myeloid Leukemia According to IDH1 Mutational Status: Real World Evidence from the Pethema Epidemiologic Registry
Martinez-Cuadron, David; (...); Montesinos, Pau
Meeting Abstract. 10.1182/blood-2023-189800. 2023
Treatment patterns and outcomes in secondary acute myeloid leukemia arising after hypomethylating agents: PETHEMA registry study.
Lloret-Madrid, Pilar; (...); Montesinos, Pau
Article. 10.1002/cncr.35696. 2025
Urinary microRNAs: Looking for a New Tool in Diagnosis, Prognosis, and Monitoring of Renal Cancer
Article. 10.1007/s11934-020-0962-9. 2020
Urine metabolomic analysis in clear cell and papillary renal cell carcinoma: A pilot study
Article. 10.1016/j.jprot.2020.103723. 2020
VALIDATION OF A MODEL WITH COAGULATION-RELATED MARKERS FOR THE DIAGNOSIS OF PROSTHETIC JOINT INFECTION
Oto, J.; (...); Medina, P.
Meeting Abstract. 2019
Validation of the Artificial Intelligence Prognostic Scoring System for Myelodysplastic Syndromes in chronic myelomonocytic leukaemia: A novel approach for improved risk stratification.
Mosquera Orgueira, Adrian; (...); Valcarcel, David
Article. 10.1111/bjh.19341. 2024
Vitronectin as a molecular player of the tumor microenvironment in neuroblastoma
Burgos-Panadero, R; (...); Noguera, R
Article. 10.1186/s12885-019-5693-2. 2019
What Do We Know about Candida auris ? State of the Art, Knowledge Gaps, and Future Directions.
Garcia-Bustos V; (...); Pemán J
Article. 10.3390/microorganisms9102177. 2021
WHO and ICC 2022 Cytogenetic Abnormalities Defining Acute Myelogenous Leukemia (AML) Myelodysplasia-Related in First-Line Decitabine in Unfit AML Patients
Ortiz Lopez, Alicia; (...); de la Fuente Burguera, Adolfo
Meeting Abstract. 2023