Portal de investigación
Antibacterial Activity of Linezolid against Gram-Negative Bacteria: Utilization of e-Poly-l-Lysine Capped Silica Xerogel as an Activating Carrier.
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Guzel Kaya G
- Medaglia S
- Candela-Noguera V
- Marcos MD
- Aznar E
- Deveci H
- Martínez-Máñez R
Grupos
Abstract
In recent times, many approaches have been developed against drug resistant Gram-negative bacteria. However, low-cost high effective materials which could broaden the spectrum of antibiotics are still needed. In this study, enhancement of linezolid spectrum, normally active against Gram-positive bacteria, was aimed for Gram-negative bacteria growth inhibition. For this purpose, a silica xerogel prepared from a low-cost precursor is used as a drug carrier owing to the advantages of its mesoporous structure, suitable pore and particle size and ultralow density. The silica xerogel is loaded with linezolid and capped with e-poly-l-lysine. The developed nano-formulation shows a marked antibacterial activity against to Escherichia coli , Pseudomonas aeruginosa and Staphylococcus aureus. In comparison to free linezolid and e-poly-l-lysine, the material demonstrates a synergistic effect on killing for the three tested bacteria. The results show that silica xerogels can be used as a potential drug carrier and activity enhancer. This strategy could provide the improvement of antibacterial activity spectrum of antibacterial agents like linezolid and could represent a powerful alternative to overcome antibiotic resistance in a near future.
Datos de la publicación
- ISSN/ISSNe:
- 1999-4923, 1999-4923
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 33233423
- Factor de Impacto:
- 1,054 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
Pharmaceutics MDPI
Citas Recibidas en Web of Science: 19
Documentos
- No hay documentos
Filiaciones
Keywords
- antibacterial activity, linezolid, mesoporous material, silica xerogel, e-poly-l-lysine
Campos de Estudio
Cita
Guzel G,Medaglia S,Candela V,TORMO MÁ,Marcos MD,Aznar E,Deveci H,Martínez R. Antibacterial Activity of Linezolid against Gram-Negative Bacteria: Utilization of e-Poly-l-Lysine Capped Silica Xerogel as an Activating Carrier. Pharmaceutics. 2020. 12. (11):1126. IF:6,321. (1).