Portal de investigación
The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Ribera, J
- Granada, I
- Morgades, M
- Vives, S
- Genesca, E
- Gonzalez, C
- Nomdedeu, J
- Escoda, L
- Mercadal, S
- Coll, R
- Gonzalez-Campos, J
- Abella, E
- Barba, P
- Bermudez, A
- Pedreno, M
- Martinez-Carballeira, D
- Hernandez-Rivas, JM
- Orfao, A
- Martinez-Lopez, J
- Esteve, J
- Bravo, P
- Garcia-Guinon, A
- Deben, G
- Moraleda, JM
- Queizan, JA
- Ortin, X
- Feliu, E
- Sole, F
- Ribera, JM
Grupos
Abstract
The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Espanol de Tratamientos en Hematologia (PETHEMA) protocols. The 5-year cumulative incidence of relapse (CIR) of low-hypodiploid B-cell precursor (BCP)-ALL was significantly higher than that of high-hypodiploids (52% vs. 12%, P = 0.013). Low-hypodiploid BCP-ALL patients aged <= 35 years showed superior survival (71% vs. 21%, P = 0.026) and lower 5-year CIR (17% vs. 66%, P = 0.090) than low-hypodiploids aged >35 years. Older adults and elderly low-hypodiploid BCP-ALL patients show dismal prognosis although achieving an end-induction good MRD response.
Datos de la publicación
- ISSN/ISSNe:
- 0007-1048, 1365-2141
- Tipo:
- Article
- Páginas:
- 263-268
- DOI:
- 10.1111/bjh.15887
- PubMed:
- 30916384
- Factor de Impacto:
- 1,844 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
BRITISH JOURNAL OF HAEMATOLOGY WILEY
Citas Recibidas en Web of Science: 7
Documentos
- No hay documentos
Filiaciones
Keywords
- acute lymphoblastic leukaemia; adults; hypodiploidy; prognosis; age
Campos de Estudio
Cita
Ribera J,Granada I,Morgades M,Vives S,Genesca E,Gonzalez C,Nomdedeu J,Escoda L,MONTESINOS P,Mercadal S,Coll R,Gonzalez J,Abella E,Barba P,Bermudez A,GIL C,TORMO M,Pedreno M,Martinez D,Hernandez JM,Orfao A,Martinez J,Esteve J,Bravo P,Garcia A,Deben G,Moraleda JM,Queizan JA,Ortin X,MORENO MJ,Feliu E,Sole F,Ribera JM. The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients. Br. J. Haematol. 2019. 186. (2):p. 263-268. IF:5,518. (1).