Portal de recerca
PROGRAMA DE TECNICO DE APOYO. MODALIDAD EMPRESAS
Dades bàsiques
- Protocol:
- PTA2012-8060-E
- EURDRACT:
- NCT:
- Centre:
- Any inici:
- 2013
- Any de finalització:
- 2020
Objectius del projecte
FAVORABLE
Documents
- No hi ha documents
Participants
Finançadors - Promotors
Resultats de l'Assaig Clínic
[Liver cell therapy in the treatment of inborn errors of metabolism in children].
Abstract of Published Item. 10.1016/j.anpedi.2013.05.018. 2013
A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury
García-Cañaveras JC; (...); Lahoz A
Article. 10.1038/srep27239. 2016
A microRNA signature for valproate-induced steatosis in human hepatocytes and its application to predict fatty liver in paediatric epileptic patients on valproate therapy.
Soluyanova P; (...); Jover R
Article. 10.1016/j.tox.2024.153974. 2024
A Network Involving Gut Microbiota, Circulating Bile Acids, and Hepatic Metabolism Genes That Protects Against Non-Alcoholic Fatty Liver Disease.
Article. 10.1002/mnfr.201900487. 2019
A novel microRNA signature for cholestatic drugs in human hepatocytes and its translation into novel circulating biomarkers for drug-induced liver injury patients.
López-Riera M; (...); Jover R
Article. 10.1093/toxsci/kfz138. 2020
A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes.
Moreno-Torres, Marta; (...); Castell, V, Jose
Article. 10.1021/acs.jproteome.1c00779. 2022
A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies.
Garcia-Llorens, Guillem; (...); Bort, Roque
Article. 10.1186/s13287-023-03311-w. 2023
A Score Model for the Continuous Assessment of Early Allograft Function after Liver Transplantation
Cortes, Miriam; (...); Lahoz, Agustin
Article. 2014
A Score Model for the Continuous Grading of Early Allograft Dysfunction Severity
Article. 10.1002/lt.23990. 2015
A simple transcriptomic signature able to predict drug-induced hepatic steatosis
Article. 10.1007/s00204-014-1197-7. 2014
Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems
Fernandez-Murga, ML; (...); Jover, R
Review. 10.1016/j.fct.2018.07.017. 2018
Angiopoietin-Like Protein 8 Is a Novel Vitamin D Receptor Target Gene Involved in Nonalcoholic Fatty Liver Pathogenesis
Garcia-Monzon, C; (...); Jover, R
Article. 10.1016/j.ajpath.2018.07.028. 2018
Angiopoietin-like protein 8 is a novel vitamin D receptor-targeted lipogenic gene associated with non-alcoholic fatty liver
Gonzalez-Rodriguez, A; (...); Garcia-Monzon, C
Meeting Abstract. 10.1016/S0168-8278(18)30948-6. 2018
Automated generation of hiPSC-derived hepatic progeny by cost-efficient compounds.
Vanmarcke G; (...); Verfaillie CM
Article. 10.1093/stmcls/sxad065. 2023
Bladder cancer recurrence surveillance by urine metabolomics analysis
Loras, A; (...); Ruiz-Cerda, JL
Article. 10.1038/s41598-018-27538-3. 2018
Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development
Article. 10.1016/j.toxlet.2016.10.008. 2016
Cluster-Partial Least Squares (c-PLS) regression analysis: Application to miRNA and metabolomic data.
Kuligowski, Julia; (...); Quintas, Guillermo
Article. 10.1016/j.aca.2023.342052. 2024
Comparing in vitro human liver models to in vivo human liver using RNA-Seq.
Gupta R; (...); Caiment F
Article. 10.1007/s00204-020-02937-6. 2020
Comparing Targeted vs. Untargeted MS2 Data-Dependent Acquisition for Peak Annotation in LC-MS Metabolomics
Ten-Domenech, I; (...); Kuligowski, J
Article. 10.3390/metabo10040126. 2020
Comparing the direct assessment of steatosis in liver explants with mid- and near-infrared vibrational spectroscopy, prior to organ transplantation.
Rienda, Ivan; (...); Quintas, Guillermo
Article. 10.1039/d3an01184d. 2023
Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury
Tolosa, L; (...); Teresa Donato, M.
Article. 10.1007/s00204-017-2036-4. 2018
Derivation of healthy hepatocyte-like cells from a female patient with ornithine transcarbamylase deficiency through X-inactivation selection.
Santamaria R; (...); Bort R
Article. 10.1038/s41598-022-06184-w. 2022
Direct conversion of human fibroblast to hepatocytes using a single inducible polycistronic vector.
Ballester M; (...); Bort R
Article. 10.1186/s13287-019-1416-5. 2019
Drug-Induced Fatty Liver Disease (DIFLD): A Comprehensive Analysis of Clinical, Biochemical, and Histopathological Data for Mechanisms Identification and Consistency with Current Adverse Outcome Pathways.
Lopez-Pascual, Ernesto; (...); Castell, Jose V.
Article. 10.3390/ijms25105203. 2024
Enhancing the accuracy of mid-infrared spectroscopy-based liver steatosis quantification using digital image analysis as a reference.
Rienda, Ivan; (...); Quintas, Guillermo
Article. 10.1039/d3an00324h. 2023
Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes.
Article. 10.1007/s00204-019-02643-y. 2020
Exploring Individual Variability in Drug-Induced Liver Injury (DILI) Responses through Metabolomic Analysis.
Moreno-Torres M; (...); Castell JV
Article. 10.3390/ijms25053003. 2024
Extending metabolome coverage for untargeted metabolite profiling of adherent cultured hepatic cells
García-Cañaveras JC; (...); Lahoz A
Article. 10.1007/s00216-015-9227-8. 2016
Extracting consistent biological information from functional results of metabolomic pathway analysis using the Mantel's test.
Ten-Doménech I; (...); Kuligowski J
Article. 10.1016/j.aca.2021.339173. 2021
Factors that influence the quality of metabolomics data in in vitro cell toxicity studies: a systematic survey.
Moreno-Torres, Marta; (...); Castell, Jose Vicente
Article. 10.1038/s41598-021-01652-1. 2021
Femoral insertion site of the graft used to replace the medial patellofemoral ligament influences the ligament dynamic changes during knee flexion and the clinical outcome (vol 25, pg 2443, 2017)
Sanchis-Alfonso, V; (...); Marti-Bonmati, L
Correction. 10.1007/s00167-018-5271-1. 2019
Glutamine/glutamate metabolism rewiring in reprogrammed human hepatocyte-like cells
Ballester, M; (...); Bort, R
Article. 10.1038/s41598-019-54357-x. 2019
Growth-promoting and tumourigenic activity of c-Myc is suppressed by Hhex
Marfil V; (...); Bort R
Article. 10.1038/onc.2014.240. 2015
Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients.
Perez-Rubio, Alvaro; (...); Jover, Ramiro
Article. 10.3390/nu15143187. 2023
Hepatocyte transplantation program: Lessons learned and future strategies
Review. 10.3748/wjg.v22.i2.874. 2016
High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins
Article. 10.1007/s00204-014-1334-3. 2015
Human neonatal hepatocyte transplantation induces long-term rescue of unconjugated hyperbilirubinemia in the Gunn rat
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.1002/lt.24121. 2015
Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing
Article. 10.1093/toxsci/kfw078. 2016
Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure.
Article. 10.1016/j.jcyt.2019.12.005. 2020
In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay
Brecklinghaus, Tim; (...); Hengstler, Jan G.
Article. 10.1016/j.toxlet.2022.08.006. 2022
Increased femoral anteversion in females with anterior knee pain relates to both the neck and the shaft of the femur.
Sanchis-Alfonso V; (...); Doménech-Fernández J
Article. 10.1007/s00402-023-05036-0. 2023
Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices
Jetten MJ; (...); Kleinjans JC
Article. 10.1016/j.tox.2014.06.007. 2014
LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells
García-Cañaveras JC; (...); Lahoz A
Article. 10.1002/elps.201500095. 2015
Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes.
Tolosa, L; (...); Donato, MT
Article. 10.1007/s00204-018-2349-y. 2019
Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes
Quintas, G; (...); Castell, JV
Article. 10.1007/s00204-021-03114-z. 2021
Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction
Cortes M; (...); Lahoz A
Article. 10.1016/j.jhep.2014.04.023. 2014
Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved.
Martínez-Sena T; (...); Castell JV
Article. 10.1007/s00204-023-03474-8. 2023
Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen.
Rodríguez-Agudo R; (...); Martínez-Chantar ML
Article. 10.3390/antiox11050897. 2022
Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients
Thiel, C; (...); Kuepfer, L
Article. 10.1007/s00204-016-1723-x. 2017
Modeling a Novel Variant of Glycogenosis IXa Using a Clonal Inducible Reprogramming System to Generate "Diseased" Hepatocytes for Accurate Diagnosis.
Garcia-Llorens, Guillem; (...); Bort, Roque
Article. 10.3390/jpm12071111. 2022
Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid in human hepatocytes
Petrov, P. D.; (...); Jover, R.
Meeting Abstract. 2021
Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways.
Article. 10.1016/j.fct.2021.112664. 2021
Monitoring of system conditioning after blank injections in untargeted UPLC-MS metabolomic analysis.
Martínez-Sena T; (...); Kuligowski J
Article. 10.1038/s41598-019-46371-w. 2019
Neonatal Livers: A Source for the Isolation of Good-Performing Hepatocytes for Cell Transplantation
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.3727/096368913X669743. 2014
New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease
Lopez-Riera, M; (...); Jover, R
Article. 10.3389/fpahr.2017.00003. 2017
Newserum miRNA biomarkers to predict liver steatosis by valproic acid in paediatric epileptic patients
Jover, R.; (...); Castell, J. V.
Meeting Abstract. 10.1016/j.toxlet.2022.07.200. 2022
Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers
Lopez-Riera, M; (...); Jover, R
Article. 10.1038/s41598-018-28854-4. 2018
Outcomes of elective liver surgery worldwide: a global, prospective, multicenter, cross-sectional study
Malago, Massimo; (...); Andreoli, Gustavo
Article. 10.1097/JS9.0000000000000711. 2023
Predicting drug-induced cholestasis: preclinical models
Petrov, PD; (...); Jover, R
Review. 10.1080/17425255.2018.1487399. 2018
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
Albrecht, W; (...); Hengstler, JG
Article. 10.1007/s00204-019-02492-9. 2019
Progress and challenges of mid-infrared spectroscopy for liver characterization focusing on steatosis, fibrosis and cancer
Ten-Domenech, Isabel; (...); Quintas, Guillermo
Review. 10.1080/05704928.2023.2215858. 2024
Protectiveness of NAM-based hazard assessment - which testing scope is required?
Zobl, Walter; (...); Escher, Sylvia E.
Article. 10.14573/altex.2309081. 2023
Quantitative Prediction of Steatosis in Patients with Non-Alcoholic Fatty Liver by Means of Hepatic MicroRNAs Present in Serum and Correlating with Hepatic Fat
Quintas, Guillermo; (...); Jover, Ramiro
Article. 10.3390/ijms23169298. 2022
Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.
Gu, XL; (...); Stoeber, R
Article. 10.1007/s00204-018-2302-0. 2018
Repression of the Nuclear Receptor Small Heterodimer Partner by Steatotic Drugs and in Advanced Nonalcoholic Fatty Liver Disease
Article. 10.1124/mol.114.096313. 2015
Safer chemicals using less animals: kick-off of the European ONTOX project
Vinken, M; (...); Piersma, AH
Review. 10.1016/j.tox.2021.152846. 2021
Silencing of hepatic fate-conversion factors induce tumorigenesis in reprogrammed hepatic progenitor-like cells
Serrano F; (...); Bort R
Article. 10.1186/s13287-016-0349-5. 2016
TESTING CHEMICAL CARCINOGENICITY BY USING A TRANSCRIPTOMICS HEPARG-BASED MODEL?
Doktorova TY; (...); Rogiers V
Article. 2014
The assessment of the potential hepatotoxicity of new drugs by in vitro metabolomics.
Quintas, Guillermo, Castell, Jose V., Moreno-Torres, Marta
Article. 10.3389/fphar.2023.1155271. 2023
The in vitro assessment of the toxicity of volatile, oxidisable, redox-cycling compounds: phenols as an example
Tolosa, L; (...); Castell, JV
Article. 10.1007/s00204-021-03036-w. 2021
The Potential Role of Metabolomics in Drug-Induced Liver Injury (DILI) Assessment.
Moreno-Torres, Marta, Quintas, Guillermo, Castell, V, Jose
Article. 10.3390/metabo12060564. 2022
The Vitamin D Receptor Regulates Glycerolipid and Phospholipid Metabolism in Human Hepatocytes
Martinez-Sena, T; (...); Jover, R
Article. 10.3390/biom10030493. 2020
Toward Rapid Screening of Liver Grafts at the Operating Room Using Mid-infrared Spectroscopy.
Pérez-Guaita D; (...); Castell JV
Article. 10.1021/acs.analchem.0c02735. 2020
Transplantation of hESC-derived hepatocytes protects mice from liver injury
Tolosa L; (...); Dubart-Kupperschmitt A
Article. 10.1186/s13287-015-0227-6. 2015
Uncovering the toxicity mechanisms of a series of carboxylic acids in liver cells through computational and experimental approaches.
Ortega-Vallbona, Rita; (...); Serrano-Candelas, Eva
Article. 10.1016/j.tox.2024.153764. 2024
Using Metabolomics to Uncover Ontogeny of Drug-Induced Hepatotoxicity and Underlying AOP Mechanisms
Martinez-Sena, T.; (...); Castell Ripoll, J. V.
Meeting Abstract. 2023