Portal de investigación
Nuevas tecnologías traslacionales para el tratamiento de enfermedades hepáticas: preacondicionamiento del hígado, nuevas fuentes celulares y biomateriales en terapia celular.
Datos básicos
- Protocolo:
- PI21/00223
- EUDRACT:
- NCT:
- Centro:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Año de incio:
- 2022
- Año de finalización:
- 2025
Documentos
- No hay documentos
Participantes
Grupos
Financiadores - Promotores
Resultados del Ensayo Clínico
[Translated article] New challenges in advanced therapies.
Megías-Vericat JE; (...); Poveda Andrés JL
Article. 10.1016/j.farma.2024.05.001. 2024
In vitro personalised model based on induced pluripotent stem cells for studying idiosyncratic hepatotoxicity
Pelecha, M.; (...); Tolosa, L.
Meeting Abstract. 10.1016/j.toxlet.2024.07.291. 2024
3D HYDROGEL MICROENVIROMENTS OF GELATIN AND HYALURONIC ACID FOR LIVER TISSUE ENGINEERING
Gallego-Ferrer, Gloria; (...); Tolosa, Laia
Article. 2022
A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes.
Moreno-Torres, Marta; (...); Castell, V, Jose
Article. 10.1021/acs.jproteome.1c00779. 2022
A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies.
Garcia-Llorens, Guillem; (...); Bort, Roque
Article. 10.1186/s13287-023-03311-w. 2023
Assessing ATR-FTIR spectroscopy for steatosis quantification in liver biopsies in a long-duration cross-sectional study
Rienda, Ivan; (...); Quintas, Guillermo
Article. 10.1016/j.microc.2024.110135. 2024
BASELINE PROFILE OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS ON TREATMENT WITH BELIMUMAB OF A SPANISH MULTICENTER COHORT
Altabas Gonzalez, I.; (...); Rua-Figueroa, I.
Meeting Abstract. 10.1136/annrheumdis-2023-eular.3003. 2023
CLINICAL SIGNIFICANCE OF ANTI-LA ANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS
Sanguesa, C.; (...); Pego-Reigosa, J. M.
Meeting Abstract. 10.1136/annrheumdis-2023-eular.6283. 2023
Cluster-Partial Least Squares (c-PLS) regression analysis: Application to miRNA and metabolomic data.
Kuligowski, Julia; (...); Quintas, Guillermo
Article. 10.1016/j.aca.2023.342052. 2024
Co-culture of multiple myeloma cell lines and bone marrow mesenchymal stem cells in a 3D microgel environment.
Garcia-Briega, M Inmaculada; (...); Ribelles, Jose Luis Gomez
Article. 10.1016/j.bioadv.2025.214243. 2025
Comparing the direct assessment of steatosis in liver explants with mid- and near-infrared vibrational spectroscopy, prior to organ transplantation.
Rienda, Ivan; (...); Quintas, Guillermo
Article. 10.1039/d3an01184d. 2023
Computational Strategies for Assessing Adverse Outcome Pathways: Hepatic Steatosis as a Case Study.
Ortega-Vallbona R; (...); Serrano-Candelas E
Article. 10.3390/ijms252011154. 2024
Challenges and perspectives of liver tissue engineering: From cell therapy to bioprinting
Rodriguez-Fernandez, Julio; (...); Tolosa, Laia
Review. 10.36922/ijb.2706. 2024
Diagnostic value of hemoglobin concentration in identifying Meckel's diverticulum in pediatric lower gastrointestinal bleeding
Couselo, Miguel; (...); Vila, Juan Jose
Article. 10.1007/s00383-024-05944-1. 2024
EFFECTIVENESS OF BELIMUMAB IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS OF A MULTICENTER SPANISH COHORT
Altabas Gonzalez, I.; (...); Rua-Figueroa, I.
Meeting Abstract. 10.1136/annrheumdis-2023-eular.3482. 2023
En bloc resection vs. Gips procedure in pilonidal sinus surgery.
Diéguez I; (...); Vila JJ
Article. 10.54847/cp.2022.02.15. 2022
Enhancing the accuracy of mid-infrared spectroscopy-based liver steatosis quantification using digital image analysis as a reference.
Rienda, Ivan; (...); Quintas, Guillermo
Article. 10.1039/d3an00324h. 2023
Evaluation of transjugular intrahepatic portosystemic shunt (TIPS) as a previous step to liver transplantation in pediatric patients.
Crehuet Gramatyka D; (...); Vila Carbó JJ
Article. 10.54847/cp.2022.02.12. 2022
FIBROMYALGIA AND GLUCOCORTICOIDS USE DRIVES SELF-PERCEIVED DEPRESSION IN SYSTEMIC LUPUS ERYTHEMATOSUS: INSIGHTS FROM A LARGE PROSPECTIVE AND MULTICENTER STUDY USING RELESSER-PROS REGISTER'S DATABASE
Rua-Figueroa, I.; (...); Pego-Reigosa, J. M.
Meeting Abstract. 10.1136/annrheumdis-2023-eular.1811. 2023
Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients.
Perez-Rubio, Alvaro; (...); Jover, Ramiro
Article. 10.3390/nu15143187. 2023
In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay
Brecklinghaus, Tim; (...); Hengstler, Jan G.
Article. 10.1016/j.toxlet.2022.08.006. 2022
Injectable cell-laden gelatin-chondroitin sulphate hydrogels for liver in vitro models.
Sanchez-Gonzalez, E; (...); Gallego-Ferrer, G
Article. 10.1016/j.ijbiomac.2024.138693. 2024
Integrating Artificial Intelligence for Academic Advanced Therapy Medicinal Products: Challenges and Opportunities
Aguilar-Gallardo, Cristobal, Bonora-Centelles, Ana
Review. 10.3390/app14031303. 2024
Magnetically Activated Piezoelectric 3D Platform Based on Poly(Vinylidene) Fluoride Microspheres for Osteogenic Differentiation of Mesenchymal Stem Cells
Guillot-Ferriols, Maria; (...); Gallego Ferrer, Gloria
Article. 10.3390/gels8100680. 2022
Mechanistic Understanding of Idiosyncratic Drug-Induced Hepatotoxicity Using Co-Cultures of Hepatocytes and Macrophages.
Villanueva-Badenas, Estela, Donato, M. Teresa, Tolosa, Laia
Article. 10.3390/antiox12071315. 2023
Mimicking cell-matrix crosstalk: bioinspired gelatin hydrogels functionalized with monomeric fibronectin as a liver in vitro model
Sanchez Gonzalez, Estela; (...); Gallego Ferrer, Gloria
Meeting Abstract. 2023
Multimodal analysis identifies microbiome changes linked to stem cell transplantation-associated diseases
Artacho, Alejandro; (...); Ubeda, Carles
Article. 10.1186/s40168-024-01948-0. 2024
New challenges of advanced therapies.
Megías-Vericat JE; (...); Poveda Andrés JL
Article. 10.1016/j.farma.2023.11.008. 2024
Novel microgel culture system as semi-solid three-dimensional in vitro model for the study of multiple myeloma proliferation and drug resistance
Clara-Trujillo S; (...); Gómez Ribelles JL
Article. 10.1016/j.bioadv.2022.212749. 2022
Oxidative-stress and long-term hepatotoxicity: comparative study in Upcyte human hepatocytes and hepaRG cells.
Article. 10.1007/s00204-022-03236-y. 2022
Pediatric living donor liver transplantation: results of laparoscopic vs. open graft removal.
Crehuet Gramatyka D; (...); Vila Carbó JJ
Article. 10.54847/cp.2022.02.13. 2022
PIEZOELECTRIC 3D PLATFORM BASED ON HYDROGEL-POLY(VINYLIDENE FLUORIDE) MICROSPHERES FOR MESENCHYMAL STEM CELL OSTEOGENIC DIFFERENTIATION
Gallego-Ferrer, Gloria; (...); Luis Gomez-Ribelles, Jose
Meeting Abstract. 2022
Primary human hepatocytes-laden scaffolds for the treatment of acute liver failure.
Rodriguez-Fernandez J; (...); Tolosa L
Article. 10.1016/j.bioadv.2023.213576. 2023
Progress and challenges of mid-infrared spectroscopy for liver characterization focusing on steatosis, fibrosis and cancer
Ten-Domenech, Isabel; (...); Quintas, Guillermo
Review. 10.1080/05704928.2023.2215858. 2024
Protectiveness of NAM-based hazard assessment - which testing scope is required?
Zobl, Walter; (...); Escher, Sylvia E.
Article. 10.14573/altex.2309081. 2023
Quantitative Prediction of Steatosis in Patients with Non-Alcoholic Fatty Liver by Means of Hepatic MicroRNAs Present in Serum and Correlating with Hepatic Fat
Quintas, Guillermo; (...); Jover, Ramiro
Article. 10.3390/ijms23169298. 2022
Rationale for combined therapies in severe-to-critical COVID-19 patients
Gonzaga, Aitor; (...); Soria, Bernat
Review. 10.3389/fimmu.2023.1232472. 2023
Re-interventions following appendectomy in children: a multicenter study.
Blanco Verdú MD; (...); de Agustín Asencio JC
Article. 10.54847/cp.2022.02.14. 2022
The Development of a Non-Invasive Screening Method Based on Serum microRNAs to Quantify the Percentage of Liver Steatosis
Soluyanova, Polina; (...); Jover, Ramiro
Article. 10.3390/biom14111423. 2024
Thorough assessment of the effectiveness of belimumab in a large Spanish multicenter cohort of systemic lupus erythematosus patients.
Altabás-González I; (...); Rúa-Figueroa I
Article. 10.1093/rheumatology/kead696. 2024
Uncovering the toxicity mechanisms of a series of carboxylic acids in liver cells through computational and experimental approaches.
Ortega-Vallbona, Rita; (...); Serrano-Candelas, Eva
Article. 10.1016/j.tox.2024.153764. 2024
Use of non-invasive scales for detecting esophageal varices in paediatric patients with portal vein thrombosis.
Diéguez Hernández-Vaquero I; (...); Vila Carbó JJ
Article. 10.1016/j.gastrohep.2023.08.001. 2024
VALIDATION ANALYSIS OF THE PHYSICIAN GLOBAL ASSESSMENT (PGA) SCALE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS INCLUDED IN RELESSER-PROS REGISTRY
Caceres Martin, L.; (...); Pego-Reigosa, J. M.
Meeting Abstract. 10.1136/annrheumdis-2023-eular.. 2023
Which scope of NAM testing is sufficient for hazard characterisation? - An investigation based on transcriptomics data
Zobl, W.; (...); Escher, S. E.
Meeting Abstract. 10.1016/j.toxlet.2022.07.675. 2022