Portal de investigación
METABONOMICA Y CITOMICA COMO NUEVOS PARADIGMAS Y ESTRATEGIAS EXPERIMENTALES PARA EL ESTUDIO DE LOS MECANISMOS DE HEPATOTOXICIDAD DE FARMACOS, PREDICCION DE SU POTENCIAL HEPATOTOXICO Y LA TRANSICION DE HEPATITIS I ATROGENICA A AUTOINMUNE.
Datos básicos
- Protocolo:
- PI10/00923
- EUDRACT:
- NO PROCEDE
- NCT:
- Centro:
- Año de incio:
- 2010
- Año de finalización:
- 2014
Objetivos del proyecto
FINALIZADO
Documentos
- No hay documentos
Participantes
-
María Teresa Donato Martín
Investigador Principal
Grupos
-
Hepatología experimental y Trasplante hepático
Investigador Principal
Laia Tolosa Pardo
-
Unidad Mixta de Investigación en Hepatología Experimental
Investigador Principal
Ramiro Jover Atienza
Financiadores - Promotores
Resultados del Ensayo Clínico
CELL SOURCES FOR HEPATIC CELL THERAPY
EUGENIA PAREJA IBARS, MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER, LAIA TOLOSA PARDO
Capítulo de un Libro. 2017
CELL-BASED THERAPEUTIC STRATEGIES FOR TREATMENT OF LIVER DISEASES.
LAIA TOLOSA PARDO, MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER, EUGENIA PAREJA IBARS
Capítulo de un Libro. 2017
[Liver cell therapy in the treatment of inborn errors of metabolism in children].
Abstract of Published Item. 10.1016/j.anpedi.2013.05.018. 2013
In vitro personalised model based on induced pluripotent stem cells for studying idiosyncratic hepatotoxicity
Pelecha, M.; (...); Tolosa, L.
Meeting Abstract. 10.1016/j.toxlet.2024.07.291. 2024
3D HYDROGEL MICROENVIROMENTS OF GELATIN AND HYALURONIC ACID FOR LIVER TISSUE ENGINEERING
Gallego-Ferrer, Gloria; (...); Tolosa, Laia
Article. 2022
A combination of transcriptomics and metabolomics uncovers enhanced bile acid biosynthesis in HepG2 cells expressing CCAAT/enhancer-binding protein ß (C/EBPß), hepatocyte nuclear factor 4a (HNF4a), and constitutive androstane receptor (CAR).
Blazquez M; (...); Bort R
Article. 10.1021/pr400085n. 2013
A Comprehensive Untargeted Metabonomic Analysis of Human Steatotic Liver Tissue by RP and HILIC Chromatography Coupled to Mass Spectrometry Reveals Important Metabolic Alterations
Garcia-Canaveras, Juan C.; (...); Lahoz, Agustin
Article. 10.1021/pr200629p. 2011
A lipidomic cell-based assay for studying drug-induced phospholipidosis and steatosis
Garcia-Canaveras, JC; (...); Lahoz, A
Article. 10.1002/elps.201700079. 2017
A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury
García-Cañaveras JC; (...); Lahoz A
Article. 10.1038/srep27239. 2016
A microRNA signature for valproate-induced steatosis in human hepatocytes and its application to predict fatty liver in paediatric epileptic patients on valproate therapy.
Soluyanova P; (...); Jover R
Article. 10.1016/j.tox.2024.153974. 2024
A Multi-Parametric Fluorescent Assay for the Screening and Mechanistic Study of Drug-Induced Steatosis in Liver Cells in Culture.
Tolosa, Laia, Gomez-Lechon, M Jose, Donato, M Teresa
Article. 10.1002/cptx.20. 2017
A Network Involving Gut Microbiota, Circulating Bile Acids, and Hepatic Metabolism Genes That Protects Against Non-Alcoholic Fatty Liver Disease.
Article. 10.1002/mnfr.201900487. 2019
A New Score System To Classify Liver Graft Functionality after Transplantation
Cortes, Miriam; (...); Lahoz, Agustin
Article. 2011
A novel microRNA signature for cholestatic drugs in human hepatocytes and its translation into novel circulating biomarkers for drug-induced liver injury patients.
López-Riera M; (...); Jover R
Article. 10.1093/toxsci/kfz138. 2020
A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes.
Moreno-Torres, Marta; (...); Castell, V, Jose
Article. 10.1021/acs.jproteome.1c00779. 2022
A read-across case study on chronic toxicity of branched carboxylic acids (1): Integration of mechanistic evidence from new approach methodologies (NAMs) to explore a common mode of action.
Escher, Sylvia E.; (...); Fisher, Ciaran
Art Exhibit Review. 10.1016/j.tiv.2021.105269. 2022
A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies.
Garcia-Llorens, Guillem; (...); Bort, Roque
Article. 10.1186/s13287-023-03311-w. 2023
A Score Model for the Continuous Assessment of Early Allograft Function after Liver Transplantation
Cortes, Miriam; (...); Lahoz, Agustin
Article. 2014
A Score Model for the Continuous Grading of Early Allograft Dysfunction Severity
Article. 10.1002/lt.23990. 2015
A simple transcriptomic signature able to predict drug-induced hepatic steatosis
Article. 10.1007/s00204-014-1197-7. 2014
Adherence to endoscopic surveillance guidelines for advanced lesions and colorectal cancer in Inflammatory Bowel Disease in Spain: a collaborative study of AEG and GETECCU
Ballester Ferre, M. P.; (...); Minguez, M.
Meeting Abstract. 10.1093/ecco-jcc/jjab076.727. 2021
Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems
Fernandez-Murga, ML; (...); Jover, R
Review. 10.1016/j.fct.2018.07.017. 2018
Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis
Article. 10.1016/j.taap.2016.04.007. 2016
ADVERSE EFFECTS OF TRIPLE THERAPY WITH BOCEPREVIR (BOC) AND TELAPREVIR (TVR) IN CLINICAL PRACTICE IN PATIENTS WITH ADVANCED HEPATIC FIBROSIS
Salmeron, J.; (...); Prieto, M.
Article. 10.1016/S0168-8278(14)61356-8. 2014
Albumin dialysis with MARS for the treatment of anabolic steroid-induced cholestasis
Diaz, FC; (...); Prieto, M
Article. 10.5604/16652681.1222114. 2016
Altered Underlying Renal Tubular Function in Patients With Chronic Hepatitis B Receiving Nucleos(t)ide Analogs in a Real-World Setting The MENTE Study
Rodríguez-Nóvoa S; (...); Castro Á
Article. 10.1097/MCG.0000000000000569. 2016
Altered underlying tubular function in HBV monoinfected patients receiving nucleos(t)ide analogs in a real-world setting: MENTE Study
Rodriguez Novoa, Sonia; (...); Castro, Angeles
Article. 2014
Alternative Cell Sources to Adult Hepatocytes for Hepatic Cell Therapy.
Pareja, E, Gomez-Lechon, MJ, Tolosa, L
Article. 10.1007/978-1-4939-6506-9_2. 2017
An in vitro tool to assess cytochrome P450 drug biotransformation-dependent cytotoxicity in engineered HepG2 cells generated by using adenoviral vectors.
Lahoz A; (...); Gómez-Lechón MJ
Article. 10.1016/j.tiv.2012.08.001. 2013
ANABOLIC ANDROGENIC STEROIDS (AAS) ILLICIT USE IS A RAPIDLY GROWING CAUSE OF DRUG-INDUCED LIVER INJURY (DILI): A PROSPECTIVE SERIES FROM THE SPANISH-LATIN-AMERICAN DILI REGISTRY
Medina-Caliz, I.; (...); Andrade, R. J.
Article. 10.1016/S0168-8278(14)60472-4. 2014
Angiopoietin-Like Protein 8 Is a Novel Vitamin D Receptor Target Gene Involved in Nonalcoholic Fatty Liver Pathogenesis
Garcia-Monzon, C; (...); Jover, R
Article. 10.1016/j.ajpath.2018.07.028. 2018
Angiopoietin-like protein 8 is a novel vitamin D receptor-targeted lipogenic gene associated with non-alcoholic fatty liver
Gonzalez-Rodriguez, A; (...); Garcia-Monzon, C
Meeting Abstract. 10.1016/S0168-8278(18)30948-6. 2018
Apicobasal Polarity Controls Lymphocyte Adhesion to Hepatic Epithelial Cells
Reglero-Real N; (...); Millán J
Article. 10.1016/j.celrep.2014.08.007. 2014
Application of FISH 7q in MDS patients without monosomy 7 or 7q deletion by conventional G-banding cytogenetics: does -7/7q- detection by FISH have prognostic value?
Ademà V; (...); Solé F
Article. 10.1016/j.leukres.2012.12.010. 2013
Application of high-content screening for the study of hepatotoxicity: Focus on food toxicology.
Review. 10.1016/j.fct.2020.111872. 2021
Assessment of the cytotoxic potential of an aqueous-ethanolic extract from Thalassia testudinum angiosperm marine grown in the Caribbean Sea.
Rodeiro, I; (...); Lopes, M
Article. 10.1111/jphp.13001. 2018
Association of Cardiac Abnormalities to the Frail Phenotype in Cirrhotic Patients on the Waitlist: From the Functional Assessment in Liver Transplantation Study
Puchades, L; (...); Lai, JC
Article. 10.1097/TP.0000000000002025. 2018
Autoantibody presentation in drug-induced liver injury and idiopathic autoimmune hepatitis: the influence of human leucocyte antigen alleles
Stephens, C; (...); Lucena, MI
Article. 10.1097/FPC.0000000000000230. 2016
Automated generation of hiPSC-derived hepatic progeny by cost-efficient compounds.
Vanmarcke G; (...); Verfaillie CM
Article. 10.1093/stmcls/sxad065. 2023
Baseline features of hepatitis C patients associated to prescription of pangenotypic antiviral treatments: results from the real-world Spanish Hepa-C registry
Turnes, Juan; (...); Perez Cachafeiro, Santiago
Meeting Abstract. 2020
Baseline Pegylated Interferon (PIFN) and Calcineurin Inhibitor (CNI): No Impact on Sustained Viral Response (SVR) Post-Liver Transplantation
Aguilera, Victoria; (...); Berenguer, Marina
Article. 2011
BASELINE PROFILE OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS ON TREATMENT WITH BELIMUMAB OF A SPANISH MULTICENTER COHORT
Altabas Gonzalez, I.; (...); Rua-Figueroa, I.
Meeting Abstract. 10.1136/annrheumdis-2023-eular.3003. 2023
Bladder cancer recurrence surveillance by urine metabolomics analysis
Loras, A; (...); Ruiz-Cerda, JL
Article. 10.1038/s41598-018-27538-3. 2018
Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development
Article. 10.1016/j.toxlet.2016.10.008. 2016
Brain abscesses in early post-liver transplantation.
Mínguez Sabater A; (...); Prieto Castillo M
Case Reports. 10.1016/j.eimc.2021.02.002. 2021
Brain abscesses in early post-liver transplantation.
Minguez Sabater, Alejandro; (...); Prieto Castillo, Martin
Article. 10.1016/j.eimce.2021.09.007. 2021
CCAAT/Enhancer-binding Protein alpha (C/EBP alpha) and Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha) Synergistically Cooperate with Constitutive Androstane Receptor to Transactivate the Human Cytochrome P450 2B6 (CYP2B6) Gene APPLICATION TO THE DEVELOPMENT OF A METABOLICALLY COMPETENT HUMAN HEPATIC CELL MODEL
Benet, Marta; (...); Jover, Ramiro
Article. 10.1074/jbc.M110.118364. 2010
Cell Models and Omics Techniques for the Study of Nonalcoholic Fatty Liver Disease: Focusing on Stem Cell-Derived Cell Models.
Article. 10.3390/antiox11010086. 2021
Cellular and molecular mechanisms involved in the neuroprotective effects of VEGF on motoneurons.
Lladó J, Tolosa L, Olmos G
Article. 10.3389/fncel.2013.00181. 2013
Clinical Application of Pluripotent Stem Cells: An Alternative Cell-Based Therapy for Treating Liver Diseases?
Tolosa L, Pareja E, Gomez-Lechon MJ
Review. 10.1097/TP.0000000000001426. 2016
Clinical characteristics and outcomes of elderly included in the Spanish Drug-Induced Liver Injury (DILI) Registry
Slim, M; (...); Andrade, RJ
Meeting Abstract. 10.1016/S0168-8278(17)31154-6. 2017
Clinical features and risk factors associated with Non-alcoholic steatohepatitis (NASH) in Spain. On behalf of HEPAmet Registry
Gallego-Duran, Rocio; (...); Romero-Gomez, Manuel
Article. 2015
Clinical outcome of hepatocyte transplantation in four pediatric patients with inherited metabolic diseases.
Ribes-Koninckx C; (...); Castell JV
Article. 10.3727/096368912X637505. 2012
Clinical outcomes of patients delisted from thewaiting list of liver transplantation after interferon-free antiviral therapy
Pascasio, JM; (...); Londono, MC
Meeting Abstract. 10.1016/S0168-8278(17)30661-X. 2017
Clinical outcomes of patients undergoing antiviral therapy while awaiting liver transplantation
Pascasio, JM; (...); Londoño MC
Article. 10.1016/j.jhep.2017.08.008. 2017
CLINICAL PRESENTATION AND OUTCOMES OF DE NOVO HEPATITIS B VIRUS INFECTION AFTER LIVER TRANSPLANTATION IN SPAIN.
Pascasio Acevedo, Juan Manuel; (...); Manuel Sousa, Jose
Meeting Abstract. 2019
CLINICAL SIGNIFICANCE OF ANTI-LA ANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS
Sanguesa, C.; (...); Pego-Reigosa, J. M.
Meeting Abstract. 10.1136/annrheumdis-2023-eular.6283. 2023
Cluster-Partial Least Squares (c-PLS) regression analysis: Application to miRNA and metabolomic data.
Kuligowski, Julia; (...); Quintas, Guillermo
Article. 10.1016/j.aca.2023.342052. 2024
Co-culture of multiple myeloma cell lines and bone marrow mesenchymal stem cells in a 3D microgel environment.
Garcia-Briega, M Inmaculada; (...); Ribelles, Jose Luis Gomez
Article. 10.1016/j.bioadv.2025.214243. 2025
Comparative analysis of eight cytotoxicity assays evaluated within the ACuteTox Project.
Clothier R; (...); Stanzel S
Article. 10.1016/j.tiv.2012.08.015. 2013
Comparing in vitro human liver models to in vivo human liver using RNA-Seq.
Gupta R; (...); Caiment F
Article. 10.1007/s00204-020-02937-6. 2020
Comparing Targeted vs. Untargeted MS2 Data-Dependent Acquisition for Peak Annotation in LC-MS Metabolomics
Ten-Domenech, I; (...); Kuligowski, J
Article. 10.3390/metabo10040126. 2020
Comparing the direct assessment of steatosis in liver explants with mid- and near-infrared vibrational spectroscopy, prior to organ transplantation.
Rienda, Ivan; (...); Quintas, Guillermo
Article. 10.1039/d3an01184d. 2023
Comparison of results of combined liver-kidney transplantation vs. isolated liver transplantation.
Aguilera V; (...); Mir J
Article. 10.1016/S1665-2681(19)31366-3. 2013
Comparison of the Prognostic Value of Liver Biopsy and FIB-4 Index in Patients Coinfected With HIV and Hepatitis C Virus
Berenguer J; (...); González-García J
Article. 10.1093/cid/ciu939. 2015
Comparison of two non-contemporaneous HCV-liver transplant cohorts: strategies to improve the efficacy of antiviral therapy.
Berenguer M; (...); Prieto M
Article. 10.1016/j.jhep.2011.12.031. 2012
Competency of different cell models to predict human hepatotoxic drugs
Gómez-Lechón MJ; (...); Donato MT
Review. 10.1517/17425255.2014.967680. 2014
Comprehensive analysis and insights gained from long-term experience of the Spanish DILI registry.
Stephens C; (...); Andrade RJ
Article. 10.1016/j.jhep.2021.01.029. 2021
Computational Strategies for Assessing Adverse Outcome Pathways: Hepatic Steatosis as a Case Study.
Ortega-Vallbona R; (...); Serrano-Candelas E
Article. 10.3390/ijms252011154. 2024
Consensus document of the Spanish Association for Study of the Liver on the treatment of hepatitis B virus infection (2020).
Rodríguez M; (...); García-Samaniego J
Article. 10.1016/j.gastrohep.2020.03.011. 2020
Control of Diabetes Mellitus in Liver Transplant Recipients
Ramos-Prol, Agustin; (...); Francisco Merino-Torres, Juan
Article. 2014
Culture and Functional Characterization of Human Hepatoma HepG2 Cells.
Donato, MT, Tolosa, L, Gomez-Lechon, MJ
Article. 10.1007/978-1-4939-2074-7_5. 2015
Current status and future perspectives of hepatocyte transplantation
Review. 10.1016/j.ciresp.2013.04.010. 2014
Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury
Tolosa, L; (...); Teresa Donato, M.
Article. 10.1007/s00204-017-2036-4. 2018
Challenges and perspectives of liver tissue engineering: From cell therapy to bioprinting
Rodriguez-Fernandez, Julio; (...); Tolosa, Laia
Review. 10.36922/ijb.2706. 2024
CHARACTERIZATION OF HBsAg LOSS IN PATIENTS WITH CHRONIC HEPATITIS B (CHB) TREATED WITH NUCLEOS/TIDE ANALOGS (NUCS): A RETROSPECTIVE MULTICENTER STUDY (HEBESAS)
Suarez, E.; (...); Fuentes, J.
Article. 10.1016/S0168-8278(15)30854-0. 2015
Characterization of Proliferating Human Hepatocytes As a Model System for Drug Interaction Studies and Toxicity Screenings
Noerenberg, A; (...); Jover, R
Meeting Abstract. 2017
Chemometric approaches to improve PLSDA model outcome for predicting human non-alcoholic fatty liver disease using UPLC-MS as a metabolic profiling tool
Quintas, Guillermo; (...); Lahoz, Agustin
Article. 10.1007/s11306-011-0292-5. 2012
Chronic kidney disease after liver transplantation: pretransplantation risk factors and predictors during follow-up.
Giusto M; (...); Merli M
Article. 10.1097/TP.0b013e3182884890. 2013
Daclatasvir combined with sofosbuvir or simeprevir in liver transplant recipients with severe recurrent hepatitis C infection
Fontana RJ; (...); Reddy KR
Article. 10.1002/lt.24416. 2016
Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure.
Chen Q; (...); Quer J
Article. 10.1016/j.antiviral.2019.104694. 2020
Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury
Medina-Caliz, I; (...); Spanish DILI Registry
Article. 10.1016/j.jhep.2016.05.003. 2016
Derivation of healthy hepatocyte-like cells from a female patient with ornithine transcarbamylase deficiency through X-inactivation selection.
Santamaria R; (...); Bort R
Article. 10.1038/s41598-022-06184-w. 2022
Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.1093/toxsci/kfs083. 2012
Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress assessment of nanoparticle-treated cells.
Aranda A; (...); Gombau L
Article. 10.1016/j.tiv.2013.01.016. 2013
Direct conversion of human fibroblast to hepatocytes using a single inducible polycistronic vector.
Ballester M; (...); Bort R
Article. 10.1186/s13287-019-1416-5. 2019
Direct-acting antivirals are effective and safe in HCV/HIV-coinfected liver transplant recipients who experience recurrence of hepatitis C: A prospective nationwide cohort study (vol 18, pg 2513, 2018)
Manzardo, C.; (...); Samuel, D.
Article. 2018
Direct-acting antivirals are effective and safe in HCV/HIV-coinfected liver transplant recipients who experience recurrence of hepatitis C: A prospective nationwide cohort study (vol 18, pg 2513, 2018)
Manzardo, C.; (...); Samuel, D.
Correction. 10.1111/ajt.15244. 2019
Distinct phenotype of hepatotoxicity associated with illicit use of anabolic androgenic steroids
Robles-Diaz M; (...); SLatinDILI Network
Article. 10.1111/apt.13023. 2015
DISTINGUISHING DRUG INDUCED AUTOIMMUNE HEPATITIS FROM IDIOPATIC AUTOIMMUNE HEPATITIS
Ortega-Alonso, A.; (...); Lucena, M. I.
Article. 10.1016/S0168-8278(15)31294-0. 2015
Documento de consenso de la AEEH sobre el tratamiento de la infección por el virus de la hepatitis B (2012).
Buti M; (...); Esteban R
Article. 10.1016/j.gastrohep.2012.04.006. 2012
DRESS cases included in the Spanish and Latin-American DILI registries: clinical phenotype and outcome
Medina-Caliz, I; (...); Andrade, RJ
Meeting Abstract. 10.1016/S0168-8278(18)31459-4. 2018
Drug-Induced Fatty Liver Disease (DIFLD): A Comprehensive Analysis of Clinical, Biochemical, and Histopathological Data for Mechanisms Identification and Consistency with Current Adverse Outcome Pathways.
Lopez-Pascual, Ernesto; (...); Castell, Jose V.
Article. 10.3390/ijms25105203. 2024
Drug-induced liver steatosis and phospholipidosis: cell-based assays for early screening of drug candidates.
Article. 2012
Early Introduction of Subcutaneous Hepatitis B Immunoglobulin Following Liver Transplantation for Hepatitis B Virus Infection: A Prospective, Multicenter Study
De Simone, P; (...); Samuel, D
Article. 10.1097/TP.0000000000001171. 2016
Effect of Calcineurin Inhibitors in the Outcome of Liver Transplantation in Hepatitis C Virus-Positive Recipients
Berenguer, Marina; (...); Prieto, Martin
Article. 10.1097/TP.0b013e3181fa93fa. 2010
Effectiveness and safety of ombitasvir, paritaprevir, ritonavir +/- dasabuvir +/- ribavirin: An early access programme for Spanish patients with genotype 1/4 chronic hepatitis C virus infection
Perello, C; (...); Spanish Collaborative Group for the Study of the Use of Hepatitis C Direct-Actin
Article. 10.1111/jvh.12637. 2017
Effectiveness of 8 weeks of glecaprevir/pibrentasvir in treatment-naive hepatitis C patients with liver cirrhosis: results from the real-world Spanish Hepa-C registry
Turnes, Juan; (...); Perez Cachafeiro, Santiago
Meeting Abstract. 2020
EFFECTIVENESS OF BELIMUMAB IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS OF A MULTICENTER SPANISH COHORT
Altabas Gonzalez, I.; (...); Rua-Figueroa, I.
Meeting Abstract. 10.1136/annrheumdis-2023-eular.3482. 2023
Effectiveness of ribavirin use associated with direct-acting antivirals in the treatment of non-cirrhotic patients with genotype 1a or 4 HCV infection in real-world practice
Ruiz-Antoran, B; (...); Panero, JLC
Meeting Abstract. 10.1016/S0168-8278(17)31448-4. 2017
EFFECTIVENESS OF TRIPLE THERAPY WITH BOCEPREVIR OR TELAPREVIR IN A MULTICENTRE CLINICAL PRACTICE COHORT OF HCV TREATMENT-EXPERIENCED PATIENTS WITH ADVANCED HEPATIC FIBROSIS. SVR-12W AFTER TREATMENT
FERNANDEZ, C.; (...); Salmeron, J.
Article. 10.1016/S0168-8278(14)61360-X. 2014
Effectiveness, safety/tolerability of OBV/PTV/r +/- DSV in patients with HCV genotype 1 or 4 with/without HIV-1 co-infection, chronic kidney disease (CKD) stage IIIb/V and dialysis in Spanish clinical practice - preliminary data Vie-KinD study
Londono, MC; (...); De Alvaro, C
Meeting Abstract. 10.1016/S0168-8278(17)31920-7. 2017
Efficacy and safety of daclatasvir-based antiviral therapy in hepatitis C virus recurrence after liver transplantation. Role of cirrhosis and genotype 3. A multicenter cohort study
Salcedo, M; (...); Bañares R
Article. 10.1111/tri.12999. 2017
Efficacy and safety of entecavir in clinical practice in treatment-naive Caucasian chronic hepatitis B patients
Buti, Maria; (...); ORIENTE Study Grp
Article. 2012
Efficacy and safety of entecavir in clinical practice in treatment-naive Caucasian chronic hepatitis B patients (vol 24, pg 535, 2012)
Buti, Maria; (...); Rodriguez, Manuel
Article. 10.1097/MEG.0b013e328356123a. 2012
Efficacy and safety of entecavir in clinical practice in treatment-naive Caucasian chronic hepatitis B patients.
Buti M; (...); Rodríguez M
Article. 10.1097/MEG.0b013e3283511287. 2012
Efficacy and safety of glecaprevir/pibrentasvir for the pangenotypic treatment of chronic hepatitis C in former intravenous drug users: Subanalysis from a Spanish real-world cohort (Hepa-C)
Puigvehi, M; (...); Carrion, JA
Meeting Abstract. 10.1016/S0618-8278(19)30399-8. 2019
Efficacy and Safety of Therapy With Simeprevir and Sofosbuvir in Liver Transplant Recipients Infected by Hepatitis C Virus Genotype 4: Cohort Spanish Society of Liver Transplantation Cohort
Sanchez Antolin G; (...); Castells L
Article. 10.1016/j.transproceed.2016.08.034. 2016
Efficacy and tolerability of interferon-free antiviral therapy in kidney transplant recipients with chronic hepatitis C
Fernández I; (...); Londoño MC
Article. 10.1016/j.jhep.2016.12.020. 2017
Efficacy of retreatment of HCV infection after liver transplantation (lt): role of aggressive approach
Berenguer, Marina; (...); Samuel, Didier
Article. 2012
Efficacy of the retreatment of hepatitis C virus infections after liver transplantation: Role of an aggressive approach
Berenguer, Marina; (...); Samuel, Didier
Article. 2013
Efficacy of the retreatment of hepatitis C virus infections after liver transplantation: role of an aggressive approach.
Berenguer M; (...); Samuel D
Article. 10.1002/lt.23555. 2013
Enhancing the accuracy of mid-infrared spectroscopy-based liver steatosis quantification using digital image analysis as a reference.
Rienda, Ivan; (...); Quintas, Guillermo
Article. 10.1039/d3an00324h. 2023
Entecavir has high efficacy and safety in white patients with chronic hepatitis B and comorbidities
Buti M; (...); Gila A
Article. 10.1097/MEG.0000000000000195. 2015
Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes.
Article. 10.1007/s00204-019-02643-y. 2020
Estrategias para evitar la recidiva viral B despues del trasplante hepatico.
Abstract of Published Item. 10.1016/S0210-5705(14)70067-6. 2014
Evaluation of cytochrome P450 activities in human hepatocytes in vitro.
Gómez-Lechón MJ; (...); Donato MT
Article. 10.1007/978-1-61779-367-7_7. 2012
Evaluation of genotoxicity and DNA protective effects of mangiferin, a glucosylxanthone isolated from Mangifera indica L. stem bark extract.
Rodeiro I; (...); Espinosa-Aguirre JJ
Article. 10.1016/j.fct.2012.06.032. 2012
Everolimus plus minimized tacrolimus on kidney function in liver transplantation: REDUCE, a prospective, randomized controlled study.
Gómez-Bravo M; (...); Santoyo J
Article. 10.17235/reed.2022.8549/2021. 2022
Exploring Individual Variability in Drug-Induced Liver Injury (DILI) Responses through Metabolomic Analysis.
Moreno-Torres M; (...); Castell JV
Article. 10.3390/ijms25053003. 2024
Exploring Mass Spectrometry Suitability to Examine Human Liver Graft Metabonomic Profiles
Cortes, M.; (...); Lahoz, A.
Article. 10.1016/j.transproceed.2010.07.049. 2010
Extending metabolome coverage for untargeted metabolite profiling of adherent cultured hepatic cells
García-Cañaveras JC; (...); Lahoz A
Article. 10.1007/s00216-015-9227-8. 2016
Extracting consistent biological information from functional results of metabolomic pathway analysis using the Mantel's test.
Ten-Doménech I; (...); Kuligowski J
Article. 10.1016/j.aca.2021.339173. 2021
Factors that influence the quality of metabolomics data in in vitro cell toxicity studies: a systematic survey.
Moreno-Torres, Marta; (...); Castell, Jose Vicente
Article. 10.1038/s41598-021-01652-1. 2021
FIBROMYALGIA AND GLUCOCORTICOIDS USE DRIVES SELF-PERCEIVED DEPRESSION IN SYSTEMIC LUPUS ERYTHEMATOSUS: INSIGHTS FROM A LARGE PROSPECTIVE AND MULTICENTER STUDY USING RELESSER-PROS REGISTER'S DATABASE
Rua-Figueroa, I.; (...); Pego-Reigosa, J. M.
Meeting Abstract. 10.1136/annrheumdis-2023-eular.1811. 2023
FIRST REAL CLINICAL PRACTICE DATA IN SPAIN ON SOFOSBUVIR, SIMEPREVIR AND DACLATASVIR IN POST-TRANSPLANT HCV RECURRENCE: THE HepatiC REGISTRY EXPERIENCE
Prieto, M.; (...); Forns, X.
Article. 10.1016/S0168-8278(15)30988-0. 2015
Fontan Circulation in Adult Patients: Acoustic Radiation Force Impulse Elastography as a Useful Tool for Liver Assessment.
Melero-Ferrer JL; (...); Rueda-Soriano J
Article. 10.1177/2150135114530172. 2014
Fontan procedure: imaging of normal post-surgical anatomy and the spectrum of cardiac and extracardiac complications
Navarro-Aguilar V; (...); Leiva-Salinas C
Review. 10.1016/j.crad.2014.10.005. 2015
Foxa1 reduces lipid accumulation in human hepatocytes and is down-regulated in nonalcoholic fatty liver.
Moya M; (...); Jover R
Article. 10.1371/journal.pone.0030014. 2012
Framingham score, renal dysfunction, and cardiovascular risk in liver transplant patients
Di Maira, Tommaso; (...); Berenguer, Marina
Article. 10.1002/lt.24128. 2015
Functional Characterization of Hepatocytes for Cell Transplantation: Customized Cell Preparation for Each Receptor
Bonora-Centelles, A.; (...); Gomez-Lechon, M. J.
Article. 10.3727/096368909X474267. 2010
Gata4 blocks somatic cell reprogramming by directly repressing Nanog.
Serrano F; (...); Bort R
Article. 10.1002/stem.1272. 2013
General Cytotoxicity Assessment by Means of the MTT Assay.
Tolosa, L, Donato, MT, Gomez-Lechon, MJ
Article. 10.1007/978-1-4939-2074-7_26. 2015
Genotype and Allele Frequencies of Drug-Metabolizing Enzymes and Drug Transporter Genes Affecting Immunosuppressants in the Spanish White Population
Bosó V; (...); Aliño SF
Article. 10.1097/FTD.0b013e3182a94e65. 2014
Glutamine/glutamate metabolism rewiring in reprogrammed human hepatocyte-like cells
Ballester, M; (...); Bort, R
Article. 10.1038/s41598-019-54357-x. 2019
Good posttransplant outcome using donors after cardiac death (DCD) when applying strict selection criteria
de la Varga, MF; (...); Castillo, MP
Meeting Abstract. 2021
Good post-transplant outcomes using liver donors after circulatory death when applying strict selection criteria: A propensity-score matched-cohort study.
Fernandez-de la Varga, Margarita; (...); Aguilera, Victoria
Article. 10.1016/j.aohep.2022.100724. 2022
Growth-promoting and tumourigenic activity of c-Myc is suppressed by Hhex
Marfil V; (...); Bort R
Article. 10.1038/onc.2014.240. 2015
Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients.
Perez-Rubio, Alvaro; (...); Jover, Ramiro
Article. 10.3390/nu15143187. 2023
Haemophagocytic syndrome in a liver transplant patient during treatment with Telaprevir.
Rodríguez-Medina B; (...); Berenguer M
Article. 10.1016/S1665-2681(19)31305-5. 2013
HCV cirrhosis: liver volume as a non-invasive predictor of liver recovery post DAA treatment
Di Maira, T; (...); Berenguer, M
Meeting Abstract. 10.1016/S0168-8278(17)31568-4. 2017
Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering.
Donato MT, Jover R, Gómez-Lechón MJ
Article. 2013
Hepatitis B surface antigen loss after discontinuing nucleos(t)ide analogue for treatment of chronic hepatitis B patients is persistent in White patients
Suarez, E; (...); Simon, MA
Article. 10.1097/MEG.0000000000001289. 2019
Hepatitis B virus quasispecies evolution after liver transplantation in patients under long-term lamivudine prophylaxis with or without hepatitis B immune globulin
Buti M; (...); Esteban R
Article. 10.1111/tid.12360. 2015
Hepatitis B virus recurrence after liver transplantation and evolution of viral quasispecies
Buti, Maria; (...); Rodriguez-Frias, Francisco
Article. 2014
Hepatitis C virus viral kinetics during a-2a or a-2b pegylated interferon plus ribavirin therapy in liver transplant recipients with different immunosuppression regimes.
Berenguer M; (...); López-Labrador FX
Article. 10.1016/j.jcv.2011.12.005. 2012
Hepatobiliary and Pancreatic: A fatal case of extensive splanchnic vein thrombosis in a patient with Covid-19.
Del Hoyo J; (...); Aguilera V
Editorial Material. 10.1111/jgh.15174. 2020
Hepatocyte transplantation program: Lessons learned and future strategies
Review. 10.3748/wjg.v22.i2.874. 2016
HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved.
Article. 10.1007/s00204-013-1012-x. 2013
High efficacy of Sofosbuvir plus Simeprevir in a large cohort of Spanish cirrhotic patients infected with genotypes 1 and 4
Mariño Z; (...); Forns, X
Article. 10.1111/liv.13470. 2017
High-content imaging technology for the evaluation of drug-induced steatosis using a multiparametric cell-based assay.
Donato MT; (...); Gómez-Lechón MJ
Article. 10.1177/1087057111427586. 2012
High-Content Screening for the Detection of Drug-Induced Oxidative Stress in Liver Cells.
Review. 10.3390/antiox10010106. 2021
High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins
Article. 10.1007/s00204-014-1334-3. 2015
High-content screening technology for studying drug-induced hepatotoxicity in cell models
Tolosa L, Gómez-Lechón MJ, Donato MT
Review. 10.1007/s00204-015-1503-z. 2015
HIV infection is not associated with increased cardiovascular (CV) risk in liver transplant (LT) recipients: a single centre comparative study
Vinaixa, C.; (...); Prieto, M.
Meeting Abstract. 2019
Human Embryonic Stem Cell Derived Hepatocyte-Like Cells as a Tool for In Vitro Hazard Assessment of Chemical Carcinogenicity
Yildirimman, Reha; (...); Herwig, Ralf
Article. 10.1093/toxsci/kfr225. 2011
Human hepatocyte transplantation in patients with hepatic failure awaiting a graft.
Article. 10.1159/000351332. 2013
Human hepatocytes derived from pluripotent stem cells: a promising cell model for drug hepatotoxicity screening
Review. 10.1007/s00204-016-1756-1. 2016
Human hepatocytes encapsulated in injectable hydrogels for their use in liver cell therapy
Rodriguez-Fernandez, J.; (...); Tolosa, L.
Meeting Abstract. 2019
Human neonatal hepatocyte transplantation induces long-term rescue of unconjugated hyperbilirubinemia in the Gunn rat
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.1002/lt.24121. 2015
Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing
Article. 10.1093/toxsci/kfw078. 2016
Iberogast-Induced Severe Hepatotoxicity Leading to Liver Transplantation
Sáez-González E; (...); Berenguer M
Letter. 10.1038/ajg.2016.260. 2016
Immunohistochemical, genetic and epigenetic profiles of hereditary and triple negative breast cancers. Relevance in personalized medicine
Murria R; (...); Bolufer P
Article. 2015
Impact of basal heart rate on long-term prognosis of heart transplant patients.
Melero-Ferrer JL; (...); Salvador-Sanz A
Article. 10.1111/tri.12082. 2013
Impact of hepatitis C virus (HCV) antiviral treatment on the need for liver transplantation (LT)
Saez-Gonzalez, E; (...); Berenguer, M
Article. 10.1111/liv.13618. 2018
Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure
Bolonio, M.; (...); Tolosa, L.
Meeting Abstract. 2019
Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure.
Article. 10.1016/j.jcyt.2019.12.005. 2020
IMPROVED OUTCOME AFTER ANTI-HCV THERAPY IS LESS MARKED WHEN THERAPY IS STARTED AT ADVANCED STAGES OF FIBROSIS
Aguilera, V.; (...); Berenguer, M.
Article. 2012
Improved Renal Function in Liver Transplant Recipients Treated for Hepatitis C Virus With a Sustained Virological Response and Mild Chronic Kidney Disease
Blé M; (...); Berenguer M
Article. 10.1002/lt.23756. 2014
Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London.
Puppi J; (...); Dhawan A
Article. 10.3727/096368911X566208. 2012
In Vitro Evaluation of Potential Hepatotoxicity Induced by Drugs
Gomez-Lechon, M. J.; (...); Donato, M. T.
Article. 10.2174/138161210791208910. 2010
In vitro modulation of the cytochrome P450 and ABCB1/P-glycoprotein activities of the aqueous extract of Allophylus cominia (L) Sw. leaves.
Pérez CL; (...); Rodeiro I
Article. 10.1515/dmpt-2017-0020. 2017
In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay
Brecklinghaus, Tim; (...); Hengstler, Jan G.
Article. 10.1016/j.toxlet.2022.08.006. 2022
In vitro/in vivo screening of oxidative homeostasis and damage to DNA, protein, and lipids using UPLC/MS-MS
Carretero, A; (...); Lahoz, A
Article. 10.1007/s00216-014-7983-5. 2014
Incidence of Development of Obesity After Heart Transplantation According to the Calcineurin Inhibitor
López-Vilella R; (...); Montero-Argudo A
Article. 10.1016/j.transproceed.2014.11.025. 2015
Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study
Chaparro, Maria; (...); Gisbert, Javier P.
Article. 10.3390/jcm10132885. 2021
Indications and results of liver retransplantation: experience with 1181 patients in the hospital universitario La Fe
Torres-Queuedo, Rodrigo; (...); Mir, Jose
Article. 10.1016/j.ciresp.2009.10.012. 2010
Induced pluripotent stem cells for the treatment of liver diseases: challenges and perspectives from a clinical viewpoint
Pareja, E, Gomez-Lechon, MJ, Tolosa, L
Review. 10.21037/atm.2020.02.164. 2020
Influence of peritoneal fluid on the expression of angiogenic and proteolytic factors in cultures of endometrial cells from women with endometriosis.
Cosín R; (...); Estelles A
Article. 10.1093/humrep/dep419. 2010
Injectable cell-laden gelatin-chondroitin sulphate hydrogels for liver in vitro models.
Sanchez-Gonzalez, E; (...); Gallego-Ferrer, G
Article. 10.1016/j.ijbiomac.2024.138693. 2024
Interaction between Hhex and SOX13 modulates Wnt/TCF activity.
Marfil V; (...); Bort R
Article. 10.1074/jbc.M109.046649. 2010
Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices
Jetten MJ; (...); Kleinjans JC
Article. 10.1016/j.tox.2014.06.007. 2014
Is hepatitis B immunoglobulin necessary for hepatitis D prophylaxis after liver transplantation? A retrospective multicenter study of a cohort of 174 patients
Rodriguez-Tajes, Sergio; (...); Forns, Xavier
Meeting Abstract. 2020
Lack of effect of CMV reactivation in the outcome of HCV-infected liver transplant(LT)patients
Aguilera, Victoria; (...); Berenguer, Marina
Article. 2015
LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells
García-Cañaveras JC; (...); Lahoz A
Article. 10.1002/elps.201500095. 2015
Ledipasvir and sofosbuvir plus ribavirin in patients with genotype 1 or 4 hepatitis C virus infection and advanced liver disease: a multicentre, open-label, randomised, phase 2 trial
Manns, M; (...); SOLAR-2 Investigators
Article. 10.1016/S1473-3099(16)00052-9. 2016
Long term follow-up in HCV infected patients with end stage chronic kidney disease after DAA therapy
Martinez-Camprecios, J; (...); Buti, M
Meeting Abstract. 2021
Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes.
Tolosa, L; (...); Donato, MT
Article. 10.1007/s00204-018-2349-y. 2019
Long-Term Complications After Liver Transplantation: Results at 15 Years After Transplantation
Berenguer, Marina; (...); Prieto, Martn
Article. 2015
Long-Term Effectiveness, Safety, and Patient- Reported Outcomes of Self-Administered Subcutaneous Hepatitis B Immunoglobulin in Liver Post-Transplant Hepatitis B Prophylaxis: A Prospective Non-Interventional Study
Roche B; (...); Samuel D
Article. 10.12659/AOT.936162. 2022
Long-term follow-up of HCV-infected patients with end-stage chronic kidney disease after sustained virological response with direct-acting antiviral therapy
Martinez-Camprecios, Joan; (...); Buti, Maria
Article. 10.1016/j.gastrohep.2022.12.004. 2023
Long-term outcome of "long-term liver transplant survivors"
Berenguer, Marina; (...); Prieto, Martin
Article. 2012
LONG-TERM OUTCOME OF LIVER TRANSPLANTATION FOR HEPATITIS B WITH ANTI-HBC POSITIVE GRAFTS
Garcia-Eliz, M.; (...); Prieto, M.
Article. 10.1016/S0168-8278(12)60208-6. 2012
Long-Term Outcome of Liver Transplantation for Hepatitis B with Anti-HBc Positive Grafts.
Garcia-Eliz, Maria; (...); Prieto, Martin
Article. 2012
Long-term outcome of 'long-term liver transplant survivors'.
Rubín A; (...); Berenguer M
Article. 10.1111/tri.12118. 2013
Low density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial Hypercholesterolemia modelling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection
Caron, J; (...); Dubart-Kupperschmitt, A
Meeting Abstract. 10.1016/S0168-8278(18)30382-9. 2018
Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection.
Caron J; (...); Dubart-Kupperschmitt A
Article. 10.1186/s13287-019-1342-6. 2019
Magnetically Activated Piezoelectric 3D Platform Based on Poly(Vinylidene) Fluoride Microspheres for Osteogenic Differentiation of Mesenchymal Stem Cells
Guillot-Ferriols, Maria; (...); Gallego Ferrer, Gloria
Article. 10.3390/gels8100680. 2022
Mammalian cell metabolomics: experimental design and sample preparation.
León Z; (...); Lahoz A
Article. 10.1002/elps.201200605. 2013
Mangifera indica L. extract and mangiferin modulate cytochrome P450 and UDP-glucuronosyltransferase enzymes in primary cultures of human hepatocytes.
Rodeiro I; (...); Teresa Donato M
Article. 10.1002/ptr.4782. 2013
Mechanistic Understanding of Idiosyncratic Drug-Induced Hepatotoxicity Using Co-Cultures of Hepatocytes and Macrophages.
Villanueva-Badenas, Estela, Donato, M. Teresa, Tolosa, Laia
Article. 10.3390/antiox12071315. 2023
Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs
Gomez-Lechon, MJ, Tolosa, L, Donato, MT
Review. 10.1002/jat.3277. 2016
Metabolic syndrome before liver transplantation: does it have an impact on post liver transplantation outcomes?
Herreras Lopez, Julia; (...); Aguilera, Victoria
Article. 10.17235/reed.2022.8384/2021. 2022
Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo
Teresa Donato, M.; (...); Lahoz, Agustin
Article. 10.1124/dmd.110.033605. 2010
Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes
Quintas, G; (...); Castell, JV
Article. 10.1007/s00204-021-03114-z. 2021
Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction
Cortes M; (...); Lahoz A
Article. 10.1016/j.jhep.2014.04.023. 2014
Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved.
Martínez-Sena T; (...); Castell JV
Article. 10.1007/s00204-023-03474-8. 2023
Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen.
Rodríguez-Agudo R; (...); Martínez-Chantar ML
Article. 10.3390/antiox11050897. 2022
Mimicking cell-matrix crosstalk: bioinspired gelatin hydrogels functionalized with monomeric fibronectin as a liver in vitro model
Sanchez Gonzalez, Estela; (...); Gallego Ferrer, Gloria
Meeting Abstract. 2023
miR-133a regulates vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1), a key protein in the vitamin K cycle.
Pérez-Andreu V; (...); Martínez C
Article. 10.2119/molmed.2012.00062. 2013
Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients
Thiel, C; (...); Kuepfer, L
Article. 10.1007/s00204-016-1723-x. 2017
Modeling a Novel Variant of Glycogenosis IXa Using a Clonal Inducible Reprogramming System to Generate "Diseased" Hepatocytes for Accurate Diagnosis.
Garcia-Llorens, Guillem; (...); Bort, Roque
Article. 10.3390/jpm12071111. 2022
Modelos Celulares hepáticos avanzados para el estudio preclíico del metabolismo y la hepatotoxicdad de fármacos.
MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER
Article. 2017
Modulation of biotransformation and elimination systems by BM-21, an aqueous ethanolic extract from Thalassia testudinum, and thalassiolin B on human hepatocytes
Rodeiro, Idania; (...); Teresa Donato, Maria
Article. 10.1016/j.jff.2011.10.002. 2012
Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid in human hepatocytes
Petrov, P. D.; (...); Jover, R.
Meeting Abstract. 2021
Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways.
Article. 10.1016/j.fct.2021.112664. 2021
Monitoring of system conditioning after blank injections in untargeted UPLC-MS metabolomic analysis.
Martínez-Sena T; (...); Kuligowski J
Article. 10.1038/s41598-019-46371-w. 2019
mTOR inhibitors a potential predisposing factor for chronic hepatitis E: Results from the prospective collaborative CHES study (Chronic Hepatitis EScreening in patients with immune impairment and increased transaminases levels).
Riveiro-Barciela, Mar; (...); Esteban, Rafael
Article. 10.1016/j.gastrohep.2023.01.010. 2023
Multimodal analysis identifies microbiome changes linked to stem cell transplantation-associated diseases
Artacho, Alejandro; (...); Ubeda, Carles
Article. 10.1186/s40168-024-01948-0. 2024
Multiparametric evaluation of the cytoprotective effect of the Mangifera indica L. stem bark extract and mangiferin in HepG2 cells.
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.1111/jphp.12071. 2013
Neonatal Livers: A Source for the Isolation of Good-Performing Hepatocytes for Cell Transplantation
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.3727/096368913X669743. 2014
New concepts and best practices for management of pre- and post-transplantation cancer.
Campistol JM; (...); Ussetti P
Article. 10.1016/j.trre.2012.07.001. 2012
New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease
Lopez-Riera, M; (...); Jover, R
Article. 10.3389/fpahr.2017.00003. 2017
Newserum miRNA biomarkers to predict liver steatosis by valproic acid in paediatric epileptic patients
Jover, R.; (...); Castell, J. V.
Meeting Abstract. 10.1016/j.toxlet.2022.07.200. 2022
Non-Alcoholic Steatosis. Creation of a Bank of Steatosic Livers
Moya, Marta; (...); Vicente Castell, Jose
Article. 2011
Noninvasive Liver Assessment in Adult Patients With Fontan Circulation Using Acoustic Radiation Force Impulse Elastography and Hepatic Magnetic Resonance Imaging.
Buendia-Fuentes, F; (...); Martinez-Dolz, L
Article. 10.1177/2150135117732674. 2018
Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers
Lopez-Riera, M; (...); Jover, R
Article. 10.1038/s41598-018-28854-4. 2018
Novel Imaging Techniques for Heart Failure.
Melero-Ferrer JL; (...); Martinez-Dolz L
Article. 10.15420/cfr.2015:29:2. 2016
Novel microgel culture system as semi-solid three-dimensional in vitro model for the study of multiple myeloma proliferation and drug resistance
Clara-Trujillo S; (...); Gómez Ribelles JL
Article. 10.1016/j.bioadv.2022.212749. 2022
Out of Milan criteria and worse intetion to treat results at large liver transplant center
Lopez, JH; (...); Haym, MB
Meeting Abstract. 10.1016/S0168-8278(18)30613-5. 2018
Outcomes of elective liver surgery worldwide: a global, prospective, multicenter, cross-sectional study
Malago, Massimo; (...); Andreoli, Gustavo
Article. 10.1097/JS9.0000000000000711. 2023
OVERCOMING BARRIERS TO CARE FOR DELTA INFECTED PATIENTS
Carvalho-Gomes, Angela; (...); Berenguer, Marina
Meeting Abstract. 2022
Overcoming barriers to care for Delta infected patients
Bono, Ariadna; (...); Berenguer, Marina
Meeting Abstract. 2023
Oxidative-stress and long-term hepatotoxicity: comparative study in Upcyte human hepatocytes and hepaRG cells.
Article. 10.1007/s00204-022-03236-y. 2022
PATIENTS SURVIVING AT LEAST 10 YEARS POST LIVER TRANSPLANTATION: LONG TERM RESULTS
Berenguer, M.; (...); Prieto, M.
Article. 2011
Phenotypic and genotypic characterization of drug-induced liver injury (DILI) with autoimmune features
Stephens, C.; (...); Andrade, Raul J.
Article. 2015
PIEZOELECTRIC 3D PLATFORM BASED ON HYDROGEL-POLY(VINYLIDENE FLUORIDE) MICROSPHERES FOR MESENCHYMAL STEM CELL OSTEOGENIC DIFFERENTIATION
Gallego-Ferrer, Gloria; (...); Luis Gomez-Ribelles, Jose
Meeting Abstract. 2022
POST-LIVER TRANSPLANTATION (LT) OUTCOME IN HIV/HCV CO-INFECTED PATIENTS. COMPARISON WITH MONOINFECTED PATIENTS WITH HCV-CIRRHOSIS
Aguilera, V.; (...); Prieto, M.
Article. 10.1016/S0168-8278(11)60519-9. 2011
Predicting drug-induced cholestasis: preclinical models
Petrov, PD; (...); Jover, R
Review. 10.1080/17425255.2018.1487399. 2018
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
Albrecht, W; (...); Hengstler, JG
Article. 10.1007/s00204-019-02492-9. 2019
Pre-Immunosuppressant Hepatitis B Virus Screening Practices Among Various Medical Specialities (HEBRA Project): Results of a Survey from 19 Spanish Hospitals
Garcia-Bengoechea, Manuel; (...); Esteban, Rafael
Article. 2012
Primary human hepatocytes-laden scaffolds for the treatment of acute liver failure.
Rodriguez-Fernandez J; (...); Tolosa L
Article. 10.1016/j.bioadv.2023.213576. 2023
Progress and challenges of mid-infrared spectroscopy for liver characterization focusing on steatosis, fibrosis and cancer
Ten-Domenech, Isabel; (...); Quintas, Guillermo
Review. 10.1080/05704928.2023.2215858. 2024
Protease inhibitors impair renal function in HCV-infected immunocompetent patients
Fernandez-Carrillo, Carlos; (...); Luis Calleja, Jose
Meeting Abstract. 2014
Protectiveness of NAM-based hazard assessment - which testing scope is required?
Zobl, Walter; (...); Escher, Sylvia E.
Article. 10.14573/altex.2309081. 2023
Psychosocial impact of the COVID-19 pandemic on patients with inflammatory bowel disease in Spain
Hernandez Camba, A.; (...); Barreiro, M.
Meeting Abstract. 10.1093/ecco-jcc/jjab076.312. 2021
Psychosocial impact of the COVID-19 pandemic on patients with inflammatory bowel disease in Spain. A post lockdown reflection.
Hernandez Camba, Alejandro; (...); Barreiro-de Acosta, Manuel
Article. 10.1016/j.gastrohep.2021.08.007. 2021
Quantitative Prediction of Steatosis in Patients with Non-Alcoholic Fatty Liver by Means of Hepatic MicroRNAs Present in Serum and Correlating with Hepatic Fat
Quintas, Guillermo; (...); Jover, Ramiro
Article. 10.3390/ijms23169298. 2022
Randomized prospective study evaluating tenofovir disoproxil fumarate prophylaxis against hepatitis B virus reactivation in anti-HBc-positive patients with rituximab-based regimens to treat hematologic malignancies: The Preblin study
Buti, M; (...); Esteban, R
Article. 10.1371/journal.pone.0184550. 2017
Real-World Effectiveness and Safety of Oral Combination Antiviral Therapy for Hepatitis C Virus Genotype 4 Infection
Crespo, J; (...); Spanish Group for the Study of the Use of Direct-acting Drugs Hepatitis C Collab
Article. 10.1016/j.cgh.2017.02.020. 2017
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Godoy P; (...); Hengstler JG
Article. 10.1007/s00204-013-1078-5. 2013
Recommendations of everolimus use in liver transplant
Rubin Suarez, Angel; (...); Prieto Castillo, Martin
Review. 10.1016/j.gastrohep.2017.05.008. 2017
Regenerative cell therapy for the treatment of hyperbilirubinemic Gunn rats with fresh and frozen human induced pluripotent stem cells-derived hepatic stem cells.
Fourrier A; (...); Nguyen TH
Article. 10.1111/xen.12544. 2020
Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.
Gu, XL; (...); Stoeber, R
Article. 10.1007/s00204-018-2302-0. 2018
Repeated CMV infection in a heart transplantation patient.
Melero-Ferrer J; (...); Salvador-Sanz A
Article. 10.1155/2012/305920. 2012
Repression of the Nuclear Receptor Small Heterodimer Partner by Steatotic Drugs and in Advanced Nonalcoholic Fatty Liver Disease
Article. 10.1124/mol.114.096313. 2015
Safer chemicals using less animals: kick-off of the European ONTOX project
Vinken, M; (...); Piersma, AH
Review. 10.1016/j.tox.2021.152846. 2021
Searching for Metabolic Biomarkers as a Probe of Liver Graft Function To Assess Organ Quality Prior to Its Transplantation
Cortes, Miriam; (...); Lahoz, Agustin
Article. 2011
Severe acute liver failure in a user of drugs of abuse
Sanchez-Montes, Cristina; (...); Berenguer, Marina
Article. 10.1016/j.gastrohep.2011.03.024. 2011
Sexual Dysfunction in Cirrhotic Patients Awaiting Liver Transplantation.
Rodriguez-Medina, Beatriz; (...); Berenguer, Marina
Article. 2013
Silencing of hepatic fate-conversion factors induce tumorigenesis in reprogrammed hepatic progenitor-like cells
Serrano F; (...); Bort R
Article. 10.1186/s13287-016-0349-5. 2016
SIMILAR POST-TRANSPLANT OUTCOMES USING DONORS AFTER CARDIAC DEATH WHEN APPLYING STRICT SELECTION CRITERIA
de la Varga, MF; (...); Aguilera, V
Meeting Abstract. 2021
Sofosbuvir Compassionate Use Program for Patients With Severe Recurrent Hepatitis C After Liver Transplantation
Forns X; (...); Habersetzer F
Article. 10.1002/hep.27681. 2015
Steatotic liver: a suitable source for the isolation of hepatic progenitor cells
Tolosa, Laia; (...); Jose Gomez-Lechon, M.
Article. 10.1111/j.1478-3231.2011.02609.x. 2011
Steatotic Liver: a suitable source of hepatic progenitor cells for liver cellular therapy
Tolosa, L; (...); Gómez-Lechón, M José
Article. 2011
Stem-cell derived hepatocyte-like cells for the assessment of drug-induced liver injury
Review. 10.1016/j.diff.2019.02.004. 2019
Survey to evaluate the implementation of the recommendations on the comprehensive diagnosis of viral hepatitis in a single extraction: where are we?
Cabezas, Joaquin; (...); Crespo, Javier
Meeting Abstract. 2023
SURVEY TO EVALUATE THE IMPLEMENTATION OF THE RECOMMENDATIONS ON THE COMPREHENSIVE DIAGNOSIS OF VIRAL HEPATITIS IN A SINGLE EXTRACTION: WHERE ARE WE?
Cabezas, Joaquin; (...); Crespo Garcia, Javier
Meeting Abstract. 2023
Synthesis and cytotoxic activity of 4-N-carboxybutyl-5-fluorocytosyl-Arg-Gln-Trp-Arg-Arg-Trp-Trp-Gln-Arg-NH2.
Somlai C; (...); Enriz RD
Article. 10.1016/j.bmcl.2012.05.045. 2012
Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method.
García-Cañaveras JC; (...); Lahoz A
Article. 10.1194/jlr.D028803. 2012
Tenofovir Disoproxil Fumarate (TDF), Emtricitabine/TDF, and Entecavir in Patients with Decompensated Chronic Hepatitis B Liver Disease
Liaw, Yun-Fan; (...); Schiff, Eugene R.
Article. 10.1002/hep.23952. 2011
TENOFOVIR FOR THE PROPHYLAXIS OF HBV REACTIVATION IN ANTI-HBC-POSITIVE PATIENTS WITH HEMATOLOGIC MALIGNANCIES TREATED WITH RITUXIMAB: PRELIMINARY RESULTS OF A RANDOMIZED STUDY (PREBLIN STUDY)
Buti, M.; (...); Esteban, R.
Article. 10.1016/S0168-8278(14)61200-9. 2014
TENOFOVIR MONOTHERAPY VERSUS LAMIVUDINE PLUS ADEFOVIR IN LAMIVUDINE-FAILURE PATIENTS RESCUED WITH LAMIVUDINE PLUS ADEFOVIR COMBINATION: INTERIM ANALYSIS OF THE TENOSIMP-B CLINICAL TRIAL
Jorquera, F.; (...); Rodriguez, M.
Article. 10.1016/S0168-8278(14)61201-0. 2014
Tenofovir vs lamivudine plus adefovir in chronic hepatitis B: TENOSIMP-B study
Rodriguez, M; (...); TENOSIMP-B Res Grp
Article. 10.3748/wjg.v23.i41.7459. 2017
TESTING CHEMICAL CARCINOGENICITY BY USING A TRANSCRIPTOMICS HEPARG-BASED MODEL?
Doktorova TY; (...); Rogiers V
Article. 2014
TH and DCX mRNAs in peripheral blood and bone marrow predict outcome in metastatic neuroblastoma patients
Yáñez Y; (...); Castel V
Article. 10.1007/s00432-015-2054-7. 2016
The assessment of the potential hepatotoxicity of new drugs by in vitro metabolomics.
Quintas, Guillermo, Castell, Jose V., Moreno-Torres, Marta
Article. 10.3389/fphar.2023.1155271. 2023
The availability of anti-TNF agents is associated with reduced early surgical requirements in Crohn's disease but not in ulcerative colitis. A nationwide study from the Eneida registry
Guasch, M; (...); Domenech, E
Meeting Abstract. 2018
The effectiveness of daclatasvir based therapy in European patients with chronic hepatitis C and advanced liver disease
Young, J; (...); Calleja, JL
Article. 10.1186/s12879-016-2106-x. 2017
The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPARa; and repressed by C/EBPa: Implications in FABP1 down-regulation in nonalcoholic fatty liver disease.
Article. 10.1016/j.bbalip.2012.12.014. 2013
The impact of the prevention strategies on the indirect effects of CMV infection in solid organ transplant recipients
Roman A; (...); Ussetti P
Article. 10.1016/j.trre.2014.01.001. 2014
The in vitro assessment of the toxicity of volatile, oxidisable, redox-cycling compounds: phenols as an example
Tolosa, L; (...); Castell, JV
Article. 10.1007/s00204-021-03036-w. 2021
The Potential Role of Metabolomics in Drug-Induced Liver Injury (DILI) Assessment.
Moreno-Torres, Marta, Quintas, Guillermo, Castell, V, Jose
Article. 10.3390/metabo12060564. 2022
The role of HBIG in real life for patients undergoing liver transplantation due to HDV-related cirrhosis
Rodriguez-Tajes, Sergio; (...); Forns, Xavier
Article. 10.1111/liv.15777. 2024
The Use of Hepatocytes to Investigate Drug Toxicity
Jose Gomez-Lechon, Maria, Castell, Jose V., Teresa Donato, Maria
Article. 10.1007/978-1-60761-688-7_21. 2010
The use of prophylactic strategies using hepatitis B immunoglobulin for hepatitis B recurrence after liver transplantation in routine clinical practice in Spain. Preliminary results of the 1st round of a delphi panel
Prieto, M; (...); Casado, MA
Meeting Abstract. 10.1016/S0168-8278(17)30671-2. 2017
The Vitamin D Receptor Regulates Glycerolipid and Phospholipid Metabolism in Human Hepatocytes
Martinez-Sena, T; (...); Jover, R
Article. 10.3390/biom10030493. 2020
Thorough assessment of the effectiveness of belimumab in a large Spanish multicenter cohort of systemic lupus erythematosus patients.
Altabás-González I; (...); Rúa-Figueroa I
Article. 10.1093/rheumatology/kead696. 2024
Toward Rapid Screening of Liver Grafts at the Operating Room Using Mid-infrared Spectroscopy.
Pérez-Guaita D; (...); Castell JV
Article. 10.1021/acs.analchem.0c02735. 2020
Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models.
Doktorova TY; (...); Rogiers V
Article. 10.1093/carcin/bgt054. 2013
Transplantation of hESC-derived hepatocytes protects mice from liver injury
Tolosa L; (...); Dubart-Kupperschmitt A
Article. 10.1186/s13287-015-0227-6. 2015
Treatment of Hepatitis C Virus Infection in Patients With Cirrhosis and Predictive Value of Model for End-Stage Liver Disease: Analysis of Data From the Hepa-C Registry
Fernández Carrillo C; (...); Calleja, JL
Article. 10.1002/hep.29097. 2017
TRIPHASIC VIRAL LOAD KINETICS OF HEPATITIS C VIRUS DURING ANTIVIRAL THERAPY POST-TRANSPLANTATION: EFFECT OF THE TYPE OF PEGYLATED-IFN AND BASELINE IMMUNOSUPPRESSION
Ortiz, C.; (...); Berenguer, M.
Article. 10.1016/S0168-8278(11)60808-8. 2011
Triple Therapy for HCV Cirrhosis in Liver Transplant Candidates. High Rate of Prevention of HCV Recurrence after Liver Transplantation (LT) in Well Selected Patients
Maria Braithwaite, Ana; (...); Berenguer, Marina
Article. 2014
T-tube or no T-tube in cadaveric orthotopic liver transplantation: the eternal dilemma: results of a prospective and randomized clinical trial.
López-Andújar R; (...); De Juan Burgueño M
Article. 10.1097/SLA.0b013e318286e0a0. 2013
Ultra-performance liquid chromatography-mass spectrometry targeted profiling of bile acids: application to serum, liver tissue, and cultured cells of different species.
García-Cañaveras JC, Donato MT, Lahoz A
Article. 10.1007/978-1-4939-1258-2_15. 2014
Uncovering the toxicity mechanisms of a series of carboxylic acids in liver cells through computational and experimental approaches.
Ortega-Vallbona, Rita; (...); Serrano-Candelas, Eva
Article. 10.1016/j.tox.2024.153764. 2024
Universal access to direct-acting antivirals treatment is not not enough to prevent late stage presentation of hepatitis C infection
Cabezas, J; (...); Crespo, J
Meeting Abstract. 10.1016/S0618-8278(19)30970-3. 2019
Upgrading cytochrome P450 activity in HepG2 cells co-transfected with adenoviral vectors for drug hepatotoxicity assessment.
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.1016/j.tiv.2011.11.008. 2012
Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing
Gomez-Lechon, MJ, Tolosa, L, Donato, MT
Review. 10.1080/17425255.2017.1238459. 2017
Use of artificial intelligence as an innovative donor-recipient matching model for liver transplantation: Results from a multicenter Spanish study
Briceño J; (...); de la Mata M
Article. 10.1016/j.jhep.2014.05.039. 2014
Use of Hy's Law and a New Composite Algorithm to Predict Acute Liver Failure in Patients With Drug-Induced Liver Injury
Robles-Diaz M; (...); Safer and Faster Evidence-based Translation Consortium
Article. 10.1053/j.gastro.2014.03.050. 2014
Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies
Donato, MT, Gomez-Lechon, MJ, Tolosa, L
Review. 10.1080/17460441.2017.1271784. 2017
Using Metabolomics to Uncover Ontogeny of Drug-Induced Hepatotoxicity and Underlying AOP Mechanisms
Martinez-Sena, T.; (...); Castell Ripoll, J. V.
Meeting Abstract. 2023
Validated assay for studying activity profiles of human liver UGTs after drug exposure: inhibition and induction studies
Teresa Donato, M.; (...); Lahoz, Agustin
Article. 10.1007/s00216-009-3441-1. 2010
VALIDATION ANALYSIS OF THE PHYSICIAN GLOBAL ASSESSMENT (PGA) SCALE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS INCLUDED IN RELESSER-PROS REGISTRY
Caceres Martin, L.; (...); Pego-Reigosa, J. M.
Meeting Abstract. 10.1136/annrheumdis-2023-eular.. 2023
VALIDATION OF A PREDICTIVE MODEL FOR CHRONIC RENAL DYSFUNCTION FOLLOWING LIVER TRANSPLANTATION
Giusto, M.; (...); Merli, M.
Article. 10.1016/S0168-8278(11)60542-4. 2011
VI consensus document by the Spanish Liver Transplantation Society
Pardo, F; (...); Briceno, J
Article. 10.1016/j.ciresp.2017.12.013. 2018
VI consensus document by the Spanish Liver Transplantation Society
Pardo, F; (...); Briceno, J
Article. 10.1016/j.gastrohep.2018.05.012. 2018
Which scope of NAM testing is sufficient for hazard characterisation? - An investigation based on transcriptomics data
Zobl, W.; (...); Escher, S. E.
Meeting Abstract. 10.1016/j.toxlet.2022.07.675. 2022
Caracterización Funcional De Hepatocitos Neonatales Criopreservados Para Su Uso En Terapia Celular Hepática
Autor/es: Rita Ortega Vallbona
Proyecto Fin de Carrera
Director/es: LAIA TOLOSA PARDO
Ensayo Multiparamétrico In Vitro Para La Evaluación De La Hepatotoxicidad Mitocondrial De Fármacos
Autor/es: Antonio Carmona Serrano
Proyecto Fin de Carrera
Director/es: LAIA TOLOSA PARDO; MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER