Portal de investigación
FORINVITOX
Datos básicos
- NumeroConcesion:
- FORINVITOX 1, START UP 2
- Año inicial:
- 2008
- Año final:
- 2008
Objetivos del proyecto
FINALIZADO
Documentos
- No hay documentos
Participantes
-
María José Gómez-Lechón Moliner
Investigador Principal
Grupos
-
Hepatología experimental y Trasplante hepático
Investigador Principal
Laia Tolosa Pardo
Financiadores
Resultados del Proyecto
CELL SOURCES FOR HEPATIC CELL THERAPY
EUGENIA PAREJA IBARS, MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER, LAIA TOLOSA PARDO
Capítulo de un Libro. 2017
CELL-BASED THERAPEUTIC STRATEGIES FOR TREATMENT OF LIVER DISEASES.
LAIA TOLOSA PARDO, MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER, EUGENIA PAREJA IBARS
Capítulo de un Libro. 2017
[Liver cell therapy in the treatment of inborn errors of metabolism in children].
Abstract of Published Item. 10.1016/j.anpedi.2013.05.018. 2013
A combination of transcriptomics and metabolomics uncovers enhanced bile acid biosynthesis in HepG2 cells expressing CCAAT/enhancer-binding protein ß (C/EBPß), hepatocyte nuclear factor 4a (HNF4a), and constitutive androstane receptor (CAR).
Blazquez M; (...); Bort R
Article. 10.1021/pr400085n. 2013
A Comprehensive Untargeted Metabonomic Analysis of Human Steatotic Liver Tissue by RP and HILIC Chromatography Coupled to Mass Spectrometry Reveals Important Metabolic Alterations
Garcia-Canaveras, Juan C.; (...); Lahoz, Agustin
Article. 10.1021/pr200629p. 2011
A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury
García-Cañaveras JC; (...); Lahoz A
Article. 10.1038/srep27239. 2016
A microRNA signature for valproate-induced steatosis in human hepatocytes and its application to predict fatty liver in paediatric epileptic patients on valproate therapy.
Soluyanova P; (...); Jover R
Article. 10.1016/j.tox.2024.153974. 2024
A Multi-Parametric Fluorescent Assay for the Screening and Mechanistic Study of Drug-Induced Steatosis in Liver Cells in Culture.
Tolosa, Laia, Gomez-Lechon, M Jose, Donato, M Teresa
Article. 10.1002/cptx.20. 2017
A Network Involving Gut Microbiota, Circulating Bile Acids, and Hepatic Metabolism Genes That Protects Against Non-Alcoholic Fatty Liver Disease.
Article. 10.1002/mnfr.201900487. 2019
A New Score System To Classify Liver Graft Functionality after Transplantation
Cortes, Miriam; (...); Lahoz, Agustin
Article. 2011
A novel microRNA signature for cholestatic drugs in human hepatocytes and its translation into novel circulating biomarkers for drug-induced liver injury patients.
López-Riera M; (...); Jover R
Article. 10.1093/toxsci/kfz138. 2020
A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes.
Moreno-Torres, Marta; (...); Castell, V, Jose
Article. 10.1021/acs.jproteome.1c00779. 2022
A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies.
Garcia-Llorens, Guillem; (...); Bort, Roque
Article. 10.1186/s13287-023-03311-w. 2023
A Score Model for the Continuous Assessment of Early Allograft Function after Liver Transplantation
Cortes, Miriam; (...); Lahoz, Agustin
Article. 2014
A Score Model for the Continuous Grading of Early Allograft Dysfunction Severity
Article. 10.1002/lt.23990. 2015
A simple transcriptomic signature able to predict drug-induced hepatic steatosis
Article. 10.1007/s00204-014-1197-7. 2014
Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems
Fernandez-Murga, ML; (...); Jover, R
Review. 10.1016/j.fct.2018.07.017. 2018
Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis
Article. 10.1016/j.taap.2016.04.007. 2016
Alternative Cell Sources to Adult Hepatocytes for Hepatic Cell Therapy.
Pareja, E, Gomez-Lechon, MJ, Tolosa, L
Article. 10.1007/978-1-4939-6506-9_2. 2017
An in vitro tool to assess cytochrome P450 drug biotransformation-dependent cytotoxicity in engineered HepG2 cells generated by using adenoviral vectors.
Lahoz A; (...); Gómez-Lechón MJ
Article. 10.1016/j.tiv.2012.08.001. 2013
Angiopoietin-Like Protein 8 Is a Novel Vitamin D Receptor Target Gene Involved in Nonalcoholic Fatty Liver Pathogenesis
Garcia-Monzon, C; (...); Jover, R
Article. 10.1016/j.ajpath.2018.07.028. 2018
Angiopoietin-like protein 8 is a novel vitamin D receptor-targeted lipogenic gene associated with non-alcoholic fatty liver
Gonzalez-Rodriguez, A; (...); Garcia-Monzon, C
Meeting Abstract. 10.1016/S0168-8278(18)30948-6. 2018
Apicobasal Polarity Controls Lymphocyte Adhesion to Hepatic Epithelial Cells
Reglero-Real N; (...); Millán J
Article. 10.1016/j.celrep.2014.08.007. 2014
Assessment of cytochrome P450 induction in human hepatocytes using the cocktail strategy plus liquid chromatography tandem mass spectrometry.
Lahoz, Agustin; (...); Gomez-Lechon, Maria Jose
Article. 10.2174/187231208785425845. 2008
Assessment of the cytotoxic potential of an aqueous-ethanolic extract from Thalassia testudinum angiosperm marine grown in the Caribbean Sea.
Rodeiro, I; (...); Lopes, M
Article. 10.1111/jphp.13001. 2018
Automated generation of hiPSC-derived hepatic progeny by cost-efficient compounds.
Vanmarcke G; (...); Verfaillie CM
Article. 10.1093/stmcls/sxad065. 2023
Bladder cancer recurrence surveillance by urine metabolomics analysis
Loras, A; (...); Ruiz-Cerda, JL
Article. 10.1038/s41598-018-27538-3. 2018
Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development
Article. 10.1016/j.toxlet.2016.10.008. 2016
CCAAT/Enhancer-binding Protein alpha (C/EBP alpha) and Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha) Synergistically Cooperate with Constitutive Androstane Receptor to Transactivate the Human Cytochrome P450 2B6 (CYP2B6) Gene APPLICATION TO THE DEVELOPMENT OF A METABOLICALLY COMPETENT HUMAN HEPATIC CELL MODEL
Benet, Marta; (...); Jover, Ramiro
Article. 10.1074/jbc.M110.118364. 2010
Clinical Application of Pluripotent Stem Cells: An Alternative Cell-Based Therapy for Treating Liver Diseases?
Tolosa L, Pareja E, Gomez-Lechon MJ
Review. 10.1097/TP.0000000000001426. 2016
Clinical outcome of hepatocyte transplantation in four pediatric patients with inherited metabolic diseases.
Ribes-Koninckx C; (...); Castell JV
Article. 10.3727/096368912X637505. 2012
Cluster-Partial Least Squares (c-PLS) regression analysis: Application to miRNA and metabolomic data.
Kuligowski, Julia; (...); Quintas, Guillermo
Article. 10.1016/j.aca.2023.342052. 2024
Comparative analysis of eight cytotoxicity assays evaluated within the ACuteTox Project.
Clothier R; (...); Stanzel S
Article. 10.1016/j.tiv.2012.08.015. 2013
Comparing in vitro human liver models to in vivo human liver using RNA-Seq.
Gupta R; (...); Caiment F
Article. 10.1007/s00204-020-02937-6. 2020
Comparing Targeted vs. Untargeted MS2 Data-Dependent Acquisition for Peak Annotation in LC-MS Metabolomics
Ten-Domenech, I; (...); Kuligowski, J
Article. 10.3390/metabo10040126. 2020
Comparing the direct assessment of steatosis in liver explants with mid- and near-infrared vibrational spectroscopy, prior to organ transplantation.
Rienda, Ivan; (...); Quintas, Guillermo
Article. 10.1039/d3an01184d. 2023
Competency of different cell models to predict human hepatotoxic drugs
Gómez-Lechón MJ; (...); Donato MT
Review. 10.1517/17425255.2014.967680. 2014
Culture and Functional Characterization of Human Hepatoma HepG2 Cells.
Donato, MT, Tolosa, L, Gomez-Lechon, MJ
Article. 10.1007/978-1-4939-2074-7_5. 2015
Current status and future perspectives of hepatocyte transplantation
Review. 10.1016/j.ciresp.2013.04.010. 2014
Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury
Tolosa, L; (...); Teresa Donato, M.
Article. 10.1007/s00204-017-2036-4. 2018
Characterization of Proliferating Human Hepatocytes As a Model System for Drug Interaction Studies and Toxicity Screenings
Noerenberg, A; (...); Jover, R
Meeting Abstract. 2017
Chemometric approaches to improve PLSDA model outcome for predicting human non-alcoholic fatty liver disease using UPLC-MS as a metabolic profiling tool
Quintas, Guillermo; (...); Lahoz, Agustin
Article. 10.1007/s11306-011-0292-5. 2012
Derivation of healthy hepatocyte-like cells from a female patient with ornithine transcarbamylase deficiency through X-inactivation selection.
Santamaria R; (...); Bort R
Article. 10.1038/s41598-022-06184-w. 2022
Development and optimization of hepatic cell models for pharmaco-toxicology and cell therapy research
Bonora-Centelles, A.; (...); Gomez-Lechon, M. J.
Article. 2008
Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.1093/toxsci/kfs083. 2012
Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress assessment of nanoparticle-treated cells.
Aranda A; (...); Gombau L
Article. 10.1016/j.tiv.2013.01.016. 2013
Direct conversion of human fibroblast to hepatocytes using a single inducible polycistronic vector.
Ballester M; (...); Bort R
Article. 10.1186/s13287-019-1416-5. 2019
Drug-Induced Fatty Liver Disease (DIFLD): A Comprehensive Analysis of Clinical, Biochemical, and Histopathological Data for Mechanisms Identification and Consistency with Current Adverse Outcome Pathways.
Lopez-Pascual, Ernesto; (...); Castell, Jose V.
Article. 10.3390/ijms25105203. 2024
Drug-induced liver steatosis and phospholipidosis: cell-based assays for early screening of drug candidates.
Article. 2012
Enhancing the accuracy of mid-infrared spectroscopy-based liver steatosis quantification using digital image analysis as a reference.
Rienda, Ivan; (...); Quintas, Guillermo
Article. 10.1039/d3an00324h. 2023
Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes.
Article. 10.1007/s00204-019-02643-y. 2020
Evaluation of cytochrome P450 activities in human hepatocytes in vitro.
Gómez-Lechón MJ; (...); Donato MT
Article. 10.1007/978-1-61779-367-7_7. 2012
Evaluation of Drug-Metabolizing and Functional Competence of Human Hepatocytes Incubated Under Hypothermia in Different Media for Clinical Infusion
Jose Gomez-Lechon, Maria; (...); Teresa Donato, Maria
Article. 10.3727/096368908786576534. 2008
Evaluation of genotoxicity and DNA protective effects of mangiferin, a glucosylxanthone isolated from Mangifera indica L. stem bark extract.
Rodeiro I; (...); Espinosa-Aguirre JJ
Article. 10.1016/j.fct.2012.06.032. 2012
Exploring Individual Variability in Drug-Induced Liver Injury (DILI) Responses through Metabolomic Analysis.
Moreno-Torres M; (...); Castell JV
Article. 10.3390/ijms25053003. 2024
Exploring Mass Spectrometry Suitability to Examine Human Liver Graft Metabonomic Profiles
Cortes, M.; (...); Lahoz, A.
Article. 10.1016/j.transproceed.2010.07.049. 2010
Extending metabolome coverage for untargeted metabolite profiling of adherent cultured hepatic cells
García-Cañaveras JC; (...); Lahoz A
Article. 10.1007/s00216-015-9227-8. 2016
Extracting consistent biological information from functional results of metabolomic pathway analysis using the Mantel's test.
Ten-Doménech I; (...); Kuligowski J
Article. 10.1016/j.aca.2021.339173. 2021
Factors that influence the quality of metabolomics data in in vitro cell toxicity studies: a systematic survey.
Moreno-Torres, Marta; (...); Castell, Jose Vicente
Article. 10.1038/s41598-021-01652-1. 2021
Foxa1 reduces lipid accumulation in human hepatocytes and is down-regulated in nonalcoholic fatty liver.
Moya M; (...); Jover R
Article. 10.1371/journal.pone.0030014. 2012
Functional Assessment of the Quality of Human Hepatocyte Preparations for Cell Transplantation
Donato, Maria Teresa; (...); Gomez-Lechon, Maria Jose
Article. 10.3727/096368908787236620. 2008
Functional Characterization of Hepatocytes for Cell Transplantation: Customized Cell Preparation for Each Receptor
Bonora-Centelles, A.; (...); Gomez-Lechon, M. J.
Article. 10.3727/096368909X474267. 2010
Gata4 blocks somatic cell reprogramming by directly repressing Nanog.
Serrano F; (...); Bort R
Article. 10.1002/stem.1272. 2013
General Cytotoxicity Assessment by Means of the MTT Assay.
Tolosa, L, Donato, MT, Gomez-Lechon, MJ
Article. 10.1007/978-1-4939-2074-7_26. 2015
Glutamine/glutamate metabolism rewiring in reprogrammed human hepatocyte-like cells
Ballester, M; (...); Bort, R
Article. 10.1038/s41598-019-54357-x. 2019
Growth-promoting and tumourigenic activity of c-Myc is suppressed by Hhex
Marfil V; (...); Bort R
Article. 10.1038/onc.2014.240. 2015
Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients.
Perez-Rubio, Alvaro; (...); Jover, Ramiro
Article. 10.3390/nu15143187. 2023
Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering.
Donato MT, Jover R, Gómez-Lechón MJ
Article. 2013
Hepatocyte transplantation program: Lessons learned and future strategies
Review. 10.3748/wjg.v22.i2.874. 2016
HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved.
Article. 10.1007/s00204-013-1012-x. 2013
High-content imaging technology for the evaluation of drug-induced steatosis using a multiparametric cell-based assay.
Donato MT; (...); Gómez-Lechón MJ
Article. 10.1177/1087057111427586. 2012
High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins
Article. 10.1007/s00204-014-1334-3. 2015
High-content screening technology for studying drug-induced hepatotoxicity in cell models
Tolosa L, Gómez-Lechón MJ, Donato MT
Review. 10.1007/s00204-015-1503-z. 2015
Human Embryonic Stem Cell Derived Hepatocyte-Like Cells as a Tool for In Vitro Hazard Assessment of Chemical Carcinogenicity
Yildirimman, Reha; (...); Herwig, Ralf
Article. 10.1093/toxsci/kfr225. 2011
Human hepatocyte transplantation in patients with hepatic failure awaiting a graft.
Article. 10.1159/000351332. 2013
Human hepatocytes derived from pluripotent stem cells: a promising cell model for drug hepatotoxicity screening
Review. 10.1007/s00204-016-1756-1. 2016
Human neonatal hepatocyte transplantation induces long-term rescue of unconjugated hyperbilirubinemia in the Gunn rat
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.1002/lt.24121. 2015
Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing
Article. 10.1093/toxsci/kfw078. 2016
Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure
Bolonio, M.; (...); Tolosa, L.
Meeting Abstract. 2019
Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure.
Article. 10.1016/j.jcyt.2019.12.005. 2020
Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London.
Puppi J; (...); Dhawan A
Article. 10.3727/096368911X566208. 2012
In Vitro Evaluation of Potential Hepatotoxicity Induced by Drugs
Gomez-Lechon, M. J.; (...); Donato, M. T.
Article. 10.2174/138161210791208910. 2010
In vitro modulation of the cytochrome P450 and ABCB1/P-glycoprotein activities of the aqueous extract of Allophylus cominia (L) Sw. leaves.
Pérez CL; (...); Rodeiro I
Article. 10.1515/dmpt-2017-0020. 2017
In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay
Brecklinghaus, Tim; (...); Hengstler, Jan G.
Article. 10.1016/j.toxlet.2022.08.006. 2022
In vitro/in vivo screening of oxidative homeostasis and damage to DNA, protein, and lipids using UPLC/MS-MS
Carretero, A; (...); Lahoz, A
Article. 10.1007/s00216-014-7983-5. 2014
Induced pluripotent stem cells for the treatment of liver diseases: challenges and perspectives from a clinical viewpoint
Pareja, E, Gomez-Lechon, MJ, Tolosa, L
Review. 10.21037/atm.2020.02.164. 2020
Influence of peritoneal fluid on the expression of angiogenic and proteolytic factors in cultures of endometrial cells from women with endometriosis.
Cosín R; (...); Estelles A
Article. 10.1093/humrep/dep419. 2010
Interaction between Hhex and SOX13 modulates Wnt/TCF activity.
Marfil V; (...); Bort R
Article. 10.1074/jbc.M109.046649. 2010
Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices
Jetten MJ; (...); Kleinjans JC
Article. 10.1016/j.tox.2014.06.007. 2014
LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells
García-Cañaveras JC; (...); Lahoz A
Article. 10.1002/elps.201500095. 2015
Liver cell culture techniques.
Castell, Jose V, Gomez-Lechon, Maria Jose
Article. 10.1007/978-1-59745-201-4_4. 2009
Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes.
Tolosa, L; (...); Donato, MT
Article. 10.1007/s00204-018-2349-y. 2019
Low density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial Hypercholesterolemia modelling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection
Caron, J; (...); Dubart-Kupperschmitt, A
Meeting Abstract. 10.1016/S0168-8278(18)30382-9. 2018
Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection.
Caron J; (...); Dubart-Kupperschmitt A
Article. 10.1186/s13287-019-1342-6. 2019
Mangifera indica L. extract and mangiferin modulate cytochrome P450 and UDP-glucuronosyltransferase enzymes in primary cultures of human hepatocytes.
Rodeiro I; (...); Teresa Donato M
Article. 10.1002/ptr.4782. 2013
Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs
Gomez-Lechon, MJ, Tolosa, L, Donato, MT
Review. 10.1002/jat.3277. 2016
Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo
Teresa Donato, M.; (...); Lahoz, Agustin
Article. 10.1124/dmd.110.033605. 2010
Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes
Quintas, G; (...); Castell, JV
Article. 10.1007/s00204-021-03114-z. 2021
Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction
Cortes M; (...); Lahoz A
Article. 10.1016/j.jhep.2014.04.023. 2014
Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved.
Martínez-Sena T; (...); Castell JV
Article. 10.1007/s00204-023-03474-8. 2023
Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen.
Rodríguez-Agudo R; (...); Martínez-Chantar ML
Article. 10.3390/antiox11050897. 2022
miR-133a regulates vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1), a key protein in the vitamin K cycle.
Pérez-Andreu V; (...); Martínez C
Article. 10.2119/molmed.2012.00062. 2013
Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients
Thiel, C; (...); Kuepfer, L
Article. 10.1007/s00204-016-1723-x. 2017
Modeling a Novel Variant of Glycogenosis IXa Using a Clonal Inducible Reprogramming System to Generate "Diseased" Hepatocytes for Accurate Diagnosis.
Garcia-Llorens, Guillem; (...); Bort, Roque
Article. 10.3390/jpm12071111. 2022
Modelos Celulares hepáticos avanzados para el estudio preclíico del metabolismo y la hepatotoxicdad de fármacos.
MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER
Article. 2017
Modulation of biotransformation and elimination systems by BM-21, an aqueous ethanolic extract from Thalassia testudinum, and thalassiolin B on human hepatocytes
Rodeiro, Idania; (...); Teresa Donato, Maria
Article. 10.1016/j.jff.2011.10.002. 2012
Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid in human hepatocytes
Petrov, P. D.; (...); Jover, R.
Meeting Abstract. 2021
Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways.
Article. 10.1016/j.fct.2021.112664. 2021
Monitoring of system conditioning after blank injections in untargeted UPLC-MS metabolomic analysis.
Martínez-Sena T; (...); Kuligowski J
Article. 10.1038/s41598-019-46371-w. 2019
Multiparametric evaluation of the cytoprotective effect of the Mangifera indica L. stem bark extract and mangiferin in HepG2 cells.
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.1111/jphp.12071. 2013
Neonatal Livers: A Source for the Isolation of Good-Performing Hepatocytes for Cell Transplantation
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.3727/096368913X669743. 2014
New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease
Lopez-Riera, M; (...); Jover, R
Article. 10.3389/fpahr.2017.00003. 2017
Newserum miRNA biomarkers to predict liver steatosis by valproic acid in paediatric epileptic patients
Jover, R.; (...); Castell, J. V.
Meeting Abstract. 10.1016/j.toxlet.2022.07.200. 2022
Non-Alcoholic Steatosis. Creation of a Bank of Steatosic Livers
Moya, Marta; (...); Vicente Castell, Jose
Article. 2011
Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers
Lopez-Riera, M; (...); Jover, R
Article. 10.1038/s41598-018-28854-4. 2018
Outcomes of elective liver surgery worldwide: a global, prospective, multicenter, cross-sectional study
Malago, Massimo; (...); Andreoli, Gustavo
Article. 10.1097/JS9.0000000000000711. 2023
Predicting drug-induced cholestasis: preclinical models
Petrov, PD; (...); Jover, R
Review. 10.1080/17425255.2018.1487399. 2018
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
Albrecht, W; (...); Hengstler, JG
Article. 10.1007/s00204-019-02492-9. 2019
Progress and challenges of mid-infrared spectroscopy for liver characterization focusing on steatosis, fibrosis and cancer
Ten-Domenech, Isabel; (...); Quintas, Guillermo
Review. 10.1080/05704928.2023.2215858. 2024
Protectiveness of NAM-based hazard assessment - which testing scope is required?
Zobl, Walter; (...); Escher, Sylvia E.
Article. 10.14573/altex.2309081. 2023
Quantitative Prediction of Steatosis in Patients with Non-Alcoholic Fatty Liver by Means of Hepatic MicroRNAs Present in Serum and Correlating with Hepatic Fat
Quintas, Guillermo; (...); Jover, Ramiro
Article. 10.3390/ijms23169298. 2022
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Godoy P; (...); Hengstler JG
Article. 10.1007/s00204-013-1078-5. 2013
Regenerative cell therapy for the treatment of hyperbilirubinemic Gunn rats with fresh and frozen human induced pluripotent stem cells-derived hepatic stem cells.
Fourrier A; (...); Nguyen TH
Article. 10.1111/xen.12544. 2020
Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.
Gu, XL; (...); Stoeber, R
Article. 10.1007/s00204-018-2302-0. 2018
Repression of the Nuclear Receptor Small Heterodimer Partner by Steatotic Drugs and in Advanced Nonalcoholic Fatty Liver Disease
Article. 10.1124/mol.114.096313. 2015
Safer chemicals using less animals: kick-off of the European ONTOX project
Vinken, M; (...); Piersma, AH
Review. 10.1016/j.tox.2021.152846. 2021
Searching for Metabolic Biomarkers as a Probe of Liver Graft Function To Assess Organ Quality Prior to Its Transplantation
Cortes, Miriam; (...); Lahoz, Agustin
Article. 2011
Sequential Hepatogenic Transdifferentiation of Adipose Tissue-Derived Stem Cells: Relevance of Different Extracellular Signaling Molecules, Transcription Factors Involved, and Expression of New Key Marker Genes
Bonora-Centelles, A.; (...); Gomez-Lechon, M. J.
Article. 10.3727/096368909X12483162197321. 2009
Silencing of hepatic fate-conversion factors induce tumorigenesis in reprogrammed hepatic progenitor-like cells
Serrano F; (...); Bort R
Article. 10.1186/s13287-016-0349-5. 2016
Steatotic liver: a suitable source for the isolation of hepatic progenitor cells
Tolosa, Laia; (...); Jose Gomez-Lechon, M.
Article. 10.1111/j.1478-3231.2011.02609.x. 2011
Steatotic Liver: a suitable source of hepatic progenitor cells for liver cellular therapy
Tolosa, L; (...); Gómez-Lechón, M José
Article. 2011
Synthesis and cytotoxic activity of 4-N-carboxybutyl-5-fluorocytosyl-Arg-Gln-Trp-Arg-Arg-Trp-Trp-Gln-Arg-NH2.
Somlai C; (...); Enriz RD
Article. 10.1016/j.bmcl.2012.05.045. 2012
Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method.
García-Cañaveras JC; (...); Lahoz A
Article. 10.1194/jlr.D028803. 2012
TESTING CHEMICAL CARCINOGENICITY BY USING A TRANSCRIPTOMICS HEPARG-BASED MODEL?
Doktorova TY; (...); Rogiers V
Article. 2014
The assessment of the potential hepatotoxicity of new drugs by in vitro metabolomics.
Quintas, Guillermo, Castell, Jose V., Moreno-Torres, Marta
Article. 10.3389/fphar.2023.1155271. 2023
The carcinoGENOMICS project: critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays.
Vinken M; (...); Rogiers V
Article. 10.1016/j.mrrev.2008.04.006. 2008
The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPARa; and repressed by C/EBPa: Implications in FABP1 down-regulation in nonalcoholic fatty liver disease.
Article. 10.1016/j.bbalip.2012.12.014. 2013
The in vitro assessment of the toxicity of volatile, oxidisable, redox-cycling compounds: phenols as an example
Tolosa, L; (...); Castell, JV
Article. 10.1007/s00204-021-03036-w. 2021
The Potential Role of Metabolomics in Drug-Induced Liver Injury (DILI) Assessment.
Moreno-Torres, Marta, Quintas, Guillermo, Castell, V, Jose
Article. 10.3390/metabo12060564. 2022
The Use of Hepatocytes to Investigate Drug Toxicity
Jose Gomez-Lechon, Maria, Castell, Jose V., Teresa Donato, Maria
Article. 10.1007/978-1-60761-688-7_21. 2010
The Vitamin D Receptor Regulates Glycerolipid and Phospholipid Metabolism in Human Hepatocytes
Martinez-Sena, T; (...); Jover, R
Article. 10.3390/biom10030493. 2020
Toward Rapid Screening of Liver Grafts at the Operating Room Using Mid-infrared Spectroscopy.
Pérez-Guaita D; (...); Castell JV
Article. 10.1021/acs.analchem.0c02735. 2020
Transcriptional Regulation of Cytochrome P450 Genes by the Nuclear Receptor Hepatocyte Nuclear Factor 4-Alpha
Jover, Ramiro, Moya, Marta, Jose Gomez-Lechon, M.
Article. 10.2174/138920009788898000. 2009
Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models.
Doktorova TY; (...); Rogiers V
Article. 10.1093/carcin/bgt054. 2013
Transplantation of hESC-derived hepatocytes protects mice from liver injury
Tolosa L; (...); Dubart-Kupperschmitt A
Article. 10.1186/s13287-015-0227-6. 2015
Uncovering the toxicity mechanisms of a series of carboxylic acids in liver cells through computational and experimental approaches.
Ortega-Vallbona, Rita; (...); Serrano-Candelas, Eva
Article. 10.1016/j.tox.2024.153764. 2024
Upgrading cytochrome P450 activity in HepG2 cells co-transfected with adenoviral vectors for drug hepatotoxicity assessment.
Tolosa L; (...); Gómez-Lechón MJ
Article. 10.1016/j.tiv.2011.11.008. 2012
Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing
Gomez-Lechon, MJ, Tolosa, L, Donato, MT
Review. 10.1080/17425255.2017.1238459. 2017
Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies
Donato, MT, Gomez-Lechon, MJ, Tolosa, L
Review. 10.1080/17460441.2017.1271784. 2017
Using Metabolomics to Uncover Ontogeny of Drug-Induced Hepatotoxicity and Underlying AOP Mechanisms
Martinez-Sena, T.; (...); Castell Ripoll, J. V.
Meeting Abstract. 2023
Validated assay for studying activity profiles of human liver UGTs after drug exposure: inhibition and induction studies
Teresa Donato, M.; (...); Lahoz, Agustin
Article. 10.1007/s00216-009-3441-1. 2010
Ensayo Multiparamétrico In Vitro Para La Evaluación De La Hepatotoxicidad Mitocondrial De Fármacos
Autor/es: Antonio Carmona Serrano
Proyecto Fin de Carrera
Director/es: LAIA TOLOSA PARDO; MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER
Campos de Estudio
Cita
FORINVITOX. (FORINVITOX 1, START UP 2). FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA; REMA; UNIVERSIDAD AUTONOMA BARCELONA. 2008-2008. IP:MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER.