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  3. HEPATOTOXICIDAD IDIOSINCRÁSICA POR FÁRMACOS: ESTRATEGIAS IN VITRO PARA DIAGNÓSTICO RETROSPECTIVO, ATRIBUCIÓN DE LA CAUSALIDAD Y EVALUACIÓN DEL POTENCIAL RIESGO CLÍNICO EN PACIENTES SUSCEPTIBLES.

HEPATOTOXICIDAD IDIOSINCRÁSICA POR FÁRMACOS: ESTRATEGIAS IN VITRO PARA DIAGNÓSTICO RETROSPECTIVO, ATRIBUCIÓN DE LA CAUSALIDAD Y EVALUACIÓN DEL POTENCIAL RIESGO CLÍNICO EN PACIENTES SUSCEPTIBLES.

Datos básicos

Código:
PI16/00333
Protocolo:
PI16/00333
EUDRACT:
NCT:
Centro:
Dotación:
128.865,00 €
Año de incio:
2017
Año de finalización:
2020
PI BIOMÉDICA NACIONAL Finan. Competitiva Pública

Objetivos del proyecto

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Documentos

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Participantes

Grupos

Financiadores - Promotores

INSTITUTO DE SALUD CARLOS III

Resultados del Ensayo Clínico

CELL SOURCES FOR HEPATIC CELL THERAPY

EUGENIA PAREJA IBARS, MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER, LAIA TOLOSA PARDO

Capítulo de un Libro. 2017


CELL-BASED THERAPEUTIC STRATEGIES FOR TREATMENT OF LIVER DISEASES.

LAIA TOLOSA PARDO, MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER, EUGENIA PAREJA IBARS

Capítulo de un Libro. 2017


In vitro personalised model based on induced pluripotent stem cells for studying idiosyncratic hepatotoxicity

Pelecha, M.; (...); Tolosa, L.

Meeting Abstract. 10.1016/j.toxlet.2024.07.291. 2024


3D HYDROGEL MICROENVIROMENTS OF GELATIN AND HYALURONIC ACID FOR LIVER TISSUE ENGINEERING

Gallego-Ferrer, Gloria; (...); Tolosa, Laia

Article. 2022


A lipidomic cell-based assay for studying drug-induced phospholipidosis and steatosis

Garcia-Canaveras, JC; (...); Lahoz, A

Article. 10.1002/elps.201700079. 2017


A microRNA signature for valproate-induced steatosis in human hepatocytes and its application to predict fatty liver in paediatric epileptic patients on valproate therapy.

Soluyanova P; (...); Jover R

Article. 10.1016/j.tox.2024.153974. 2024


A Multi-Parametric Fluorescent Assay for the Screening and Mechanistic Study of Drug-Induced Steatosis in Liver Cells in Culture.

Tolosa, Laia, Gomez-Lechon, M Jose, Donato, M Teresa

Article. 10.1002/cptx.20. 2017


A Network Involving Gut Microbiota, Circulating Bile Acids, and Hepatic Metabolism Genes That Protects Against Non-Alcoholic Fatty Liver Disease.

Petrov PD; (...); Jover R

Article. 10.1002/mnfr.201900487. 2019


A novel microRNA signature for cholestatic drugs in human hepatocytes and its translation into novel circulating biomarkers for drug-induced liver injury patients.

López-Riera M; (...); Jover R

Article. 10.1093/toxsci/kfz138. 2020


A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes.

Moreno-Torres, Marta; (...); Castell, V, Jose

Article. 10.1021/acs.jproteome.1c00779. 2022


A population-based screening for hepatitis C antibodies and active infection using a point-of-care test in a low prevalence area.

Carvalho-Gomes Â; (...); Berenguer M

Article. 10.1371/journal.pone.0228351. 2020


A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies.

Garcia-Llorens, Guillem; (...); Bort, Roque

Article. 10.1186/s13287-023-03311-w. 2023


Accuracy of CT colonography in the preoperative staging of colon cancer: a prospective study of 217 patients.

Maupoey Ibáñez J; (...); García-Granero Ximénez E

Article. 10.1111/codi.14724. 2019


Adherence to endoscopic surveillance guidelines for advanced lesions and colorectal cancer in Inflammatory Bowel Disease in Spain: a collaborative study of AEG and GETECCU

Ballester Ferre, M. P.; (...); Minguez, M.

Meeting Abstract. 10.1093/ecco-jcc/jjab076.727. 2021


Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems

Fernandez-Murga, ML; (...); Jover, R

Review. 10.1016/j.fct.2018.07.017. 2018


Alternative Cell Sources to Adult Hepatocytes for Hepatic Cell Therapy.

Pareja, E, Gomez-Lechon, MJ, Tolosa, L

Article. 10.1007/978-1-4939-6506-9_2. 2017


An international, multicenter, survey-based analysis of practice and management of acute liver failure.

Gurakar, Ahmet; (...); Coilly, Audrey

Article. 10.1097/LVT.0000000000000402. 2024


Angiopoietin-Like Protein 8 Is a Novel Vitamin D Receptor Target Gene Involved in Nonalcoholic Fatty Liver Pathogenesis

Garcia-Monzon, C; (...); Jover, R

Article. 10.1016/j.ajpath.2018.07.028. 2018


Angiopoietin-like protein 8 is a novel vitamin D receptor-targeted lipogenic gene associated with non-alcoholic fatty liver

Gonzalez-Rodriguez, A; (...); Garcia-Monzon, C

Meeting Abstract. 10.1016/S0168-8278(18)30948-6. 2018


Application of high-content screening for the study of hepatotoxicity: Focus on food toxicology.

Donato MT, Tolosa L

Review. 10.1016/j.fct.2020.111872. 2021


Assessment of the cytotoxic potential of an aqueous-ethanolic extract from Thalassia testudinum angiosperm marine grown in the Caribbean Sea.

Rodeiro, I; (...); Lopes, M

Article. 10.1111/jphp.13001. 2018


Automated generation of hiPSC-derived hepatic progeny by cost-efficient compounds.

Vanmarcke G; (...); Verfaillie CM

Article. 10.1093/stmcls/sxad065. 2023


BASELINE PROFILE OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS ON TREATMENT WITH BELIMUMAB OF A SPANISH MULTICENTER COHORT

Altabas Gonzalez, I.; (...); Rua-Figueroa, I.

Meeting Abstract. 10.1136/annrheumdis-2023-eular.3003. 2023


Bladder cancer recurrence surveillance by urine metabolomics analysis

Loras, A; (...); Ruiz-Cerda, JL

Article. 10.1038/s41598-018-27538-3. 2018


Budesonide as first-line treatment in patients with autoimmune hepatitis seems inferior to standard predniso(lo)ne administration.

Diaz-Gonzalez, Alvaro; (...); Londoño MC

Article. 10.1097/HEP.0000000000000018. 2023


CA125: a new biomarker in patients with Fontan circulation (vol 76, pg 112, 2023)

Fuentes, Francisco Buendia; (...); Soriano, Joaquin Rueda

Correction. 10.1016/j.rec.2023.03.018. 2023


CA125: a new biomarker in patients with Fontan circulation.

Fuentes, Francisco Buendia; (...); Soriano, Joaquin Rueda

Article. 10.1016/j.rec.2022.05.029. 2022


Cell Models and Omics Techniques for the Study of Nonalcoholic Fatty Liver Disease: Focusing on Stem Cell-Derived Cell Models.

Pelechá M; (...); Tolosa L

Article. 10.3390/antiox11010086. 2021


Clinical characteristics and outcomes of elderly included in the Spanish Drug-Induced Liver Injury (DILI) Registry

Slim, M; (...); Andrade, RJ

Meeting Abstract. 10.1016/S0168-8278(17)31154-6. 2017


Clinical presentation, causative drugs and outcome of patients with autoimmune features in two prospective DILI registries.

Garcia-Cortes, Miren; (...); Andrade, Raul J.

Article. 10.1111/liv.15623. 2023


CLINICAL SIGNIFICANCE OF ANTI-LA ANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS

Sanguesa, C.; (...); Pego-Reigosa, J. M.

Meeting Abstract. 10.1136/annrheumdis-2023-eular.6283. 2023


Cluster-Partial Least Squares (c-PLS) regression analysis: Application to miRNA and metabolomic data.

Kuligowski, Julia; (...); Quintas, Guillermo

Article. 10.1016/j.aca.2023.342052. 2024


CMV reactivation after liver transplantation (LT) in HIV infected is similar to non-HIV patients: a single center comparative study

Garcia-Garcia, Sonia; (...); Aguilera Sancho, Victoria

Meeting Abstract. 2023


CMV reactivation is associated with lower hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT)

Aguilera Sancho, Victoria; (...); Berenguer, Marina

Meeting Abstract. 2022


c-MYC Triggers Lipid Remodelling During Early Somatic Cell Reprogramming to Pluripotency

Prieto, Javier; (...); Torres, Josema

Article. 10.1007/s12015-021-10239-2. 2021


Comparing in vitro human liver models to in vivo human liver using RNA-Seq.

Gupta R; (...); Caiment F

Article. 10.1007/s00204-020-02937-6. 2020


Comparing Targeted vs. Untargeted MS2 Data-Dependent Acquisition for Peak Annotation in LC-MS Metabolomics

Ten-Domenech, I; (...); Kuligowski, J

Article. 10.3390/metabo10040126. 2020


Comparing the direct assessment of steatosis in liver explants with mid- and near-infrared vibrational spectroscopy, prior to organ transplantation.

Rienda, Ivan; (...); Quintas, Guillermo

Article. 10.1039/d3an01184d. 2023


Comprehensive analysis and insights gained from long-term experience of the Spanish DILI registry.

Stephens C; (...); Andrade RJ

Article. 10.1016/j.jhep.2021.01.029. 2021


Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury

Tolosa, L; (...); Teresa Donato, M.

Article. 10.1007/s00204-017-2036-4. 2018


Cytomegalovirus reactivation in liver transplant recipients due to hepatitis C cirrhosis is associated with higher cardiovascular risk - an observational, retrospective study

Aguilera, V; (...); Berenguer, M

Article. 10.1111/tri.13145. 2018


Cytomegalovirus reactivation is associated with lower hepatocelullar carcinoma recurrence rates after liver transplantation

Aguilera Sancho, Victoria; (...); Rodriguez-Peralvarez, Manuel

Meeting Abstract. 2023


Challenges and perspectives of liver tissue engineering: From cell therapy to bioprinting

Rodriguez-Fernandez, Julio; (...); Tolosa, Laia

Review. 10.36922/ijb.2706. 2024


Characteristics and impact of sex in a cohort of patients with primary sclerosing cholangitis: Experience of a transplant center in the Mediterranean basin.

Mínguez Sabater A; (...); Berenguer, Marina

Article. 10.1016/j.gastrohep.2021.03.017. 2022


CHARACTERISTICS AND IMPACT OF SEX IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS: A MULTICENTER STUDY FROM A CLASSICALLY LOW PREVALENCE AREA

Minguez, Alejandro; (...); Berenguer, Marina

Meeting Abstract. 2021


Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries.

Medina-Caliz, Inmaculada; (...); Alvarez-Alvarez, Ismael

Article. 10.1007/s00204-023-03630-0. 2023


Characterization of Proliferating Human Hepatocytes As a Model System for Drug Interaction Studies and Toxicity Screenings

Noerenberg, A; (...); Jover, R

Meeting Abstract. 2017


Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure.

Chen Q; (...); Quer J

Article. 10.1016/j.antiviral.2019.104694. 2020


Derivation of healthy hepatocyte-like cells from a female patient with ornithine transcarbamylase deficiency through X-inactivation selection.

Santamaria R; (...); Bort R

Article. 10.1038/s41598-022-06184-w. 2022


Development and Validation of a Scoring System to Predict Response to Obeticholic Acid in Primary Biliary Cholangitis (vol 22, pg 2062, 2024)

De Vincentis, A.; (...); Conde, Isabel

Correction. 2025


Development and validation of a scoring system to predict response to obeticholic acid in primary biliary cholangitis.

De Vincentis, Antonio; (...); Carbone, Marco

Article. 10.1016/j.cgh.2024.05.008. 2024


Direct conversion of human fibroblast to hepatocytes using a single inducible polycistronic vector.

Ballester M; (...); Bort R

Article. 10.1186/s13287-019-1416-5. 2019


Does Surgeon Fatigue Influence the Results of Liver Transplantation?

Bosca, A; (...); Lopez-Andujar, R

Article. 10.1016/j.transproceed.2018.03.139. 2019


DRESS cases included in the Spanish and Latin-American DILI registries: clinical phenotype and outcome

Medina-Caliz, I; (...); Andrade, RJ

Meeting Abstract. 10.1016/S0168-8278(18)31459-4. 2018


Drug-Induced Fatty Liver Disease (DIFLD): A Comprehensive Analysis of Clinical, Biochemical, and Histopathological Data for Mechanisms Identification and Consistency with Current Adverse Outcome Pathways.

Lopez-Pascual, Ernesto; (...); Castell, Jose V.

Article. 10.3390/ijms25105203. 2024


Early liver transplantation for acute alcoholic hepatitis In a spanish liver transplant center

Aguilera Sancho, Victoria; (...); Berenguer, Marina

Meeting Abstract. 2023


EFFECTIVENESS AND SAFETY OF SECOND-LINE THERAPY IN PRIMARY BILIARY CHOLANGITIS (PBC): A PROSPECTIVE MULTICENTER REAL-WORLD COHORT

Gomez-Dominguez, Elena; (...); Fernandez-Rodriguez, Conrado

Meeting Abstract. 2023


Effectiveness and Safety of Sofosbuvir/Velpatasvir/ Voxilaprevir in Patients with Chronic Hepatitis C Previously Treated with DAAs.

Llaneras J; (...); Buti M

Article. 10.1016/j.jhep.2019.06.002. 2019


EFFECTIVENESS OF BELIMUMAB IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS OF A MULTICENTER SPANISH COHORT

Altabas Gonzalez, I.; (...); Rua-Figueroa, I.

Meeting Abstract. 10.1136/annrheumdis-2023-eular.3482. 2023


Effectiveness of obeticholic acid (OCA) in southern European patients with primary biliary cholangitis (PBC) as a second line therapy. A multicenter, international, real-world cohort

Garcia-Buey, Luisa; (...); Fernandez Rodriguez, Conrado Manuel

Meeting Abstract. 2020


EFFICACY AND SAFETY OF BUDESONIDE AS FIRST LINE TREATMENT IN PATIENTS WITH AUTOIMMUNE HEPATITIS: SPANISH MULTICENTER STUDY

Diaz-Gonzalez, Alvaro; (...); Carlota Londono, Maria

Meeting Abstract. 2021


Endothelin-1-Mediated Drug Resistance in EGFR-Mutant Non-Small Cell Lung Carcinoma

Pulido, I; (...); Shimamura, T

Article. 10.1158/0008-5472.CAN-20-0141. 2020


Enhancing the accuracy of mid-infrared spectroscopy-based liver steatosis quantification using digital image analysis as a reference.

Rienda, Ivan; (...); Quintas, Guillermo

Article. 10.1039/d3an00324h. 2023


Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes.

Petrov PD; (...); Jover R

Article. 10.1007/s00204-019-02643-y. 2020


Ertapenem neurotoxicity in liver transplantation.

Martinez Delgado, Sara; (...); Conde, Isabel

Article. 10.17235/reed.2021.8469/2021. 2022


Evaluation of patient safety and satisfaction in a program of ambulatory laparoscopic cholecystectomy program with expanded criteria

Sala-Hernandez, A; (...); Andujar, RL

Article. 10.1016/j.ciresp.2018.06.021. 2019


Exploring Individual Variability in Drug-Induced Liver Injury (DILI) Responses through Metabolomic Analysis.

Moreno-Torres M; (...); Castell JV

Article. 10.3390/ijms25053003. 2024


Extended distal pancreatectomy with thoracic wall resection after neoadjuvant FOLFIRINOX: Is there a limit of resection for pancreatic cancer after downstaging?

Giuliani T; (...); Lopez Andujar R

Case Reports. 10.14701/ahbps.2020.24.1.90. 2020


Extracting consistent biological information from functional results of metabolomic pathway analysis using the Mantel's test.

Ten-Doménech I; (...); Kuligowski J

Article. 10.1016/j.aca.2021.339173. 2021


Extrahepatic Autoimmune Comorbidities in Patients with Primary Biliary Cholangitis. Lack of Association with Prognosis and Therapeutic Response to Ursodeoxycholic Acid.

Reig, A; (...); Spanish Col Hai Register

Meeting Abstract. 2018


Factors that influence the quality of metabolomics data in in vitro cell toxicity studies: a systematic survey.

Moreno-Torres, Marta; (...); Castell, Jose Vicente

Article. 10.1038/s41598-021-01652-1. 2021


FIBROMYALGIA AND GLUCOCORTICOIDS USE DRIVES SELF-PERCEIVED DEPRESSION IN SYSTEMIC LUPUS ERYTHEMATOSUS: INSIGHTS FROM A LARGE PROSPECTIVE AND MULTICENTER STUDY USING RELESSER-PROS REGISTER'S DATABASE

Rua-Figueroa, I.; (...); Pego-Reigosa, J. M.

Meeting Abstract. 10.1136/annrheumdis-2023-eular.1811. 2023


FibroScan compared to liver biopsy for accurately detecting recurrent hepatic steatosis and fibrosis after liver transplantation for metabolic dysfunction-associated steatohepatitis

Martinez-Arenas, Laura; (...); Berenguer, Marina

Meeting Abstract. 2024


FibroScan compared to liver biopsy for accurately detecting recurrent hepatic steatosis and fibrosis after liver transplantation for metabolic dysfunction-associated steatohepatitis

Martinez-Arenas, L.; (...); Berenguer, M.

Meeting Abstract. 2024


FibroScan compared to liver biopsy for accurately staging recurrent hepatic steatosis and fibrosis after transplantation for MASH.

Martinez-Arenas, Laura; (...); Berenguer, Marina

Article. 10.1111/liv.16085. 2024


From conventional two-stage hepatectomy to ALPPS: Fifteen years of experience in a hepatobiliary surgery unit

Maupoey Ibanez, Javier; (...); Lopez-Andujar, Rafael

Article. 10.1016/j.hbpd.2021.08.0011499-3872. 2021


Gender differences in liver transplantation (LT) for acute liver failure (ALF) in a multicentre ALF-LT Spanish cohort

Conde, Isabel; (...); Aguilera Sancho, Victoria

Meeting Abstract. 2023


Gender differences in liver transplantation (LT) for acute liver failure (ALF) in a multicentre ALF-LT Spanish cohort

Conde, I.; (...); Aguilera, V.

Meeting Abstract. 2023


GLUD1 determines murine muscle stem cell fate by controlling mitochondrial glutamate levels.

Soro-Arnáiz I; (...); Morscher RJ

Article. 10.1016/j.devcel.2024.07.015. 2024


Glutamine/glutamate metabolism rewiring in reprogrammed human hepatocyte-like cells

Ballester, M; (...); Bort, R

Article. 10.1038/s41598-019-54357-x. 2019


Good posttransplant outcome using donors after cardiac death (DCD) when applying strict selection criteria

de la Varga, MF; (...); Castillo, MP

Meeting Abstract. 2021


Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients.

Perez-Rubio, Alvaro; (...); Jover, Ramiro

Article. 10.3390/nu15143187. 2023


Hepatitis C-related cirrhosis: Current status

Conde, I, Vinaixa, C, Berenguer, M

Review. 10.1016/j.medcli.2016.09.019. 2017


Herbal and Dietary Supplement-Induced Liver Injuries in the Spanish DILI Registry

Medina-Caliz, I; (...); Spanish DILI Registry

Article. 10.1016/j.cgh.2017.12.051. 2018


High-Content Screening for the Detection of Drug-Induced Oxidative Stress in Liver Cells.

Donato M, Tolosa L

Review. 10.3390/antiox10010106. 2021


Human hepatocytes encapsulated in injectable hydrogels for their use in liver cell therapy

Rodriguez-Fernandez, J.; (...); Tolosa, L.

Meeting Abstract. 2019


Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure

Bolonio, M.; (...); Tolosa, L.

Meeting Abstract. 2019


Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure.

Donato MT; (...); Tolosa L

Article. 10.1016/j.jcyt.2019.12.005. 2020


In vitro modulation of the cytochrome P450 and ABCB1/P-glycoprotein activities of the aqueous extract of Allophylus cominia (L) Sw. leaves.

Pérez CL; (...); Rodeiro I

Article. 10.1515/dmpt-2017-0020. 2017


In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay

Brecklinghaus, Tim; (...); Hengstler, Jan G.

Article. 10.1016/j.toxlet.2022.08.006. 2022


Incidence of fungal and other opportunistic infections in patients with autoimmune hepatitis: a spanish multicentre study

Diaz-Gonzalez, Alvaro; (...); Crespo, Javier

Meeting Abstract. 2024


Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study

Chaparro, Maria; (...); Gisbert, Javier P.

Article. 10.3390/jcm10132885. 2021


Induced pluripotent stem cells for the treatment of liver diseases: challenges and perspectives from a clinical viewpoint

Pareja, E, Gomez-Lechon, MJ, Tolosa, L

Review. 10.21037/atm.2020.02.164. 2020


Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8(+) T cell stemness and antitumor immunity

Hermans, D; (...); Leonard, WJ

Article. 10.1073/pnas.1920413117. 2020


Late complications of pancreas transplant.

Maupoey Ibáñez J, Boscà Robledo A, López-Andujar R

Article. 10.5500/wjt.v10.i12.404. 2020


LipidMS 3.0: an R-package and a web-based tool for LC-MS/MS data processing and lipid annotation.

Alcoriza-Balaguer MI; (...); Lahoz, Agustin

Article. 10.1093/bioinformatics/btac581. 2022


LipidMS: An R Package for Lipid Annotation in Untargeted Liquid Chromatography-Data Independent Acquisition-Mass Spectrometry Lipidomics

Alcoriza-Balaguer, MI; (...); Lahoz, A

Article. 10.1021/acs.analchem.8b03409. 2019


Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes.

Tolosa, L; (...); Donato, MT

Article. 10.1007/s00204-018-2349-y. 2019


Long-term prospective follow-up of a primary biliary cholangitis (PBC) multicenter cohort treated with Obeticholic Acid (OCA). Interaction effect of triple therapy with fibrates

Gomez-Dominguez, Elena; (...); Fernandez-Rodriguez, Conrado

Meeting Abstract. 2023


Low density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial Hypercholesterolemia modelling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection

Caron, J; (...); Dubart-Kupperschmitt, A

Meeting Abstract. 10.1016/S0168-8278(18)30382-9. 2018


Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection.

Caron J; (...); Dubart-Kupperschmitt A

Article. 10.1186/s13287-019-1342-6. 2019


Machine Learning-Based Analysis in the Management of Iatrogenic Bile Duct Injury During Cholecystectomy: a Nationwide Multicenter Study

Lopez-Lopez, Victor; (...); Robles-Campos, Ricardo

Article. 10.1007/s11605-022-05398-7. 2022


Mechanistic Understanding of Idiosyncratic Drug-Induced Hepatotoxicity Using Co-Cultures of Hepatocytes and Macrophages.

Villanueva-Badenas, Estela, Donato, M. Teresa, Tolosa, Laia

Article. 10.3390/antiox12071315. 2023


Metabolic syndrome before liver transplantation: does it have an impact on post liver transplantation outcomes?

Herreras Lopez, Julia; (...); Aguilera, Victoria

Article. 10.17235/reed.2022.8384/2021. 2022


Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes

Quintas, G; (...); Castell, JV

Article. 10.1007/s00204-021-03114-z. 2021


Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved.

Martínez-Sena T; (...); Castell JV

Article. 10.1007/s00204-023-03474-8. 2023


Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen.

Rodríguez-Agudo R; (...); Martínez-Chantar ML

Article. 10.3390/antiox11050897. 2022


Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients

Thiel, C; (...); Kuepfer, L

Article. 10.1007/s00204-016-1723-x. 2017


Modeling a Novel Variant of Glycogenosis IXa Using a Clonal Inducible Reprogramming System to Generate "Diseased" Hepatocytes for Accurate Diagnosis.

Garcia-Llorens, Guillem; (...); Bort, Roque

Article. 10.3390/jpm12071111. 2022


Modelos Celulares hepáticos avanzados para el estudio preclíico del metabolismo y la hepatotoxicdad de fármacos.

MARÍA JOSÉ GÓMEZ-LECHÓN MOLINER

Article. 2017


Molecular characterization of Hepatitis C virus resistance-associated substitutions after interferon-free treatment failure by massive parallel sequencing

Chen, Q; (...); Quer, J

Meeting Abstract. 10.1016/S0168-8278(17)31950-5. 2017


Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid in human hepatocytes

Petrov, P. D.; (...); Jover, R.

Meeting Abstract. 2021


Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways.

Petrov PD; (...); Jover R

Article. 10.1016/j.fct.2021.112664. 2021


Monitoring of system conditioning after blank injections in untargeted UPLC-MS metabolomic analysis.

Martínez-Sena T; (...); Kuligowski J

Article. 10.1038/s41598-019-46371-w. 2019


Multimodal analysis identifies microbiome changes linked to stem cell transplantation-associated diseases

Artacho, Alejandro; (...); Ubeda, Carles

Article. 10.1186/s40168-024-01948-0. 2024


New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease

Lopez-Riera, M; (...); Jover, R

Article. 10.3389/fpahr.2017.00003. 2017

  • Open Access.

Newserum miRNA biomarkers to predict liver steatosis by valproic acid in paediatric epileptic patients

Jover, R.; (...); Castell, J. V.

Meeting Abstract. 10.1016/j.toxlet.2022.07.200. 2022


Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers

Lopez-Riera, M; (...); Jover, R

Article. 10.1038/s41598-018-28854-4. 2018


Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

Ringel, AE; (...); Haigis, MC

Article. 10.1016/j.cell.2020.11.009. 2020


Outcomes of elective liver surgery worldwide: a global, prospective, multicenter, cross-sectional study

Malago, Massimo; (...); Andreoli, Gustavo

Article. 10.1097/JS9.0000000000000711. 2023


Overlap of primary biliary cholangitis and autoimmune hepatitis. Natural history and prognosis in a large cohort of patients from Spain

Reig, A; (...); Grp Registro Col-Hai Enfermedades

Meeting Abstract. 2019


Oxidative-stress and long-term hepatotoxicity: comparative study in Upcyte human hepatocytes and hepaRG cells.

Donato MT; (...); Tolosa L

Article. 10.1007/s00204-022-03236-y. 2022


PANCREAS TRANSPLANTATION FROM DONORS DECLARED DEATH BY CIRCULATORY CRITERIA: INITIAL EXPERIENCE IN SPAIN

Ferrer, J; (...); Dominguez-Gil, B

Meeting Abstract. 2021


Pediatric living donor liver transplantation: results of laparoscopic vs. open graft removal.

Crehuet Gramatyka D; (...); Vila Carbó JJ

Article. 10.54847/cp.2022.02.13. 2022


Performance of the fibroscan and other noninvasive scales for detecting hepatic fibrosis in patients with nonalcoholic fatty liver disease

Saez, E; (...); Zaragoza, A

Meeting Abstract. 10.1016/S0168-8278(17)30585-8. 2017


Performance of the OraQuick Hepatitis C virus antibody test in oral fluid and fingerstick blood before and after treatment-induced viral clearance

Pallares, C; (...); Lopez-Labrador, FX

Article. 10.1016/j.jcv.2018.02.016. 2018


Pilot validation study of a rapid test in oral fluid for population screening of hepatitis C virus infection

Pallares, C; (...); Berenguer, M

Meeting Abstract. 10.1016/S0168-8278(17)31165-0. 2017


Population screening using a point-of-care test reveals unexpectedly low prevalence of active HCV infection in Spain

Carvalho-Gomes, A; (...); Berenguer, M

Meeting Abstract. 2017


Predicting drug-induced cholestasis: preclinical models

Petrov, PD; (...); Jover, R

Review. 10.1080/17425255.2018.1487399. 2018


PREDICTION OF BIOCHEMICAL RESPONSE IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS TREATED WITH OBETICHOLIC ACID: DERIVATION AND EXTERNAL VALIDATION OF THE OCA RESPONSE SCORE (ORS)

De Vincentis, Antonio; (...); Carbone, Marco

Meeting Abstract. 2023


Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

Albrecht, W; (...); Hengstler, JG

Article. 10.1007/s00204-019-02492-9. 2019


Predictive models of treatment benefit in patients with autoimmune hepatitis and decompensated cirrhosis at diagnosis

Arvaniti, Pinelopi; (...); Carlota Londono, Maria

Meeting Abstract. 2023


Primary biliary cholangitis and SARS-CoV-2 infection: incidence, susceptibility and outcomes.

Ampuero J; (...); Molina E

Letter. 10.1136/gutjnl-2021-325700. 2021


Primary human hepatocytes-laden scaffolds for the treatment of acute liver failure.

Rodriguez-Fernandez J; (...); Tolosa L

Article. 10.1016/j.bioadv.2023.213576. 2023


Primary sclerosing cholangitis as an indication for liver transplantation. Results and conditioning factors: relationship with associated intestinal pathology

Fernandez, Ainhoa; (...); Salcedo, Magdalena

Meeting Abstract. 2023


Primary sclerosing cholangitis as an indication for liver transplantation. Results and conditioning factors: relationship with associated intestinal pathology

Fernandez-Yunquera, A.; (...); Salcedo, M. M.

Meeting Abstract. 2023


Primary Sclerosing Cholangitis: Gender Effects in Valencia's Low-Prevalence Region.

Minguez, Alejandro; (...); Berenguer, Marina

Article. 10.1007/s10620-024-08368-y. 2024


Progress and challenges of mid-infrared spectroscopy for liver characterization focusing on steatosis, fibrosis and cancer

Ten-Domenech, Isabel; (...); Quintas, Guillermo

Review. 10.1080/05704928.2023.2215858. 2024


Prophylaxis for tuberculosis and pneumocystis jirovecii does not seem necessary in patients with autoimmune hepatitis treated with corticosteroid therapy: spanish multicentre study

Diaz-Gonzalez, Alvaro; (...); Crespo, Javier

Meeting Abstract. 2024


Protectiveness of NAM-based hazard assessment - which testing scope is required?

Zobl, Walter; (...); Escher, Sylvia E.

Article. 10.14573/altex.2309081. 2023


Psychosocial impact of the COVID-19 pandemic on patients with inflammatory bowel disease in Spain

Hernandez Camba, A.; (...); Barreiro, M.

Meeting Abstract. 10.1093/ecco-jcc/jjab076.312. 2021

  • Open Access.

Psychosocial impact of the COVID-19 pandemic on patients with inflammatory bowel disease in Spain. A post lockdown reflection.

Hernandez Camba, Alejandro; (...); Barreiro-de Acosta, Manuel

Article. 10.1016/j.gastrohep.2021.08.007. 2021


Quantitative Prediction of Steatosis in Patients with Non-Alcoholic Fatty Liver by Means of Hepatic MicroRNAs Present in Serum and Correlating with Hepatic Fat

Quintas, Guillermo; (...); Jover, Ramiro

Article. 10.3390/ijms23169298. 2022


Real-Life Effectiveness and Safety of Velpatasvir/Sofosbuvir/Voxilaprevir for Previously Daa Treated Patients with Chronic Hepatitis C

Llaneras, J; (...); Buti, M

Meeting Abstract. 2018


Real-life effectiveness of voxilaprevir/sofosbuvir/velpatasvir in hepatitis C patients previously treated with sofosbuvir/velpatasvir or glecaprevir/pibrentasvir

Ruiz-Cobo, Juan Carlos; (...); Lens, Sabela

Meeting Abstract. 2023


Recurrence of Hepatocellular Carcinoma after Liver Transplantation: Clinical Patterns and Hierarchy of Salvage Treatments

Giuliani, Tommaso; (...); Lopez-Andujar, Rafael

Article. 10.1159/000539460. 2024


Regenerative cell therapy for the treatment of hyperbilirubinemic Gunn rats with fresh and frozen human induced pluripotent stem cells-derived hepatic stem cells.

Fourrier A; (...); Nguyen TH

Article. 10.1111/xen.12544. 2020


Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.

Gu, XL; (...); Stoeber, R

Article. 10.1007/s00204-018-2302-0. 2018


Reply to the Letter ``A challenge for medium and small pancreatic transplant groups: How can the learning curve from the retrieval team affect the pancreas graft thrombosis?''

Argente-Pla, Maria; (...); Francisco Merino-Torres, Juan

Letter. 2021


Reply to the Letter «A challenge for medium and small pancreatic transplant groups: How can the learning curve from the retrieval team affect the pancreas graft thrombosis?».

Argente-Pla M; (...); Merino-Torres JF

Letter. 10.1016/j.ciresp.2021.06.007. 2021


Reply to the Letter A challenge for medium and small pancreatic transplant groups: How can the learning curve from the retrieval team affect the pancreas graft thrombosis?.

Argente-Pla, Maria; (...); Merino-Torres, Juan Francisco

Article. 10.1016/j.cireng.2021.06.019. 2021


Results after 13 years of kidney-pancreas transplantation in type 1 diabetic patients in Comunidad Valenciana.

Argente-Pla, Maria; (...); Merino-Torres, Juan Francisco

Article. 10.1016/j.cireng.2021.10.001. 2021


Results after 13 years of kidney-pancreas transplantation in type 1 diabetic patients in Comunidad Valenciana.

Argente-Pla, Maria; (...); Merino-Torres JF

Article. 10.1016/j.ciresp.2020.09.012. 2021


Reviewing the metabolome coverage provided by LC-MS: Focus on sample preparation and chromatography-A tutorial

Roca; (...); Lahoz

Review. 2021


Reviewing the metabolome coverage provided by LC-MS: Focus on sample preparation and chromatography-A tutorial.

Roca M; (...); Lahoz A

Article. 10.1016/j.aca.2020.12.025. 2021


RpeakChrom: Novel R package for the automated characterization and optimization of column efficiency in high-performance liquid chromatography analysis

Peris-Diaz, MD; (...); Lahoz, A

Article. 10.1002/elps.201700180. 2017


Safer chemicals using less animals: kick-off of the European ONTOX project

Vinken, M; (...); Piersma, AH

Review. 10.1016/j.tox.2021.152846. 2021


Selective Indication of T-Tube in Liver Transplantation: Prospective Validation of the Results of a Randomized Controlled Trial

Lopez-Andujar, R; (...); Montalva, EM

Article. 10.1016/j.transproceed.2018.03.133. 2019


SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia.

García-Cañaveras JC; (...); Rabinowitz JD

Article. 10.1038/s41375-020-0845-6. 2020


Simultaneous pancreas-kidney transplantation: which graft warns the most?

Giuliani, Tommaso; (...); Andujar, Rafael Lopez

Article. 10.1007/s00423-023-02876-7. 2023


Sparse N-way partial least squares by L1-penalization

Hervas, D; (...); Ferrer, A

Article. 10.1016/j.chemolab.2019.01.004. 2019


Stem-cell derived hepatocyte-like cells for the assessment of drug-induced liver injury

Donato, MT, Tolosa, L

Review. 10.1016/j.diff.2019.02.004. 2019


Surgical management of a complete section of the oesophagus during total thyroidectomy

Maupoey Ibáñez J; (...); Mingol Navarro F

Editorial Material. 10.1016/j.ciresp.2016.06.002. 2017


Targeting ELOVL6 to disrupt c-MYC driven lipid metabolism in pancreatic cancer enhances chemosensitivity

Garcia, Ana Garcia; (...); Sanchez-Arevalo Lobo, Victor Javier

Article. 10.1038/s41467-025-56894-8. 2025


Textbook outcome in patients with biliary duct injury during cholecystectomy.

Lopez-Lopez V; (...); Robles-Campos R

Article. 10.1016/j.gassur.2024.02.027. 2024


The assessment of the potential hepatotoxicity of new drugs by in vitro metabolomics.

Quintas, Guillermo, Castell, Jose V., Moreno-Torres, Marta

Article. 10.3389/fphar.2023.1155271. 2023


The availability of anti-TNF agents is associated with reduced early surgical requirements in Crohn's disease but not in ulcerative colitis. A nationwide study from the Eneida registry

Guasch, M; (...); Domenech, E

Meeting Abstract. 2018


The in vitro assessment of the toxicity of volatile, oxidisable, redox-cycling compounds: phenols as an example

Tolosa, L; (...); Castell, JV

Article. 10.1007/s00204-021-03036-w. 2021


The Potential Role of Metabolomics in Drug-Induced Liver Injury (DILI) Assessment.

Moreno-Torres, Marta, Quintas, Guillermo, Castell, V, Jose

Article. 10.3390/metabo12060564. 2022


The Vitamin D Receptor Regulates Glycerolipid and Phospholipid Metabolism in Human Hepatocytes

Martinez-Sena, T; (...); Jover, R

Article. 10.3390/biom10030493. 2020


Thorough assessment of the effectiveness of belimumab in a large Spanish multicenter cohort of systemic lupus erythematosus patients.

Altabás-González I; (...); Rúa-Figueroa I

Article. 10.1093/rheumatology/kead696. 2024


Toward Rapid Screening of Liver Grafts at the Operating Room Using Mid-infrared Spectroscopy.

Pérez-Guaita D; (...); Castell JV

Article. 10.1021/acs.analchem.0c02735. 2020


Toxic epidermal necrolysis with severe hepatic involvement

Torres-Navarro, I; (...); Botella-Estrada, R

Letter. 10.1111/ddg.14110. 2020


Toxische epidermale Nekrolyse mit schwerer hepatischer Beteiligung.

Torres-Navarro I; (...); Botella-Estrada R

Letter. 10.1111/ddg.14110_g. 2020


Trends in liver transplantation for acute liver failure. A Spanish multicenter study

Conde, Isabel; (...); Berenguer, Marina

Meeting Abstract. 2022


Tumor Microenvironment-Derived Metabolites: A Guide to Find New Metabolic Therapeutic Targets and Biomarkers

García-Cañaveras JC, Lahoz A

Review. 10.3390/cancers13133230. 2021


Two stage hepatectomy (TSH) versus ALPPS for initially unresectable colorectal liver metastases: A systematic review and meta-analysis.

Díaz Vico T; (...); Granero Trancon, Jose Electo

Article. 10.1016/j.ejso.2022.11.010. 2022


Uncovering the toxicity mechanisms of a series of carboxylic acids in liver cells through computational and experimental approaches.

Ortega-Vallbona, Rita; (...); Serrano-Candelas, Eva

Article. 10.1016/j.tox.2024.153764. 2024


Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing

Gomez-Lechon, MJ, Tolosa, L, Donato, MT

Review. 10.1080/17425255.2017.1238459. 2017


Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies

Donato, MT, Gomez-Lechon, MJ, Tolosa, L

Review. 10.1080/17460441.2017.1271784. 2017


Using Metabolomics to Uncover Ontogeny of Drug-Induced Hepatotoxicity and Underlying AOP Mechanisms

Martinez-Sena, T.; (...); Castell Ripoll, J. V.

Meeting Abstract. 2023


VALIDATION ANALYSIS OF THE PHYSICIAN GLOBAL ASSESSMENT (PGA) SCALE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS INCLUDED IN RELESSER-PROS REGISTRY

Caceres Martin, L.; (...); Pego-Reigosa, J. M.

Meeting Abstract. 10.1136/annrheumdis-2023-eular.. 2023


Vascular injury during cholecystectomy: A multicenter critical analysis behind the drama.

Lopez-Lopez, Victor; (...); Robles-Campos, Ricardo

Article. 10.1016/j.surg.2022.06.020. 2022


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