EFECTO DE LA MODULACION DEL FACTOR INDUCIBLE POR HIPOXIA (HIF) SOBRE LA DEGENERACION RETINIANA EN RETINOSIS PIGMENTARIA

Datos básicos

Protocolo:
PI12/00481
EUDRACT:
NCT:
Centro:
Año de incio:
2013
Año de finalización:
2016
PI BIOMÉDICA NACIONAL Finan. Competitiva Pública 72.715,80 €

Documentos

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Participantes

Grupos

Financiadores - Promotores

FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA
INSTITUTO DE SALUD CARLOS III

Resultados del Ensayo Clínico


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[Sensimed Triggerfish(®) as a new system for continuous recording of 24-hour intraocular pressure in glaucoma patients].

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Letter. 10.1016/j.oftal.2012.12.013. 2013


A Reductive Metabolic Switch Protects Infants with Transposition of Great Arteries Undergoing Atrial Septostomy against Oxidative Stress.

Pineiro-Ramos, Jose David; (...); Vento M

Article. 10.3390/antiox10101502. 2021

  • Open Access.

A UPLC-MS/MS method for the determination of oxidative stress biomarkers in amniotic fluid.

Cascant-Vilaplana MM; (...); Vento, Maximo

Article. 10.1016/j.freeradbiomed.2021.12.310. 2022


Adalimumab Reduces Photoreceptor Cell Death in A Mouse Model of Retinal Degeneration

Martínez-Fernández de la Cámara C; (...); Rodrigo R

Article. 10.1038/srep11764. 2015

  • Open Access.

Adalimumab Therapy Optimization in Refractory Uveitis Due to Behcet's Disease after Achieving Remission. interventional Versus Control Group

Atienza-Mateo, B; (...); Blanco, R

Meeting Abstract. 2017


Adrenic acid non-enzymatic peroxidation products in biofluids of moderate preterm infants.

Sánchez-Illana Á; (...); Kuligowski J

Article. 10.1016/j.freeradbiomed.2019.02.024. 2019

  • Open Access.

Aflibercept as First-Line Therapy in Patients with Treatment-Naive Neovascular Age-Related Macular Degeneration: Prospective Case Series Analysis in Real-Life Clinical Practice

Udaondo, P; (...); Cisneros-Lanuza, A

Article. 10.1159/000445724. 2016


AFM-IR for Nanoscale Chemical Characterization in Life Sciences: Recent Developments and Future Directions.

V D Dos Santos, A Catarina; (...); Ramer, Georg

Article. 10.1021/acsmeasuresciau.3c00010. 2023

  • Open Access.

Ahmed valve, suture-less implantation: A new approach to an easier technique.

García-Delpech S; (...); Díaz-Llopis M

Article. 10.1097/IJG.0b013e318264ba4d. 2013


Altered antioxidant-oxidant status in the aqueous humor and peripheral blood of patients with retinitis pigmentosa.

Martínez-Fernández de la Cámara C; (...); Rodrigo R

Article. 10.1371/journal.pone.0074223. 2013

  • Open Access.

Altered antioxidant-oxidant status in the aqueous humor and peripheral blood of patients with retinitis pigmentosa.

Martínez-Fernández de la Cámara C; (...); Rodrigo R

Article. 2013

  • Open Access.

Alternative ultraviolet A lamp for corneal collagen crosslinking.

Diaz-Llopis M; (...); Garcia-Pous M

Article. 10.2147/OPTH.S33866. 2013

  • Open Access.

AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease

Vázquez-Manrique RP; (...); Neri C

Article. 10.1093/hmg/ddv513. 2016

  • Open Access.

Analysis of lipid peroxidation biomarkers in extremely low gestational age neonate urines by UPLC-MS/MS

Kuligowski J; (...); Vento M

Article. 10.1007/s00216-014-7824-6. 2014


Analysis of longitudinal data using constrained repeated random sampling-cross validation (CORRS-CV) and partial least squares

Ten-Domenech, Isabel; (...); Kuligowski, Julia

Article. 10.1016/j.chemolab.2023.104776. 2023


Analysis of longitudinal metabolomic data using multivariate curve resolution-alternating least squares and pathway analysis

Ten-Domenech, Isabel; (...); Kuligowski, Julia

Article. 10.1016/j.chemolab.2022.104720. 2023

  • Open Access.

Analysis of multi-source metabolomic data using joint and individual variation explained (JIVE)

Kuligowski J; (...); Quintás G

Article. 10.1039/c5an00706b. 2015


Analysis of the Association between Fatigue and the Plasma Lipidomic Profile of Inflammatory Bowel Disease Patients.

Horta D; (...); Calvet X

Article. 10.1021/acs.jproteome.0c00462. 2021

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Anti-TNF-alpha therapy in patients with refractory uveitis due to Behcet's disease: a 1-year follow-up study of 124 patients

Calvo-Río V; (...); González-Gay MA

Article. 10.1093/rheumatology/keu266. 2014


Application of Discriminant Analysis and Cross-Validation on Proteomics Data.

Kuligowski J, Pérez-Guaita D, Quintás G

Article. 10.1007/978-1-4939-3106-4_11. 2016


Assessing ATR-FTIR spectroscopy for steatosis quantification in liver biopsies in a long-duration cross-sectional study

Rienda, Ivan; (...); Quintas, Guillermo

Article. 10.1016/j.microc.2024.110135. 2024


Assessment of discriminant models in infrared imaging using constrained repeated random sampling - Cross validation.

Perez-Guaita, D; (...); Quintas, G

Article. 10.1016/j.aca.2018.05.019. 2018


Assessment of Oxidative Damage to Proteins and DNA in Urine of Newborn Infants by a Validated UPLC-MS/MS Approach

Kuligowski J; (...); Escobar J

Article. 10.1371/journal.pone.0093703. 2014

  • Open Access.

Assessment of phospholipid synthesis related biomarkers for perinatal asphyxia: a piglet study

Sanchez-Illana, A; (...); Kuligowski, J

Article. 10.1038/srep40315. 2017

  • Open Access.

Assessment of the statistical significance of classifications in infrared spectroscopy based diagnostic models

Pérez-Guaita D; (...); Wood BR

Article. 10.1039/c4an01783h. 2015


Atmospheric compensation in Fourier transform infrared (FT-IR) spectra of clinical samples.

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Article. 10.1366/13-07159. 2013


ATR-FTIR spectroscopy for the routine quality control of exosome isolations

Ramos-Garcia, V; (...); Kuligowski, J

Article. 10.1016/j.chemolab.2021.104401. 2021


ATR-Spin: an open-source 3D printed device for direct cytocentrifugation onto attenuated total reflectance crystals.

Pérez-Guaita D; (...); Wood B

Article. 10.1039/d1lc00813g. 2021


Biological mineral content in Iberian skeletal cremains for control of diagenetic factors employing multivariate statistics

Gallello, Gianni; (...); Bernabeu, Joan

Article. 10.1016/j.jas.2013.01.022. 2013


Biomarkers of oxidative stress derived damage to proteins and DNA in human breast milk

Sanchez-Illana, A; (...); Kuligowski, J

Article. 10.1016/j.aca.2018.01.054. 2018


Biomonitoring of bisphenols A, F, Sin human milk and probabilistic risk assessment for breastfed infants

Dualde, P; (...); Yusa, V

Article. 10.1016/j.scitotenv.2019.03.024. 2019


Biomonitoring of parabens in human milk and estimated daily intake for breastfed infants.

Dualde, P; (...); Yusa, V

Article. 10.1016/j.chemosphere.2019.124829. 2020


Biomonitoring of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in human milk: Exposure and risk assessment for lactating mothers and breastfed children from Spain

Hernandez, CS; (...); BETTERMILK

Article. 10.1016/j.scitotenv.2020.140710. 2020


Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease-A Retrospective, Case-Control Pilot Study.

Escobar-Diaz, Maria C.; (...); Camprubi-Camprubi, Marta

Article. 10.3390/antiox11020299. 2022

  • Open Access.

CD4/CD8 ratio in aqueous humor in Uveitis.

Sanz-Marco E; (...); Diaz-Llopis M

Letter. 10.3109/09273948.2013.801993. 2013


cGMP-Phosphodiesterase Inhibition Prevents Hypoxia-Induced Cell Death Activation in Porcine Retinal Explants

Olivares-González L; (...); Rodrigo R

Article. 10.1371/journal.pone.0166717. 2016

  • Open Access.

Cluster-Partial Least Squares (c-PLS) regression analysis: Application to miRNA and metabolomic data.

Kuligowski, Julia; (...); Quintas, Guillermo

Article. 10.1016/j.aca.2023.342052. 2024


Comparing Targeted vs. Untargeted MS2 Data-Dependent Acquisition for Peak Annotation in LC-MS Metabolomics

Ten-Domenech, I; (...); Kuligowski, J

Article. 10.3390/metabo10040126. 2020

  • Open Access.

Comparing the direct assessment of steatosis in liver explants with mid- and near-infrared vibrational spectroscopy, prior to organ transplantation.

Rienda, Ivan; (...); Quintas, Guillermo

Article. 10.1039/d3an01184d. 2023


Concomitant mutations in inherited retinal dystrophies: why the reproductive and therapeutic counselling should be addressed cautiously.

Rodriguez-Munoz, Ana; (...); Millan, Jose

Article. 10.1097/IAE.0000000000003103. 2021

  • Open Access.

Current Practice in Untargeted Human Milk Metabolomics.

Ten-Doménech I; (...); Quintás G

Review. 10.3390/metabo10020043. 2020

  • Open Access.

Current Practices in LC-MS Untargeted Metabolomics: A Scoping Review on the Use of Pooled Quality Control Samples.

Broeckling, Corey D.; (...); Mosley, Jonathan D.

Article. 10.1021/acs.analchem.3c02924. 2023

  • Open Access.

Changes of the plasma metabolome of newly born piglets subjected to postnatal hypoxia and resuscitation with air

Solberg R; (...); Vento M

Article. 10.1038/pr.2016.66. 2016

  • Open Access.

Decreased DNA hydroxymethylation and increased DNA demethylation are associated with high antioxidant response in systemic lupus erythematosus patients.

Fragío Gil JJ; (...); Román Ivorra JA

Case Reports. 10.1016/j.medcli.2020.10.023. 2021


Detection of batch effects in liquid chromatography-mass spectrometry metabolomic data using guided principal component analysis

Kuligowski J; (...); Quintás G

Article. 10.1016/j.talanta.2014.07.031. 2014


Determination of biomarkers of protein oxidation in tissue and plasma

Torres-Cuevas I; (...); Vento M

Meeting Abstract. 10.1016/j.freeradbiomed.2014.10.822. 2014


Development of a reliable analytical method to determine lipid peroxidation biomarkers in newborn plasma samples

Cháfer-Pericás C; (...); Vento M

Article. 10.1016/j.talanta.2016.03.010. 2016


Development of a reliable method based on ultra-performance liquid chromatography coupled to tandem mass spectrometry to measure thiol-associated oxidative stress in whole blood samples

Escobar J; (...); Cháfer-Pericás C

Article. 10.1016/j.jpba.2016.02.007. 2016


Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress assessment of nanoparticle-treated cells.

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Article. 10.1016/j.tiv.2013.01.016. 2013


Direct Derivatization in Dried Blood Spots for Oxidized and Reduced Glutathione Quantification in Newborns.

Ten-Domenech, Isabel; (...); Kuligowski, Julia

Article. 10.3390/antiox11061165. 2022

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Discriminant analysis and feature selection in mass spectrometry imaging using constrained repeated random sampling - Cross validation (CORRS-CV)

Perez-Guaita, D, Quintas, G, Kuligowski, J

Article. 10.1016/j.aca.2019.10.039. 2020

  • Open Access.

Do Intestinal Unicellular Parasites Have a Role in the Inflammatory and Redox Status among the Severely Obese?

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Article. 10.3390/antiox11112090. 2022

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Do levels of lipid peroxidation biomarkers reflect the degree of brain injury in newborns?

Cascant-Vilaplana, Mari Merce; (...); Vento, Maximo

Article. 10.1089/ars.2021.0168. 2021

  • Open Access.

Do lower levels of fetal hemoglobin in preterm infants relate to oxidative stress?

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Article. 10.1089/ars.2023.0378. 2023


Does Pasteurized Donor Human Milk Efficiently Protect Preterm Infants Against Oxidative Stress?

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Article. 10.1089/ars.2019.7821. 2019

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Early molecular markers of ventilator-associated pneumonia in bronchoalveolar lavage in preterm infants

Pinilla-Gonzalez, Alejandro; (...); Cernada, Maria

Article. 10.1038/s41390-022-02271-w. 2023

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Effect of a Marathon on Skin Temperature Response After a Cold-Stress Test and Its Relationship With Perceptive, Performance, and Oxidative-Stress Biomarkers

Priego-Quesada, JI; (...); Palmer, RS

Article. 10.1123/ijspp.2019-0963. 2020


Effect of autologous umbilical cord blood transfusion in the development of retinopathy of prematurity: randomized clinical trial - study protocol.

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Article. 10.3389/fped.2023.1269797. 2023

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Effect of donor human milk on host-gut microbiota and metabolic interactions in preterm infants.

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Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants.

Parra-Llorca, Anna; (...); Cernada, Maria

Article. 10.3390/children10030602. 2023

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Energetic and Spectroscopic Properties of the Low-Lying Isomers of C5H: A High-Level Ab Initio Study

Torrejon-Rodriguez, Laura; (...); Torres, Maximo Vento

Article. 10.3390/atoms11090115. 2023

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Enhancing the accuracy of mid-infrared spectroscopy-based liver steatosis quantification using digital image analysis as a reference.

Rienda, Ivan; (...); Quintas, Guillermo

Article. 10.1039/d3an00324h. 2023


Establishing a framework for best practices for quality assurance and quality control in untargeted metabolomics.

Mosley JD; (...); Zanetti KA

Article. 10.1007/s11306-023-02080-0. 2024

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Eter etilico: un viejo aliado contra la blefaritis por Demodex resistente a ivermectina oral.

Hervas Ontiveros A; (...); Diaz-Llopis M

Letter. 10.1016/j.oftal.2013.06.004. 2014


Evaluation of batch effect elimination using quality control replicates in LC-MS metabolite profiling

Sanchez-Illana, Angel; (...); Kuligowski, Julia

Article. 10.1016/j.aca.2018.02.053. 2018


Evaluation of the effect of chance correlations on variable selection using Partial Least Squares-Discriminant Analysis.

Kuligowski J; (...); Quintás G

Article. 10.1016/j.talanta.2013.07.048. 2013

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Evolution of Energy Related Metabolites in Plasma from Newborns with Hypoxic-Ischemic Encephalopathy during Hypothermia Treatment

Sanchez-Illana, A; (...); HYPOTOP Study Group

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Expanding the clinical and molecular heterogeneity of nonsyndromic inherited retinal dystrophies.

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Article. 10.1016/j.jmoldx.2020.01.003. 2020

  • Open Access.

Exposure and Risk Assessment of Hg, Cd, As, Tl, Se, and Mo in Women of Reproductive Age Using Urinary Biomonitoring.

Coscollà C; (...); Yusà V

Article. 10.1002/etc.4996. 2021


External cavity-quantum cascade laser (EC-QCL) spectroscopy for protein analysis in bovine milk

Kuligowski, Julia; (...); Lendl, Bernhard

Article. 10.1016/j.aca.2017.02.003. 2017

  • Open Access.

Extracting consistent biological information from functional results of metabolomic pathway analysis using the Mantel's test.

Ten-Doménech I; (...); Kuligowski J

Article. 10.1016/j.aca.2021.339173. 2021


Fact-based nutrition for infants and lactating mothers-The NUTRISHIELD study.

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Fast profiling of primary, secondary, conjugated, and sulfated bile acids in human urine and murine feces samples.

Ramos-Garcia, Victoria; (...); Kuligowski, Julia

Article. 10.1007/s00216-023-04802-8. 2023


Fast quantification of bovine milk proteins employing external cavity-quantum cascade laser spectroscopy

Schwaighofer, A; (...); Lendl, B

Article. 10.1016/j.foodchem.2018.01.082. 2018

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Fatty Acid Determination in Human Milk Using Attenuated Total Reflection Infrared Spectroscopy and Solvent-Free Lipid Separation.

Akhgar CK; (...); Lendl B

Article. 10.1177/00037028211065502. 2022

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Feeding the preterm infant: an overview of the evidence.

Poulimeneas D; (...); NUTRISHIELD Consortium

Review. 10.1080/09637486.2020.1754352. 2021

  • Open Access.

Fetal-to-Neonatal Transition under Hypoxic Conditions in Mice Pups

Torres-Cuevas, I.; (...); Vento, M.

Meeting Abstract. 2014


GC-MS analysis of short chain fatty acids and branched chain amino acids in urine and faeces samples from newborns and lactating mothers.

Ramos-Garcia, Victoria; (...); Quintas, Guillermo

Article. 10.1016/j.cca.2022.05.005. 2022


Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies

Broadhurst, D; (...); Dunn, WB

Review. 10.1007/s11306-018-1367-3. 2018

  • Open Access.

HIF-1 alpha stabilization reduces retinal degeneration in a mouse model of retinitis pigmentosa

Olivares-Gonzalez, L; (...); Rodrigo, R

Article. 10.1096/fj.201700985R. 2018

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High and ultra-high definition of infrared spectral histopathology gives an insight into chemical environment of lung metastases in breast cancer

Augustyniak, K; (...); Malek, K

Article. 10.1002/jbio.201800345. 2019


High Concentration of Protein Oxidation Biomarker O-Tyr/Phe Predicts Better Outcome in Childhood Bacterial Meningitis.

Rugemalira, Emilie; (...); Pelkonen, Tuula

Article. 10.3390/antiox12030621. 2023

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High Oxygen Does Not Increase Reperfusion Injury Assessed with Lipid Peroxidation Biomarkers after Cardiac Arrest: A Post Hoc Analysis of the COMACARE Trial

Humaloja J; (...); Skrifvars MB

Article. 10.3390/jcm10184226. 2021

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High performance liquid chromatography with mid-infrared detection based on a broadly tunable quantum cascade laser

Beskers TF; (...); Lendl B

Article. 10.1039/c3an01546g. 2014


Hypoxemia events in preterm neonates are associated with urine oxidative biomarkers.

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Article. 10.1038/s41390-023-02646-7. 2023

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Identification of omega-3 oxylipins in human milk-derived extracellular vesicles with pro-resolutive actions in gastrointestinal inflammation.

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Article. 10.3389/fimmu.2023.1293737. 2023

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Impact of Donor Human Milk in the Preterm Very Low Birth Weight Gut Transcriptome Profile by Use of Exfoliated Intestinal Cells.

Parra-Llorca A; (...); Vento M

Article. 10.3390/nu11112677. 2019

  • Open Access.

Impact of Maternal Health and Stress on Steroid Hormone Profiles in Human Milk: Implications for Infant Development.

Ten-Doménech I; (...); Kuligowski J

Article. 10.1016/j.jlr.2024.100688. 2024

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Improving insights from metabolomic functional analysis combining multivariate tools.

Kuligowski J, Moreno-Torres M, Quintás G

Article. 10.1016/j.aca.2024.343062. 2024


Improving the performance of hollow waveguide-based infrared gas sensors via tailored chemometrics.

Perez-Guaita D; (...); Mizaikoff B

Article. 10.1007/s00216-013-7230-5. 2013


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Martínez-Fernández de la Cámara C; (...); Rodrigo R

Article. 10.1186/s12974-014-0172-9. 2014

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Infrared biospectroscopy for a fast qualitative evaluation of sample preparation in metabolomics

Kuligowski J; (...); Quintás G

Article. 10.1016/j.talanta.2014.04.009. 2014


Innovative Biomarkers for Obesity and Type 1 Diabetes Based on Bifidobacterium and Metabolomic Profiling.

Nobili, Angelica; (...); Refinetti, Paulo

Article. 10.3390/microorganisms12050931. 2024

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Intra-batch effect correction in liquid chromatography-mass spectrometry using quality control samples and support vector regression (QC-SVRC)

Kuligowski J; (...); Quintás G

Article. 10.1039/c5an01638j. 2015


INTRASKELETAL CHEMICAL VARIATION RELATED TO DIAGENETIC PROCESSES: A LATE ROMAN NECROPOLIS CASE

Gallello, Gianni; (...); Pastor, Agustin

Article. 10.7203/SAGVNTVM.47.4116. 2015


Intravitreal administration of adalimumab delays retinal degeneration in rd10 mice.

Olivares-González L; (...); Rodrigo R

Article. 10.1096/fj.202000044RR. 2020

  • Open Access.

IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans

Nagy AI; (...); Baylis HA

Article. 10.15252/embr.201439585. 2015

  • Open Access.

Isolation and Lipidomic Screening of Human Milk Extracellular Vesicles.

Ramos-Garcia, Victoria; (...); Kuligowski, Julia

Article. 10.1007/978-1-0716-2699-3_18. 2023


Joint Microbiota Activity and Dietary Assessment through Urinary Biomarkers by LC-MS/MS.

Ramos-Garcia, Victoria; (...); Kuligowski, Julia

Article. 10.3390/nu15081894. 2023

  • Open Access.

Lack of association between the protein tyrosine phosphatase non-receptor type 22 R263Q and R620W functional genetic variants and endogenous non-anterior uveitis.

Cénit MC; (...); Martín J

Article. 2013


Levels of thrombopoietin in aqueous humor of patients with noninfectious acute anterior uveitis.

Mondejar JJ; (...); Diaz-Llopis M

Article. 10.2147/OPTH.S56350. 2015

  • Open Access.

Longitudinal perturbations of plasma nuclear magnetic resonance profiles in neonatal encephalopathy.

Cascant-Vilaplana MM; (...); Vento, Maximo

Article. 10.1038/s41390-023-02464-x. 2023


Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation

Guerrero-Gomez, D; (...); Miranda-Vizuete, A

Article. 10.1038/s41418-018-0270-9. 2019

  • Open Access.

Macular retinal vessel density assessment of the superficial, deep plexus and choriocapillaris in patients with retinitis pigmentosa and in healthy individuals using SS-OCT Angiography

Valencia-Perez, C; (...); Millan, JM

Meeting Abstract. 2019

  • Open Access.

MAINTENANCE TREATMENT WITH ADALIMUMAB IN REFRACTORY UVEITIS DUE TO BEHCET'S DISEASE: OPTIMISED VS NON-OPTIMISED GROUP

Martin-Varillas, JL; (...); Blanco, R

Meeting Abstract. 10.1136/annrheumdis-2018-eular.3963. 2018

  • Open Access.

Mass spectrometric detection of biomarkers for early assessment of intraamniotic fluid infection.

Cháfer-Pericás C; (...); Kuligowski J

Article. 10.1016/j.dib.2015.11.020. 2015

  • Open Access.

Metabolic dysregulation in term infants from SARS-CoV-2-infected mothers.

Cascant-Vilaplana, Mari Merce; (...); Cernada, Maria

Letter. 10.1007/s12519-023-00735-5. 2023


Metabolic Phenotypes of Hypoxic-Ischemic Encephalopathy with Normal vs. Pathologic Magnetic Resonance Imaging Outcomes

Pineiro-Ramos, JD; (...); Vento, M

Article. 10.3390/metabo10030109. 2020

  • Open Access.

Metabolomic Analysis of Gastric Cancer Progression within the Correa's Cascade Using Ultraperformance Liquid Chromatography-Mass Spectrometry

Kuligowski J; (...); Quintás G

Article. 10.1021/acs.jproteome.6b00281. 2016


Metabolomic Analysis of the Effect of Postnatal Hypoxia on the Retina in a Newly Born Piglet Model.

Solberg R; (...); Quintás G

Article. 10.1371/journal.pone.0066540. 2013

  • Open Access.

Metabolomic Diversity of Human Milk Cells over the Course of Lactation-A Preliminary Study.

Ten-Domenech, Isabel; (...); Kuligowski, Julia

Article. 10.3390/nu15051100. 2023

  • Open Access.

Metabolomics 2022 workshop report: state of QA/QC best practices in LC-MS-based untargeted metabolomics, informed through mQACC community engagement initiatives.

Dunn, Warwick B.; (...); Vuckovic, Dajana

Letter. 10.1007/s11306-023-02060-4. 2023

  • Open Access.

Metabolomics 2023 workshop report: moving toward consensus on best QA/QC practices in LC-MS-based untargeted metabolomics.

Mosley, Jonathan D.; (...); Schock, Tracey B.

Article. 10.1007/s11306-024-02135-w. 2024

  • Open Access.

Metabolomics, Oxidative, and Nitrosative Stress in the Perinatal Period.

Kuligowski, Julia, Vento, Maximo

Article. 10.3390/antiox11071357. 2022

  • Open Access.

Metformin intake associates with better cognitive function in patients with Huntington's disease

Hervas, David; (...); Vazquez-Manrique, Rafael P.

Article. 10.1371/journal.pone.0179283. 2017

  • Open Access.

Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease

Sanchis, A; (...); Vazquez-Manrique, RP

Article. 10.1038/s12276-019-0264-9. 2019

  • Open Access.

Methotrexate as a treatment in ocular cicatricial moderate pemphigoid.

Hervás Ontiveros A; (...); Díaz-Llopis M

Article. 10.1016/j.oftal.2013.10.009. 2014


Model selection for within-batch effect correction in UPLC-MS metabolomics using quality control - Support vector regression

Sanchez-Illana, A; (...); Kuligowski, J

Article. 10.1016/j.aca.2018.04.055. 2018


Modified locally weighted--partial least squares regression improving clinical predictions from infrared spectra of human serum samples.

Perez-Guaita D; (...); Guardia Mde L

Article. 10.1016/j.talanta.2013.01.035. 2013


Monitoring of system conditioning after blank injections in untargeted UPLC-MS metabolomic analysis.

Martínez-Sena T; (...); Kuligowski J

Article. 10.1038/s41598-019-46371-w. 2019

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Monitoring of Urinary Oxidative Stress Biomarker Levels in Newborns with Hypoxic-Ischemic Encephalopathy

Vilaplana, MMC; (...); Kuligowski, Julia

Meeting Abstract. 10.1016/j.freeradbiomed.2020.10.291. 2020


NAC and Vitamin D Improve CNS and Plasma Oxidative Stress in Neonatal HIE and Are Associated with Favorable Long-Term Outcomes

Jenkins DD; (...); Wiest DB

Article. 10.3390/antiox10091344. 2021

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Noninvasive monitoring of evolving urinary metabolic patterns in neonatal encephalopathy.

Piñeiro-Ramos JD; (...); Vento M

Article. 10.1038/s41390-021-01553-z. 2021


Normalization approaches for extracellular vesicle-derived lipidomic fingerprints - A human milk case study

Ten-Domenech, Isabel; (...); Kuligowski, Julia

Article. 10.1016/j.chemolab.2024.105070. 2024


Novel biomarkers in amniotic fluid for early assessment of intraamniotic infection

Cháfer-Pericás C; (...); Kuligowski J

Article. 10.1016/j.freeradbiomed.2015.09.014. 2015


Novel free-radical mediated lipid peroxidation biomarkers in newborn plasma

Sanchez-Illana, Angel; (...); Kuligowski, Julia

Article. 10.1016/j.aca.2017.09.026. 2017

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Nutraceutical Supplementation Ameliorates Visual Function, Retinal Degeneration, and Redox Status in rd10 Mice

Olivares-Gonzalez, Lorena; (...); Rodrigo, Regina

Article. 10.3390/antiox10071033. 2021

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NUTRARET: Effect of 2-Year Nutraceutical Supplementation on Redox Status and Visual Function of Patients With Retinitis Pigmentosa: A Randomized, Double-Blind, Placebo-Controlled Trial

Olivares-Gonzalez, Lorena; (...); Rodrigo, Regina

Article. 10.3389/fnut.2022.847910. 2022

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On-Capillary Surface-Enhanced Raman Spectroscopy: Determination of Glutathione in Whole Blood Microsamples

Sanchez-Illana, Angel; (...); Kuligowski, Julia

Article. 10.1021/acs.analchem.8b01492. 2018


Oxidative stress biomarkers in the preterm infant.

Sánchez-Illana Á; (...); Kuligowski J

Review. 10.1016/bs.acc.2020.08.011. 2020


Oxidative stress in brain during fetal-to-neonatal transition under an hypoxic atmosphere

Isabel Torres-Cuevas, Maria; (...); Vento, M.

Meeting Abstract. 10.1016/j.freeradbiomed.2016.04.095. 2016


OXIDATIVE STRESS LEVELS ARE INCREASED IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS WITH A HIGHER ACCUMULATIVE DAMAGE SCORE

Grau Garcia, E.; (...); Roman Ivorra, J.

Meeting Abstract. 10.1136/annrheumdis-2016-eular.3183. 2016


Oxidative Stress, a Crossroad between Rare Diseases and Neurodegeneration

Espinos, C; (...); Pallardo, FV

Review. 10.3390/antiox9040313. 2020

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Torres-Cuevas, Isabel; (...); Vento, Maximo

Review. 10.1016/j.redox.2017.03.011. 2017

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Cernada M; (...); Vento M

Article. 10.1016/S0378-3782(13)70004-5. 2013


Oxygen Supplementation to Stabilize Preterm infants in the Fetal to Neonatal Transition: No Satisfactory Answer

Torres-Cuevas I; (...); Vento M

Review. 10.3389/fped.2016.00029. 2016

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Oxylipin profile of human milk and human milk-derived extracellular vesicles.

Albiach-Delgado, Abel; (...); Quintas, Guillermo

Article. 10.1016/j.aca.2024.342759. 2024


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Martínez-Fernández de la Cámara C; (...); Rodrigo R

Article. 10.1016/j.exer.2013.03.015. 2013


Plasma metabolite score correlates with Hypoxia time in a newly born piglet model for asphyxia

Kuligowskia, J; (...); Vento, M

Article. 10.1016/j.redox.2017.02.002. 2017

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Plasma Metabolite Score Correlates with Hypoxia Time in a Newly Born Piglet Model for Asphyxia

Kuligowski, J; (...); Vento, M

Meeting Abstract. 2017


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MacFarlane PM; (...); Hibbs AM

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Pomegranate Extract Administration Reverses Loss of Motor Coordination and Prevents Oxidative Stress in Cerebellum of Aging Mice

Verdu, David; (...); Vina, Jose

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Portable point-of-care surface enhanced Raman scattering spectroscopy for the quantification of glutathione in whole blood microsamples.

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Ten-Domenech, Isabel; (...); Quintas, Guillermo

Review. 10.1080/05704928.2023.2215858. 2024


Protein Oxidation Biomarkers and Myeloperoxidase Activation in Cerebrospinal Fluid in Childhood Bacterial Meningitis.

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Recent advancements of EC-QCL based mid-IR transmission spectroscopy of proteins and application to analysis of bovine milk

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Olivares-González L; (...); Rodrigo R

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Redox Status, Dose and Antioxidant Intake in Healthcare Workers Occupationally Exposed to Ionizing Radiation

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KULIGOWSKI, J.; (...); Vento, Máximo

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Repair of the prevalent c.2299delG mutation in the USH2A gene using CRISPR/Cas9 nucleases

Fuster-Garcia, C; (...); Aller, E

Meeting Abstract. 2018


Retinal Inflammation, Cell Death and Inherited Retinal Dystrophies.

Olivares-Gonzalez, Lorena; (...); Rodrigo, Regina

Review. 10.3390/ijms22042096. 2021

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Searching molecular biomarkers correlating with BSID-III at 24months in infants with neonatal hypoxic-ischemic encephalopathy.

Cascant-Vilaplana, Mari Merce; (...); Vento, Maximo

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Navarro-Esteve, Victor; (...); Quintas, Guillermo

Article. 10.1016/j.carpta.2024.100644. 2025


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Sánchez-Illana Á, Piñeiro-Ramos JD, Kuligowski J

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Solvent-Free Lipid Separation and Attenuated Total Reflectance Infrared Spectroscopy for Fast and Green Fatty Acid Profiling of Human Milk

Akhgar, Christopher Karim; (...); Lendl, Bernhard

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STEROID HORMONE SIGNALING MAY REGULATE HOMEOSTASIS OF POLYQ-CONTAINING PROTEINS IN C. ELEGANS

Gomez-Escribano, A. P.; (...); Vazquez-Manrique, R.

Meeting Abstract. 10.1136/jnnp-2018-EHDN.26. 2018


Study of USH1 splicing variants through minigenes and transcript analysis from nasal epithelial cells.

Aparisi MJ; (...); Millán JM

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Successful Optimization of Adalimumab Therapy in Refractory Uveitis Due to Behcet's Disease

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  • Open Access.

Surface enhanced Raman spectroscopic direct determination of low molecular weight biothiols in umbilical cord whole blood

Kuligowski J; (...); Lendl B

Article. 10.1039/c5an01865j. 2016

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Synergistic activation of AMPK prevents from polyglutamine-induced toxicity in Caenorhabditis elegans.

Gómez-Escribano AP; (...); Vázquez-Manrique RP

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SYNERGISTIC COMBINATIONS OF METFORMIN AND SALICYLATE REDUCE POLYGLUTAMINE TOXICITY IN C. ELEGANS

Bono-Yague, Jose; (...); Vazquez-Manrique, Rafael

Meeting Abstract. 10.1136/jnnp-2018-EHDN.256. 2018


Targeted next generation sequencing for molecular diagnosis of Usher syndrome

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The diabetic retinopathy clinical research network analysis of the cost-effectiveness of aflibercept, bevacizumab and ranibizumab for the treatment of diabetic macular oedema and its application in Spain.

Navarro-Navarro, A; (...); Rodrigo, R

Letter. 10.1016/j.oftal.2016.12.010. 2017


The effect of Holder pasteurization on the lipid and metabolite composition of human milk.

Ten-Domenech, Isabel; (...); Quintas, Guillermo

Article. 10.1016/j.foodchem.2022.132581. 2022

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The effect of inhaled nitric oxide treatment on biomarkers of oxidative/nitrosative damage to proteins and DNA/RNA.

Albiach-Delgado, Abel; (...); Vento, Maximo

Article. 10.1016/j.freeradbiomed.2025.01.020. 2025


The mechanistic functional landscape of retinitis pigmentosa: a machine learning-driven approach to therapeutic target discovery

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Topiramate plus Cooling for Hypoxic-Ischemic Encephalopathy: A Randomized, Controlled, Multicenter, Double-Blinded Trial

Nunez-Ramiro, A; (...); Hypotop Study Grp

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Toward a Noninvasive, Label-Free Screening Method for Determining Spore Inoculum Quality of Penicillium chrysogenum Using Raman Spectroscopy

Wieland, K; (...); Lendl, B

Article. 10.1177/0003702817727728. 2017


Toward Rapid Screening of Liver Grafts at the Operating Room Using Mid-infrared Spectroscopy.

Pérez-Guaita D; (...); Castell JV

Article. 10.1021/acs.analchem.0c02735. 2020


Transcriptome profiles discriminate between Gram-positive and Gram-negative sepsis in preterm neonates.

Cernada M; (...); Serna E

Article. 10.1038/s41390-021-01444-3. 2021


Treatment of refractory dry eye associated with graft versus host disease with 0.03% tacrolimus eyedrops.

Sanz-Marco E; (...); Diaz-Llopis M

Article. 10.1089/jop.2012.0265. 2013


Ultra high performance liquid chromatography coupled to tandem mass spectrometry determination of lipid peroxidation biomarkers in newborn serum samples

Cháfer-Pericás C; (...); Escobar J

Article. 10.1016/j.aca.2015.06.028. 2015


Urinary Lipid Peroxidation Byproducts: Are They Relevant for Predicting Neonatal Morbidity in Preterm Infants?

Kuligowski J; (...); Vento M

Article. 10.1089/ars.2015.6262. 2015

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Usefulness of adalimumab in the treatment of refractory uveitis associated with juvenile idiopathic arthritis.

García-De-Vicuña C; (...); Antón J

Article. 10.1155/2013/560632. 2013


USH2A Gene Editing Using the CRISPR System

Fuster-Garcia, C; (...); Aller, E

Article. 10.1016/j.omtn.2017.08.003. 2017

  • Open Access.

UV resonance Raman spectroscopy: a process analytical tool for host cell DNA and RNA dynamics in mammalian cell lines

Lorna Ashton; (...); Royston Goodacre

Article. 2015


Xantogranuloma necrobiotico. Diagnostico diferencial, tratamiento e implicaciones sistemicas. A proposito de un caso.

Sanz-Marco E; (...); Diaz-Llopis M

Abstract of Published Item. 10.1016/j.oftal.2012.11.007. 2014


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