Portal de investigación
Spanish Consensus on the Prevention and Treatment of Pseudomonas aeruginosa Bronchial Infections in Cystic Fibrosis Patients
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Cantón R
- Máiz L
- Escribano A
- Olveira C
- Oliver A
- Asensio O
- Gartner S
- Quintana-Gallego E
- Salcedo A
- Girón R
- Barrio MI
- Pastor MD
- Prados C
- Martínez-Martínez MT
- Barberán J
- Castón JJ
- Martínez-Martínez L
- Vázquez C
- de Gracia J
- en representación del Grupo Español de Consenso del Tratamiento Antimicrobiano e
Grupos
Abstract
Pseudomonas aeruginosa is the main pathogen in bronchopulmonary infections in cystic fibrosis (CF) patients. It can only be eradicated at early infection stages while reduction of its bacterial load is the therapeutic goal during chronic infection or exacerbations. Neonatal screening and pharmacokinetic/pharmacodynamic knowledge has modified the management of CF-patients. A culture based microbiological follow-up should be performed in patients with no infection with P. aeruginosa. At initial infection, inhaled colistin (0,5-2 MU/tid), tobramycin (300 mg/bid) or aztreonam (75 mg/tid) with or without oral ciprofloxacin (15-20 mg/kg/bid, 2-3 weeks) are recommended. In chronic infections, treatment is based on continuous administration of colistin or with a 28-day on-off regimen with tobramycin or aztreonam. During mild-moderate exacerbations oral ciprofloxacin (2-3 weeks) can be administered while serious exacerbations must be treated with intravenous combination therapy (beta-lactam with an aminoglycoside or a fluoroquinolone). Future studies will support antibiotic rotation and/or new combination therapies. Epidemiological measures are also recommended to avoid new P. aeruginosa infections and "patient-to-patient transmission" of this pathogen. (C) 2014 SEPAR. Published by Elsevier Espana, S.L.U. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 0300-2896, 1579-2129
- Tipo:
- Article
- Páginas:
- 140-150
- PubMed:
- 25614377
- Factor de Impacto:
- 0,524 SCImago ℠
- Cuartil:
- Q3 SCImago ℠
ARCHIVOS DE BRONCONEUMOLOGIA ELSEVIER ESPANA SLU
Citas Recibidas en Web of Science: 36
Documentos
- No hay documentos
Filiaciones
Keywords
- Cystic fibrosis; Pseudomonas aeruginosa; Bronchial infection; Antibiotic treatment
Campos de Estudio
Cita
Cantón R,Máiz L,Escribano A,Olveira C,Oliver A,Asensio O,Gartner S,ROMA E,Quintana E,Salcedo A,Girón R,Barrio MI,Pastor MD,Prados C,Martínez MT,Barberán J,Castón JJ,Martínez L,POVEDA JL,Vázquez C,de Gracia J,SOLÉ A,en representación E. Spanish Consensus on the Prevention and Treatment of Pseudomonas aeruginosa Bronchial Infections in Cystic Fibrosis Patients. Arch. Bronconeumol. 2015. 51. (3):p. 140-150. IF:1,771. (3).