Portal de investigación
- Inicio
- Proyectos y Estudios
- ENSAYO CLÍNICO DE FASE III, RANDOMIZADO, CONTROLADO CON PLACEBO PARA EVALUAR LA SEGURIDAD Y EFICACIA DE MK 8228 (LETERMOVIR) EN LA PREVENCIÓN DE LA INFECCIÓN CLÍNICAMENTE SIGNIFICATIVA POR CITOMEGALOVIRUS (CMV) EN ADULTOS CMV SEROPOSITIVOS QUE VAYAN A REC IBIR UN TRASPLANTE ALOGÉNICO DE CÉLULAS MADRE HEMATOPOYÉTICAS.
ENSAYO CLÍNICO DE FASE III, RANDOMIZADO, CONTROLADO CON PLACEBO PARA EVALUAR LA SEGURIDAD Y EFICACIA DE MK 8228 (LETERMOVIR) EN LA PREVENCIÓN DE LA INFECCIÓN CLÍNICAMENTE SIGNIFICATIVA POR CITOMEGALOVIRUS (CMV) EN ADULTOS CMV SEROPOSITIVOS QUE VAYAN A REC IBIR UN TRASPLANTE ALOGÉNICO DE CÉLULAS MADRE HEMATOPOYÉTICAS.
Datos básicos
- Protocolo:
- 8228-001
- EUDRACT:
- 2013-003831-31
- NCT:
- Centro:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Año de incio:
- 2014
- Año de finalización:
- 2016
Objetivos del proyecto
Observaciones: Estado Comité: FINALIZADO
Documentos
- No hay documentos
Participantes
Grupos
Financiadores - Promotores
Resultados del Ensayo Clínico
[Farewell open letter to SEFH members].
Editorial Material. 10.7399/fh.2015.39.6.10128. 2015
A systematic review and meta-analysis of the impact of WT1 polymorphism rs16754 in the effectiveness of standard chemotherapy in patients with acute myeloid leukemia
Megías-Vericat JE; (...); Aliño SF
Article. 10.1038/tpj.2015.80. 2016
Advances in haploidentical stem cell transplantation for hematologic malignancies
Review. 10.3109/10428194.2016.1167204. 2016
Aflibercept in exudative age related macular degeneration refractory to ranibizumab.
Ruiz Ramos J; (...); Gallego-Pinazo R
Article. 10.1016/j.oftal.2015.07.018. 2015
Assessment of the quality of sample labelling for clinical research.
Pérez-Huertas P; (...); Poveda-Andrés JL
Article. 10.7399/fh.2016.40.2.9753. 2016
Association of SNPs with the efficacy and safety of immunosuppressant therapy after heart transplantation
Sánchez-Lázaro I; (...); Aliño SF
Article. 10.2217/pgs.15.39. 2015
Autoimmune cytopenias after umbilical cord blood transplantation in adults with hematological malignancies: a single-center experience
Article. 10.1038/bmt.2014.107. 2014
Biosimilares: viejas polemicas con nuevos argumentos.
Poveda-Andrés JL, Bosó-Ribelles V
Editorial Material. 10.7399/fh.2015.39.3.8978. 2015
Bloodstream Infections in Adult Patients Undergoing Cord Blood Transplantation from Unrelated Donors after Myeloablative Conditioning Regimen
Article. 10.1016/j.bbmt.2014.12.038. 2015
Calidad y Legibilidad de la Hoja de Informacion al Paciente en Estudios con Analisis Farmacogenetico.
Ruiz Ramos J; (...); Poveda Andrés JL
Article. 2015
Clinical evaluation of rituximab treatment for neuromyelitis optica
Fernández-Megía MJ; (...); Poveda-Andrés JL
Article. 10.1016/j.nrl.2014.09.001. 2015
Clinical experiences with cannabinoids in spasticity management in multiple sclerosis
Lorente Fernández L; (...); Casanova-Estruch B
Article. 10.1016/j.nrl.2013.06.014. 2014
Comparative Study of Post-Transplant Lymphoproliferative Disorders after Solid Organ Transplantation Versus Hematopoietic Stem Cell Transplantation
Romero, Samuel, Sr.; (...); Sanz, Miguel Angel
Article. 2015
Comparison of outcomes after unrelated cord blood and unmanipulated haploidentical stem cell transplantation in adults with acute leukemia
Ruggeri A; (...); ALWP-EBMT study
Article. 10.1038/leu.2015.98. 2015
Cost-effectiveness of methoxy polyethylene glycolepoetin beta versus conventional epoetin in the treatment of anaemia secondary to chronic kidney disease in clinical practice
Lorente-Fernandez, L; (...); Poveda-Andres, JL
Article. 10.1136/ejhpharm-2013-000426. 2015
C-Reactive Protein at Discharge, Diabetes Mellitus and >= 1 Hospitalization During Previous Year Predict Early Readmission in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Crisafulli E; (...); Menéndez R
Article. 10.3109/15412555.2014.933954. 2015
Diffusion tensor imaging as a prognostic biomarker for motor recovery and rehabilitation after stroke
Puig, J; (...); Pedraza, S
Review. 10.1007/s00234-017-1816-0. 2017
Dose banding aplicado a la elaboracion de antineoplasicos: una revision narrativa de la literatura.
Pérez Huertas P; (...); Poveda Andrés JL
Article. 10.7399/fh.2015.39.4.8839. 2015
Drug Interaction Between Oral Cyclosporine Modified and Iron
Domingo-Chiva, E; (...); Poveda-Andres, JL
Article. 10.1177/1060028013514734. 2014
ECONOMIC IMPACT LINKED TO THE REDUCTION OF EXACERBATIONS WHEN A TREATMENT REGIME WITH INHALED ANTIBIOTICS IS SWITCHED TO AZTREONAM LYSINE IN PATIENTS WITH CYSTIC FIBROSIS AND CHRONIC PULMONARY INFECTION CAUSED BY PSEUDOMONAS AERUGINOSA
Sole A; (...); Casado MA
Meeting Abstract. 10.1016/j.jval.2014.08.1659. 2014
Eculizumab for the treatment of pregnancy-related atypical hemolytic uremic syndrome
Cañigral C; (...); Sanz MA
Letter. 10.1007/s00277-013-1970-3. 2014
Effect of CD8(+) Cell Content on Umbilical Cord Blood Transplantation in Adults with Hematological Malignancies
Moscardó F; (...); Sanz GF
Article. 10.1016/j.bbmt.2014.06.038. 2014
Effect of CYP3A5*3 on kidney transplant recipients treated with tacrolimus: a systematic review and meta-analysis of observational studies
Rojas L; (...); Aliño SF
Article. 10.1038/tpj.2014.38. 2015
Engraftment kinetics and graft failure after single umbilical cord blood transplantation using a myeloablative conditioning regimen
Ruggeri A; (...); Netcord
Article. 10.3324/haematol.2014.109280. 2014
Epstein-Barr virus-associated posttransplant lymphoproliferative disorder after allogeneic stem cell transplantation
Review. 10.1097/CCO.0000000000000119. 2014
Executive summary of the GESIDA/National AIDS Plan Consensus Document on antiretroviral therapy in adults infected by the human immunodeficiency virus (updated January 2015)
Expert Panel of GESIDA and the National AIDS Plan; (...); Rivero A
Article. 10.1016/j.eimc.2015.03.017. 2015
Experience in the management of immunosuppressant treatment with hepatitis C virus protease inhibitors
Ruiz Ramos J; (...); Poveda Andrés JL
Article. 10.1016/j.gastrohep.2014.05.004. 2014
EXPERTS CONSENSUS ON THE FUTURE OF RARE DISEASES CARE AND ORPHAN DRUGS ACCESS IN SPAIN: A DELPHI STUDY
Paz S; (...); Urcelay J
Meeting Abstract. 10.1016/j.jval.2015.09.2016. 2015
Ex-vivo T-cell depleted peripheral blood stem cell transplantation from HLA-matched sibling donors for the treatment of severe aplastic anemia
Cano-Ferri, I.; (...); Sanz, G.
Meeting Abstract. 2015
Hazardous drugs: new challenges, new opportunities.
Valero García S; (...); Poveda Andrés JL
Article. 10.7399/fh.2016.40.2.10462. 2016
Hematologic neoplasms: interpreting lung findings in chest computed tomography.
Calvillo Batllés P; (...); Compte Torrero L
Article. 10.1016/j.rx.2015.07.003. 2015
High-permeability region size on perfusion CT predicts hemorrhagic transformation after intravenous thrombolysis in stroke
Puig, J; (...); Castellanos, M
Article. 10.1371/journal.pone.0188238. 2017
Impact of natural-killer immune reconstitution on the development of cytomegalovirus infection, non-relapse mortality, and graft versus host disease after allogeneic stem cell transplantation
Rodriguez-Veiga, R.; (...); Sanz, M. A.
Meeting Abstract. 2015
Impact of Single Nucleotide Polymorphisms (SNPs) on Immunosuppressive Therapy in Lung Transplantation
Ruiz J; (...); Aliño SF
Article. 10.3390/ijms160920168. 2015
Impact of Transporter Genes Polymorphisms in Standard Induction of Acute Myeloid Leukemia
Eduardo Megias, Juan; (...); Angel Sanz, Miguel
Meeting Abstract. 2015
Incidence and risk factors of post-engraftment invasive fungal disease in adult allogeneic hematopoietic stem cell transplant recipients receiving oral azoles prophylaxis
Montesinos P; (...); Sanz MA
Article. 10.1038/bmt.2015.181. 2015
Incompatibility of undiluted busulfan injection with a needle-free valve
Cueto-Sola, M; (...); Poveda-Andres, JL
Letter. 10.2146/ajhp140111. 2014
Influence of ABCB1 polymorphisms upon the effectiveness of standard treatment for acute myeloid leukemia: A systematic review and meta-analysis of observational studies
Megías-Vericat JE; (...); Aliño SF
Review. 10.1038/tpj.2014.80. 2015
Influence of Single Nucleotide Polymorphisms in Anthracycline Metabolism Pathway in Standard Induction of Acute Myeloid Leukemia
Eduardo Megias, Juan; (...); Angel Sanz, Miguel
Meeting Abstract. 2015
Inhaled Corticosteroids Do Not Influence the Early Inflammatory Response and Clinical Presentation of Hospitalized Subjects With COPD Exacerbation
Crisafulli E; (...); Torres A
Article. 10.4187/respcare.03036. 2014
N. VICTOR JIMENEZ TORRES (1942-2015) IN MEMORIAM
Climente Martí M, Poveda Andrés JL, Culebras J
Biographical-Item. 10.3305/nh.2015.32.4.9704. 2015
Outcome of graft failure after allogeneic stem cell transplant: study of 89 patients
Ferrà C; (...); Ribera JM
Article. 10.3109/10428194.2014.930849. 2015
Outcome of patients with abnl(17p) acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation
Middeke JM; (...); Schetelig J
Article. 10.1182/blood-2013-12-544957. 2014
Passenger lymphocyte syndrome in liver transplant recipients: a description of 12 cases
Article. 10.2450/2015.0148-14. 2015
Pharmacogenomics and the treatment of acute myeloid leukemia
Megías-Vericat JE; (...); Aliño SF
Review. 10.2217/pgs-2016-0055. 2016
Positive impact of ABCB1 polymorphisms in overall survival and complete remission in acute myeloid leukemia: a systematic review and meta-analysis
Megías-Vericat JE; (...); Aliño SF
Letter. 10.1038/tpj.2015.79. 2016
Predicting In-Hospital Treatment Failure (<= 7 days) in Patients with COPD Exacerbation Using Antibiotics and Systemic Steroids
Crisafulli E; (...); Menéndez R
Article. 10.3109/15412555.2015.1057276. 2016
Prognostic Impact of Anthracycline Metabolism Gene Polymorphisms in Newly Diagnosed Acute Myeloid Leukemia Adults
Eduardo Megias, Juan; (...); Angel Sanz, Miguel
Article. 2014
Prognostic Impact of Cytarabine Pathway Gene Polymorphisms in Acute Myeloid Leukemia Adults Undergoing Induction Chemotherapy
Eduardo Megias, Juan; (...); Angel Sanz, Miguel
Article. 2014
PROGNOSTIC IMPACT OF TRANSPORTER GENE POLYMORPHISMS IN NEWLY DIAGNOSED ACUTE MYELOID LEUKEMIA ADULTS
Megias Vericat, J. E.; (...); Sanz, M. A.
Article. 2015
Review of Cutaneous Graft-vs-Host Disease.
Ballester-Sánchez R; (...); Botella-Estrada R
Article. 10.1016/j.ad.2015.10.003. 2016
Spanish Consensus on the Prevention and Treatment of Pseudomonas aeruginosa Bronchial Infections in Cystic Fibrosis Patients
Cantón R; (...); Solé A
Article. 10.1016/j.arbres.2014.09.021. 2015
Study on the Linezolid Prescription According to the Approval of Indication in a University Hospital
Pérez-Cebrián M; (...); Llopis-González A
Article. 2015
T Cell-Depleted Related HLA-Mismatched Peripheral Blood Stem Cell Transplantation as Salvage Therapy for Graft Failure after Single Unit Unrelated Donor Umbilical Cord Blood Transplantation
Moscardó F; (...); Sanz GF
Article. 10.1016/j.bbmt.2014.03.024. 2014
The role of bone marrow biopsy and FDG-PET/CT in identifying bone marrow infiltration in the initial diagnosis of high grade non-Hodgkin B-cell lymphoma and Hodgkin lymphoma. accuracy in a multicenter series of 372 patients
Chen-Liang TH; (...); Ortuño FJ
Article. 10.1002/ajh.24044. 2015
The role of phototherapy in cutaneous chronic graft-vs-host disease: a retrospective study and review of the literature.
Ballester-Sánchez R; (...); Botella-Estrada R
Article. 10.1016/j.ad.2015.04.009. 2015
Trans-arterial chemoembolization with doxorubicin-eluting particles versus conventional trans-arterial chemoembolization in unresectable hepatocellular carcinoma: A study of effectiveness, safety and costs.
Megías Vericat JE; (...); Poveda Andrés JL
Article. 10.1016/j.rx.2015.01.008. 2015
Transfusion Management and Immunohematologic Complications in Liver Transplantation: Experience of a Single Institution
Article. 10.1159/000370260. 2015
Transfusion of ABO non-identical platelets does not influence the clinical outcome of patients undergoing autologous haematopoietic stem cell transplantation
Article. 10.2450/2015.0195-14. 2015
Treatment of invasive fungal disease using anidulafungin alone or in combination for hematologic patients with concomitant hepatic or renal impairment
Montesinos P; (...); Sanz MÁ
Article. 10.1016/j.riam.2014.10.003. 2015
Umbilical cord blood transplantation in adults with advanced hodgkin's disease: high incidence of post-transplant lymphoproliferative disease
Piñana JL; (...); GETH GITMO groups
Article. 10.1111/ejh.12557. 2016
Use of 2 hydroxypropyl-beta-cyclodextrin therapy in two adult Niemann Pick Type C patients
García-Robles AA; (...); Poveda JL
Letter. 10.1016/j.jns.2016.04.048. 2016
Validation of a risk score for post-engraftment invasive fungal disease in 414 adult allogeneic hematopoietic stem cell transplant recipients
Montesinos, P.; (...); Sanz, M. A.
Meeting Abstract. 2016