Portal de investigación
- Inicio
- Proyectos y Estudios
- ENSAYO CLÍNICO FASE II, MULTICÉNTRICO, ALEATORIZADO EN GRUPOS PARALELOS, DOBLE CIEGO, CONTROLADO CON PLACEBO, DE BÚSQUEDA DE DOSIS PARA EXPLORAR LOS EFECTOS FARMACODINÁMICOS, LA SEGURIDAD, LA TOLERABILIDAD Y LA FARMACOCINÉTICA DE CUATRO REGÍMENES DE DOSIS DISTINTOS DEL ESTIMULADOR ORAL SGC BAY1021189, DURANTE 12 SEMANAS, EN PACIENTES CON DESCOMPENSACIÓN DE LA INSUFICIENCIA CARDIACA Y LA FRACCIÓN DE EYECCIÓN REDUCIDA.
ENSAYO CLÍNICO FASE II, MULTICÉNTRICO, ALEATORIZADO EN GRUPOS PARALELOS, DOBLE CIEGO, CONTROLADO CON PLACEBO, DE BÚSQUEDA DE DOSIS PARA EXPLORAR LOS EFECTOS FARMACODINÁMICOS, LA SEGURIDAD, LA TOLERABILIDAD Y LA FARMACOCINÉTICA DE CUATRO REGÍMENES DE DOSIS DISTINTOS DEL ESTIMULADOR ORAL SGC BAY1021189, DURANTE 12 SEMANAS, EN PACIENTES CON DESCOMPENSACIÓN DE LA INSUFICIENCIA CARDIACA Y LA FRACCIÓN DE EYECCIÓN REDUCIDA.
Datos básicos
- Protocolo:
- BAY1021189/15371
- EUDRACT:
- 2013-002287-11
- NCT:
- Centro:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Año de incio:
- 2014
- Año de finalización:
- 2015
Objetivos del proyecto
Observaciones: Estado Comité: CENTRO CERRADO
Documentos
- No hay documentos
Participantes
Financiadores - Promotores
Resultados del Ensayo Clínico
Analisis de las causas de suspension de tratamiento con triple terapia antiviral en pacientes con hepatitis C.
Ruiz Ramos J; (...); Poveda Andrés JL
Abstract of Published Item. 10.7399/fh.2014.38.3.1171. 2014
Anidulafungin-Induced Alopecia
Ruiz-Ramos J; (...); Poveda-Andrés JL
Article. 10.1177/1060028014524534. 2014
Association of SNPs with the efficacy and safety of immunosuppressant therapy after heart transplantation
Sánchez-Lázaro I; (...); Aliño SF
Article. 10.2217/pgs.15.39. 2015
ATP synthase subunit alpha and LV mass in ischaemic human hearts
Roselló-Lletí E; (...); Rivera M
Article. 10.1111/jcmm.12477. 2015
Biosimilares: viejas polemicas con nuevos argumentos.
Poveda-Andrés JL, Bosó-Ribelles V
Editorial Material. 10.7399/fh.2015.39.3.8978. 2015
Calidad y Legibilidad de la Hoja de Informacion al Paciente en Estudios con Analisis Farmacogenetico.
Ruiz Ramos J; (...); Poveda Andrés JL
Article. 2015
Clinical experiences with cannabinoids in spasticity management in multiple sclerosis
Lorente Fernández L; (...); Casanova-Estruch B
Article. 10.1016/j.nrl.2013.06.014. 2014
Cost-effectiveness of methoxy polyethylene glycolepoetin beta versus conventional epoetin in the treatment of anaemia secondary to chronic kidney disease in clinical practice
Lorente-Fernandez, L; (...); Poveda-Andres, JL
Article. 10.1136/ejhpharm-2013-000426. 2015
Current situation of management of systolic heart failure in Spain: VIDA-IC study results.
Anguita M; (...); Investigators of the VIDA–IC Study
Letter. 10.1016/j.rec.2014.03.014. 2014
Chronic Renal Dysfunction in Maintenance Heart Transplant Patients: The ICEBERG Study
González-Vílchez F; (...); Guinea G
Article. 10.1016/j.transproceed.2013.09.031. 2014
Diagnostic power of echocardiographic speckle tracking of the tricuspid annular motion to assess right ventricular dysfunction
Alonso P; (...); Salvador A
Letter. 10.1016/j.ijcard.2013.12.157. 2014
Differential Gene Expression of Cardiac Ion Channels in Human Dilated Cardiomyopathy
Micaela Molina-Navarro, Maria; (...); Rivera, Miguel
Article. 2013
Differential gene expression of C-type natriuretic peptide and its related molecules in dilated and ischemic cardiomyopathy. A new option for the management of heart failure
Tarazón E; (...); Portolés M
Letter. 10.1016/j.ijcard.2014.04.037. 2014
Does the calcineurin inhibitor have influence on cytomegalovirus infection in heart transplantation?
Rodríguez-Serrano M; (...); Salvador-Sanz A
Article. 10.1111/ctr.12282. 2014
Does the Calcineurin Inhibitor Have Influence on Cytomegalovirus Infection in Heart Transplantation?
Sanchez-Lazaro, I.; (...); Salvador-Sanz, A.
Article. 10.1016/j.healun.2014.01.067. 2014
Donor/recipient sex mismatch and survival after heart transplantation: only an issue in male recipients? An analysis of the Spanish Heart Transplantation Registry
Martinez-Selles M; (...); Spanish Registry of Heart Transplantation
Article. 10.1111/tri.12488. 2015
Drug Interaction Between Oral Cyclosporine Modified and Iron
Domingo-Chiva, E; (...); Poveda-Andres, JL
Article. 10.1177/1060028013514734. 2014
ECONOMIC IMPACT LINKED TO THE REDUCTION OF EXACERBATIONS WHEN A TREATMENT REGIME WITH INHALED ANTIBIOTICS IS SWITCHED TO AZTREONAM LYSINE IN PATIENTS WITH CYSTIC FIBROSIS AND CHRONIC PULMONARY INFECTION CAUSED BY PSEUDOMONAS AERUGINOSA
Sole A; (...); Casado MA
Meeting Abstract. 10.1016/j.jval.2014.08.1659. 2014
Effect of CYP3A5*3 on kidney transplant recipients treated with tacrolimus: a systematic review and meta-analysis of observational studies
Rojas L; (...); Aliño SF
Article. 10.1038/tpj.2014.38. 2015
Endoplasmic Reticulum Stress Induces Different Molecular Structural Alterations in Human Dilated and Ischemic Cardiomyopathy
Ortega A; (...); Portolés M
Article. 10.1371/journal.pone.0107635. 2014
Estudio de utilizacion de boceprevir y telaprevir para el tratamiento de la hepatitis C cronica.
Marrero-Álvarez P; (...); Poveda-Andrés JL
Abstract of Published Item. 10.7399/FH.2014.38.1.1128. 2014
Evaluation of humoral immunity profiles to identify heart recipients at risk for development of severe infections: A multicenter prospective study
Sarmiento, E; (...); Carbone, J
Article. 10.1016/j.healun.2016.10.004. 2017
Evaluation of the preoperative vasoactive-inotropic score as a predictor of postoperative outcomes in patients undergoing heart transplantation
Barge-Caballero E; (...); Crespo-Leiro M
Letter. 10.1016/j.ijcard.2015.03.098. 2015
Experience in the management of immunosuppressant treatment with hepatitis C virus protease inhibitors
Ruiz Ramos J; (...); Poveda Andrés JL
Article. 10.1016/j.gastrohep.2014.05.004. 2014
Functional Networks of Nucleocytoplasmic Transport-Related Genes Differentiate Ischemic and Dilated Cardiomyopathies. A New Therapeutic Opportunity
Molina-Navarro MM; (...); Rivera M
Article. 10.1371/journal.pone.0104709. 2014
Gene expression network analysis reveals new transcriptional regulators as novel factors in human ischemic cardiomyopathy
Herrer I; (...); Rivera M
Article. 10.1186/s12920-015-0088-y. 2015
Genotype and Allele Frequencies of Drug-Metabolizing Enzymes and Drug Transporter Genes Affecting Immunosuppressants in the Spanish White Population
Bosó V; (...); Aliño SF
Article. 10.1097/FTD.0b013e3182a94e65. 2014
High-permeability region size on perfusion CT predicts hemorrhagic transformation after intravenous thrombolysis in stroke
Puig, J; (...); Castellanos, M
Article. 10.1371/journal.pone.0188238. 2017
Hyperkalemia in heart failure patients: current challenges and future prospects
Lopez-Vilella, R; (...); Almenar-Bonet, L
Review. 10.2147/RRCC.S75680. 2016
Impact of short-termmechanical circulatory support with extracorporeal devices on postoperative outcomes after emergency heart transplantation: Data from a multi-institutional Spanish cohort
Barge-Caballero E; (...); Crespo-Leiro M
Article. 10.1016/j.ijcard.2014.06.036. 2014
Incidence of Development of Obesity After Heart Transplantation According to the Calcineurin Inhibitor
López-Vilella R; (...); Montero-Argudo A
Article. 10.1016/j.transproceed.2014.11.025. 2015
Incompatibility of undiluted busulfan injection with a needle-free valve
Cueto-Sola, M; (...); Poveda-Andres, JL
Letter. 10.2146/ajhp140111. 2014
Indirect effects of cytomegalovirus infection and the utility of utility of valganciclovir
Martinez-Dolz, L.; (...); Almenar-Bonet, L.
Article. 2014
Influence of ABCB1 polymorphisms upon the effectiveness of standard treatment for acute myeloid leukemia: A systematic review and meta-analysis of observational studies
Megías-Vericat JE; (...); Aliño SF
Review. 10.1038/tpj.2014.80. 2015
Intravenous sildenafil in right ventricular dysfunction with pulmonary hypertension following a heart transplant.
Bonet LA; (...); Sanz AS
Article. 10.5301/HEART.2014.12492. 2014
Metabolic syndrome in heart transplantation: impact on survival and renal function.
Martínez-Dolz L; (...); Montero JA
Article. 10.1111/tri.12149. 2013
National Consensus on the Diagnosis, Risk Stratification and Treatment of Patients with Pulmonary Embolism. Spanish Society of Pneumology and Thoracic Surgery (SEPAR). Society Española Internal Medicine (SEMI). Spanish Society of Thrombosis and Haemostasis (SETH). Spanish Society of Cardiology (ESC). Spanish Society of Medicine Accident and Emergency (SEMES). Spanish Society of Angiology and Surgery Vascular (SEACV).
Uresandi F; (...); Society Española Internal Medicine (SEMI)
Article. 10.1016/j.arbres.2013.07.008. 2013
Prevalence of fragmented QRS complex and factors related with its occurrence
Martinez-Dolz, L.; (...); Almenar-Bonet, L.
Article. 2014
Primary graft failure after heart transplantation: characteristics in a contemporary cohort and performance of the RADIAL risk score.
Cosío Carmena MD; (...); Segovia J
Article. 10.1016/j.healun.2013.08.004. 2013
Prognostic Impact of Anthracycline Metabolism Gene Polymorphisms in Newly Diagnosed Acute Myeloid Leukemia Adults
Eduardo Megias, Juan; (...); Angel Sanz, Miguel
Article. 2014
Prognostic Impact of Cytarabine Pathway Gene Polymorphisms in Acute Myeloid Leukemia Adults Undergoing Induction Chemotherapy
Eduardo Megias, Juan; (...); Angel Sanz, Miguel
Article. 2014
Rejection after conversion to a proliferation signal inhibitor in chronic heart transplantation.
González-Vílchez F; (...); Farrero M
Article. 10.1111/ctr.12241. 2013
RNA Sequencing Analysis Identifies New Human Collagen Genes Involved in Cardiac Remodeling
Gil-Cayuela C; (...); Portolés M
Letter. 10.1016/j.jacc.2015.01.029. 2015
RNA-sequencing analysis reveals new alterations in cardiomyocyte cytoskeletal genes in patients with heart failure
Herrer I; (...); Portolés M
Article. 10.1038/labinvest.2014.54. 2014
Single Nucleotide Polymorphisms, SNPs, Associated With the Efficacy and Security of Immunosuppressive Treatment in Heart Transplantation
Sanchez-Lazaro, I.; (...); Salvador-Sanz, A.
Article. 10.1016/j.healun.2014.01.392. 2014
SNPs and taxane toxicity in breast cancer patients
Bosó V; (...); Aliño SF
Article. 10.2217/PGS.14.127. 2014
Spanish Consensus on the Prevention and Treatment of Pseudomonas aeruginosa Bronchial Infections in Cystic Fibrosis Patients
Cantón R; (...); Solé A
Article. 10.1016/j.arbres.2014.09.021. 2015
Spanish Heart Transplant Registry. 29th Official Report of the Spanish Society of Cardiology Working Group on Heart Failure
Gonzalez-Vilchez, F; (...); Representation Equipos Espanoles T
Article. 10.1016/j.recesp.2018.07.020. 2018
Spanish Heart Transplant Registry. 30th Official Report of the Spanish Society of Cardiology Working Group on Heart Failure (1984-2018)
Gonzalez-Vilchez, F; (...); Abella-Anton, R
Article. 10.1016/j.rec.2019.09.005. 2019
Spanish Heart Transplant Registry. 31th Official Report of the Heart Failure Association of the Spanish Society of Cardiology.
González-Vilchez F; (...); Groba Marco MDV
Article. 10.1016/j.rec.2020.06.035. 2020
Spanish Heart Transplantation Registry. 24th official report of the Spanish Society of Cardiology Working Group on Heart Failure and Heart Transplantation (1984-2012).
González-Vílchez F; (...); Spanish Heart Transplant Teams
Article. 10.1016/j.rec.2013.08.004. 2013
Spanish Heart Transplantation Registry. 25th official report of the Spanish Society of Cardiology Working Group on Heart Failure and Heart Transplantation (1984-2013).
González-Vílchez F; (...); Spanish Heart Transplantation Teams
Article. 10.1016/j.rec.2014.09.005. 2014
Study of Natriuretic Peptides Levels in the Left Ventricular Tissue of Patients With Dilated Cardiomyopathy Using RNA-Seq
Rosello Lleti, Esther; (...); Portoles Sanz, Manuel
Article. 2013
Study on the Linezolid Prescription According to the Approval of Indication in a University Hospital
Pérez-Cebrián M; (...); Llopis-González A
Article. 2015
The falling incidence of hematologic cancer after heart transplantation
Crespo-Leiro, MG; (...); Muniz, J
Article. 10.1111/ctr.12432. 2014
The impact of the prevention strategies on the indirect effects of CMV infection in solid organ transplant recipients
Roman A; (...); Ussetti P
Article. 10.1016/j.trre.2014.01.001. 2014
Treatment adherence and other patient-reported outcomes as cost determinants in multiple sclerosis: a review of the literature
Lizan, L; (...); Polanco, C
Review. 10.2147/PPA.S67253. 2014
Use of a "CNI holidays" strategy in acute renal dysfunction late after heart transplant. Report of two cases.
Article. 2014
Use of mTOR inhibitors in chronic heart transplant recipients with renal failure: Calcineurin-inhibitors conversion or minimization?
Gonzalez-Vilchez F; (...); Blasco T
Article. 10.1016/j.ijcard.2013.11.036. 2014