Standardising acute myeloid leukaemia classification systems: a perspective from a panel of international experts.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Shallis RM
  • Daver N
  • Altman JK
  • Komrokji RS
  • Pollyea DA
  • Badar T
  • Bewersdorf JP
  • Bhatt VR
  • de Botton S
  • de la Fuente Burguera A
  • Carraway HE
  • Desai P
  • Dillon R
  • Duployez N
  • El Chaer F
  • Fathi AT
  • Freeman SD
  • Gojo I
  • Grunwald MR
  • Jonas BA
  • Konopleva M
  • Lin TL
  • Mannis GN
  • Mascarenhas J
  • Michaelis LC
  • Mims AS
  • Pozdnyakova O
  • Pratz KW
  • Schuh AC
  • Sekeres MA
  • Smith CC
  • Stahl M
  • Subklewe M
  • Uy GL
  • Voso MT
  • Walter RB
  • Wang ES
  • Zeidner JF
  • Žucenka A
  • Zeidan AM

Grupos

Abstract

The existence of two acute myeloid leukaemia classification systems-one put forth by WHO and one by the International Consensus Classification in 2022-is concerning. Although both systems appropriately move towards genomic disease definitions and reduced emphasis on blast enumeration, there are consequential disagreements between the two systems on what constitutes a diagnosis of acute myeloid leukaemia. This fundamental problem threatens the ability of heath-care providers to diagnose acute myeloid leukaemia, communicate with patients and other health-care providers, and deliver appropriate and consistent management strategies for patients with the condition. Clinical trial eligibility, standardised response assessments, and eventual drug development and regulatory pathways might also be negatively affected by the discrepancies. In this Viewpoint, we review the merits and limitations of both classification systems and illustrate how the coexistence, as well as application of both systems is an undue challenge to patients, clinicians, hematopathologists, sponsors of research, and regulators. Lastly, we emphasise the urgency and propose a roadmap, by which the two divergent classification systems can be harmonised.

Copyright © 2023 Elsevier Ltd. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
2352-3026, 2352-3026

Lancet Haematology  ELSEVIER SCI LTD

Tipo:
Article
Páginas:
767-776
PubMed:
37572683
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
5,189 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 18

Citas Recibidas en Scopus: 15

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Keywords

  • VARIANT ALLELIC FREQUENCY; MYELODYSPLASTIC SYNDROME; SCORING SYSTEM; MUTATIONS; FEATURES; CRITERIA; PROPOSAL; OUTCOMES; TP53; NPM1

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