Portal de investigación
Molecular characterization of pregnancy-associated breast cancer and insights on timing from GEICAM-EMBARCAM study.
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Pena-Enriquez, Regina
- Bermejo, Begona
- Pollan, Marina
- Diaz-Chacon, Alejandra
- Jerez Gilarranz, Yolanda
- Ponce Lorenzo, Jose J
- Fernandez Aramburo, Antonio
- Cantos Sanchez de Ibarguen, Blanca
- Galve-Calvo, Elena
- Jimenez-Arranz, Alvaro
- Fernandez, Yolanda
- Perez, Maria Eva
- De La Cruz, Susana
- Anton-Torres, Antonio
- Moreno, Fernando
- Vidal-Losada, Maria Jesus
- Lopez-Ceballos, Maria Helena
- Blancas, Isabel
- Echarri, Maria Jose
- Rincon, Raul
- Caballero, Rosalia
- Guerrero-Zotano, Angel
- Guil-Luna, Silvia
- de la Haba-Rodriguez, Juan
Grupos
Abstract
Pregnancy-associated breast cancer (PABC), diagnosed during or shortly after pregnancy, is a challenging entity with an aggressive biology and poor prognosis. This study analyzed the clinicopathological characteristics and gene expression profile of 33 PABC and 26 non-PABC patients using the nCounter BC360 Panel (NanoString). Notably, PABC showed a higher prevalence of basal-like tumors than non-PABC (48.48% vs 15.38%, p=0.012) and displayed 73 differentially expressed genes (e.g., DEPDC1, CCNA2, PSAT1, CDKN3, and FAM83D), enriched in DNA repair and cell proliferation pathways. Through the PPI network, we also identified a cluster of cell-cycle regulation genes like MYC, FOXM1, or PTEN. Interestingly, differences emerged when comparing patients diagnosed during gestation (PABC-GS) and the postpartum period (PABC-PP), with PABC-PP showing increased expression of immune-related genes, including PD-1, and greater immune cell infiltration (Tregs, macrophages, neutrophils, B-cells). These findings suggest an enhanced proliferative capacity and impaired DNA repair in PABC, and underscore the role of immune infiltration in postpartum cases; providing insights into its aggressive nature and potential targets.
© 2025. The Author(s).
Datos de la publicación
- ISSN/ISSNe:
- 2374-4677, 2374-4677
- Tipo:
- Article
- Páginas:
- 12-12
- PubMed:
- 39922815
- Enlace a otro recurso:
- www.scopus.com
- Factor de Impacto:
- 2,863 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
npj Breast Cancer NATURE PORTFOLIO
Citas Recibidas en Web of Science: 14
Documentos
- No hay documentos
Filiaciones
Keywords
- MAMMARY-GLAND INVOLUTION; RISK; PROGNOSIS; WOMEN; EPIDEMIOLOGY; MACROPHAGES; METASTASIS; DEFINITION; MECHANISMS; AGE