Insights from a 7-Year Dementia Cohort (VALCODIS): ApoE Genotype Evaluation.

Autores de IIS La Fe

• 

  Miguel Baquero Toledo

  Autor

• Laura Ferré González

  Autor

• Lourdes Álvarez Sánchez

  Autor

• Inés Ferrer Cairols

  Autor

• Lorena García Vallés

  Autor

• Gemma María García Lluch

  Autor

• María Del Carmen Peña Bautista

  Autor

• 

  María Consuelo Cháfer Pericás

  Autor

Participantes ajenos a IIS La Fe

• Pereto, Mar
• Raga, Luis
• Muria, Beatriz
• Prieto, Aitana
• Jareno, Ines

Grupos

• Grupo de Investigación en Enfermedad de Alzheimer (GINEA)

Abstract

Background: The VALCODIS (Valencian Cognitive Diseases Study) cohort was designed and studied at the Hospital Universitari i Politecnic La Fe (Valencia, Spain) for the research of cognitive diseases, especially in the search for new biomarkers of Alzheimer's disease (AD). Methods: Participants in the VALCODIS cohort had cerebrospinal fluid (CSF) and blood samples, neuroimaging, and neuropsychological tests. The ApoE genotype was evaluated to identify its relationship with CSF biomarkers and neuropsychological tests in AD and non-AD participants. Results: A total of 1249 participants were included. They were mainly AD patients (n = 547) but also patients with other dementias (frontotemporal lobar dementia (n = 61), Lewy body dementia without AD CSF signature (n = 10), vascular dementia (n = 24) and other specific causes of cognitive impairment (n = 442), and patients with subjective memory complaints (n = 165)). In the ApoE genotype evaluation, significant differences were found for Abeta42 levels between genotypes in both AD and non-AD patients, as well as a negative correlation between tau values and a cognitive test in non-carriers and epsilon4 heterozygous. Conclusions: The VALCODIS cohort provides biologically diagnosed patients with demographical, clinical and biochemical data, and biological samples for further studies on early AD diagnosis. Also, the ApoE genotype evaluation showed correlations between CSF biomarkers and neuropsychological tests.

Keywords

• Alzheimer’s; ApoE; biomarkers; cognitive disease; dementia; neuropsychology