Identificación de biomarcadores presintomáticos y mínimamente invasivos de la enfermedad de alzheimer: peroxidación lipídica, e integración lipidómica-epigenómica.
Datos básicos
- Código:
- PI19/00570
- Protocolo:
- PI19/00570
- EUDRACT:
- NCT:
- Centro:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Dotación:
- 87.120,00 €
- Año de incio:
- 2020
- Año de finalización:
- 2023
Documentos
- No hay documentos
Financiadores - Promotores
Resultados del Ensayo Clínico
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Article. 10.1016/j.cca.2019.10.023. 2020
Plasma isoprostanoids assessment as Alzheimer's disease progression biomarkers.
Peña-Bautista C; (...); Cháfer-Pericás C
Article. 10.1111/jnc.15183. 2020
Plasma lipid peroxidation biomarkers for early and non-invasive Alzheimer Disease detection
Pena-Bautista, C; (...); Chafer-Pericas, C
Article. 10.1016/j.freeradbiomed.2018.06.038. 2018
Plasma Lipidomics Approach in Early and Specific Alzheimer's Disease Diagnosis.
Pena-Bautista, Carmen; (...); Chafer-Pericas, Consuelo
Article. 10.3390/jcm11175030. 2022
Plasma lipidomics in early APP/PS1 female mouse model and its relationship with brain: Is it affected by the estrous cycle?
Ferre-Gonzalez, Laura; (...); Chafer-Pericas, Consuelo
Article. 10.1186/s13195-024-01549-x. 2024
Plasma metabolomics in early Alzheimer's disease patients diagnosed with amyloid biomarker
Pena-Bautista, Carmen; (...); Chafer-Pericas, Consuelo
Article. 10.1016/j.jprot.2019.04.008. 2019
Plasma Oncostatin M, TNF-a, IL-7, and IL-13 Network Predicts Crohn's Disease Response to Infliximab, as Assessed by Calprotectin Log Drop.
Mateos B; (...); Beltrán B
Article. 10.1159/000508069. 2020
Potential oxidative stress biomarkers of mild cognitive impairment due to Alzheimer disease
Garcia-Blanco, Ana; (...); Chafer-Pericas, Consuelo
Review. 10.1016/j.jns.2017.01.020. 2017
Pre-diagnostic alterations in circulating bile acid profiles in the development of hepatocellular carcinoma.
Stepien, Magdalena; (...); Jenab, Mazda
Article. 10.1002/ijc.33885. 2022
Preliminary case control study to establish the correlation between novel peroxidation biomarkers in cord serum and the severity of hypoxic ischemic encephalopathy
Chafer-Pericas C; (...); Vento M
Article. 10.1016/j.freeradbiomed.2016.06.006. 2016
Prognostic value of cerebrospinal fluid biomarkers in mild cognitive impairment due to Alzheimer disease.
López-Cuevas R; (...); Cháfer-Pericás C
Article. 10.1016/j.nrl.2020.07.026. 2020
Prognostic value of cerebrospinal fluid biomarkers in mild cognitive impairment due to Alzheimer disease.
Lopez-Cuevas, R; (...); Chafer-Pericas, C
Article. 10.1016/j.nrleng.2020.07.024. 2023
Protein-bound tyrosine oxidation, nitration and chlorination by-products assessed by ultraperformance liquid chromatography coupled to tandem mass spectrometry
Torres-Cuevas I; (...); Escobar J
Article. 10.1016/j.aca.2016.01.054. 2016
Quantitative Evaluation of Neonatal Brain Elasticity Using Shear Wave Elastography.
Garcés Iñigo E; (...); Martí-Bonmatí L
Article. 10.1002/jum.15464. 2020
Real-world long-term effectiveness of ustekinumab in Crohn's disease: Results from the ENEIDA registry
Iborra Colomino, M. I.; (...); Nos, P.
Meeting Abstract. 2020
Recent evidence in epigenomics and proteomics biomarkers for early and minimally invasive diagnosis of Alzheimer's and Parkinson's diseases.
Mayo, Sonia; (...); Chafer-Pericas, Consuelo
Review. 10.2174/1570159X19666201223154009. 2020
Redox Status, Dose and Antioxidant Intake in Healthcare Workers Occupationally Exposed to Ionizing Radiation
Sebastia, N; (...); Rodrigo, R
Article. 10.3390/antiox9090778. 2020
Reference ranges for cortisol and alpha-amylase in mother and newborn saliva samples at different perinatal and postnatal periods
García-Blanco A; (...); Cháfer-Pericás C
Article. 10.1016/j.jchromb.2016.04.035. 2016
Relationship between neuroimaging and emotion recognition in Mild Cognitive Impairment patients.
Gandia-Ferrero, Maria Teresa; (...); Marti-Bonmati, Luis
Article. 10.1016/j.bbr.2023.114844. 2024
Relationship between Plasma Lipid Profile and Cognitive Status in Early Alzheimer Disease.
Pena-Bautista, Carmen; (...); Chafer-Pericas, Consuelo
Article. 10.3390/ijms25105317. 2024
Reliable determination of new lipid peroxidation compounds as potential early Alzheimer Disease biomarkers
Garcia-Blanco, Ana; (...); Chafer-Pericas, Consuelo
Article. 10.1016/j.talanta.2018.03.002. 2018
Response to the comment on "Can stress biomarkers predict preterm birth in women with threatened preterm labor?"
Garcia-Blanco, A; (...); Vento, M
Letter. 10.1016/j.psyneuen.2017.07.490. 2017
Reviewing the metabolome coverage provided by LC-MS: Focus on sample preparation and chromatography-A tutorial
Review. 2021
Reviewing the metabolome coverage provided by LC-MS: Focus on sample preparation and chromatography-A tutorial.
Article. 10.1016/j.aca.2020.12.025. 2021
SERUM 24,25-DIHYDROXYVITAMIN D-3 IS AN ACCURATE INDICATOR OF FOLLICULAR VITAMIN D STATUS AND OOCYTE AGING IN IVF PATIENTS.
Lara-Molina, Evelin E.; (...); Pellicer, Antonio
Meeting Abstract. 2021
Short-term neuropsychiatric outcomes and quality of life in COVID-19 survivors.
Méndez R; (...); Menéndez R
Article. 10.1111/joim.13262. 2021
Specific plasma micro-RNA profiles for prediction of recurrence in Crohn's disease in pre-surgery and established recurrence scenarios
Moret, I; (...); Beltran, B
Meeting Abstract. 2020
Specific Plasma MicroRNA Signatures in Predicting and Confirming Crohn's Disease Recurrence: Role and Pathogenic Implications.
Moret-Tatay, Ines; (...); Beltran, Belen
Article. 10.14309/ctg.0000000000000416. 2021
Stress and neurodegeneration.
Peña-Bautista C; (...); Cháfer-Pericás C
Review. 10.1016/j.cca.2020.01.019. 2020
Study of the pathophysiological mechanisms associated with the onset and course of neurodevelopmental disorders in preterm infants (the PeriSTRESS-PremTEA study): Rationale, objectives, design and sample description.
Navalón P; (...); García-Blanco A
Article. 10.1016/j.rpsm.2021.02.002. 2021
Synergistic activation of AMPK prevents from polyglutamine-induced toxicity in Caenorhabditis elegans.
Gómez-Escribano AP; (...); Vázquez-Manrique RP
Article. 10.1016/j.phrs.2020.105105. 2020
Systematic review of brain and blood lipidomics in Alzheimer's disease mouse models.
Ferre-Gonzalez, Laura, Lloret, Ana, Chafer-Pericas, Consuelo
Article. 10.1016/j.plipres.2023.101223. 2023
The association of salivary caffeine levels with serum concentrations in premature infants with apnea of prematurity
Garcia-Robles, Ana; (...); Saenz Gonzalez, Pilar
Article. 10.1007/s00431-022-04628-z. 2022
The cross-sectional area of the median nerve: An independent prognostic biomarker in amyotrophic lateral sclerosis
Martinez-Paya, J. J.; (...); Vazquez-Costa, J. F.
Article. 10.1016/j.nrl.2022.01.008. 2024
The cross-sectional area of the median nerve: An independent prognostic biomarker in amyotrophic lateral sclerosis.
Martinez-Paya, J J; (...); Vazquez-Costa, J F
Article. 10.1016/j.nrleng.2024.07.003. 2024
The metabolomic differential plasma profile between dialysates. Pursuing to understand the mechanisms of citrate dialysate clinical benefits.
Broseta, Jose Jesus; (...); Hernandez-Jaras, Julio
Article. 10.3389/fphys.2022.1013335. 2022
The Potential of Extracellular Microvesicle-microRNAs in Precapillary Pulmonary Hypertension.
Tura-Ceide, Olga; (...); Barbera, Joan Albert
Article. 10.1165/rcmb.2024-0282LE. 2025
The Potential Role of Efficacy and Safety Evaluation of N-Acetylcysteine Administration During Liver Procurement. The NAC-400 Single Center Randomized Controlled Trial
Gomez-Gavara, C; (...); Lopez-Andujar, R
Article. 10.1097/TP.0000000000003487. 2021
THE ROLE OF CXCL4, CXCL8 AND GDF-15 IN SYSTEMIC SCLEROSIS
Rodriguez, JEO; (...); Ivorra, JAR
Meeting Abstract. 10.1136/annrheumdis-2020-eular.5019. 2020
The worldwide epidemic of Vitamin D deficiency: are we contributing by using inaccurate and unreliable measurement methods?
Molina, EEL; (...); Diaz-Gimeno, P
Meeting Abstract. 2020
Trajectories of stress biomarkers and anxious-depressive symptoms from pregnancy to postpartum period in women with a trauma history
Ghosn, F; (...); Blanco, AG
Article. 10.1080/20008198.2019.1601990. 2019
Ultra high performance liquid chromatography coupled to tandem mass spectrometry determination of lipid peroxidation biomarkers in newborn serum samples
Cháfer-Pericás C; (...); Escobar J
Article. 10.1016/j.aca.2015.06.028. 2015
Understanding the course of Attention-Deficit/Hyperactivity Disorder in Children Born After a Suspected Preterm Labor: A 6-Year Cohort Study.
Buesa, Julia; (...); Garcia-Blanco, Ana
Article. 10.1016/j.ajogmf.2024.101289. 2024
Uremic Toxins and Inflammation: Metabolic Pathways Affected in Non-Dialysis-Dependent Stage 5 Chronic Kidney Disease
Peris-Fernandez, Maria; (...); Hernandez-Jaras, Julio
Article. 10.3390/biomedicines12030607. 2024
Urine metabolomic analysis in clear cell and papillary renal cell carcinoma: A pilot study
Article. 10.1016/j.jprot.2020.103723. 2020
Validated analytical method to determine new salivary lipid peroxidation compounds as potential neurodegenerative biomarkers.
Peña-Bautista C; (...); Cháfer-Pericás C
Article. 10.1016/j.jpba.2018.11.043. 2019
Validation of urine p-cresol glucuronide as renal cell carcinoma non-invasive biomarker
Oto, Julia; (...); Medina, Pilar
Article. 10.1016/j.jprot.2024.105357. 2025
Variant in CACNA1G as a Possible Genetic Modifier of Neonatal Epilepsy in an Infant with a De Novo SCN2A Mutation
Nieto-Barcelo, Juan Jose; (...); Tomas Vila, Miguel
Article. 10.1055/s-0041-1723958. 2021