A systematic review and meta-analysis of the impact of WT1 polymorphism rs16754 in the effectiveness of standard chemotherapy in patients with acute myeloid leukemia

Autores de IIS La Fe

• Juan Eduardo Megías Vericat

  Autor

• María José Herrero Cervera

  Autor

• Luis Esteban Rojas Orellana

  Autor

• Pau Montesinos Fernández

  Autor

• Virginia Bosó Ribelles

  Autor

• Federico Moscardo Garcia

  Autor

• David Martínez Cuadrón

  Autor

• José Luis Poveda Andrés

  Autor

• Miguel Ángel Sanz Alonso

  Autor

• Salvador F Aliño Pellicer

  Autor

Grupos

• Farmacogenética

• Hematología y Hemoterapia

Abstract

The polymorphism rs16754 of the WT1 gene has been described as a possible prognostic marker in different acute myeloid leukemia (AML) cohorts; however, it is not supported by all the studies. We performed the first meta-analysis evaluating the effect of this polymorphism upon the effectiveness of standard AML therapy. Fourteen cohort studies were included (3618 patients). Patients with the variant allele showed a significant higher overall survival (OS) at 5 years (OR: 1.24, 95% CI: 1.06-1.45, P = 0.007, with dominant model). WT1 did not influence complete remission, but a higher disease-free survival was observed with the variant allele. In the subgroup analysis, Caucasians, pediatric and patients treated with idarubicin and etoposide carrying the variant allele showed consistent results in OS, whereas patients with cytogenetically normal AML did not show differences. To verify the effect of this polymorphism upon other outcomes, studies in larger and multiracial populations are needed.

Keywords

• SINGLE-NUCLEOTIDE POLYMORPHISM; TUMOR 1 GENE; NO PROGNOSTIC IMPACT; MUTATIONS; CANCER; PREDICTS; SUSCEPTIBILITY; ASSOCIATION; ADULTS; AML