Portal de investigación
- Inicio
- Proyectos y Estudios
- ESTUDIO DE FASE III, ALEATORIZADO, DE GRUPOS PARALELOS, DOBLE CIEGO, DOBLE SIMULACION, CONTROLADO CON COMPARADOR ACTIVO Y MULTICENTRICO PARA EVALUAR LA EFICACIA Y LA SEGURIDAD DE PGL4001 (ULIPRISTAL) FRENTE A UN AGONISTA GNRH (LEUPRORELIN 3.75MG) PARA EL TRATAMIENTO PRE-OPERATORIO DE MIOMAS UTERINOS SINTOMATICOS
ESTUDIO DE FASE III, ALEATORIZADO, DE GRUPOS PARALELOS, DOBLE CIEGO, DOBLE SIMULACION, CONTROLADO CON COMPARADOR ACTIVO Y MULTICENTRICO PARA EVALUAR LA EFICACIA Y LA SEGURIDAD DE PGL4001 (ULIPRISTAL) FRENTE A UN AGONISTA GNRH (LEUPRORELIN 3.75MG) PARA EL TRATAMIENTO PRE-OPERATORIO DE MIOMAS UTERINOS SINTOMATICOS
Datos básicos
- Protocolo:
- PGL07-022
- EUDRACT:
- 2008-001805-40
- NCT:
- Centro:
- Año de incio:
- Año de finalización:
Documentos
- No hay documentos
Participantes
Financiadores - Promotores
Resultados del Ensayo Clínico
5-aza-2 '-deoxycitidine inhibits cell proliferation, extracellular matrix formation and Wnt/beta-catenin pathway in human uterine leiomyomas
Carbajo-García MC; (...); Ferrero H
Article. 10.1186/s12958-021-00790-5. 2021
Accuracy of ICG compared with technetium-99 m for sentinel lymph node biopsy in vulvar cancer
Guijarro-Campillo, Alberto Rafael; (...); Domingo, Santiago
Article. 10.1016/j.ejogrb.2023.12.037. 2024
An International Multi-Center Cohort Study on ß-blockers for the Treatment of Symptomatic Children with Catecholaminergic Polymorphic Ventricular Tachycardia.
Peltenburg PJ; (...); Wilde AAM
Article. 10.1161/CIRCULATIONAHA.121.056018. 2022
Association of Left Ventricular Systolic Dysfunction Among Carriers of Truncating Variants in Filamin C With Frequent Ventricular Arrhythmia and End-stage Heart Failure
Akhtar, MM; (...); European Genetic Cardiomyopathies
Article. 10.1001/jamacardio.2021.1106. 2021
Cadaveric Adipose-Derived Stem Cells for Regenerative Medicine and Research.
Milian, Lara; (...); Zorio, Esther
Article. 10.3390/ijms242115696. 2023
Cardiomyopathy associated with primary carnitine deficiency in adults: lack of complete response in patients with delayed treatment initiation
Cervera, Borja Guerrero; (...); Zorio, Esther
Letter. 10.1016/j.recesp.2023.08.011. 2024
Cardiomyopathy associated with primary carnitine deficiency in adults: lack of complete response in patients with delayed treatment initiation.
Guerrero Cervera B; (...); Zorio E
Case Reports. 10.1016/j.rec.2023.08.011. 2024
Case Report: Probable Myocarditis After Covid-19 mRNA Vaccine in a Patient With Arrhythmogenic Left Ventricular Cardiomyopathy.
Alania-Torres, Edgardo; (...); Valle-Munoz, Alfonso
Case Reports. 10.3389/fcvm.2021.759119. 2021
Clinical and molecular characterization of a group of Spanish and German patients with Noonan syndrome
Lopez Gonzalez, Vanesa; (...); Guillen-Navarro, Encarna
Meeting Abstract. 2022
Clinical Risk Prediction in Patients With Left Ventricular Myocardial Noncompaction
Casas, G; (...); Rodriguez-Palomares, JF
Article. 10.1016/j.jacc.2021.06.016. 2021
Clinical, echocardiographic and analytical patterns of biomarkers in cardiac amyloidosis; a real-world analysis.
Lopez Vilella, R. Raquel; (...); Almenar Bonet, L.
Meeting Abstract. 2024
comprehensive CMR analysis improves risk stratification in left ventricular noncompaction
Casas, G.; (...); Rodriguez-Palomares, J. F.
Meeting Abstract. 2023
Correlation of Methylation Status and Gene Expression Shows Epigenetics Involvement in Key Biological Processes of Uterine Leiomyoma Development.
Carbajo-Garcia, MC; (...); Ferrero, Hortensia
Meeting Abstract. 2021
Characterization of Ca2+ handling in induced-pluripotent cardiomyocytes from a CPVT family harbouring the RyR2(R420Q) mutation
Blasco, Almudena Val; (...); Gomez, Ana M.
Meeting Abstract. 2022
Characterization of hereditary transthyretin cardiac amyloidosis in Spain.
Alvarez Rubio, Jorge; (...); AC-TTRv-Spain Investigator Group
Article. 10.1016/j.rec.2021.07.020. 2022
Deciphering the Role of Histone Modifications in Uterine Leiomyoma: Acetylation of H3K27 Regulates the Expression of Genes Involved in Proliferation, Cell Signaling, Cell Transport, Angiogenesis and Extracellular Matrix Formation.
Carbajo-Garcia, Maria Cristina; (...); Ferrero, Hortensia
Article. 10.3390/biomedicines10061279. 2022
Disparate molecular mechanisms in cardiac ryanodine receptor channelopathies
Zhang, Yadan; (...); Zissimopoulos, Spyros
Article. 10.3389/fmolb.2024.1505698. 2024
Electrocardiographic findings in patients with arrhythmogenic cardiomyopathy and right bundle branch block ventricular tachycardia.
Laredo, Mikael; (...); Belhassen, Bernard
Article. 10.1093/europace/euac267. 2023
Electrophysiological Phenotype-Genotype Study of Sustained Monomorphic Ventricular Tachycardia in Inherited, High Arrhythmic Risk, Left Ventricular Cardiomyopathy.
Cabrera-Borrego, Eva; (...); Jimenez-Jaimez, Juan
Article. 10.1161/CIRCEP.124.013145. 2024
Endometrial cancer: predictors and oncological safety of tumor tissue manipulation.
Quintana-Berto, Raquel; (...); Domingo, Santiago
Article. 10.1007/s12094-023-03310-6. 2023
Extracellular Kir2.1(C122Y) Mutant Upsets Kir2.1-PIP(2) Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome.
Cruz FM; (...); Jalife J
Article. 10.1161/CIRCRESAHA.123.323895. 2024
Facts and Gaps in Exercise Influence on Arrhythmogenic Cardiomyopathy: New Insights From a Meta-Analysis Approach.
Martínez-Solé J; (...); Zorio E
Review. 10.3389/fcvm.2021.702560. 2021
Flecainide Is Associated With a Lower Incidence of Arrhythmic Events in a Large Cohort of Patients With Catecholaminergic Polymorphic Ventricular Tachycardia.
Bergeman, Auke T.; (...); van der Werf, Christian
Article. 10.1161/CIRCULATIONAHA.123.064786. 2023
H3K4me3 mediates uterine leiomyoma pathogenesis via neuronal processes, synapsis components, proliferation, and Wnt/beta-catenin and TGF-beta pathways.
Carbajo-García MC; (...); Ferrero, Hortensia
Article. 10.1186/s12958-023-01060-2. 2023
Hereditary transthyretin amyloidosis caused by the Val142Ile variant in Spain.
de Frutos, Fernando; (...); Gonzalez-Costello, Jose
Article. 10.1016/j.rec.2024.12.012. 2025
Histone deacetylase inhibition by suberoylanilide hydroxamic acid: a therapeutic approach to treat human uterine leiomyoma.
Carbajo-Garcia, Maria Cristina; (...); Ferrero, Hortensia
Article. 10.1016/j.fertnstert.2021.10.012. 2022
Hypertrophic cardiomyopathy due to truncating variants in myosin binding protein C: a Spanish cohort
Melendo-Viu, Maria; (...); Palomino Doza, Julian A.
Article. 10.1136/openhrt-2024-002891. 2024
Impact of SARS-CoV-2 infection in patients with cardiac amyloidosis: Results of a multicentre registry.
Larrañaga-Moreira JM; (...); Barriales-Villa R
Article. 10.1016/j.medcli.2023.06.025. 2023
Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry
Gimeno, Juan R.; (...); Lakdawala, Neal K.
Article. 10.1002/ehf2.13964. 2022
Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation
Yin L; (...); Gómez AM
Article. 10.1161/CIRCRESAHA.121.319094. 2021
Importance of genotype for risk stratification in arrhythmogenic right ventricular cardiomyopathy using the 2019 ARVC risk calculator
Protonotarios, Alexandros; (...); Elliott, Perry M.
Article. 10.1093/eurheartj/ehac235. 2022
In Silico Saturation Mutagenesis Identifies Novel Driver Genes in Uterine Fibroids
Machado-Lopez, Alba; (...); Mas, Aymara
Meeting Abstract. 2022
Inhibition of cell proliferation and extracellular matrix formation in human uterine leiomyomas by 5-aza-2 '-deoxycitidine via Wnt/beta-catenin pathway
Carbajo-Garcia, MC; (...); Ferrero, H
Meeting Abstract. 2021
Integrative analysis of the DNA methylome and transcriptome in uterine leiomyoma shows altered regulation of genes involved in metabolism, proliferation, extracellular matrix and vesicles.
Carbajo-Garcia, Maria Cristina; (...); Ferrero, Hortensia
Article. 10.1002/path.5920. 2022
Integrative Genomic and Transcriptomic Profiling Reveals a Differential Molecular Signature in Uterine Leiomyoma versus Leiomyosarcoma.
Machado-Lopez A; (...); Mas A
Article. 10.3390/ijms23042190. 2022
Left ventricular ejection fraction decline and cardiovascular events in suspected cardiomyopathy with excessive trabeculation: toward precision medicine.
Casas, Guillem; (...); Rodriguez-Palomares, Jose F
Article. 10.1016/j.rec.2025.01.011. 2025
Natural History of MYH7-related Dilated Cardiomyopathy.
de Frutos, Fernando; (...); Garcia-Pavia, Pablo
Article. 10.1016/j.jacc.2022.07.023. 2022
Neutrophil Extracellular Traps and Cancer: Trapping Our Attention with Their Involvement in Ovarian Cancer.
Castano, Maria; (...); Gilabert-Estelles, Juan
Article. 10.3390/ijms24065995. 2023
New ECG biomarkers and sex-stratified models for the detection of Arrhythmogenic Cardiomyopathy with left ventricular involvement
Jimenez-Serrano, Santiago; (...); Castells, Francisco
Article. 10.1016/j.bspc.2024.107224. 2025
New Roles for Old Friends: Involvement of the Innate Immune System in Tumor Progression.
Castano, Maria; (...); Gilabert-Estelles, Juan
Editorial Material. 10.3390/ijms24087604. 2023
Non Coding RNAs as Regulators of Wnt/ß-Catenin and Hippo Pathways in Arrhythmogenic Cardiomyopathy
Piquer-Gil, Marina; (...); Zorio, Esther
Review. 10.3390/biomedicines10102619. 2022
Oncological outcomes of intraperitoneal chemotherapy in advanced ovarian cancer: BRCA mutation role.
Padilla-Iserte P; (...); Domingo S
Article. 10.1016/j.ejso.2024.108263. 2024
Oncological safety of hysteroscopy in endometrial cancer.
Quintana-Berto, Raquel; (...); Domingo, Santiago
Article. 10.1136/ijgc-2022-003586. 2022
Penetrance of Dilated Cardiomyopathy in Genotype-Positive Relatives.
Cabrera-Romero E; (...); Garcia-Pavia P
Article. 10.1016/j.jacc.2024.02.036. 2024
Phenotype and Clinical Outcomes in Desmin-Related Arrhythmogenic Cardiomyopathy.
Bermudez-Jimenez FJ; (...); Jimenez-Jaimez J
Article. 10.1016/j.jacep.2024.02.031. 2024
Polymorphisms in ACE, ACE2, AGTR1 genes and severity of COVID-19 disease.
Sabater Molina, Maria; (...); Gimeno Blanes, Juan R.
Article. 10.1371/journal.pone.0263140. 2022
Potential Role of Nervous System Related Functions in Uterine Leiomyoma Pathogenesis
Carbajo-Garcia, Maria Cristina; (...); Ferrero, Hortensia
Meeting Abstract. 2022
Pregnancy in women with dilated cardiomyopathy genetic variants.
Restrepo-Córdoba MA; (...); García-Pavía P
Article. 10.1016/j.rec.2024.04.002. 2024
Preoperative sampling in endometrial cancer: evaluation of the histopathological agreement with definitive surgical specimen
Quintana-Bertó R; (...); Domingo S
Article. 10.1007/s12094-022-02893-w. 2022
Prognosis of left ventricular noncompaction with preserved ejection fraction
Casas, G.; (...); Rodriguez-Palomares, J. F.
Meeting Abstract. 2021
Reduced Levels of miR-145-3p Drive Cell Cycle Progression in Advanced High-Grade Serous Ovarian Cancer
Gonzalez-Canto, Eva; (...); Mari-Alexandre, Josep
Article. 10.3390/cells13221904. 2024
Renin-angiotensin system polymorphisms as potential modifier in COVID-19 outcome
Sabater Molina, Maria; (...); Gimeno Blanes, Juan Ramon
Meeting Abstract. 2022
Role of Syndecans in Ovarian Cancer: New Diagnostic and Prognostic Biomarkers and Potential Therapeutic Targets.
Oto, Julia; (...); Gotte, Martin
Article. 10.3390/cancers15123125. 2023
Single Cell Transcriptomes from Uterine Fibroids and Fibroid-Free Myometrium Elucidate Myometrial Tumorigenesis.
Wang, WX; (...); Simon, C
Meeting Abstract. 2021
The EP300/TP53 pathway, a suppressor of the Hippo and canonical WNT pathways, is activated in human hearts with arrhythmogenic cardiomyopathy in the absence of overt heart failure.
Rouhi L; (...); Marian AJ
Article. 10.1093/cvr/cvab197. 2021
The prevalence of left and right bundle branch block morphology ventricular tachycardia amongst patients with arrhythmogenic cardiomyopathy and sustained ventricular tachycardia: insights from the European Survey on Arrhythmogenic Cardiomyopathy.
Belhassen, Bernard; (...); Milman, Anat
Article. 10.1093/europace/euab190. 2021
Titin Missense Variants as a Cause of Familial Dilated Cardiomyopathy.
Dominguez, Fernando; (...); Garcia-Pavia, Pablo
Letter. 10.1161/CIRCULATIONAHA.122.062833. 2023
TRACER COMPARED WITH TECHNETIUM-99M FOR SENTINEL LYMPH NODE BIOPSY IN VULVAR CANCER
De La Cruz, Marta Arnaez; (...); Domingo, Santiago
Meeting Abstract. 10.1136/ijgc-2023-ESGO.823. 2023
Uterine fibroid surgical treatment
Satorres, Elena; (...); Monleon, Javier
Editorial Material. 10.1016/j.medcli.2023.07.008. 2023
Validation of multiparametric approaches for the prediction of sudden cardiac death in patients with Brugada syndrome and electrophysiological study.
Rodríguez-Mañero M; (...); Arbelo E
Article. 10.1016/j.rec.2021.07.007. 2021