Portal de investigación
The EP300/TP53 pathway, a suppressor of the Hippo and canonical WNT pathways, is activated in human hearts with arrhythmogenic cardiomyopathy in the absence of overt heart failure.
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Rouhi L
- Fan S
- Cheedipudi SM
- Molina MS
- Yao Y
- Robertson MJ
- Coarfa C
- Gimeno JR
- Molina P
- Gurha P
- Marian AJ
Grupos
Abstract
Arrhythmogenic cardiomyopathy (ACM) is a primary myocardial disease that typically manifests with cardiac arrhythmias, progressive heart failure and sudden cardiac death (SCD). ACM is mainly caused by mutations in genes encoding desmosome proteins. Desmosomes are cell-cell adhesion structures and hubs for mechanosensing and mechanotransduction. The objective was to identify the dysregulated molecular and biological pathways in human ACM in the absence of overt heart failure.
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.
Datos de la publicación
- ISSN/ISSNe:
- 0008-6363, 1755-3245
- Tipo:
- Article
- Páginas:
- 1466-1478
- DOI:
- 10.1093/cvr/cvab197
- PubMed:
- 34132777
- Factor de Impacto:
- 2,711 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
CARDIOVASCULAR RESEARCH OXFORD UNIV PRESS
Citas Recibidas en Web of Science: 35
Documentos
- No hay documentos
Filiaciones
Keywords
- Cardiomyopathy, Gene expression, Hippo pathway, RNA-Sequencing, TP53, WNT pathway
Campos de Estudio
Cita
Rouhi L,Fan S,Cheedipudi SM,BRAZA A,Molina MS,Yao Y,Robertson MJ,Coarfa C,Gimeno JR,Molina P,Gurha P,ZORIO E,Marian AJ. The EP300/TP53 pathway, a suppressor of the Hippo and canonical WNT pathways, is activated in human hearts with arrhythmogenic cardiomyopathy in the absence of overt heart failure. Cardiovasc. Res. 2021. 118. (6):p. 1466-1478. IF:14,239. (1).