Impact of SARS-CoV-2 infection in patients with cardiac amyloidosis: Results of a multicentre registry.

Autores de IIS La Fe

• 

  Francisco Domínguez Hernández

  Autor

• 

  Esther Zorio Grima

  Autor

Participantes ajenos a IIS La Fe

• Larrañaga-Moreira JM
• Rodriguez-Serrano AI
• Lalario A
• Barriales-Villa R
• Dilemma International Cardiomyopathy, Heart Failure Registry Investigators Group

Grupos

• Biología Reproductiva y Bioingeniería en Reproducción Humana

• Cardiopatías familiares, muerte súbita y mecanismos de enfermedad (CAFAMUSME)

Abstract

BACKGROUND: Descriptions on impact of SARS-CoV-2 infection in patients with cardiac amyloidosis (CA) are lacking. Our aim was to describe the prognosis of those patients. METHODS: Retrospective observational study of unvaccinated patients with CA who developed SARS-CoV-2 infection enrolled in eleven centres (March 2020 to May 2021). Descriptive analysis of basal characteristics, hospitalization, mortality, and severe clinical course was performed. Comparisons to a population-based control group were made. RESULTS: Forty-one patients were identified. Most patients had wild-type transthyretin CA (61%) and were on NYHA Class II-III (80.5%). CA patients were commonly hospitalized (73.2%) and those were more symptomatic than outpatients (p=0.035). The 24.4% of CA patients died as consequence of SARS-CoV-2 infection. Patients with CA had an increased risk of hospitalization [OR 6.23 (3.05-12.74), p<0.001] and mortality [OR 2.18 (1.01-4.68), p=0.047] when compared to control population after adjustment by age and sex. After a medium follow-time of 311 days, 41.5% of the CA cohort died. CONCLUSIONS: SARS-CoV-2 infection is associated with high mortality and hospitalization rates in patients with CA, which exceed that expected by their sex and advanced age.

Copyright © 2023 Elsevier España, S.L.U. All rights reserved.

Keywords

• Amiloidosis cardíaca; COVID-19; Cardiac amyloidosis; Heart failure; Infección por SARS-CoV-2; Insuficiencia cardíaca; Prognosis; Pronóstico; Registries; Registro; SARS-CoV-2 infection