Vascular endothelial growth factor haplotypes are associated with severe ischaemic complications in giant cell arteritis regardless of the disease phenotype.

Fecha de publicación: 01/05/2022 Fecha Ahead of Print: 23/03/2022

Autores de IIS La Fe

Francisco Miguel Ortiz Sanjuán

Autor

Participantes ajenos a IIS La Fe

Prieto-Pena, D.
Remuzgo-Martinez, S.
Genre, F.
Ocejo-Vinyals, J. Gonzalo
Atienza-Mateo, B.
Muñoz-Jimenez A
Romero-Yuste, S.
Moriano, C.
Galindez-Agirregoikoa, E.
Calvo, I
Ortego-Centeno, N.
Alvarez-Rivas, N.
Miranda-Filloy, J. A.
Llorente, I
Blanco, R.
Gualillo, O.
Martin, J.
Marquez, A.
Castañeda S
Ferraz-Amaro, I
Lopez-Mejias, R.
Gonzalez-Gay, M. A.

Grupos

Reumatología

Leader

José Andrés Román Ivorra

Abstract

OBJECTIVES: To determine whether functional vascular endothelial growth factor (VEGF) polymorphisms influence the expression of the clinical phenotype of giant cell arteritis (GCA). We also evaluated whether VEGF polymorphism is associated with the development of severe ischaemic manifestations in patients with GCA regardless of the clinical phenotype, classic cranial GCA or predominantly extracranial GCA large vessel vasculitis (LVV). METHODS: VEGF rs833061 T/C, rs2010963 G/C and rs3025039 C/T polymorphisms were genotyped in 185 patients with biopsy-proven cranial GCA, 105 with extracranial LVV-GCA and 490 healthy controls. Allelic combinations (haplotypes) of VEGF were carried out. Comparisons were performed between patients with GCA and healthy controls as well as between patients with GCA stratified according to the clinical phenotype and the presence of severe ischaemic manifestations. RESULTS: No significant differences in genotype, allele, and haplotype frequencies of VEGF were found between patients with GCA and healthy controls as well as between GCA patients with the classic cranial pattern and the extracranial LVV-GCA pattern of the disease. However, the VEGF CGC haplotype (OR= 1.63 [1.05-2.53]) and the CGT haplotype (OR= 2.55 [1.10-5.91]) were significantly more frequent in GCA patients with severe ischaemic complications compared to those patients without these complications. CONCLUSIONS: VEGF haplotypes seem to play a role in the development of severe ischaemic manifestations in GCA patients, regardless of the clinical phenotype of expression of the disease.

Datos de la publicación

ISSN/ISSNe:: 0392-856X, 1593-098X
Tipo:: Article
Páginas:: 727-733
DOI:: 10.55563/clinexprheumatol/8mku9c
Factor de Impacto:: 1,123 SCImago ℠
Cuartil:: Q1 SCImago ℠

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Métricas

Filiaciones

Prieto-Pena, D.:: Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, and Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, Spain
Remuzgo-Martinez, S.:: Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, Spain
Genre, F.:: Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, Spain
Ocejo-Vinyals, J. Gonzalo:: Department of Immunology, Hospital Universitario Marqués de Valdecilla, Santander, Spain
Atienza-Mateo, B.:: Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, and Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, Spain
Muñoz-Jimenez A:: Department of Rheumatology, Hospital Universitario Virgen del Rocío, Sevilla, Spain
Ortiz-Sanjuan, F.:: Department of Rheumatology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
Romero-Yuste, S.:: Department of Rheumatology, Complejo Hospitalario Universitario Pontevedra, Spain
Moriano, C.:: Department of Rheumatology, Complejo Asistencial Universitario de León, Spain
Galindez-Agirregoikoa, E.:: Department of Rheumatology, Hospital Universitario de Basurto, Bilbao, Spain
Calvo, I:: Department of Rheumatology, Hospital Universitario de Basurto, Bilbao, Spain
Ortego-Centeno, N.:: Autoimmune Diseases Unit, Hospital Universitario San Cecilio, Instituto de Investigación Biosanitaria de Granada (IBS Granada), Department of Internal Medicine, University of Granada, Spain
Alvarez-Rivas, N.:: Department of Rheumatology, Hospital Universitario San Agustín, Avilés, Spain
Miranda-Filloy, J. A.:: Division of Rheumatology, Hospital Universitario Lucus Augusti, Lugo, Spain
Llorente, I:: Department of Rheumatology, Hospital Universitario de la Princesa, IIS-Princesa, Cátedra EPID Future, Universidad Autónoma de Madrid (UAM), Madrid, Spain
Blanco, R.:: Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, and Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, Spain
Gualillo, O.:: Health Research Institute of Santiago, and The NEIRID Group (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Santiago University Clinical Hospital, Santiago de Compostela, Spain
Martin, J.:: Instituto de Parasitología y Biomedicina 'López-Neyra', CSIC, PTS Granada, Spain
Marquez, A.:: Instituto de Parasitología y Biomedicina 'López-Neyra', CSIC, PTS Granada, Spain
Castañeda S:: Department of Rheumatology, Hospital Universitario de la Princesa, IIS-Princesa, Cátedra EPID Future, Universidad Autónoma de Madrid (UAM), Madrid, Spain
Ferraz-Amaro, I:: Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain
Lopez-Mejias, R.:: Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, Spain
Gonzalez-Gay, M. A.:: Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander

Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, and School of Medicine, Universidad de Cantabria, Santander, Spain

and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.