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  3. Estudio en fase 2a, multicéntrico, aleatorizado, con doble enmascaramiento, controlado con placebo y de grupos paralelos para evaluar la eficacia, la seguridad y la tolerabilidad de JTT861 administrado durante 12 semanas en pacientes con insuficiencia cardíaca con fracción de eyección reducida (POWER-HF).

Estudio en fase 2a, multicéntrico, aleatorizado, con doble enmascaramiento, controlado con placebo y de grupos paralelos para evaluar la eficacia, la seguridad y la tolerabilidad de JTT861 administrado durante 12 semanas en pacientes con insuficiencia cardíaca con fracción de eyección reducida (POWER-HF).

Datos básicos

Código:
AT861-G-22-002
Protocolo:
AT861-G-22-002
EUDRACT:
NCT:
Centro:
HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
Dotación:
Año de incio:
2024
Año de finalización:
ENSAYO CLÍNICO

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AKROS PHARMA

Resultados del Ensayo Clínico

[[en]]Peripheral access ultrafiltration in adults with complex congenital heart disease and refractory congestion.

Guerrero Cervera B; (...); Almenar Bonet L

Article. 10.1016/j.rec.2024.08.015. 2024

  • Open Access.

[Translated article] Knowledge of biological therapy in patients with immune-mediated diseases. BIOINFO study.

Segui-Solanes, Carlos; (...); Borras-Blasco, Joaquin

Article. 10.1016/j.farma.2024.08.002. 2024

  • Open Access.

[Translated article] New challenges in advanced therapies.

Megías-Vericat JE; (...); Poveda Andrés JL

Article. 10.1016/j.farma.2024.05.001. 2024

  • Open Access.

[Translated article] Pharmacokinetic-guided switching from standard half-life factor VIII to extended half-life pegylated factor VIII in haemophilia A therapy in clinical practice.

Chovi-Trull, Maria; (...); Andres, Jose Luis Poveda

Article. 10.1016/j.farma.2024.12.007. 2025


Analysis of complications in patients with ECMO as a bridge to transplantation since the beginning of the technique (2007-2023)

Guerrero Cervera, Borja; (...); Almenar Bonet, Luis

Meeting Abstract. 2024


Annual evolution of the prescription of drugs with prognostic implications in acute decompensated heart failure with reduced ejection fraction.

López-Vilella R; (...); Almenar Bonet L

Article. 10.1186/s12872-024-03728-y. 2024

  • Open Access.

Benefits of physical activity self-monitoring in patients with haemophilia: a prospective study with one-year follow-up.

Pérez-Alenda S; (...); Núñez-Cortés R

Article. 10.1111/hae.14988. 2024

  • Open Access.

Cardiomyopathy associated with primary carnitine deficiency in adults: lack of complete response in patients with delayed treatment initiation

Cervera, Borja Guerrero; (...); Zorio, Esther

Letter. 10.1016/j.recesp.2023.08.011. 2024

  • Open Access.

Clinical profiling of patients admitted with acute heart failure: a comprehensive survival analysis.

Lopez-Vilella, Raquel; (...); Almenar Bonet, Luis

Article. 10.3389/fcvm.2024.1381514. 2024

  • Open Access.

Clinical utility and safety of finerenone in patients with heart failure: Rationale and design of FINE registry.

Alonso Salinas, Gonzalo Luis; (...); Diez-Villanueva, Pablo

Article. 10.1002/ehf2.15260. 2025

  • Open Access.

Clinical, echocardiographic and analytical patterns of biomarkers in cardiac amyloidosis; a real-world analysis.

Lopez Vilella, R. Raquel; (...); Almenar Bonet, L.

Meeting Abstract. 2024


Comparative Temporal Analysis of Morbidity and Early Mortality in Heart Transplantation with Extracorporeal Membrane Oxygenation Support: Exploring Trends over Time

Lopez-Vilella, Raquel; (...); Bonet, Luis Almenar

Article. 10.3390/biomedicines12092109. 2024

  • Open Access.

Comprehensive survival analysis in acute heart failure: profiling patients through clinical examination at admission

Raquel Lopez Vilella, R.; (...); Almenar Bonet, L.

Meeting Abstract. 2024


Cost-effectiveness and cost-utility analysis of haemate-P versus other von willebrand disease treatments in Spain.

Megias-Vericat, Juan E; (...); Yan, Songkai

Article. 10.1080/13696998.2025.2474886. 2025


Destination Therapy Strategies of Advanced Heart Failure in Elderly Non-Heart Transplant Candidates: A Propensity Matching Analysis from the LEVO-D and REGALAD Registries

Dobarro, David; (...); Gonzalez-Costello, Jose

Article. 10.3390/life14121570. 2024

  • Open Access.

Development and testing of a mobile app for systematic collection of patient-reported outcomes (PROs) in patients with hemophilia.

Megias-Vericat, J E; (...); Poveda Andres, J L

Letter. 10.1016/j.thromres.2024.109122. 2024


Electrophysiological Phenotype-Genotype Study of Sustained Monomorphic Ventricular Tachycardia in Inherited, High Arrhythmic Risk, Left Ventricular Cardiomyopathy.

Cabrera-Borrego, Eva; (...); Jimenez-Jaimez, Juan

Article. 10.1161/CIRCEP.124.013145. 2024

  • Open Access.

Facilitators and barriers to perform physical activity in patients post-heart transplantation: a qualitative study.

Klompstra L; (...); Marques-Sule E

Article. 10.1093/eurjcn/zvae144. 2024

  • Open Access.

Impact of left ventricular unloading on postheart transplantation outcomes in patients bridged with VA-ECMO.

Enríquez-Vázquez D; (...); Crespo-Leiro MG

Article. 10.1016/j.rec.2024.09.005. 2024

  • Open Access.

Impact of preoperative left ventricular unloading on post-transplant outcomes of candidates bridged with venoarterial extracorporeal membrane oxygenation

Enriquez Vazquez, D.; (...); Crespo-Leiro, M.

Meeting Abstract. 2024


Impact on Survival of Heart and Heart-Lung Transplantation in Patients With Cyanotic and Noncyanotic Congenital Heart Diseases.

Donoso-Trenado, Victor; (...); Almenar-bonet, Luis

Article. 10.1016/j.transproceed.2024.12.005. 2024


Improvement in left atrial strain following ferric carboxymaltose in heart failure: an analysis of the Myocardial-IRON trial.

Santas E; (...); Núñez J

Article. 10.1002/ehf2.14630. 2023

  • Open Access.

Left atrial strain in adults after the arterial switch operation for transposition of the great arteries.

Buendia-Fuentes, Francisco; (...); Rueda, Joaquin

Article. 10.1111/echo.15750. 2024

  • Open Access.

Lower heart rate in patients with acute heart failure: the role of left ventricular ejection fraction

Lorenzo, Miguel; (...); Nunez, Julio

Article. 10.1080/14017431.2024.2386977. 2024

  • Open Access.

Mental, emotional and social dimensions of quality of life and their relationship with physical and functional status in adults with haemophilia.

Rodríguez MA; (...); Chimeno-Hernández A

Article. 10.1016/j.thromres.2024.109181. 2024

  • Open Access.

Multicenter Clinical Trial to Evaluate the Efficacy of a Preventive Strategy Against Cytomegalovirus Infection in Heart Transplant Patients Based on the Specific T Cells Response

Garcia-Romero, E.; (...); Gonzalez-Costello, J.

Meeting Abstract. 2024


New challenges of advanced therapies.

Megías-Vericat JE; (...); Poveda Andrés JL

Article. 10.1016/j.farma.2023.11.008. 2024

  • Open Access.

No Obesity Paradox for Health-Related Quality of Life in Patients with Heart Failure and Reduced Ejection Fraction: Insights from the VIDA Multicenter Study

Cassado-Valls, Paula; (...); Comin-Colet, Josep

Article. 10.3390/jcm13247558. 2024

  • Open Access.

Particularities of foundational therapy in patients with newly diagnosed heart failure and reduced LVEF secondary to tachycardiomyopathy

Esteban Fernandez, A. Alberto; (...); De Juan Baguda, J.

Meeting Abstract. 2024


Pharmacogenetics in Response to Biological Agents in Inflammatory Bowel Disease: A Systematic Review.

Ballesta-Lopez, Octavio; (...); Poveda-Andres, Jose Luis

Article. 10.3390/ijms26041760. 2025

  • Open Access.

Practical Requirements for the Development of an Advanced Cardiorenal Unit

Almenar-Bonet, Luis; (...); Sanchez-Perez, Pilar

Review. 10.1159/000536104. 2024

  • Open Access.

Predicting Sarcopenia and Frailty Risk in Patients Post Heart Transplantation.

Sentandreu-Mano, Trinidad; (...); Machado, Felipe V C

Article. 10.1111/ctr.70027. 2025


Prevalence, characteristics, and phenotype associated with tachycardiomyopathy in a cohort of patients first hospitalized for heart failure with reduced ejection fraction

Otero Garcia, O.; (...); Gonzalez-Juanatey, J. R.

Meeting Abstract. 2024


Prognostic determinants in patients with heart failure with reduced ejection fraction after a first hospitalisation for acute heart failure. COMFE registry

Vega, D. Garcia; (...); Gonzalez-Juanatey, J. R.

Meeting Abstract. 10.1093/eurheartj/ehae666.1187. 2024

  • Open Access.

Prognostic determinants in patients with heart failure with reduced ejection fraction after a first hospitalisation for acute heart failure. implications for their clinical management. COMFE registry

Garcia Vega, D. David; (...); Gonzalez-Juanatey, J. R.

Meeting Abstract. https://doi.org/10.1093/eurheartj/ehae666.1187. 2024

  • Open Access.

Role of spot urinary sodium in outpatients with heart failure.

Lorenzo, Miguel; (...); Nunez, Julio

Article. 10.1016/j.rec.2024.07.002. 2024

  • Open Access.

Role of vericiguat in management of patients with heart failure with reduced ejection fraction after worsening episode.

Olivella, Aleix; (...); Facila Rubio, Lorenzo

Article. 10.1002/ehf2.14647. 2023

  • Open Access.

Sinus rhythm restoration as an independent predictor of left ventricular ejection fraction improvement in patients with the first hospitalization for heart failure and reduced ejection fraction

Otero Garcia, O. Oscar; (...); Gonzalez-Juanatey, J. R.

Meeting Abstract. https://doi.org/10.1093/eurheartj/ehae666.836. 2024

  • Open Access.

Sinus rhythm restoration as an independent predictor of left ventricular ejection fraction improvement in patients with the first hospitalization for heart failure and reduced ejection fraction

Garcia, O. Otero; (...); Gonzalez-Juanatey, J. R.

Meeting Abstract. 10.1093/eurheartj/ehae666.836. 2024

  • Open Access.

Spanish heart transplant registry. 35th official report of the Heart Failure Association of the Spanish Society of Cardiology.

González-Vílchez F; (...); García-Romero E

Article. 10.1016/j.rec.2024.05.015. 2024

  • Open Access.

Spot urinary sodium in outpatients with chronic heart failure. A longitudinal analysis

Lorenzo Hernandez, M. Miguel; (...); Nunez, J.

Meeting Abstract. 2024


Structural heart transcatheter interventions in orthotopic cardiac transplant and left ventricular assist devices recipients: A nationwide study.

Blasco-Turrion, Sara; (...); Amat-Santos, Ignacio J.

Article. 10.1016/j.ijcard.2024.132340. 2024


Toxic-metabolic encephalopathy induced by metronidazole and disulfiram: classics never die.

Chovi-Trull, Maria; (...); Poveda-Andres, Jose Luis

Article. 10.1136/ejhpharm-2024-004184. 2024


Unveiling the prognostic journey: renal function trajectories in 'de novo' heart failure with reduced ejection fraction - insights from a cohort study and their impact on patient outcomes

Garcia, O. Otero; (...); Gonzalez-Juanatey, J. R.

Meeting Abstract. 10.1093/eurheartj/ehae666.835. 2024

  • Open Access.

Use of cutting or scoring balloons in patients with native coronary artery disease: systematic review and meta-analysis

Romero, Jose Antonio Sorolla; (...); Sanchez, Jorge Sanz

Letter. https://doi.org/10.24875/RECICE.M24000448. 2024

  • Open Access.

Usefulness of biomarkers to predict prognosis after heart transplant

Lopez-Vilella, Raquel; (...); Boneta, Luis Almenar

Article. 10.1016/j.rec.2024.04.019. 2024

  • Open Access.

What clinical parameters are associated with the prescription at hospital discharge of all medications with prognostic improvement? Analysis in de novo heart failure with reduced ejection fraction

Lopez Vilella, R. Raquel; (...); Bonet, Almenar

Meeting Abstract. 2024


What factors are associated with myocardial recovery following admission for acute heart failure? Study in patients with de novo diagnosis and reduced left ventricular ejection fraction

Donoso Trenado, V.; (...); Almenar-Bonet, L.

Meeting Abstract. 2024


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