Common and specific proteins and pathways in heart and cerebral ischemia

Autores de IIS La Fe

• Irene María Escudero Martínez

  Autor

Participantes ajenos a IIS La Fe

• Pala, Elena
• Garcia-Rodriguez, Paula
• Bustamante, Alejandro
• Penalba, Anna
• Lamana-Vallverdu, Marcel
• Guaman-Pilco, Daisy R.
• Delgado, Pilar
• Riba, Iolanda
• Jimenez-Balado, Joan
• Planas, Alejandra
• Simo-Servat, Olga
• Montaner, Joan

Grupos

• Unidad Mixta de Investigación Cerebrovascular

  Leader

  Juan Bautista Salom Sanvalero

Abstract

Objective: To understand the similarities and differences between acute ischemic stroke and acute myocardial infarction (AMI) to help in the development of specific or common treatment strategies. Methods: Using an aptamer-based proteomic array, we measured and compared 1310 circulating proteins in the blood of 40 patients with AIS, 9 patients with AMI, and 31 healthy controls. Pathway enrichment analysis was performed using GSEA and g:profiler.Results: Ninety-four proteins were differentially expressed in AIS, and 284 were differentially expressed in AMI. Of these, 8 were specific to cerebral ischemia, and 197 were specific to myocardial infarction. Forty-two proteins were altered in both ischemia processes. Most altered pathways in AIS could be classified as immune response, cell cycle processing, molecular transport, or signaling. Pathways altered in AMI were mostly related to lipid metabolism and transport, highlighting cholesterol metabolic processes and estrogen signaling. In both types of ischemia, we found pathways related to metabolism, specifically purine metabolism, and signaling processes, such as TNF signaling or MAPK1/3.Conclusions: The present study revealed proteins and pathways that were specifically altered in cerebral ischemia, in cardiac ischemia, or in both diseases, providing information on the similarities and differences of ischemic conditions. The role of common and specific proteins and pathways should be explored in detail to find possible therapeutic targets.

Copyright © 2023. Published by Elsevier Inc.

Keywords

• Acute myocardial infarct; Ischemic stroke; Heart ischemia; Cerebral ischemia; Proteomic array proteins