Portal de investigación
MICROBIAL COMPARATIVE GENOMICS-MICROGEN
Datos básicos
- NumeroConcesion:
- CSD2009-00006_CONSOLIDER
- Año inicial:
- 2009
- Año final:
- 2015
Objetivos del proyecto
FINALIZADO
Documentos
- No hay documentos
Participantes
Grupos
Financiadores
Resultados del Proyecto
A Cutting-Edge Bioinformatics Tool for Neoantigen Identification in Unpaired RNA-Seq Samples of AML
Perez Miguez, Carlos; (...); Montesinos, Pau
Meeting Abstract. 10.1182/blood-2024-201407. 2024
A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species
Bacigalupe, R; (...); Fitzgerald, JR
Article. 10.1126/sciadv.aax0063. 2019
A super-family of transcriptional activators regulates bacteriophage packaging and lysis in Gram-positive bacteria.
Quiles-Puchalt N; (...); Penadés JR
Article. 10.1093/nar/gkt508. 2013
ACUTE MYELOID LEUKEMIA IN PATIENTS 70 AND ABOVE. AZACITIDINE VERSUS INTENSIVE CHEMOTHERAPY
De La Fuente, A.; (...); Ramos, F.
Meeting Abstract. 2014
Adaptation of Staphylococcus aureus to ruminant and equine hosts involves SaPI-carried variants of von Willebrand factor-binding protein
Viana, David; (...); Penades, Jose R.
Article. 10.1111/j.1365-2958.2010.07312.x. 2010
An ex vivo cystic fibrosis model recapitulates key clinical aspects of chronic Staphylococcus aureus infection.
Sweeney E; (...); Harrison F
Article. 10.1099/mic.0.000987. 2021
Antibacterial Activity of Linezolid against Gram-Negative Bacteria: Utilization of e-Poly-l-Lysine Capped Silica Xerogel as an Activating Carrier.
Guzel Kaya G; (...); Martínez-Máñez R
Article. 10.3390/pharmaceutics12111126. 2020
Application of FISH 7q in MDS patients without monosomy 7 or 7q deletion by conventional G-banding cytogenetics: does -7/7q- detection by FISH have prognostic value?
Ademà V; (...); Solé F
Article. 10.1016/j.leukres.2012.12.010. 2013
Aptamer-Capped nanoporous anodic alumina for Staphylococcus aureus detection
Pla, L; (...); Martinez-Manez, R
Article. 10.1016/j.snb.2020.128281. 2020
Autologous or allogeneic hematopoietic stem cell transplantation as front-line treatment for adult secondary acute myeloid leukemia patients: the PETHEMA registry experience.
Serrano, Josefina; (...); Montesinos, Pau
Article. 10.1016/j.jtct.2025.02.011. 2025
Caspofungin for the treatment of invasive fungal disease in hematological patients (ProCAS Study).
Jarque I; (...); Spanish Pethema Group
Article. 10.3109/13693786.2012.693213. 2013
Climate change, animals, and Candida auris: insights into the ecological niche of a new species from a one health approach.
Garcia-Bustos, Victor; (...); Peman, Javier
Article. 10.1016/j.cmi.2023.03.016. 2023
Clinical and biological significance of isolated Y chromosome loss in myelodysplastic syndromes and chronic myelomonocytic leukemia. A report from the Spanish MDS Group
Nomdedeu, M; (...); Spanish MDS Group
Article. 10.1016/j.leukres.2017.10.011. 2017
Clonal Evolution Analysis Using Next Generation Sequencing (NGS) Panel in a Cohort of 3,025 Patients With Acute Myeloid Leukemia (AML)
Colmenares, Rafael; (...); Montesinos, Pau
Meeting Abstract. 2023
Comparison of the 2022 and 2017 European LeukemiaNet risk classifications in a real-life cohort of the PETHEMA group
Sargas, Claudia; (...); Montesinos, Pau
Article. 10.1038/s41408-023-00835-5. 2023
Considering Bone Marrow Blasts From Nonerythroid Cellularity Improves the Prognostic Evaluation of Myelodysplastic Syndromes
Arenillas L; (...); Florensa L
Article. 10.1200/JCO.2016.66.9705. 2016
Control of Staphylococcus aureus pathogenicity island excision.
Mir-Sanchis I; (...); Penadés JR
Article. 10.1111/j.1365-2958.2012.08145.x. 2012
Conventional PCR Versus Next Generation Sequencing for Diagnosis of FLT3, IDH and NPM1 Mutations in Acute Myeloid Leukemia: Interim Analysis of the PCR-LMA Protocol of the Pethema Group
Boluda, Blanca; (...); Montesinos, Pau
Meeting Abstract. 10.1182/blood-2022-160136. 2022
Convergent evolution involving dimeric and trimeric dUTPases in pathogenicity island mobilization
Donderis, J; (...); Marina, A
Article. 10.1371/journal.ppat.1006581. 2017
Cytogenetic risk stratification in chronic myelomonocytic leukemia.
Article. 10.3324/haematol.2010.030957. 2011
Characteristics and outcome of adult patients with acute promyelocytic leukemia and increased body mass index treated with the PETHEMA Protocols.
Sobas M; (...); PETHEMA, HOVON, PALG, GATLA cooperative groups
Article. 10.1111/ejh.13346. 2020
Characterization of the Differential Pathogenicity of Candida auris in a Galleria mellonella Infection Model.
Garcia-Bustos V; (...); Pemán J
Article. 10.1128/Spectrum.00013-21. 2021
Data-Driven Multiparameter Flow Cytometry (MFC) Classification of Blast Differentiation in Elderly Patients with Acute Myeloid Leukemia (AML)
Gonzalez, Carmen; (...); Paiva, Bruno
Meeting Abstract. 10.1182/blood-2023-180646. 2023
Dose-intensive chemotherapy including rituximab in Burkitt's leukemia or lymphoma regardless of human immunodeficiency virus infection status: final results of a phase 2 study (Burkimab).
Ribera JM; (...); Bernal T
Article. 10.1002/cncr.27918. 2013
dUTPases, the unexplored family of signalling molecules.
Penadés JR; (...); Marina A
Article. 10.1016/j.mib.2013.02.005. 2013
Early-Onset Myelodysplastic Syndromes (MDS) with Ring Sideroblasts (RS) without SF3B1 Mutations in Adults: Enrichment with Germline Variants in Genes Responsible for Congenital Sideroblastic Anemias
Jauregui, Sandra Novoa; (...); Jerez, Andres
Meeting Abstract. 10.1182/blood-2023-185836. 2023
Enhanced Antibacterial Activity through Silver Nanoparticles Deposited onto Carboxylated Graphene Oxide Surface
Barjola, Arturo; (...); Gimenez, Enrique
Article. 10.3390/nano12121949. 2022
Erythroleukemia shares biological features and outcome with myelodysplastic syndromes with excess blasts: a rationale for its inclusion into future classifications of myelodysplastic syndromes
Calvo X; (...); Florensa L
Article. 10.1038/modpathol.2016.146. 2016
Essential Topics for the Regulatory Consideration of Phages as Clinically Valuable Therapeutic Agents: A Perspective from Spain
Vazquez, Roberto; (...); Garcia, Pilar
Review. 10.3390/microorganisms10040717. 2022
Evolution of the Genetic and Biological Studies Performed at Diagnosis in Patients with Acute Myeloid Leukemia Included in the Pethema Epidemiological Registry (REALMOL Study)
Labrador, Jorge; (...); Manuel Alonso-Dominguez, Juan
Meeting Abstract. 10.1182/blood-2022-163016. 2022
Evolutionary Genomics of Staphylococcus aureus Reveals Insights into the Origin and Molecular Basis of Ruminant Host Adaptation
Guinane, Caitriona M.; (...); Fitzgerald, J. Ross
Article. 10.1093/gbe/evq031. 2010
Evolving patterns and clinical outcome of genetic studies performed at diagnosis in acute myeloid leukemia patients: Real life data from the PETHEMA Registry.
Labrador, Jorge; (...); Montesinos, Pau
Article. 10.1002/cncr.35431. 2024
Exploring Potential Molecular Mechanisms of Drug Response in FLT3-ITD Negative AML Patients Treated with Quizartinib Vs Placebo Plus Standard Chemotherapy in the Quiwi Trial
Mosquera Orgueira, Adrian; (...); Montesinos, Pau
Meeting Abstract. 10.1182/blood-2023-180710. 2023
Extracellular proteases inhibit protein-dependent biofilm formation in Staphylococcus aureus
Marti, Miguel; (...); Penades, Jose R.
Article. 10.1016/j.micinf.2009.10.005. 2010
FREQUENCY AND CLINICAL IMPACT OF CDKN2A/B GENE LOCUS IN AN ADULT T-ALL COHORT OF PATIENTS ENROLLED IN THE SPANISH PETHEMA GROUP PROTOCOLS
Genesca, E; (...); Ribera, JM
Meeting Abstract. 2017
Genomics improves risk stratification of adults with T-cell acute lymphoblastic leukemia patients enrolled in measurable residual disease-oriented trials.
Gonzalez-Gil, Celia; (...); Genesca, Eulalia
Article. 10.3324/haematol.2022.281196. 2023
Host-pathogen interactions upon Candida auris infection: fungal behaviour and immune response in Galleria mellonella
Garcia-Bustos, Victor; (...); Ruiz-Sauri, Amparo
Article. 10.1080/22221751.2021.2017756. 2022
Human papilloma virus DNA detection in clinical samples using fluorogenic probes based on oligonucleotide gated nanoporous anodic alumina films.
Hernández-Montoto A; (...); Martínez-Máñez R
Article. 10.1002/adhm.202203326. 2023
Impact of Center-related Characteristics and Macroeconomic Factors on the Outcome of Adult Patients With Acute Lymphoblastic Leukemia Treated With Pediatric-inspired Protocols.
Barba P; (...); Ribera JM
Article. 10.1097/HS9.0000000000000810. 2023
IMPACT OF CYTOGENETIC ABNORMALITIES DEFINING AML MYELODYSPLASIA-RELATED (WHO AND ICC 2022) IN FIRST LINE DECITABINE IN UNFIT AML PATIENTS
de la Fuente, Adolfo; (...); Tormo, Mar
Meeting Abstract. 2023
Impact of FLT3-ITD Mutation Status and Its Ratio in a Cohort of 2901 Patients Undergoing Upfront Intensive Chemotherapy: A PETHEMA Registry Study.
Ayala, Rosa; (...); Montesinos, Pau
Article. 10.3390/cancers14235799. 2022
Impact of trisomy 19 on outcome according to genetic makeup in patients with acute myeloid leukemia.
Kayser, Sabine; (...); Schlenk, Richard F.
Article. 10.3324/haematol.2022.282127. 2023
In vitro activity of anidulafungin in combination with amphotericin B or voriconazole against biofilms of five Candida species
Valentín A; (...); Martínez JP
Article. 10.1093/jac/dkw316. 2016
Indolent Acute Myeloid Leukemia with Long Survival in Patients Treated with Best Supportive Care Only: A Pethema Registry Study
Labrador, Jorge; (...); Montesinos, Pau
Meeting Abstract. 10.1182/blood-2022-162591. 2022
INTENSIVE CHEMOTHERAPY VERSUS DECITABINE FIRST LINE LAM OVER 60 YEARS OLD
De la Fuente, A.; (...); Montesinos, P.
Meeting Abstract. 2019
Lack of negative impact of Philadelphia chromosome in older patients with acute lymphoblastic leukaemia in the thyrosine kinase inhibitor era: comparison of two prospective parallel protocols.
Ribera JM; (...); PETHEMA Group
Letter. 10.1111/bjh.12043. 2012
Long-term antibacterial Ag plus -release biomaterials based on anodized Ti6Al4V and silver nanoparticles
Molina, J.; (...); Tormo-Mas, M. A.
Article. 10.1016/j.colsurfa.2023.132243. 2023
Machine Learning Improves Risk Stratification in Myelodysplastic Neoplasms: An Analysis of the Spanish Group of Myelodysplastic Syndromes.
Mosquera Orgueira, Adrian; (...); Valcarcel, David
Article. 10.1097/HS9.0000000000000961. 2023
Microstructural, mechanical, electrochemical, and biological studies of an electron beam melted Ti-6Al-4V alloy
Romero-Resendiz, L.; (...); Amigo-Borras, V
Article. 10.1016/j.mtcomm.2022.103337. 2022
Mobilisation Mechanism of Pathogenicity Islands by Endogenous Phages in Staphylococcus aureus clinical strains.
Cervera-Alamar, M; (...); Tormo-Mas, MA
Article. 10.1038/s41598-018-34918-2. 2018
Molecular identification of Candida auris by PCR amplification of species-specific GPI protein-encoding genes
Ruiz-Gaitan, AC; (...); de Groot PWJ
Article. 10.1016/j.ijmm.2018.06.014. 2018
Molecular Landscape and Validation of New Genomic Classification in 2668 Adult AML Patients: Real Life Data from the PETHEMA Registry.
Sargas, Claudia; (...); On Behalf Of Pethema Group
Article. 10.3390/cancers15020438. 2023
Molecular profiling refines minimal residual disease-based prognostic assessment in adults with Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia.
Ribera J; (...); Ribera JM
Article. 10.1002/gcc.22788. 2019
Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands
Angeles Tormo-Mas, Maria; (...); Penades, Jose R.
Article. 10.1038/nature09065. 2010
MUTATIONAL PROFILE IN PATIENTS DIAGNOSED WITH LOW-RISK SMD WITHOUT THE RINGED SIDEROBLASTS
Abaigar, M; (...); Campelo, MD
Meeting Abstract. 2018
Nanoemulsion Increases the Antifungal Activity of Amphotericin B against Four Candida auris Clades: In Vitro and In Vivo Assays.
Marena, Gabriel Davi; (...); Peman, Javier
Article. 10.3390/microorganisms11071626. 2023
NATIONAL EXPERIENCE WITH THE USE OF VENETOCLAX IN PATIENTS WITH RELAPSED OR REFRACTORY ACUTE MYELOID LEUKEMIA
Labrador, J.; (...); Montesinos, P.
Meeting Abstract. 2020
Oligonucleotide-capped nanoporous anodic alumina biosensor as diagnostic tool for rapid and accurate detection of Candida auris in clinical samples.
Pla, Luis; (...); Santiago-Felipe, Sara
Article. 10.1080/22221751.2020.1870411. 2020
Outcomes after intensive chemotherapy for secondary and myeloid-related changes acute myeloid leukemia patients aged 60 to 75 years old: a retrospective analysis from the PETHEMA registry
Martinez-Cuadron, David; (...); Montesinos, Pau
Article. 10.3324/haematol.2022.282506. 2024
Pethema NGS-AML Project. Final Analysis and Clinical Validation of New Genomic Classifications
Sargas, Claudia; (...); Montesinos, Pau
Meeting Abstract. 10.1182/blood-2022-166639. 2022
Phage dUTPases control transfer of virulence genes by a proto-oncogenic G protein-like mechanism.
Tormo-Más MÁ; (...); Penadés JR
Article. 10.1016/j.molcel.2012.12.013. 2013
Prognostic impact of gene mutations in myelodysplastic syndromes with ring sideroblasts
Martin, I; (...); Sanz, G
Article. 10.1038/s41408-017-0016-9. 2017
Prognostic Impact of NPM1 and FLT3-ITD Mutations in Patients Treated with Non-Intensive Regimens: A Pethema Registry Study
Uriel Suarez, Edwin; (...); Montesinos, Pau
Meeting Abstract. 10.1182/blood-2022-167365. 2022
Prognostic Significance of Complex Karyotype and Monosomal Karyotype in Adult Patients With Acute Lymphoblastic Leukemia Treated With Risk-Adapted Protocols
Motlló C; (...); Feliu E
Article. 10.1002/cncr.28950. 2014
Radical genome remodelling accompanied the emergence of a novel host-restricted bacterial pathogen
Yebra, G; (...); Penades, JR
Article. 10.1371/journal.ppat.1009606. 2021
Real-World Outcomes Using Front-Line Midostaurine in Combination with Intensive Chemotherapy for Patients Aged = 60 Years Old with FLT3 Mutated Acute Myeloid Leukemia
Requena, Gaspar Aspas; (...); Matinez-Cuadron, David
Meeting Abstract. 10.1182/blood-2023-190128. 2023
RESULTS OF THE TREATMENT OF LYMPHOBLASTIC LYMPHOMA WITH PROTOCOLS OF LYMPHOBLASTIC ACUTE LEUKEMIA OF PETHEMA GROUP
Sagues, M.; (...); Ribera, J. M.
Meeting Abstract. 2019
RETROSPECTIVE STUDY OF AZACITIDINE IN PATIENTS OF ADVANCED AGE WITH ACUTE MYELOID LEUKEMIA (LMA). RESULTS OF THE ALMA/ PETHEMA COHORT IN COMPARISON WITH THE MRC RISK INDEX SCORE
Falantes, J.; (...); Ramos, F.
Meeting Abstract. 2015
RinA controls phage-mediated packaging and transfer of virulence genes in Gram-positive bacteria
Desamparados Ferrer, Maria; (...); Penades, Jose R.
Article. 10.1093/nar/gkr158. 2011
Salvage Therapy with Second-Generation Inhibitors for FLT3 Mutated Acute Myeloid Leukemia: A Real-World Study by the CETLAM and PETHEMA Groups
Vives, Susana; (...); PETHEMA Grp
Article. 10.3390/cancers16234028. 2024
SARS-CoV-2 N protein IgG antibody detection employing nanoporous anodized alumina: A rapid and selective alternative for identifying naturally infected individuals in populations vaccinated with spike protein (S)-based vaccines
Esteve-Sanchez, Yoel; (...); Climent, Estela
Article. 10.1016/j.snb.2024.136378. 2024
SARS-CoV-2-reactive antibody waning, booster effect and breakthrough SARS-CoV-2 infection in hematopoietic stem cell transplant and cell therapy recipients at one year after vaccination.
Pinana, Jose Luis; (...); Solano, Carlos
Article. 10.1038/s41409-023-01946-0. 2023
Selective and Sensitive Probe Based in Oligonucleotide-Capped Nanoporous Alumina for the Rapid Screening of Infection Produced by Candida albicans.
Ribes À; (...); Martinez-Manez, R
Article. 10.1021/acssensors.9b00169. 2019
Simultaneous analysis of the expression of 14 genes with individual prognostic value in myelodysplastic syndrome patients at diagnosis: WT1 detection in peripheral blood adversely affects survival.
Santamaría C; (...); González M
Article. 10.1007/s00277-012-1538-7. 2012
Single nucleotide polymorphism array karyotyping: a diagnostic and prognostic tool in myelodysplastic syndromes with unsuccessful conventional cytogenetic testing.
Arenillas L; (...); Solé F
Article. 10.1002/gcc.22112. 2013
Structure-function analysis of the SaPIbov1 replication origin in Staphylococcus aureus.
Ubeda C; (...); Novick RP
Article. 10.1016/j.plasmid.2012.01.006. 2012
Supervised Machine Learning Improves Risk Stratification in Newly Diagnosed Myelodysplastic Syndromes: An Analysis of the Spanish Group of Myelodysplastic Syndromes
Mosquera Orgueira, Adrian; (...); Valcarcel, David
Meeting Abstract. 10.1182/blood-2022-159429. 2022
The FLT3-like Gene Expression Signature Predicts Response to Quizartinib in Wild-Type FLT3 Acute Myeloid Leukemia: An Analysis of the Pethema Quiwi Trial
Mosquera Orgueira, Adrian; (...); Montesinos, Pau
Meeting Abstract. 10.1182/blood-2023-180482. 2023
The Optimization of the Synthesis of Antibacterial Coatings on Ti6Al4V Coupons Obtained by Electron Beam Melting
Molina, Javier; (...); Bosch, Francisco
Article. 10.3390/met14080855. 2024
The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients
Ribera, J; (...); Ribera, JM
Article. 10.1111/bjh.15887. 2019
The transcriptomic landscape of elderly acute myeloid leukemia identifies B7H3 and BANP as a favorable signature in high-risk patients.
Villar, Sara; (...); Montesinos, Pau
Article. 10.3389/fonc.2022.1054458. 2022
Transcriptional and Genomic Characterization of Measurable Residual Disease (MRD) Cells in Acute Myeloid Leukemia (AML)
Patricia Simoes, Catia; (...); Paiva, Bruno
Meeting Abstract. 10.1182/blood-2022-163159. 2022
Transcriptional and genomic characterization of measurable residual disease in acute myeloid leukaemia.
Simoes, Catia; (...); Montesinos, Pau
Letter. 10.1111/bjh.18815. 2023
Treatment Outcomes in Unfit Patients with Newly Acute Myeloid Leukemia According to IDH1 Mutational Status: Real World Evidence from the Pethema Epidemiologic Registry
Martinez-Cuadron, David; (...); Montesinos, Pau
Meeting Abstract. 10.1182/blood-2023-189800. 2023
Treatment patterns and outcomes in secondary acute myeloid leukemia arising after hypomethylating agents: PETHEMA registry study.
Lloret-Madrid, Pilar; (...); Montesinos, Pau
Article. 10.1002/cncr.35696. 2025
VALIDATION OF PRECISION MEDICINE TEST FOR ACUTE MYELOID LEUKEMIA IN AN OBSERVATIONAL CLINICAL TRIAL
Montesinos, P; (...); Sanz, MA
Meeting Abstract. 2017
Validation of the Artificial Intelligence Prognostic Scoring System for Myelodysplastic Syndromes in chronic myelomonocytic leukaemia: A novel approach for improved risk stratification.
Mosquera Orgueira, Adrian; (...); Valcarcel, David
Article. 10.1111/bjh.19341. 2024
What Do We Know about Candida auris ? State of the Art, Knowledge Gaps, and Future Directions.
Garcia-Bustos V; (...); Pemán J
Article. 10.3390/microorganisms9102177. 2021
WHAT IS THE OUTCOME OF PATIENTS IN THE INTERMEDIATE IPSS-R SCORE GROUP? SPANISH APPROACH FOR BETTER STRATIFICATION WITH CLASSICAL TOOLS
Guijo, AMR; (...); Diez-Campelo, M
Meeting Abstract. 10.1016/S0145-2126(17)30374-0. 2017
WHO and ICC 2022 Cytogenetic Abnormalities Defining Acute Myelogenous Leukemia (AML) Myelodysplasia-Related in First-Line Decitabine in Unfit AML Patients
Ortiz Lopez, Alicia; (...); de la Fuente Burguera, Adolfo
Meeting Abstract. 2023
Campos de Estudio
Cita
MICROBIAL COMPARATIVE GENOMICS-MICROGEN. (CSD2009-00006_CONSOLIDER). FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA; MINISTERIO DE ECONOMIA Y COMPETITIVIDAD. 2009-2015. IP:MARÍA ÁNGELES TORMO MAS.