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- RESOLTEX: INVESTIGACIÓN EN EL FRACCIONAMIENTO DE ACEITES ENRIQUECIDOS CON PRECURSORES DE MEDIADORES LIPIDICOS CON ACTIVIDAD ANTI-INFLAMATORIA Y PRO-RESOLUTIVA. APLICACIÓN AL DISEÑO Y DESARROLLO DE APÓSITOS PARA TRATAMIENTO DE CICATRIZACIÓN DE HERIDAS CRÓN ICAS Y QUEMADURAS.
RESOLTEX: INVESTIGACIÓN EN EL FRACCIONAMIENTO DE ACEITES ENRIQUECIDOS CON PRECURSORES DE MEDIADORES LIPIDICOS CON ACTIVIDAD ANTI-INFLAMATORIA Y PRO-RESOLUTIVA. APLICACIÓN AL DISEÑO Y DESARROLLO DE APÓSITOS PARA TRATAMIENTO DE CICATRIZACIÓN DE HERIDAS CRÓN ICAS Y QUEMADURAS.
Datos básicos
- Código:
- RTC-2015-4185-1
- Protocolo:
- RTC-2015-4185-1
- EUDRACT:
- NCT:
- Centro:
- Dotación:
- 211.463,00 €
- Año de incio:
- 2015
- Año de finalización:
- 2019
Objetivos del proyecto
CONCEDIDO
Documentos
- No hay documentos
Participantes
Financiadores - Promotores
Resultados del Ensayo Clínico
Conductive polycaprolactone/gelatin/polyaniline nanofibres as functional scaffolds for cardiac tissue regeneration
Gil-Castell, O.; (...); Ribes-Greus, A.
Article. 10.1016/j.reactfunctpolym.2021.105064. 2022
A Fibrosis Biomarker Early Predicts Cardiotoxicity Due to Anthracycline-Based Breast Cancer Chemotherapy
de la Fuente, Ana; (...); Ravassa, Susana
Article. 10.3390/cancers14122941. 2022
Activation of mesenchymal stem cells migration and spreading is mediated by crosslink of HIF, NOTCH and SUMO pathways
Ciria, M.; (...); Sepulveda, P.
Meeting Abstract. 2016
Adipose tissue mesenchymal stem cell-derived extracellular vesicles as a biological therapy in osteoarthritic cells
Tofino-Vian, M; (...); Alcaraz, MJ
Meeting Abstract. 2019
Analysis of Exosome Transfer in Mammalian Cells by Fluorescence Recovery after Photobleaching
Gonzalez-King, H; (...); Sepulveda, P
Article. 10.21769/BioProtoc.2692. 2018
Anthracycline mediated cardiotoxicity: Detection of miRNA based early biomarkers for the prediction of myocardial injury. Hecatos study
Coloma, C. Salvador; (...); Santaballa, A.
Meeting Abstract. 10.1093/annonc/mdw365.69. 2016
ATR-FTIR spectroscopy for the routine quality control of exosome isolations
Ramos-Garcia, V; (...); Kuligowski, J
Article. 10.1016/j.chemolab.2021.104401. 2021
Atypical Presentation of a Marjolin Ulcer After a Burn: A Case Report.
Sánchez-García A; (...); Pérez-Del Caz MD
Article. 10.1097/PSN.0000000000000322. 2020
Balance of Active, Passive, and Anatomical Cardiac Properties in Doxorubicin-Induced Heart Failure.
Lewalle A; (...); Niederer SA
Article. 10.1016/j.bpj.2019.07.033. 2019
Bromelain-based enzymatic burn debridement: Spanish multidisciplinary consensus
Serracanta, Jordi; (...); Martin-Luengo, Ana
Article. 10.1007/s00238-022-01999-2. 2022
Candidemia in major burns patients
ANA ISABEL RENAU ESCRIG; (...); Pemán J
Article. 10.1111/myc.12488. 2016
Cardiomyocyte exosomes regulate glycolytic flux in endothelium by direct transfer of GLUT transporters and glycolytic enzymes
Garcia NA; (...); Diez-Juan A
Article. 10.1093/cvr/cvv260. 2016
Cardiopulmonary Rehabilitation Improves Respiratory Muscle Function and Functional Capacity in Children with Congenital Heart Disease. A Prospective Cohort Study
Ferrer-Sargues FJ; (...); Iranzo, MACI
Article. 10.3390/ijerph17124328. 2020
Circulating exosomes deliver free fatty acids from the bloodstream to cardiac cells: Possible role of CD36
Garcia, NA; (...); Sepulveda, P
Article. 10.1371/journal.pone.0217546. 2019
Co-administration of human MSC overexpressing HIF-1a increases human CD34(+) cell engraftment in vivo.
Preciado S; (...); Sánchez-Guijo F
Article. 10.1186/s13287-021-02669-z. 2021
Corrigendum to "Plasmatic Membrane Expression of Adhesion Molecules in Human Cardiac Progenitor/Stem Cells Might Explain Their Superior Cell Engraftment after Cell Transplantation".
Ontoria-Oviedo I; (...); Sepúlveda P
Correction. 10.1155/2022/9786160. 2022
Changes in human skin composition due to intrinsic aging: a histologic and morphometric study.
Arnal-Forne, Marta; (...); Ruiz-Sauri, Amparo
Article. 10.1007/s00418-024-02305-w. 2024
Characterisation of iPSCs from a patient with transposition of the great arteries
Ontoria-Oviedo, I; (...); Sepulveda, P
Meeting Abstract. 2017
Characterization of hiPSC-CMs derived from pediatric cancer patients treated with anthracyclines that suffered cardiotoxicity
Reinal, I.; (...); Sepulveda, P.
Meeting Abstract. 2021
Diagnostic preformance of mass spectometry metabolomics for assessment of early myocardial ischemia
Munoz, B. Igual; (...); Sepulveda-Sanchis, P. S. S.
Meeting Abstract. 2016
Early detection of chemotherapy-induced cardiotoxicity in breast cancer patients
Salvador-Coloma, C; (...); Santaballa, A
Meeting Abstract. 2018
EHTIC study: Evaluation of a new hemostatic agent based on tissue factor in skin grafting procedures
Rojas, Santiago; (...); EHTIC Study Investigators Grp
Article. 10.1016/j.burns.2017.01.007. 2017
Electrospun poly(hydroxybutyrate) scaffolds promote engraftment of human skin equivalents via macrophage M2 polarization and angiogenesis
Castellano, D; (...); Ontoria-Oviedo, I
Article. 10.1002/term.2420. 2018
Estudio comparativo de los cambios funcionales y estructurales producidos en un modelo porcino de infarto de miocardio agudo y cronico.
Hernándiz A; (...); Sepúlveda P
Article. 10.1016/j.acmx.2015.09.009. 2016
EVs derived from HIF-overexpressing MSC primed with a pro-inflammatory cocktail promote M2 macrophage polarization and reduce fibrosis and endothelium activation in vitro and in a mouse ulcerous colitis model.
Gomez-Ferrer, M.; (...); Sepulveda, P.
Meeting Abstract. 2021
Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Downregulate Senescence Features in Osteoarthritic Osteoblasts
Tofiño-Vian M; (...); Alcaraz, MJ
Article. 10.1155/2017/7197598. 2017
Extracellular vesicles from dental pulp mesenchymal stem cells modulate macrophage phenotype during acute and chronic cardiac inflammation in athymic nude rats with myocardial infarction.
Amaro-Prellezo, Elena; (...); Sepulveda, Pilar
Article. 10.1186/s41232-024-00340-7. 2024
Extracellular Vesicles Secreted by Hypoxic AC10 Cardiomyocytes Modulate Fibroblast Cell Motility.
Ontoria-Oviedo, I; (...); Sepulveda, P
Article. 10.3389/fcvm.2018.00152. 2018
Femoral insertion site of the graft used to replace the medial patellofemoral ligament influences the ligament dynamic changes during knee flexion and the clinical outcome (vol 25, pg 2443, 2017)
Sanchis-Alfonso, V; (...); Marti-Bonmati, L
Correction. 10.1007/s00167-018-5271-1. 2019
Genotype FBN1/Phenotype relationship in a cohort of patients with Marfan syndrome.
Hernándiz A; (...); Sepúlveda P
Article. 10.1111/cge.13879. 2020
Glucose Starvation in Cardiomyocytes Enhances Exosome Secretion and Promotes Angiogenesis in Endothelial Cells
Garcia NA; (...); Sepúlveda P
Article. 10.1371/journal.pone.0138849. 2015
HIF-1 alpha and Pro-Inflammatory Signaling Improves the Immunomodulatory Activity of MSC-Derived Extracellular Vesicles
Gomez-Ferrer, M; (...); Dorronsoro, A
Article. 10.3390/ijms22073416. 2021
HIF-Overexpression and Pro-Inflammatory Priming in Human Mesenchymal Stromal Cells Improves the Healing Properties of Extracellular Vesicles in Experimental Crohn's Disease.
Gómez-Ferrer M; (...); Sepúlveda P
Article. 10.3390/ijms222011269. 2021
Higher serum prealbumin levels are associated with higher graft take and wound healing in adult burn patients: A prospective observational trial.
Vanaclocha N; (...); Miranda Alonso FJ
Article. 10.1016/j.burns.2023.12.015. 2024
Histological Differentiation Provides Useful, Additive and Independent Prognostic Information to Proliferation Index in G2 and G3 Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs)
Canovas, MS; (...); Garcia-Carbonero, R
Meeting Abstract. 2017
Hydrogen Sulfide Improves Cardiomyocyte Function in a Cardiac Arrest Model
Garcia, NA; (...); Sepulveda, P
Article. 10.12659/AOT.901410. 2017
Hypoxia Inducible Factor-1 alpha Potentiates Jagged 1-Mediated Angiogenesis by Mesenchymal Stem Cell-Derived Exosomes
Gonzalez-King, H; (...); Sepulveda, P
Article. 10.1002/stem.2618. 2017
Identification of omega-3 oxylipins in human milk-derived extracellular vesicles with pro-resolutive actions in gastrointestinal inflammation.
Gómez-Ferrer M; (...); Sepúlveda P
Article. 10.3389/fimmu.2023.1293737. 2023
IFN gamma Regulates Activated V delta 2+T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells
Fechter, K; (...); Trigueros, C
Article. 10.1371/journal.pone.0169362. 2017
In vitro model of atrial fibrillation: investigating the initiation and maintenance mechanisms of atrial remodeling using hiPSC-derived atrial cardiomyocytes
Casini, M.; (...); Sepulveda, P.
Meeting Abstract. 2023
In vitro validation of biomedical polyester-based scaffolds: Poly(lactide-co-glycolide) as model-case
Gil-Castell, O; (...); Ribes-Greus, A
Article. 10.1016/j.polymertesting.2018.01.027. 2018
Increased femoral anteversion in females with anterior knee pain relates to both the neck and the shaft of the femur.
Sanchis-Alfonso V; (...); Doménech-Fernández J
Article. 10.1007/s00402-023-05036-0. 2023
Initial evaluation and management of the critical burn patient
Vivo, C, Galeiras, R, del Caz, MDP
Review. 10.1016/j.medin.2015.11.010. 2016
Instantaneous Specific Burn Debridement With an Enzymatic Debriding Agent: A New Resource for the Treatment of Burns.
Salmerón-González E; (...); Valverde-Navarro AA
Article. 10.1097/PSN.0000000000000250. 2019
Intracellular role of IL - 6 in mesenchymal stromal cell immunosuppression and proliferation
Dorronsoro, Akaitz; (...); Trigueros C
Article. 2020
Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation.
Dorronsoro, Akaitz; (...); Trigueros, Cesar
Article. 10.1038/s41598-020-78864-4. 2020
Isolation and Lipidomic Screening of Human Milk Extracellular Vesicles.
Ramos-Garcia, Victoria; (...); Kuligowski, Julia
Article. 10.1007/978-1-0716-2699-3_18. 2023
Isolation of extracellular vesicles derived from mesenchymal stem cells by ultracentrifugation and tangential flow filtration followed by size-exclusion chromatography: a functional comparison
Amaro-Prellezo, E.; (...); Sepulveda, P.
Meeting Abstract. 2021
Management of Hand Burn With Pedicled Converted Anterolateral Thigh Free Flap.
García-Sánchez JM; (...); Pérez Del Caz MD
Article. 10.1097/PSN.0000000000000254. 2019
Mesenchymal Stem Cell Migration and Proliferation Are Mediated by Hypoxia-Inducible Factor-1 alpha Upstream of Notch and SUMO Pathways
Ciria, M; (...); Sepulveda, P
Article. 10.1089/scd.2016.0331. 2017
Microvesicles from Human Adipose Tissue-Derived Mesenchymal Stem Cells as a New Protective Strategy in Osteoarthritic Chondrocytes
Tofino-Vian M; (...); Alcaraz MJ
Article. 10.1159/000489739. 2018
miR-4732-3p in Extracellular Vesicles From Mesenchymal Stromal Cells Is Cardioprotective During Myocardial Ischemia
Sánchez-Sánchez R; (...); Sepúlveda P
Article. 10.3389/fcell.2021.734143. 2021
miRNA-4732-3p as a possible therapeutic tool for the treatment of myocardial ischemia
Sanchez-Sanchez, R.; (...); Sepulveda, P.
Meeting Abstract. 2021
Modeling Cardiotoxicity in Pediatric Oncology Patients Using Patient-Specific iPSC-Derived Cardiomyocytes Reveals Downregulation of Cardioprotective microRNAs.
Reinal, Ignacio; (...); Sepulveda, Pilar
Article. 10.3390/antiox12071378. 2023
Modeling Transposition of the Great Arteries with Patient-Specific Induced Pluripotent Stem Cells.
Ontoria-Oviedo, Imelda; (...); Sepulveda, Pilar
Article. 10.3390/ijms222413270. 2021
Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds.
Verheijen, Marcha; (...); HeCaToS Consortium
Article. 10.1038/s41597-022-01825-1. 2022
Necessity of a human leukocyte antigen-B*58:01 screening test for preventing severe cutaneous adverse reactions
Sanchez-Garcia, A; (...); Perez-del-Caz, MD
Letter. 10.1097/FPC.0000000000000372. 2019
Non-classical Notch signaling by MDA-MB-231 breast cancer cell-derived small extracellular vesicles promotes malignancy in poorly invasive MCF-7 cells.
Gonzalez-King, Hernan; (...); Garcia, Nahuel A.
Article. 10.1038/s41417-021-00411-8. 2022
Normalization approaches for extracellular vesicle-derived lipidomic fingerprints - A human milk case study
Ten-Domenech, Isabel; (...); Kuligowski, Julia
Article. 10.1016/j.chemolab.2024.105070. 2024
Notch ligand Jagged 1 in MSC-HIF exosomes and its angiogenic potential
Gonzalez-King, H.; (...); Sepulveda, P.
Meeting Abstract. 2016
Oncostatin M-Enriched Small Extracellular Vesicles Derived from Mesenchymal Stem Cells Prevent Isoproterenol-Induced Fibrosis and Enhance Angiogenesis.
Tejedor, Sandra; (...); Sepulveda, Pilar
Article. 10.3390/ijms24076467. 2023
Optimization of Mesenchymal Stromal Cell (MSC) Manufacturing Processes for a Better Therapeutic Outcome
Fernandez-Santos, Maria Eugenia; (...); Zapata, Agustin G.
Article. 10.3389/fimmu.2022.918565. 2022
Over-Expression of HIF-1A In Mesenchymal Stromal Cells Increases Human CD34+Cells Clonogenic Capacity in Vitro And Engraftment Ability in A Xenotransplantation Model
Preciado, S; (...); Sanchez-Guijo, F
Meeting Abstract. 2021
Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells
Martinez, VG; (...); Vicente, A
Article. 10.1186/s13287-017-0659-2. 2017
Oxylipin profile of human milk and human milk-derived extracellular vesicles.
Albiach-Delgado, Abel; (...); Quintas, Guillermo
Article. 10.1016/j.aca.2024.342759. 2024
Paracrine Anti-inflammatory Effects of Adipose Tissue-Derived Mesenchymal Stem Cells in Human Monocytes
Guillen, MI; (...); Alcaraz, MJ
Article. 10.3389/fphys.2018.00661. 2018
Paracrine effects of human adipose-derived mesenchymal stem cells in inflammatory stress-induced senescence features of osteoarthritic chondrocytes
Platas J; (...); Alcaraz MJ
Article. 10.18632/aging.101007. 2016
Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice.
Lerida-Viso, Araceli; (...); Martinez-Manez, Ramon
Article. 10.1016/j.phrs.2022.106356. 2022
Plasmatic Membrane Expression of Adhesion Molecules in Human Cardiac Progenitor/Stem Cells Might Explain Their Superior Cell Engraftment after Cell Transplantation.
Ontoria-Oviedo I; (...); Sepúlveda P
Article. 10.1155/2020/8872009. 2020
Platelet rich plasma and plasma rich in growth factors for split-thickness skin graft donor site treatment in the burn patient setting: A randomized clinical trial.
García-Sánchez JM; (...); Pérez-Del-Caz MD
Article. 10.1016/j.burns.2021.10.001. 2021
Podocalyxin-like protein 1 is a relevant marker for human c-kit(pos) cardiac stem cells
Moscoso I; (...); Bernad A
Article. 10.1002/term.1795. 2016
Polycaprolactone/gelatin-based scaffolds with tailored performance: in vitro and in vivo validation
Gil-Castell, O; (...); Ribes-Greus, A
Article. 10.1016/j.msec.2019.110296. 2020
Polymer Conjugation of Docosahexaenoic Acid Potentiates Cardioprotective Therapy in Preclinical Models of Myocardial Ischemia/Reperfusion Injury.
Tejedor S; (...); Vicent MJ
Article. 10.1002/adhm.202002121. 2021
Polypeptide-corticosteroid conjugates as a topical treatment approach to psoriasis.
Dolz-Pérez I; (...); Vicent MJ
Article. 10.1016/j.jconrel.2019.12.016. 2020
Potency of Human Cardiosphere-Derived Cells from Patients with Ischemic Heart Disease Is Associated with Robust Vascular Supportive Ability
Harvey, E; (...); Martin-Rendon, E
Article. 10.1002/sctm.16-0229. 2017
Priorities in Cardio-Oncology Basic and Translational Science: GCOS 2023 Symposium Proceedings: JACC: CardioOncology State-of-the-Art Review.
Salloum FN; (...); López-Fernández T
Article. 10.1016/j.jaccao.2023.08.003. 2023
Prognostic Significance of Venous Thromboembolic Events in Disseminated Germ Cell Cancer Patients
Gonzalez-Billalabeitia, E; (...); Spanish Germ Cell Cancer Group
Article. 10.1093/jnci/djw265. 2017
Prognostic value and clinical predictors of intramyocardial hemorrhage measured by CMR T2* sequences in STEMI.
Ferré-Vallverdú M; (...); Igual-Muñoz B
Article. 10.1007/s10554-020-02142-7. 2021
Reliable assessment of carbon black nanomaterial of a variety of cell culture media for in vitro toxicity assays by asymmetrical flow field-flow fractionation.
Boughbina-Portoles, Aaron; (...); Campins-Falco, Pilar
Article. 10.1007/s00216-023-04597-8. 2023
Subtype-specific differentiation of atrial and ventricular cardiomyocytes from human iPSCs
Casini, M.; (...); Sepulveda, P.
Meeting Abstract. 2021
Targeted Disruption of the SUCNR1 Metabolic Receptor Leads to Dichotomous Effects on Obesity
McCreath KJ; (...); Cervera AM
Article. 10.2337/db14-0346. 2015
Technical detail for the care of a large burned patient with an abdominal coverage defect and prosthetic mesh exposure
Garcia-Vilarino, E; (...); del Caz, MDP
Article. 2019
The combination of cell and gene therapy as new generation tool to boost MSCs immunosuppressive and tissue regeneration properties
Dorronsoro, A; (...); Sepulveda, P
Meeting Abstract. 2017
The Vascular Niche for Adult Cardiac Progenitor Cells.
Herrero, Diego; (...); Bernad, Antonio
Article. 10.3390/antiox11050882. 2022
Topical Administration of a Marine Oil Rich in Pro-Resolving Lipid Mediators Accelerates Wound Healing in Diabetic db/db Mice through Angiogenesis and Macrophage Polarization.
Ontoria-Oviedo, Imelda; (...); Sepulveda, Pilar
Article. 10.3390/ijms23179918. 2022
TOWARDS EXTRACELLULAR VESICLE THERAPEUTICS: ANNEXIN-A1 AS A POTENTIAL CHONDROPROTECTIVE MICROVESICLE EFFECTOR IN OSTEOARTHRITIS
Tofino-Vian, M; (...); Alcaraz, MJ
Meeting Abstract. 2018
Two-component Peptidic Molecular Gels for Topical Drug Delivery of Naproxen
Martí-Centelles, Rosa; (...); Escuder, Beatriu
Article. 10.1021/acsabm.0c01422. 2021
Use of Amniotic Membrane as a Biological Dressing for the Treatment of Torpid Venous Ulcers: A Case Report.
Alonso-Carpio M; (...); Pérez-Del Caz MD
Article. 10.1097/PSN.0000000000000313. 2020
Use of an electrospun bioveil is safe and does not decrease skin graft take on burn wounds: A randomised, controlled clinical trial.
Perez-Del-Caz, Maria Dolores; (...); Perez-Plaza, Aranzazu
Article. 10.1016/j.burns.2025.107427. 2025
Use of the Meek Micrografting Technique for Coverage of Extensive Burns: A Case Report.
Sánchez-García A; (...); Pérez-Del Caz MD
Article. 10.1097/PSN.0000000000000262. 2019