Portal de investigación
DESARROLLO Y VALIDACIÓN DE UN MODELO DE ISQUEMIA MIOCÁRDICA PRECOZ MEDIANTE ESPECTROMETRÍA DE MASAS.
Datos básicos
- Protocolo:
- APM-39/15
- EUDRACT:
- NCT:
- Centro:
- Año de incio:
- 2015
- Año de finalización:
- 2015
Objetivos del proyecto
CONCEDIDO
Documentos
- No hay documentos
Participantes
Resultados del Ensayo Clínico
Conductive polycaprolactone/gelatin/polyaniline nanofibres as functional scaffolds for cardiac tissue regeneration
Gil-Castell, O.; (...); Ribes-Greus, A.
Article. 10.1016/j.reactfunctpolym.2021.105064. 2022
A Fibrosis Biomarker Early Predicts Cardiotoxicity Due to Anthracycline-Based Breast Cancer Chemotherapy
de la Fuente, Ana; (...); Ravassa, Susana
Article. 10.3390/cancers14122941. 2022
Activation of mesenchymal stem cells migration and spreading is mediated by crosslink of HIF, NOTCH and SUMO pathways
Ciria, M.; (...); Sepulveda, P.
Meeting Abstract. 2016
Analysis of Exosome Transfer in Mammalian Cells by Fluorescence Recovery after Photobleaching
Gonzalez-King, H; (...); Sepulveda, P
Article. 10.21769/BioProtoc.2692. 2018
Anthracycline mediated cardiotoxicity: Detection of miRNA based early biomarkers for the prediction of myocardial injury. Hecatos study
Coloma, C. Salvador; (...); Santaballa, A.
Meeting Abstract. 10.1093/annonc/mdw365.69. 2016
Aortic arch dilation in bicuspid aortic valve disease: Predictive factors and medium-term follow-up
Berbel, A; (...); Montero, JA
Article. 10.1016/j.circv.2016.11.056. 2017
Assessment of late cardiomyopathy by magnetic resonance imaging in patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and idarubicin
Rodriguez-Veiga, R; (...); spanish PETHEMA group
Article. 10.1007/s00277-017-3004-z. 2017
ATR-FTIR spectroscopy for the routine quality control of exosome isolations
Ramos-Garcia, V; (...); Kuligowski, J
Article. 10.1016/j.chemolab.2021.104401. 2021
Atypical presentation of a giant atrial myxoma
Dominguez-Massa, C, Bel-Minguez, AM, Montero-Argudo, JA
Article. 10.1016/j.circv.2017.07.003. 2018
Balance of Active, Passive, and Anatomical Cardiac Properties in Doxorubicin-Induced Heart Failure.
Lewalle A; (...); Niederer SA
Article. 10.1016/j.bpj.2019.07.033. 2019
Cardiomyocyte exosomes regulate glycolytic flux in endothelium by direct transfer of GLUT transporters and glycolytic enzymes
Garcia NA; (...); Diez-Juan A
Article. 10.1093/cvr/cvv260. 2016
Cardiopulmonary Rehabilitation Improves Respiratory Muscle Function and Functional Capacity in Children with Congenital Heart Disease. A Prospective Cohort Study
Ferrer-Sargues FJ; (...); Iranzo, MACI
Article. 10.3390/ijerph17124328. 2020
CFD analysis of the HVAD's hemodynamic performance and blood damage with insight into gap clearance
Gil A; (...); Montero JA
Article. 10.1007/s10237-022-01585-2. 2022
Circulating exosomes deliver free fatty acids from the bloodstream to cardiac cells: Possible role of CD36
Garcia, NA; (...); Sepulveda, P
Article. 10.1371/journal.pone.0217546. 2019
Co-administration of human MSC overexpressing HIF-1a increases human CD34(+) cell engraftment in vivo.
Preciado S; (...); Sánchez-Guijo F
Article. 10.1186/s13287-021-02669-z. 2021
Corrigendum to "Plasmatic Membrane Expression of Adhesion Molecules in Human Cardiac Progenitor/Stem Cells Might Explain Their Superior Cell Engraftment after Cell Transplantation".
Ontoria-Oviedo I; (...); Sepúlveda P
Correction. 10.1155/2022/9786160. 2022
Changes in human skin composition due to intrinsic aging: a histologic and morphometric study.
Arnal-Forne, Marta; (...); Ruiz-Sauri, Amparo
Article. 10.1007/s00418-024-02305-w. 2024
Characterisation of iPSCs from a patient with transposition of the great arteries
Ontoria-Oviedo, I; (...); Sepulveda, P
Meeting Abstract. 2017
Characterization of hiPSC-CMs derived from pediatric cancer patients treated with anthracyclines that suffered cardiotoxicity
Reinal, I.; (...); Sepulveda, P.
Meeting Abstract. 2021
Diagnostic preformance of mass spectometry metabolomics for assessment of early myocardial ischemia
Munoz, B. Igual; (...); Sepulveda-Sanchis, P. S. S.
Meeting Abstract. 2016
Dissected aberrant right subclavian artery with Kommerell diverticulum.
Domínguez-Massa C; (...); Montero-Argudo JA
Article. 10.1016/j.repc.2017.07.023. 2019
Early detection of chemotherapy-induced cardiotoxicity in breast cancer patients
Salvador-Coloma, C; (...); Santaballa, A
Meeting Abstract. 2018
Electrospun poly(hydroxybutyrate) scaffolds promote engraftment of human skin equivalents via macrophage M2 polarization and angiogenesis
Castellano, D; (...); Ontoria-Oviedo, I
Article. 10.1002/term.2420. 2018
Estudio comparativo de los cambios funcionales y estructurales producidos en un modelo porcino de infarto de miocardio agudo y cronico.
Hernándiz A; (...); Sepúlveda P
Article. 10.1016/j.acmx.2015.09.009. 2016
EVs derived from HIF-overexpressing MSC primed with a pro-inflammatory cocktail promote M2 macrophage polarization and reduce fibrosis and endothelium activation in vitro and in a mouse ulcerous colitis model.
Gomez-Ferrer, M.; (...); Sepulveda, P.
Meeting Abstract. 2021
Extracellular vesicles from dental pulp mesenchymal stem cells modulate macrophage phenotype during acute and chronic cardiac inflammation in athymic nude rats with myocardial infarction.
Amaro-Prellezo, Elena; (...); Sepulveda, Pilar
Article. 10.1186/s41232-024-00340-7. 2024
Extracellular Vesicles Secreted by Hypoxic AC10 Cardiomyocytes Modulate Fibroblast Cell Motility.
Ontoria-Oviedo, I; (...); Sepulveda, P
Article. 10.3389/fcvm.2018.00152. 2018
Extrathoracic Aneurysms in Marfan Syndrome: A Systematic Review of the Literature.
Requejo-Garcia, Lucia; (...); Miralles-Hernandez, Manuel
Article. 10.1016/j.avsg.2022.08.005. 2022
Genotype FBN1/Phenotype relationship in a cohort of patients with Marfan syndrome.
Hernándiz A; (...); Sepúlveda P
Article. 10.1111/cge.13879. 2020
Giant Circumflex Aneurysm with Arteriovenous Fistula Surgery Guided by Three-dimensional Printing.
Blanco-Herrera OR; (...); Montero-Argudo JA
Editorial Material. 10.1016/j.athoracsur.2019.11.051. 2020
Glucose Starvation in Cardiomyocytes Enhances Exosome Secretion and Promotes Angiogenesis in Endothelial Cells
Garcia NA; (...); Sepúlveda P
Article. 10.1371/journal.pone.0138849. 2015
HIF-1 alpha and Pro-Inflammatory Signaling Improves the Immunomodulatory Activity of MSC-Derived Extracellular Vesicles
Gomez-Ferrer, M; (...); Dorronsoro, A
Article. 10.3390/ijms22073416. 2021
HIF-Overexpression and Pro-Inflammatory Priming in Human Mesenchymal Stromal Cells Improves the Healing Properties of Extracellular Vesicles in Experimental Crohn's Disease.
Gómez-Ferrer M; (...); Sepúlveda P
Article. 10.3390/ijms222011269. 2021
Hydrogen Sulfide Improves Cardiomyocyte Function in a Cardiac Arrest Model
Garcia, NA; (...); Sepulveda, P
Article. 10.12659/AOT.901410. 2017
Hypoxia Inducible Factor-1 alpha Potentiates Jagged 1-Mediated Angiogenesis by Mesenchymal Stem Cell-Derived Exosomes
Gonzalez-King, H; (...); Sepulveda, P
Article. 10.1002/stem.2618. 2017
Identification of omega-3 oxylipins in human milk-derived extracellular vesicles with pro-resolutive actions in gastrointestinal inflammation.
Gómez-Ferrer M; (...); Sepúlveda P
Article. 10.3389/fimmu.2023.1293737. 2023
IFN gamma Regulates Activated V delta 2+T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells
Fechter, K; (...); Trigueros, C
Article. 10.1371/journal.pone.0169362. 2017
In vitro model of atrial fibrillation: investigating the initiation and maintenance mechanisms of atrial remodeling using hiPSC-derived atrial cardiomyocytes
Casini, M.; (...); Sepulveda, P.
Meeting Abstract. 2023
In vitro validation of biomedical polyester-based scaffolds: Poly(lactide-co-glycolide) as model-case
Gil-Castell, O; (...); Ribes-Greus, A
Article. 10.1016/j.polymertesting.2018.01.027. 2018
Incidence of Development of Obesity After Heart Transplantation According to the Calcineurin Inhibitor
López-Vilella R; (...); Montero-Argudo A
Article. 10.1016/j.transproceed.2014.11.025. 2015
Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans - joint RENEB and EURADOS inter-laboratory comparisons
Ainsbury, E; (...); Woda, C
Article. 10.1080/09553002.2016.1206233. 2017
Intracellular role of IL - 6 in mesenchymal stromal cell immunosuppression and proliferation
Dorronsoro, Akaitz; (...); Trigueros C
Article. 2020
Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation.
Dorronsoro, Akaitz; (...); Trigueros, Cesar
Article. 10.1038/s41598-020-78864-4. 2020
Involvement of the-420C > G RETN polymorphism in myocardial fibrosis in patients with hypertrophic cardiomyopathy
Hernández-Romero D; (...); Marín F
Article. 10.1111/joim.12334. 2015
Isolation and Lipidomic Screening of Human Milk Extracellular Vesicles.
Ramos-Garcia, Victoria; (...); Kuligowski, Julia
Article. 10.1007/978-1-0716-2699-3_18. 2023
Isolation of extracellular vesicles derived from mesenchymal stem cells by ultracentrifugation and tangential flow filtration followed by size-exclusion chromatography: a functional comparison
Amaro-Prellezo, E.; (...); Sepulveda, P.
Meeting Abstract. 2021
Mesenchymal Stem Cell Migration and Proliferation Are Mediated by Hypoxia-Inducible Factor-1 alpha Upstream of Notch and SUMO Pathways
Ciria, M; (...); Sepulveda, P
Article. 10.1089/scd.2016.0331. 2017
miR-4732-3p in Extracellular Vesicles From Mesenchymal Stromal Cells Is Cardioprotective During Myocardial Ischemia
Sánchez-Sánchez R; (...); Sepúlveda P
Article. 10.3389/fcell.2021.734143. 2021
miRNA-4732-3p as a possible therapeutic tool for the treatment of myocardial ischemia
Sanchez-Sanchez, R.; (...); Sepulveda, P.
Meeting Abstract. 2021
Mitral repair results in endocarditis
Dominguez-Massa, C; (...); Montero-Argudo, JA
Article. 10.1016/j.circv.2020.08.005. 2020
Modeling Cardiotoxicity in Pediatric Oncology Patients Using Patient-Specific iPSC-Derived Cardiomyocytes Reveals Downregulation of Cardioprotective microRNAs.
Reinal, Ignacio; (...); Sepulveda, Pilar
Article. 10.3390/antiox12071378. 2023
Modeling Transposition of the Great Arteries with Patient-Specific Induced Pluripotent Stem Cells.
Ontoria-Oviedo, Imelda; (...); Sepulveda, Pilar
Article. 10.3390/ijms222413270. 2021
Mortality risk score in aortic surgery. Initial experience with the implementation of a new predictive model
Berbel, A; (...); Montero, JA
Article. 10.1016/j.circv.2014.10.009. 2015
Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds.
Verheijen, Marcha; (...); HeCaToS Consortium
Article. 10.1038/s41597-022-01825-1. 2022
New Cell Adhesion Molecules in Human Ischemic Cardiomyopathy. PCDHGA3 Implications in Decreased Stroke Volume and Ventricular Dysfunction
Ortega, Ana; (...); Rosello-Lleti, Esther
Article. 10.1371/journal.pone.0160168. 2016
Non-classical Notch signaling by MDA-MB-231 breast cancer cell-derived small extracellular vesicles promotes malignancy in poorly invasive MCF-7 cells.
Gonzalez-King, Hernan; (...); Garcia, Nahuel A.
Article. 10.1038/s41417-021-00411-8. 2022
Normalization approaches for extracellular vesicle-derived lipidomic fingerprints - A human milk case study
Ten-Domenech, Isabel; (...); Kuligowski, Julia
Article. 10.1016/j.chemolab.2024.105070. 2024
Notch ligand Jagged 1 in MSC-HIF exosomes and its angiogenic potential
Gonzalez-King, H.; (...); Sepulveda, P.
Meeting Abstract. 2016
Oncostatin M-Enriched Small Extracellular Vesicles Derived from Mesenchymal Stem Cells Prevent Isoproterenol-Induced Fibrosis and Enhance Angiogenesis.
Tejedor, Sandra; (...); Sepulveda, Pilar
Article. 10.3390/ijms24076467. 2023
Optimization of Mesenchymal Stromal Cell (MSC) Manufacturing Processes for a Better Therapeutic Outcome
Fernandez-Santos, Maria Eugenia; (...); Zapata, Agustin G.
Article. 10.3389/fimmu.2022.918565. 2022
Over-Expression of HIF-1A In Mesenchymal Stromal Cells Increases Human CD34+Cells Clonogenic Capacity in Vitro And Engraftment Ability in A Xenotransplantation Model
Preciado, S; (...); Sanchez-Guijo, F
Meeting Abstract. 2021
Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells
Martinez, VG; (...); Vicente, A
Article. 10.1186/s13287-017-0659-2. 2017
Oxylipin profile of human milk and human milk-derived extracellular vesicles.
Albiach-Delgado, Abel; (...); Quintas, Guillermo
Article. 10.1016/j.aca.2024.342759. 2024
Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice.
Lerida-Viso, Araceli; (...); Martinez-Manez, Ramon
Article. 10.1016/j.phrs.2022.106356. 2022
Plasmatic Membrane Expression of Adhesion Molecules in Human Cardiac Progenitor/Stem Cells Might Explain Their Superior Cell Engraftment after Cell Transplantation.
Ontoria-Oviedo I; (...); Sepúlveda P
Article. 10.1155/2020/8872009. 2020
Platelet rich plasma and plasma rich in growth factors for split-thickness skin graft donor site treatment in the burn patient setting: A randomized clinical trial.
García-Sánchez JM; (...); Pérez-Del-Caz MD
Article. 10.1016/j.burns.2021.10.001. 2021
Podocalyxin-like protein 1 is a relevant marker for human c-kit(pos) cardiac stem cells
Moscoso I; (...); Bernad A
Article. 10.1002/term.1795. 2016
Polycaprolactone/gelatin-based scaffolds with tailored performance: in vitro and in vivo validation
Gil-Castell, O; (...); Ribes-Greus, A
Article. 10.1016/j.msec.2019.110296. 2020
Polymer Conjugation of Docosahexaenoic Acid Potentiates Cardioprotective Therapy in Preclinical Models of Myocardial Ischemia/Reperfusion Injury.
Tejedor S; (...); Vicent MJ
Article. 10.1002/adhm.202002121. 2021
Postoperative prognostic impact of replacement fibrosis in patients with aortic valve stenosis
Munoz, BI; (...); Serrano, RP
Meeting Abstract. 2020
Potency of Human Cardiosphere-Derived Cells from Patients with Ischemic Heart Disease Is Associated with Robust Vascular Supportive Ability
Harvey, E; (...); Martin-Rendon, E
Article. 10.1002/sctm.16-0229. 2017
Priorities in Cardio-Oncology Basic and Translational Science: GCOS 2023 Symposium Proceedings: JACC: CardioOncology State-of-the-Art Review.
Salloum FN; (...); López-Fernández T
Article. 10.1016/j.jaccao.2023.08.003. 2023
Prognostic value and clinical predictors of intramyocardial hemorrhage measured by CMR T2* sequences in STEMI.
Ferré-Vallverdú M; (...); Igual-Muñoz B
Article. 10.1007/s10554-020-02142-7. 2021
Reliable assessment of carbon black nanomaterial of a variety of cell culture media for in vitro toxicity assays by asymmetrical flow field-flow fractionation.
Boughbina-Portoles, Aaron; (...); Campins-Falco, Pilar
Article. 10.1007/s00216-023-04597-8. 2023
SERCA2a as non-invasive biomarker of heart transplant rejection
Rosello-Lleti, EE; (...); Rivera, M
Meeting Abstract. 2017
Short-term mechanical circulatory support
Bertolin, LD, Puerta, ST, Argudo, JAM
Article. 10.1016/j.circv.2016.06.007. 2016
Subtype-specific differentiation of atrial and ventricular cardiomyocytes from human iPSCs
Casini, M.; (...); Sepulveda, P.
Meeting Abstract. 2021
Takeuchi technique in the anomalous origin of the left coronary artery from the pulmonary artery.
Domínguez-Massa C; (...); Hornero-Sos F
Article. 10.24875/ACME.M19000044. 2019
Targeted Disruption of the SUCNR1 Metabolic Receptor Leads to Dichotomous Effects on Obesity
McCreath KJ; (...); Cervera AM
Article. 10.2337/db14-0346. 2015
Tecnica de Takeuchi en el origen anmalo de la arteria coronaria izquierda de la arteria pulmonar.
Domínguez-Massa C; (...); Hornero-Sos F
Article. 10.24875/ACM.M19000033. 2019
The combination of cell and gene therapy as new generation tool to boost MSCs immunosuppressive and tissue regeneration properties
Dorronsoro, A; (...); Sepulveda, P
Meeting Abstract. 2017
The morphology and primary lesion of the bicuspid aortic valve determines the aortic disease pattern
Hernandez, CE; (...); Montero, JA
Article. 10.1016/j.circv.2011.11.002. 2015
The Vascular Niche for Adult Cardiac Progenitor Cells.
Herrero, Diego; (...); Bernad, Antonio
Article. 10.3390/antiox11050882. 2022
Topical Administration of a Marine Oil Rich in Pro-Resolving Lipid Mediators Accelerates Wound Healing in Diabetic db/db Mice through Angiogenesis and Macrophage Polarization.
Ontoria-Oviedo, Imelda; (...); Sepulveda, Pilar
Article. 10.3390/ijms23179918. 2022
Treatment of Hepatic Embryonal Undifferentiated Sarcoma With Cardiothoracic Involvement.
Domínguez-Massa C; (...); Montero-Argudo JA
Article. 10.1177/2150135118775411. 2020
TWEAK and NT-proBNP levels predict exercise capacity in hypertrophic cardiomyopathy
Hernández-Romero D; (...); Marín F
Article. 10.1111/eci.12394. 2015
Two-component Peptidic Molecular Gels for Topical Drug Delivery of Naproxen
Martí-Centelles, Rosa; (...); Escuder, Beatriu
Article. 10.1021/acsabm.0c01422. 2021
Use of an electrospun bioveil is safe and does not decrease skin graft take on burn wounds: A randomised, controlled clinical trial.
Perez-Del-Caz, Maria Dolores; (...); Perez-Plaza, Aranzazu
Article. 10.1016/j.burns.2025.107427. 2025