Redox Status in Retinitis Pigmentosa.

Fecha de publicación: 01/01/2023

Autores de IIS La Fe

Lorena Olivares González

Autor
Sheyla Velasco Gomariz

Autor
José María Millán Salvador

Autor
Regina Rodrigo Nicolás

Autor

Participantes ajenos a IIS La Fe

Campillo I

Grupos

Biomedicina Molecular, Celular y Genómica

Leader

José María Millán Salvador
Unidad mixta de investigación en enfermedades raras (CIPF)

Leader

José María Millán Salvador

Abstract

Retinitis pigmentosa (RP) is the most common form of inherited retinal dystrophy characterized by the progressive loss of vision. It is a rare disease. Despite being a genetic disease, its progression is influenced by oxidative damage and chemokines and cytokines released by the activated immune cells (e.g., macrophages or microglia). The role of oxidative stress is very important in the retina. Rods are the main consumers of oxygen (O(2)), so they are constantly exposed to oxidative stress and lipid peroxidation. According to the oxidative hypothesis, after rod death in the early stages of the disease, O(2) would accumulate in large quantities in the retina, producing hyperoxia and favoring the accumulation of reactive oxygen species and reactive nitrogen species that would cause oxidative damage to lipids, proteins, and DNA, exacerbating the process of retinal degeneration. Evidence shows alterations in the antioxidant-oxidant state in patients and in animal models of RP. In recent years, therapeutic approaches aimed at reducing oxidative stress have emerged as useful therapies to slow down the progression of RP. We focus this review on oxidative stress and its relationship with the progression of RP.

Datos de la publicación

ISSN/ISSNe:: 0065-2598, 2214-8019
Tipo:: Article
Páginas:: 443-448
DOI:: 10.1007/978-3-031-27681-1_65
Factor de Impacto:: 0,398 SCImago ℠
Cuartil:: Q3 SCImago ℠

Documentos

No hay documentos

Métricas

Filiaciones

Olivares-González L:: Pathophysiology and Therapies for Vision Disorders, Principe Felipe Research Center (CIPF), Valencia, Spain

Instituto de Investigación. Joint Unit on Rare Diseases CIPF-La Fe, Valencia, Spain
Velasco S:: Pathophysiology and Therapies for Vision Disorders, Principe Felipe Research Center (CIPF), Valencia, Spain

Instituto de Investigación. Joint Unit on Rare Diseases CIPF-La Fe, Valencia, Spain
Campillo I:: Pathophysiology and Therapies for Vision Disorders, Principe Felipe Research Center (CIPF), Valencia, Spain

Instituto de Investigación. Joint Unit on Rare Diseases CIPF-La Fe, Valencia, Spain
Millán JM:: Instituto de Investigación. Joint Unit on Rare Diseases CIPF-La Fe, Valencia, Spain

Rare Diseases Networking Biomedical Research Centre (CIBERER), Madrid, Spain

Instituto de Investigación. Molecular, Cellular and Genomic Biomedicine, Health Research Institute La Fe, Valencia, Spain
Rodrigo R:: Pathophysiology and Therapies for Vision Disorders, Principe Felipe Research Center (CIPF), Valencia, Spain

Instituto de Investigación. Joint Unit on Rare Diseases CIPF-La Fe, Valencia, Spain

Rare Diseases Networking Biomedical Research Centre (CIBERER), Madrid, Spain

Keywords

Antioxidant response; Cell death; Hyperoxia; Inflammation; Oxidative damage; Retinitis pigmentosa

Proyectos asociados

CARACTERIZACION MOLECULAR DE PACIENTES CON SINDROME DE USHER. ESTUDIO DE LOS GENES RESPONSABLES: CDH23 Y PCDH15 Y CANDIDATOS: WHRN, CXADR Y PDZK7

Investigador Principal: JOSÉ MARÍA MILLÁN SALVADOR

PI07/0558 . INSTITUTO DE SALUD CARLOS III; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2008

MOLECULAR MAECHANISMS OF RETINAL DEGENERATION IN HUMANS WITH RETINITIS PIGMENTOSA. ROLE OF INFLAMMATION, OXIDATIVE STRESS AND GLIAL ACTIVATION

CP09/00118 (MIGUEL SERVET) . INSTITUTO DE SALUD CARLOS III; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2010

RED DE BIOBANCOS (BIOBANCOS)

RD09/0076/00021 . INSTITUTO DE SALUD CARLOS III; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2010

CARACTERIZACION MOLECULAR EN PACIENTES CON SINDROME DE USHER TIPO I MEDIANTE LA APLICACION DE LAS TECNICAS DE SECUENCIACION Y CGH-ARRAY EN GENES RESPONSABLES Y GENES CANDIDATOS

FPU_AP2009-3344 . MINISTERIO DE EDUCACION, CULTURA Y DEPORTE; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2010