Associations between Non-Essential Trace Elements in Women's Biofluids and IVF Outcomes in Euploid Single-Embryo Transfer Cycles.

Fecha de publicación: 08/08/2024

Autores de IIS La Fe

• Roberto González Martín

  Autor

• Andrea Palomar Rios

  Autor

• Stefania Salsano

  Autor

• Alicia Quiñonero Villora

  Autor

• Juan Manuel Gilés Jiménez

  Autor

• María Del Carmen Vidal Martínez

  Autor

• José Bellver Pradas

  Autor

• Francisco Domínguez Hernández

  Autor

Participantes ajenos a IIS La Fe

• Perez-Deben, Silvia
• Caracena, Laura
• Rucandio, Isabel
• Fernandez-Saavedra, Rocio
• Fernandez-Martinez, Rodolfo
• Conde-Vilda, Estefania
• Quejido, Alberto J

Grupos

• Biología Reproductiva y Bioingeniería en Reproducción Humana

  

  Leader

  Nicolás Garrido Puchalt

• Endocrinología Reproductiva e Infertilidad

  Leader

  José Remohí Giménez

Abstract

Previous studies have found inconsistent associations between heavy metals and metalloids (cadmium, lead, mercury, and arsenic), and reproductive outcomes. The biofluid concentrations of ten non-essential trace elements (Hg, Pb, As, Ba, Sr, Rb, Cs, Sn, Ni, and Co) were evaluated in 51 Spanish women undergoing ICSI, PGT-A, and SET/FET. Nine out of ten non-essential elements were detectable in follicular fluid, whole blood, and urine collected the day of vaginal oocyte retrieval (VOR) and the day of embryo transfer and then analyzed by ICP-MS or Tricell DMA-80 for mercury. Elevated mercury and strontium concentrations in follicular fluid were associated with poor ovarian response and preimplantation outcomes. Worst preimplantation outcomes were also identified in women with elevated whole-blood strontium or mercury, urinary arsenic, barium, and tin the day of VOR. High concentrations of urinary rubidium on VOR day were linked with enhanced fertilization and blastocyst development. Excessive titanium in whole blood was associated with lower odds of implantation, clinical pregnancy, and achieving a live birth in a given IVF cycle. Excessive urinary arsenic on the day of embryo transfer was associated with lower odds of live birth. Although these preliminary results need to be confirmed in larger populations, distinguishing organic and inorganic element forms, our findings show that some non-essential elements have a detrimental impact on human IVF outcomes.