Portal de recerca
Estudio transcriptómico y secretómico de embriones euploides y aneuploides desde etapas preimplantacionales hasta etapas postimplantacionales tempranas. . AICO. Francisco Domínguez y Patricia Díaz
Dades bàsiques
- Protocol:
- CIAICO/2022/203
- EURDRACT:
- NCT:
- Centre:
- Any inici:
- 2023
- Any de finalització:
- 2025
Documents
- No hi ha documents
Participants
Grups d'Investigació
Finançadors - Promotors
Resultats de l'Assaig Clínic
3D In Vitro Modelling of Embryo-Endometrial Interface Unravels Entosis Role on Cell-in-Cell Invasion During Human Embryo Implantation.
Palomar, Andrea; (...); Dominguez, Francisco
Meeting Abstract. 2024
A 12-h Difference in Exogenous Progesterone Initiation Does Not Have an Impact on Ongoing Pregnancy Rates in Artificial Cycles, as Long as Luteal Phase Support Starts Five Days Before Blastocyst Transfer.
Rodríguez-Varela C; (...); Labarta E
Article. 10.1007/s43032-024-01759-6. 2024
A gene expression risk signature of endometrial failure for prognosis in In Vitro Fertilization (IVF) patients
Diaz-Gimeno, P.; (...); Pellicer, A.
Meeting Abstract. 2023
A retrospective analysis shows a high effect in reproductive outcomes as age increases associated to endometrial factor in IVF advanced maternal age (AMA) patients
Sebastian-Leon, P.; (...); Diaz-Gimeno, P.
Meeting Abstract. https://doi.org/10.1093/humrep/deae108.751. 2024
Age-related uterine changes and its association with poor reproductive outcomes: a systematic review and meta-analysis
Marti-Garcia, Diana; (...); Diaz-Gimeno, Patricia
Review. 10.1186/s12958-024-01323-6. 2024
Altered endometrial receptivity: walking across the long path of precision medicine.
Diaz-Gimeno, Patricia, Sebastian-Leon, Patricia, Pellicer, Antonio
Letter. 10.1016/j.fertnstert.2024.06.010. 2024
Antioxidant Supplementation Alleviates Mercury-Induced Cytotoxicity and Restores the Implantation-Related Functions of Primary Human Endometrial Cells.
Palomar, Andrea; (...); Dominguez, Francisco
Article. 10.3390/ijms24108799. 2023
Antioxidant Treatment Revert Mercury-Induced Damage in an In Vitro Human Primary Stromal Cells (hEnSC) Invasion Model
Palomar Rios, Andrea; (...); Dominguez, Francisco
Meeting Abstract. 2023
ASSESSING PRE- AND POST-INTRACYTOPLASMIC SPERM INJECTION (ICSI) OOCYTE IMAGES WITH ARTIFICIAL INTELLIGENCE (AI): PREDICTING FERTILIZATION AND BLASTOCYST DEVELOPMENT.
Murria, Lucia; (...); Meseguer, Marcos
Meeting Abstract. 10.1016/j.fertnstert.2024.07.552. 2024
Assessment of Decidualization and Oxidative Stress in Primary Human Endometrial Stromal Cells (hEnSC) After Mercury-Induced Damage
Palomar Rios, Andrea; (...); Dominguez, Francisco
Meeting Abstract. 2023
Association of blood cadmium and lead levels with self-reported reproductive lifespan and pregnancy loss: The national health and nutrition examination survey 1999-2018
Gonzalez-Martin, Roberto; (...); Dominguez, Francisco
Article. 10.1016/j.envres.2023.116514. 2023
Associations between Essential Trace Elements in Women's Biofluids and IVF Outcomes in Euploid Single Embryo Transfer Cycles
Gonzalez-Martin, Roberto; (...); Dominguez, Francisco
Meeting Abstract. 2024
Associations between Non-Essential Trace Elements in Women's Biofluids and IVF Outcomes in Euploid Single-Embryo Transfer Cycles.
Gonzalez-Martin, Roberto; (...); Dominguez, Francisco
Article. 10.3390/jox14030062. 2024
Beyond chromosome screening: The impact of progesterone and in vitro oxidative stress on failed euploid blastocyst transfers
Cuadrado Torroglosa, I.; (...); Dominguez, F.
Meeting Abstract. https://doi.org/10.1093/humrep/deae108.752. 2024
Bioaccumulation of Non-Essential Trace Elements Detected in Women's Follicular Fluid, Urine, and Plasma Is Associated with Poor Reproductive Outcomes following Single Euploid Embryo Transfer: A Pilot Study.
Palomar A; (...); Dominguez F
Article. 10.3390/ijms241713147. 2023
Circulating Follicular Fluid microRNAs as Potential Biomarkers for Endometriosis.
Jose Soriano, Maria; (...); Diaz-Garcia, Cesar
Meeting Abstract. 2023
CONTRACTIONS AFTER BLASTOCYST VITRIFICATION-WARMING: SHRINKAGE RATE AND TIMING CORRELATE WITH ONGOING PREGNANCY.
Conversa Martinez, Laura; (...); Meseguer, Marcos
Meeting Abstract. 10.1016/j.fertnstert.2024.07.748. 2024
Corrigendum to 'Prediction of ovarian response using the automated Elecsys anti-Müllerian hormone assay in gonadotrophin-releasing hormone antagonist cycles' [Reproductive BioMedicine Online (2023) 46 2: 295-301].
Bosch E; (...); Nelson SM
Correction. 10.1016/j.rbmo.2024.103946. 2024
Corticosteroids, androgens, progestogens and oestrogens in the endometrial microenvironment, and their association with endometrial progression and function
Marti-Garcia, Diana; (...); Diaz-Gimeno, Patricia
Article. 10.1016/j.rbmo.2024.104377. 2024
Cumulative live birth rate following progestin-primed ovarian stimulation: controversial results with own and donated oocytes.
Letter. 10.1016/j.rbmo.2024.103859. 2024
Deciphering a shared transcriptomic regulation and the relative contribution of each regulator type through endometrial gene expression signatures.
Parraga-Leo A; (...); Diaz-Gimeno P
Article. 10.1186/s12958-023-01131-4. 2023
Deciphering the role of PGRMC2 in the human endometrium during the menstrual cycle and in vitro decidualization using an in vitro approach.
Medina-Laver Y; (...); Dominguez F
Article. 10.1093/humrep/deae044. 2024
Detecting partial premature ovulation during follicular aspiration compromises the quantity, but not the quality, of the oocytes retrieved in stimulated in vitro fertilization (IVF) cycles.
Gomez, Victor Hugo; (...); Bosch, Ernesto
Article. 10.5935/1518-0557.20240003. 2024
Editorial: Single cell analysis in endocrinology, reproduction, and metabolism.
Dominguez, Francisco, Blesson, Chellakkan S.
Editorial Material. 10.3389/fendo.2023.1282987. 2023
Effects of In Vitro Culture Systems with Fallopian Tube Extracellular Matrix on Rabbit Embryo Gene Expression.
Frances-Herrero, Emilio; (...); Cervello, Irene
Meeting Abstract. 2024
Embryo long-term storage does not affect assisted reproductive technologies outcome: analysis of 58,001 vitrified blastocysts over 11 years.
Article. 10.1016/j.ajog.2024.03.033. 2024
Endometrial cortisol and estradiol levels as indicators of pregnancy prognosis and their association with State-Trait Anxiety Inventory (STAI) psychological questionnaire punctuations in IVF patients
Marti-Garcia, D.; (...); Diaz-Gimeno, P.
Meeting Abstract. 2023
Endometrial receptivity tests in reproduction: a SWOT analysis.
Garcia-Velasco, Juan A; (...); Fontes, Juan
Article. 10.1016/j.xagr.2023.100260. 2023
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
Li, Elizabeth; (...); NIHR Global Hlth Res Unit Surg
Article. 10.1093/bjs/znad370. 2024
EXPOSURE TO SMOKE AND HEAVY METALS IS ASSOCIATED WITH POORER SEMEN QUALITY IN FERTILE MEN.
Gonzalez Martin, Roberto; (...); Dominguez, Francisco
Meeting Abstract. 10.1016/j.fertnstert.2024.07.707. 2024
Growth Factor-Enriched Xenogeneic Ovarian ECM Hydrogels: A Promising Treatment for Premature Ovarian Failure.
Frances-Herrero, Emilio; (...); Cervello, Irene
Meeting Abstract. 2024
Higher Concentrations of Essential Trace Elements in Women Undergoing IVF May Be Associated with Poor Reproductive Outcomes Following Single Euploid Embryo Transfer.
Gonzalez-Martin, Roberto; (...); Dominguez, Francisco
Article. 10.3390/cells13100839. 2024
Human embryos diagnosed as mosaic and aneuploid after preimplantation genetic testing for aneuploidy are associated with increased levels of apoptosis in trophectoderm cells
Martin, A.; (...); De los Santos, M. J.
Meeting Abstract. 2023
Identification of miR-30c-5p microRNA in Serum as a Candidate Biomarker to Diagnose Endometriosis.
Chico-Sordo L; (...); García-Velasco JA
Article. 10.3390/ijms25031853. 2024
Impact of SARS-CoV-2 infection in patients with cardiac amyloidosis: Results of a multicentre registry.
Larrañaga-Moreira JM; (...); Barriales-Villa R
Article. 10.1016/j.medcli.2023.06.025. 2023
Impact of vaginal microbiome on vaginal absorption of exogenous progesterone: a pilot study
Labarta, E.; (...); Spath, K.
Meeting Abstract. https://doi.org/10.1093/humrep/deae108.1031. 2024
Live birth rates following individualized dosing algorithm of follitropin delta in a long GnRH agonist protocol.
Sanchez, Manuel Fernandez; (...); Mannaerts, Bernadette
Article. 10.1186/s12958-023-01090-w. 2023
Longitudinal profiling of human androgenotes through single-cell analysis unveils paternal gene expression dynamics in early embryo development.
Vendrell, X; (...); Dominguez, F
Article. 10.1093/humrep/deae072. 2024
Luteal phase support using micronized vaginal progesterone as pessaries or capsules in artificial cycles: is there any difference?
Article. 10.1016/j.rbmo.2023.103638. 2024
Machine learning tool for predicting mature oocyte yield and trigger day from start of stimulation: towards personalized treatment.
Garg, Akhil; (...); Meseguer, Marcos
Article. 10.1016/j.rbmo.2024.104441. 2024
Medroxyprogesterone acetate: an alternative to GnRH-antagonist in oocyte vitrification for social fertility preservation and preimplantation genetic testing for aneuploidy.
Giles, Juan; (...); Bosch, Ernesto
Article. 10.1016/j.rbmo.2023.04.013. 2023
Microbiome preterm birth DREAM challenge: Crowdsourcing machine learning approaches to advance preterm birth research.
Golob JL; (...); Sirota M
Article. 10.1016/j.xcrm.2023.101350. 2024
Minimum number of mature oocytes needed to obtain at least one euploid blastocyst according to female age in In Vitro Fertilization cycles.
Rodriguez-Varela, Cristina; (...); Bosch, Ernesto
Article. 10.1016/j.fertnstert.2024.06.002. 2024
Morning or evening start of exogenous progesterone five days before blastocyst transfer does not have an impact on ongoing pregnancy rates in artificial cycles.
Labarta, E.; (...); Bosch, E.
Meeting Abstract. 2023
Mosaic results after preimplantation genetic testing for aneuploidy may be accompanied by changes in global gene expression.
Martin, A.; (...); de los Santos, M. J.
Article. 10.3389/fmolb.2023.1180689. 2023
Nervous system drugs are predicted as potential repurposing candidates for treatment in endometrial failure
Parraga-Leo, A.; (...); Diaz-Gimeno, P.
Meeting Abstract. 2023
Non-Essential Trace Elements Female Exposure Negatively Affects IVF Outcomes in Euploid Single Embryo Transfer Cycles
Rios, Palomar; (...); Dominguez, Francisco
Meeting Abstract. 2023
Non-Essential Trace Elements in women's biofluids are associated with worse IVF outcomes in euploid single embryo transfer cycles
Gonzalez-Martin, R.; (...); Dominguez, F.
Meeting Abstract. 2023
NON-INVASIVE BIOMARKERS FOR EMBRYO SELECTION IN IVF: UNVEILING SECRETED SIGNATURES FOR IMPLANTATION PREDICTION.
Yague Serrano, Roberto; (...); Dominguez, Francisco
Meeting Abstract. 10.1016/j.fertnstert.2024.07.633. 2024
OOCYTE ASSESSMENT BASED ON ARTIFICIAL INTELLIGENCE (AI) FOR THE PREDICTION OF BLASTOCYST DEVELOPMENT: A COMPARATIVE ANALYSIS OF FRESH AND VITRIFIED DONOR OOCYTES
Murria, Lucia; (...); Cobo, Ana
Meeting Abstract. 10.1016/j.fertnstert.2024.08.093. 2024
OOCYTE ASSESSMENT BASED ON ARTIFICIAL INTELLIGENCE (AI). ARE OOCYTE SCORES RELATED TO SUBSEQUENT EMBRYO QUALITY?
Murria, Lucia; (...); Meseguer, Marcos
Meeting Abstract. 2024
Oocyte Maturity, Embryology Outcomes and miRNA Signature of Different Size Follicles from Poor Responder Patients.
Yague-Serrano, Roberto; (...); Dominguez, Francisco
Meeting Abstract. 2024
Oviductal extracellular matrix hydrogels enhance in vitro culture of rabbit embryos and reduce deficiencies during assisted reproductive technologies
Frances-Herrero, Emilio; (...); Cervello, Irene
Article. 10.1038/s41598-024-77583-4. 2024
Phytoestrogens Present in Follicular Fluid and Urine Are Positively Associated with IVF Outcomes following Single Euploid Embryo Transfer.
Gonzalez-Martin, Roberto; (...); Dominguez, Francisco
Article. 10.3390/ijms241310852. 2023
Positive Association Between Essential Trace Elements in Female Biological Matrices and IVF Outcomes in Euploid Single Embryo Transfer Cycles
Gonzalez-Martin, Roberto; (...); Dominguez, Francisco
Meeting Abstract. 2023
Predicting risk of endometrial failure: a biomarker signature that identifies a novel disruption independent of endometrial timing in patients undergoing hormonal replacement cycles.
Diaz-Gimeno P; (...); Pellicer A
Article. 10.1016/j.fertnstert.2024.03.015. 2024
Profiling secreted proteins in human embryos: Time-specific discrimination of ploidy and confirmation of enhanced post-implantation development with maternal co-culture
Palomar, A.; (...); Sanchez-Ribas, I.
Meeting Abstract. https://doi.org/10.1093/humrep/deae108.558. 2024
Proteomic Profiling Identifies Candidate Diagnostic Biomarkers of Hydrosalpinx in Endometrial Fluid: A Pilot Study.
Gonzalez-Martin, Roberto; (...); Dominguez, Francisco
Article. 10.3390/ijms25020968. 2024
Secretion of beta-human chorionic gonadotropin (b-hCG) by post-implantation embryos differs according to different chromosomal status.
Palomar, A.; (...); Sanchez-Ribas, I.
Meeting Abstract. 2023
Serum progesterone is lower in ovarian stimulation with highly purified HMG compared to recombinant FSH owing to a different regulation of follicular steroidogenesis: a randomized controlled trial
Bosch, Ernesto; (...); Pellicer, Antonio
Article. 10.1093/humrep/dead251. 2024
Serum Progesterone Is Lower in Ovarian Stimulation With Highly Purified HMG Compared to Recombinant FSH Owing to a Different Regulation of Follicular Steroidogenesis: A Randomized Controlled Trial
Bosch, Ernesto; (...); Pellicer, Antonio
Article. 10.1097/01.ogx.0001023608.76803.23. 2024
Spanish cardiac catheterization and coronary intervention registry. 32nd official report of the Interventional Cardiology Association of the Spanish Society of Cardiology (1990-2022).
Jurado-Román A; (...); García de la Borbolla Fernández R
Article. 10.1016/j.rec.2023.07.012. 2023
State-Trait Anxiety Inventory (STAI) punctuations as a non-invasive method for evaluating endometrial prognosis associated with cortisol and estradiol endometrial levels in IVF patients
Marti-Garcia, D.; (...); Diaz-Gimeno, P.
Meeting Abstract. https://doi.org/10.1093/humrep/deae108.817. 2024
Targeted Elimination of Human Chromosome 21 (HSA21) in Adult and Embryo Stem Cell Lines Using a Novel CRISPR-Cas3 GenomeEditing Tool
Rios, Andrea Palomar; (...); Sanchez-Ribas, Immaculada
Meeting Abstract. 2023
Telomere length of white blood cells is a non-invasive marker of reproductive aging in women
Molina, E. E. Lara; (...); Diaz-Gimeno, P.
Meeting Abstract. https://doi.org/10.1093/humrep/deae108.1035. 2024
Testing an artificial intelligence algorithm to predict fetal heartbeat of vitrified-warmed blastocysts from a single image: predictive ability in different settings.
Conversa L; (...); Meseguer M
Article. 10.1093/humrep/deae178. 2024
TESTING THE ABILITY OF AN ARTIFICIAL INTELLIGENCE (AI) ALGORITHM IN PREDICTING IMPLANTATION AND ONGOING PREGNANCY POTENTIAL OF VITRIFIED-WARMED BLASTOCYSTS FROM A SINGLE IMAGE
Conversa Martinez, Laura; (...); Meseguer, Marcos
Meeting Abstract. 2023
The effect of vitrification on blastocyst mitochondrial DNA dynamics and gene expression profiles.
Perez-Sanchez, Marta; (...); de Los Santos, Maria Jose
Article. 10.1007/s10815-023-02952-3. 2023
The Impact of Essential Trace Elements on Ovarian Response and Reproductive Outcomes following Single Euploid Embryo Transfer.
Gonzalez-Martin, Roberto; (...); Dominguez, Francisco
Article. 10.3390/ijms241310968. 2023
The NR2F2-HAND2 signaling axis regulates progesterone actions in the uterus at early pregnancy.
Oh Y; (...); Wu SP
Article. 10.3389/fendo.2023.1229033. 2023
Transcriptomic Profiling of Aneuploid Embryos during PostImplantation Development Reveals Divergent Fates According to Chromosomal Load.
Palomar, Andrea; (...); Sanchez-Ribas, Immaculada
Meeting Abstract. 2024
Unraveling PGRMC2 Functions in Decidualized Human Endometrial Stromal Cells by RNA Sequencing.
Medina-Laver, Yassmin; (...); Dominguez, Francisco
Meeting Abstract. 2023
UNRAVELLING THE TRANSCRIPTOMIC CONTRIBUTION OF THE MATERNAL HAPLOID GENOME IN EARLY EMBRYO DEVELOPMENT WITH A UNIPARENTAL SINGLE CELL LEVEL APPROACH
De Castro, Pedro; (...); Dominguez, Francisco
Meeting Abstract. 2023
USE OF ARTIFICIAL INTELLIGENCE FOR PREDICTING LIVE BIRTH IN VITRIFIED BLASTOCYST CYCLES
Coello, Aila; (...); Meseguer, Marcos
Meeting Abstract. 10.1016/j.fertnstert.2024.07.812. 2024
Use of the Endometrial Receptivity Array to Guide Personalized Embryo Transfer After a Failed Transfer Attempt Was Associated With a Lower Cumulative and Per Transfer Live Birth Rate During Donor and Autologous Cycles
Cozzolino, Mauro; (...); Garrido, Nicolas
Editorial Material. 10.1097/OGX.0000000000001123. 2023
Validation of a model capable of estimating the minimum number of mature oocytes needed to obtain at least one euploid blastocyst regarding female age
Rodriguez Varela, C.; (...); Bosch, E.
Meeting Abstract. 2023
VMAP: Vaginal Microbiome Atlas during Pregnancy
Parraga-Leo, Antonio; (...); Sirota, Marina
Article. 10.1093/jamiaopen/ooae099. 2024
Whole-exome sequencing and Drosophila modelling reveal mutated genes and pathways contributing to human ovarian failure
Henarejos-Castillo, Ismael; (...); Diaz-Gimeno, Patricia
Article. 10.1186/s12958-024-01325-4. 2024