Portal de investigación
Perfiles transcriptómicos y secretómicos tras cultivo extendido de embriones humanos euploides y aneuploides para el cromosoma 21
Datos básicos
- Protocolo:
- PI20/00405
- EUDRACT:
- NCT:
- Centro:
- Año de incio:
- 2021
- Año de finalización:
- 2024
Documentos
- No hay documentos
Participantes
Grupos
Financiadores - Promotores
Resultados del Ensayo Clínico
3D In Vitro Modelling of Embryo-Endometrial Interface Unravels Entosis Role on Cell-in-Cell Invasion During Human Embryo Implantation.
Palomar, Andrea; (...); Dominguez, Francisco
Meeting Abstract. 2024
-81 TRANSCRIPTIONAL PROFILE OF STRESSED HUMAN EMBRYOS: STUDY OF EARLY-STAGE ARRESTED EMBRYOS.
Perez-Sanchez, Marta; (...); Jose De Los Santos, Ma
Meeting Abstract. 2021
A NEW ENDOMETRIAL TRANSCRIPTOMIC STRATIFICATION IN THE MID-SECRETORY PHASE REVEALS A NEW TAXONOMY FOR ENDOMETRIAL PROGNOSIS IN INFERTILITY
Maria Sanchez-Reyes, Josefa; (...); Diaz Gimeno, Patricia
Meeting Abstract. 2022
An Analysis of the Digestive and Reproductive Tract Microbiota in Infertile Women with Obesity.
Bellver, Jose; (...); Moreno, Inmaculada
Article. 10.3390/ijms252312600. 2024
Analysis of serum and endometrial progesterone in determining endometrial receptivity.
Labarta E; (...); Diaz-Gimeno P
Article. 10.1093/humrep/deab184. 2021
Aneuploidy in Human Embryos May Elicit a Premature Differentiation Response in the Inner Cell Mass.
Martin, A; (...); de los Santos, MJ
Meeting Abstract. 2021
Antioxidant Supplementation Alleviates Mercury-Induced Cytotoxicity and Restores the Implantation-Related Functions of Primary Human Endometrial Cells.
Palomar, Andrea; (...); Dominguez, Francisco
Article. 10.3390/ijms24108799. 2023
Antioxidant Treatment Ameliorates Mercury-Induced Damage on Viability and Function of Human Endometrial Epithelial Cells.
Palomar, Andrea; (...); Dominguez, Francisco
Meeting Abstract. 2022
Antioxidant Treatment Revert Mercury-Induced Damage in an In Vitro Human Primary Stromal Cells (hEnSC) Invasion Model
Palomar Rios, Andrea; (...); Dominguez, Francisco
Meeting Abstract. 2023
Assessment of Decidualization and Oxidative Stress in Primary Human Endometrial Stromal Cells (hEnSC) After Mercury-Induced Damage
Palomar Rios, Andrea; (...); Dominguez, Francisco
Meeting Abstract. 2023
Association of blood cadmium and lead levels with self-reported reproductive lifespan and pregnancy loss: The national health and nutrition examination survey 1999-2018
Gonzalez-Martin, Roberto; (...); Dominguez, Francisco
Article. 10.1016/j.envres.2023.116514. 2023
Associations between Essential Trace Elements in Women's Biofluids and IVF Outcomes in Euploid Single Embryo Transfer Cycles
Gonzalez-Martin, Roberto; (...); Dominguez, Francisco
Meeting Abstract. 2024
Associations between Non-Essential Trace Elements in Women's Biofluids and IVF Outcomes in Euploid Single-Embryo Transfer Cycles.
Gonzalez-Martin, Roberto; (...); Dominguez, Francisco
Article. 10.3390/jox14030062. 2024
Beyond chromosome screening: The impact of progesterone and in vitro oxidative stress on failed euploid blastocyst transfers
Cuadrado Torroglosa, I.; (...); Dominguez, F.
Meeting Abstract. https://doi.org/10.1093/humrep/deae108.752. 2024
Bioaccumulation of Non-Essential Trace Elements Detected in Women's Follicular Fluid, Urine, and Plasma Is Associated with Poor Reproductive Outcomes following Single Euploid Embryo Transfer: A Pilot Study.
Palomar A; (...); Dominguez F
Article. 10.3390/ijms241713147. 2023
Circulating Follicular Fluid microRNAs as Potential Biomarkers for Endometriosis.
Jose Soriano, Maria; (...); Diaz-Garcia, Cesar
Meeting Abstract. 2023
Cumulative live birth rate following progestin-primed ovarian stimulation: controversial results with own and donated oocytes.
Letter. 10.1016/j.rbmo.2024.103859. 2024
Characterization of the Non-Classic Progesterone Receptor Membrane Component 2 (PGRMC2) during the Human Menstrual Cycle and In Vitro Decidualization.
Medina-Laver, Y; (...); Dominguez, F
Meeting Abstract. 2021
Deciphering a shared transcriptomic regulation and the relative contribution of each regulator type through endometrial gene expression signatures.
Parraga-Leo A; (...); Diaz-Gimeno P
Article. 10.1186/s12958-023-01131-4. 2023
Deciphering the role of PGRMC1 during human decidualization using an in vitro approach.
Salsano S; (...); Domínguez F
Article. 10.1210/clinem/dgab303. 2021
Deciphering the Role of PGRMC2 in Decidualization and Trophoblast Invasion Using Primary In Vitro Models
Medina-Laver, Yassmin; (...); Dominguez, Francisco
Meeting Abstract. 2022
Deciphering the role of PGRMC2 in the human endometrium during the menstrual cycle and in vitro decidualization using an in vitro approach.
Medina-Laver Y; (...); Dominguez F
Article. 10.1093/humrep/deae044. 2024
Editorial: Single cell analysis in endocrinology, reproduction, and metabolism.
Dominguez, Francisco, Blesson, Chellakkan S.
Editorial Material. 10.3389/fendo.2023.1282987. 2023
Endometrial cortisol and estradiol levels as indicators of pregnancy prognosis and their association with State-Trait Anxiety Inventory (STAI) psychological questionnaire punctuations in IVF patients
Marti-Garcia, D.; (...); Diaz-Gimeno, P.
Meeting Abstract. 2023
Entosis Act Through the Rho-ROCK Signalling Pathway During Human Embryo Implantation
Palomar, Andrea; (...); Dominguez, Francisco
Meeting Abstract. 2022
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
Li, Elizabeth; (...); NIHR Global Hlth Res Unit Surg
Article. 10.1093/bjs/znad370. 2024
Evaluation of salivary ELISA for Oestradiol and Progesterone monitoring in IVF patients
Bosch Aparicio, E.; (...); White, R.
Meeting Abstract. 2023
EXPOSURE TO SMOKE AND HEAVY METALS IS ASSOCIATED WITH POORER SEMEN QUALITY IN FERTILE MEN.
Gonzalez Martin, Roberto; (...); Dominguez, Francisco
Meeting Abstract. 10.1016/j.fertnstert.2024.07.707. 2024
Higher Concentrations of Essential Trace Elements in Women Undergoing IVF May Be Associated with Poor Reproductive Outcomes Following Single Euploid Embryo Transfer.
Gonzalez-Martin, Roberto; (...); Dominguez, Francisco
Article. 10.3390/cells13100839. 2024
Human embryos diagnosed as mosaic and aneuploid after preimplantation genetic testing for aneuploidy are associated with increased levels of apoptosis in trophectoderm cells
Martin, A.; (...); De los Santos, M. J.
Meeting Abstract. 2023
Identification of miR-30c-5p microRNA in Serum as a Candidate Biomarker to Diagnose Endometriosis.
Chico-Sordo L; (...); García-Velasco JA
Article. 10.3390/ijms25031853. 2024
Identifying and optimizing human endometrial gene expression signatures for endometrial dating.
Diaz-Gimeno P; (...); Pellicer A
Article. 10.1093/humrep/deab262. 2022
IMPACT OF GONADOTROPHIN RECEPTOR POLYMORPHISMS ON THE RELATIONSHIP BETWEEN SERUM AMH AND OVARIAN RESPONSE.
Bosch, Ernesto; (...); Labarta, Elena
Meeting Abstract. 2021
Impact of low serum progesterone levels on the day of embryo transfer on pregnancy outcome: a prospective cohort study in artificial cycles with vaginal progesterone.
Article. 10.1093/humrep/deaa322. 2021
Impact of SARS-CoV-2 infection in patients with cardiac amyloidosis: Results of a multicentre registry.
Larrañaga-Moreira JM; (...); Barriales-Villa R
Article. 10.1016/j.medcli.2023.06.025. 2023
Impaired endometrial decidualization with a hyperinflammation environment is involved in poor reproductive outcomes in adenomyosis patients
Corachan, A.; (...); Ferrero, H.
Meeting Abstract. 2023
Intentional endometrial injury significantly improves ongoing pregnancy rates of an oocyte donation program in patients without recurrent implantation failure (RIF): a randomized controlled trial.
Vidal, C.; (...); Garrido, N.
Meeting Abstract. 2023
Longitudinal profiling of human androgenotes through single-cell analysis unveils paternal gene expression dynamics in early embryo development.
Vendrell, X; (...); Dominguez, F
Article. 10.1093/humrep/deae072. 2024
Medroxyprogesterone acetate as an alternative to gonadotropin-realeasing hormone antagonist in vitrified oocyte donation cycles: embryo assessment and clinical outcome
Murria, L.; (...); Cobo, A.
Meeting Abstract. https://doi.org/10.1093/humrep/deae108.966. 2024
Medroxyprogesterone acetate is a useful alternative to a gonadotropin-releasing hormone antagonist in oocyte donation: a randomized, controlled trial.
Article. 10.1016/j.fertnstert.2021.02.036. 2021
Medroxyprogesterone acetate: an alternative to GnRH-antagonist in oocyte vitrification for social fertility preservation and preimplantation genetic testing for aneuploidy.
Giles, Juan; (...); Bosch, Ernesto
Article. 10.1016/j.rbmo.2023.04.013. 2023
Mercury Disturb Reproductive Functions of Primary Endometrial Stromal Cells (ESC).
Gonzalez-Martin, R; (...); Dominguez, F
Meeting Abstract. 2021
Mercury impairs human primary endometrial stromal cell function.
Palomar, Andrea; (...); Dominguez, Francisco
Article. 10.1093/biolre/ioac016. 2022
MITOCHONDRIAL DNA REPLICATION AFTER BLASTOCYST VITRIFICATION: A HEROIC ACT OF SURVIVAL OR AN ALERT FOR THE FUTURE?.
Perez-Sanchez, Marta; (...); Jose De Los Santos, Ma
Meeting Abstract. 2021
Mosaic results after preimplantation genetic testing for aneuploidy may be accompanied by changes in global gene expression.
Martin, A.; (...); de los Santos, M. J.
Article. 10.3389/fmolb.2023.1180689. 2023
Nervous system drugs are predicted as potential repurposing candidates for treatment in endometrial failure
Parraga-Leo, A.; (...); Diaz-Gimeno, P.
Meeting Abstract. 2023
Non-Essential Trace Elements Female Exposure Negatively Affects IVF Outcomes in Euploid Single Embryo Transfer Cycles
Rios, Palomar; (...); Dominguez, Francisco
Meeting Abstract. 2023
Non-Essential Trace Elements in women's biofluids are associated with worse IVF outcomes in euploid single embryo transfer cycles
Gonzalez-Martin, R.; (...); Dominguez, F.
Meeting Abstract. 2023
NON-INVASIVE BIOMARKERS FOR EMBRYO SELECTION IN IVF: UNVEILING SECRETED SIGNATURES FOR IMPLANTATION PREDICTION.
Yague Serrano, Roberto; (...); Dominguez, Francisco
Meeting Abstract. 10.1016/j.fertnstert.2024.07.633. 2024
Oocyte Maturity, Embryology Outcomes and miRNA Signature of Different Size Follicles from Poor Responder Patients.
Yague-Serrano, Roberto; (...); Dominguez, Francisco
Meeting Abstract. 2024
Phytoestrogen concentration in women's urine and follicular fluid are associated with better IVF outcomes in euploid single embryo transfer cycles
Gonzalez Martin, R.; (...); Dominguez, F.
Meeting Abstract. 2022
Phytoestrogens Present in Follicular Fluid and Urine Are Positively Associated with IVF Outcomes following Single Euploid Embryo Transfer.
Gonzalez-Martin, Roberto; (...); Dominguez, Francisco
Article. 10.3390/ijms241310852. 2023
Positive Association Between Essential Trace Elements in Female Biological Matrices and IVF Outcomes in Euploid Single Embryo Transfer Cycles
Gonzalez-Martin, Roberto; (...); Dominguez, Francisco
Meeting Abstract. 2023
Predicting risk of endometrial failure: a biomarker signature that identifies a novel disruption independent of endometrial timing in patients undergoing hormonal replacement cycles.
Diaz-Gimeno P; (...); Pellicer A
Article. 10.1016/j.fertnstert.2024.03.015. 2024
Profiling secreted proteins in human embryos: Time-specific discrimination of ploidy and confirmation of enhanced post-implantation development with maternal co-culture
Palomar, A.; (...); Sanchez-Ribas, I.
Meeting Abstract. https://doi.org/10.1093/humrep/deae108.558. 2024
Progestin-primed ovarian stimulation.
Giles, Juan, Cruz, Fabio, Garcia-Velasco, Juan A
Article. 10.1097/GCO.0000000000000941. 2024
Proteomic Profiling Identifies Candidate Diagnostic Biomarkers of Hydrosalpinx in Endometrial Fluid: A Pilot Study.
Gonzalez-Martin, Roberto; (...); Dominguez, Francisco
Article. 10.3390/ijms25020968. 2024
Role of Endometrial Extracellular Vesicles miRNAs as Potential Autocrine Regulators of Gene Expression During Embryo Implantation Process in Adenomyosis.
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Meeting Abstract. 2024
Secretion of beta-human chorionic gonadotropin (b-hCG) by post-implantation embryos differs according to different chromosomal status.
Palomar, A.; (...); Sanchez-Ribas, I.
Meeting Abstract. 2023
SERUM P LEVELS MEASURED ON THE DAY OF EMBRYO TRANSFER IN FRESH IVF CYCLES yam OWN OOCYTES ARE NOT RELATED TO PREGNANCY OUTCOME.
Labarta, Elena; (...); Bosch, Ernesto
Meeting Abstract. 2022
Single Cell Transcriptome Description of Early Development Haploid Androgenotes and Parthenotes
de Castro, Pedro; (...); Dominguez, Francisco
Meeting Abstract. 2022
State-Trait Anxiety Inventory (STAI) punctuations as a non-invasive method for evaluating endometrial prognosis associated with cortisol and estradiol endometrial levels in IVF patients
Marti-Garcia, D.; (...); Diaz-Gimeno, P.
Meeting Abstract. https://doi.org/10.1093/humrep/deae108.817. 2024
Targeted Elimination of Human Chromosome 21 (HSA21) in Adult and Embryo Stem Cell Lines Using a Novel CRISPR-Cas3 GenomeEditing Tool
Rios, Andrea Palomar; (...); Sanchez-Ribas, Immaculada
Meeting Abstract. 2023
The effect of vitrification on blastocyst mitochondrial DNA dynamics and gene expression profiles.
Perez-Sanchez, Marta; (...); de Los Santos, Maria Jose
Article. 10.1007/s10815-023-02952-3. 2023
The Impact of Essential Trace Elements on Ovarian Response and Reproductive Outcomes following Single Euploid Embryo Transfer.
Gonzalez-Martin, Roberto; (...); Dominguez, Francisco
Article. 10.3390/ijms241310968. 2023
The morphokinetic signature of mosaic embryos: evidence in support of their own genetic identity.
Martín Á; (...); José de Los Santos M
Article. 10.1016/j.fertnstert.2020.12.031. 2021
The NR2F2-HAND2 signaling axis regulates progesterone actions in the uterus at early pregnancy.
Oh Y; (...); Wu SP
Article. 10.3389/fendo.2023.1229033. 2023
The Use of Vaginal Lubricants and Ultrasound Gels Can have Deleterious Effects on Sperm Function.
Soriano, Maria Jose; (...); Rubio, Jose Maria
Article. 10.4103/jhrs.JHRS_128_18. 2021
Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders.
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Article. 10.1186/s12958-023-01182-7. 2024
Transcriptomic Analysis of Adenomyosis Mid-Secretory Endometrial Organoids Reveals Deregulated Molecular Mechanisms Involved in Implantation Failure and Pregnancy Loss
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Meeting Abstract. 2023
Transcriptomic analysis reveals deregulated molecular mechanisms related to miscarriage, preeclampsia, and pregnancy complications during gestational endometrial phase in adenomyosis
Juarez-Barber, E.; (...); Ferrero, H.
Meeting Abstract. 2023
Transcriptomic Profiling of Aneuploid Embryos during PostImplantation Development Reveals Divergent Fates According to Chromosomal Load.
Palomar, Andrea; (...); Sanchez-Ribas, Immaculada
Meeting Abstract. 2024
Unraveling PGRMC2 Functions in Decidualized Human Endometrial Stromal Cells by RNA Sequencing.
Medina-Laver, Yassmin; (...); Dominguez, Francisco
Meeting Abstract. 2023
UNRAVELLING THE TRANSCRIPTOMIC CONTRIBUTION OF THE MATERNAL HAPLOID GENOME IN EARLY EMBRYO DEVELOPMENT WITH A UNIPARENTAL SINGLE CELL LEVEL APPROACH
De Castro, Pedro; (...); Dominguez, Francisco
Meeting Abstract. 2023
UNVEILING ENDOMETRIOSIS: TRANSCRIPTOMIC PROFILING REVEALS MOLECULAR DYSREGULATION IN GESTATIONAL ENDOMETRIAL ORGANOIDS.
Bas-Rivas, Alba; (...); Ferrero, Hortensia
Meeting Abstract. 10.1016/j.fertnstert.2024.07.589. 2024
Uterine natural killer cells: from foe to friend in reproduction.
Díaz-Hernández I; (...); Domínguez F
Article. 10.1093/humupd/dmaa062. 2021
What Do We Know about Classical and Non-Classical Progesterone Receptors in the Human Female Reproductive Tract? A Review.
Medina-Laver, Yassmin; (...); Dominguez, Francisco
Article. 10.3390/ijms222011278. 2021