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  3. Effect of CD8(+) Cell Content on Umbilical Cord Blood Transplantation in Adults with Hematological Malignancies

Effect of CD8(+) Cell Content on Umbilical Cord Blood Transplantation in Adults with Hematological Malignancies

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Carbonell F
  • Salazar C
  • Puig N
  • Montoro JA
  • Roig R

Grupos

Abstract

Total nucleated (TNCs) and CD34(+) cells are considered major determinants of outcome after umbilical cord blood (UCB) transplantation but the effect of other cell subtypes present in the graft is unknown. This single-center cohort study included patients with hematological malignancies who received UCB transplantation after a myeloablative conditioning regimen. UCB units were primarily selected according to cell content, both TNCs and CD34(+) cells, and also according to the degree of HLA matching. Counts of several cell subtypes of the infused UCB unit, together with HLA disparities and other patient- and transplantation-related characteristics, were analyzed by multivariable methodology for their association with myeloid and platelet engraftment, graft-versus-host disease, nonrelapse mortality (NRM), disease-free survival (DFS), and overall survival (OS). Two hundred patients (median age, 32 years) were included in the study. In multivariable analyses, a greater number of CD8(+) cells was significantly associated with better results for myeloid (P = .001) and platelet (P = .008) engraftment, NRM (P = .02), DFS (P = .007), and OS (P = .01). CD34(+) cell content was predictive of myeloid engraftment (P < .001). This study suggests that the outcome after UCB transplantation in adults with hematological malignancies could be better when UCB grafts had a greater CD8(+) cell content. (C) 2014 American Society for Blood and Marrow Transplantation.

Datos de la publicación

ISSN/ISSNe:
1083-8791, 1523-6536

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION  ELSEVIER SCIENCE INC

Tipo:
Article
Páginas:
1744-1750
PubMed:
25008329
Factor de Impacto:
1,946 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 19

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Keywords

  • Single umbilical cord blood; Transplantation; Engraftment; Cell dose; Adults; Hematological malignancies

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