ESTUDIO DE FASE 3, ABIERTO, DE GRUPOS PARALELOS, MULTICÉNTRICO Y DE EXTENSIÓN DE UN ESTUDIO PREVIO, PARA EVALUAR EL TRATAMIENTO A LARGO PLAZO CON BIMEKIZUMAB EN SUJETOS CON HIDROSADENITIS SUPURATIVA MODERADA O SEVERA.
Datos básicos
- Código:
- Protocolo:
- EUDRACT:
- NCT:
- Centro:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Dotación:
- Año de incio:
- 2022
- Año de finalización:
- 2025
Documentos
- No hay documentos
Participantes
Grupos
Resultados del Ensayo Clínico
"Phytophotodermatitis as a clinical problem and as a therapeutic option: case report and review of the literature".
Mansilla-Polo, Miguel; (...); Botella-Estrada, Rafael
Article. 10.1016/j.pdpdt.2023.103304. 2023
[[Tranaslated article]]Primary Cutaneous Lymphoma Registry of the Spanish Academy of Dermatology and Venereology (AEDV): Data for the First 5 Years.
López DF; (...); Ortiz-Romero, P. L.
Article. 10.1016/j.ad.2022.11.013. 2023
[[Translated article]]Drug Survival in Cyclosporine Treatment for Moderate to Severe Atopic Dermatitis: Analysis of the Spanish Atopic Dermatitis Registry (BIOBADATOP).
Couselo-Rodríguez C; (...); Flórez Á
Article. 10.1016/j.ad.2023.07.028. 2024
[[Translated article]]Requirements for Accessing New Dermatology Drugs in Spain: Results of the EQUIDAD Study.
Sanchez-Diaz, M; (...); Carrascosa-Carrillo, J M
Article. 10.1016/j.ad.2024.01.019. 2024
[Translated article] BIOBADATOP Spanish Atopic Dermatitis Registry: Description and Early Findings.
Munera-Campos M; (...); Carrascosa JM
Article. 10.1016/j.ad.2023.05.010. 2023
[Translated article] Cybersecurity: a priority for pharmacy services in the age of artificial intelligence
Marin, Cayetano M. Hernandez, Monte-Boquet, Emilio, Andres, Jose Luis Poveda
Editorial Material. 10.1016/j.farma.2024.08.009. 2024
[Translated article] Fatal outcome in classic Kaposi's sarcoma.
Mansilla-Polo M, Botella-Estrada R
Article. 10.1016/j.ad.2024.03.015. 2024
[Translated article] Good humanisation practices in the healthcare of patients with rare diseases in Pharmacy Services
Company Albir MJ, Andrés JLP, Solsona MDE
Article. 10.1016/j.farma.2023.10.004. 2024
[Translated article] New challenges in advanced therapies.
Megías-Vericat JE; (...); Poveda Andrés JL
Article. 10.1016/j.farma.2024.05.001. 2024
[Translated article] Pharmacokinetic-guided switching from standard half-life factor VIII to extended half-life pegylated factor VIII in haemophilia A therapy in clinical practice.
Chovi-Trull, Maria; (...); Andres, Jose Luis Poveda
Article. 10.1016/j.farma.2024.12.007. 2025
[Translated article] Real-world effectiveness and safety of nivolumab in patients with relapsed or refractory classical Hodgkin lymphoma.
Fernandez, Laura Lorente; (...); Andres, Jose Luis Poveda
Article. 10.1016/j.farma.2024.09.006. 2024
A Case of Localised Immediate Hypersensitivity Reaction to Bimekizumab.
Lasheras-Perez, Miguel Antonio; (...); Ibanez-Echevarria, Ethel
Article. 10.1111/cod.14774. 2025
A multi-criteria decision analysis on the value of nintedanib for interstitial lung diseases.
Zozaya, Neboa; (...); Verde, Luis
Article. 10.1017/S0266462322000459. 2022
Assessing the value of moderate-to-severe atopic dermatitis treatment using multi-criteria decision analysis (MCDA).
Pereyra-Rodríguez JJ; (...); Ortiz de Frutos FJ
Letter. 10.1111/jdv.19432. 2023
BIOBADATOP Spanish Atopic Dermatitis Registry: Description and Early Findings.
Munera-Campos M; (...); Carrascosa JM
Article. 10.1016/j.ad.2023.03.001. 2023
Casal necklace.
Mansilla-Polo, Miguel, Martin-Torregrosa, Daniel, Botella-Estrada, Rafael
Article. 10.1016/j.medcli.2023.03.035. 2023
Clinicopathological characteristics of cutaneous and mucocutaneous leishmaniasis in patients treated with TNF-alpha inhibitors.
Palacios-Diaz, Rodolfo David; (...); Botella-Estrada, Rafael
Article. 10.1111/ddg.15007. 2023
Consensus recommendations for the improvement of inter- and intra-centre care coordination in the management of hemophilia.
Montoro-Ronsano JB; (...); Soto-Ortega I
Article. 10.1016/j.farma.2023.01.003. 2023
Consensus recommendations for the improvement of inter- and intra-centre care coordination in the management of hemophilia.
Montoro-Ronsano, Jose Bruno; (...); Soto-Ortega, Inmaculada
Article. 10.1016/j.farma.2023.04.002. 2023
Contact dermatitis by face mask.
Mansilla-Polo M, Navarro-Mira MÁ, Botella-Estrada R
Article. 10.1016/j.medcli.2023.01.004. 2023
Correction: 'Lesion on the back of the hand in a hematopoietic stem cell transplant recipient'.
Mansilla-Polo M; (...); Botella-Estrada R
Correction. 10.1007/s15010-024-02259-0. 2024
COST-EFFECTIVENESS ANALYSIS OF DIFELIKEFALIN FOR THE TREATMENT OF CHRONIC KIDNEY DISEASE ASSOCIATED-PRURITUS IN SPAIN
Sanchez-Alvarez, Emilio E.; (...); Hernaez Colque, M.
Meeting Abstract. 2024
Cutaneous larva migrans.
Mansilla-Polo, Miguel; (...); Botella-Estrada, Rafael
Article. 10.1016/j.medcli.2023.03.037. 2023
Cutaneous sarcoidosis after platelet-rich plasma injections and permanent eyebrow make-up.
Torregrosa DM; (...); Estrada RB
Case Reports. 10.1016/j.ad.2023.06.023. 2024
Cybersecurity, a priority for pharmacy services in the age of artificial intelligence.
Hernández Marín CM, Monte-Boquet E, Poveda Andrés JL
Editorial Material. 10.1016/j.farma.2024.08.001. 2024
Chikungunya fever with a positive tourniquet test: a novel description.
Mansilla-Polo M; (...); Botella-Estrada R
Article. 10.1093/ced/llae089. 2024
Delusional parasitosis (Ekbom's syndrome).
Mansilla-Polo, M, Martin-Torregrosa, D, Botella-Estrada, R
Article. 10.1016/j.semerg.2024.102423. 2024
Dermatologic Consultations for Patients Hospitalized in Non-Dermatologic Wards: Results of a 384-Patient Cross-Sectional Study From a Tertiary Referral Hospital
Mansilla-Polo, M.; (...); Botella-Estrada, R.
Letter. 10.1016/j.ad.2024.10.030. 2024
Dermatologic consultations for patients hospitalized in non-dermatologic wards: results of a 384-patient cross-sectional study from a tertiary referral hospital.
Mansilla-Polo, M; (...); Botella-Estrada, R
Case Reports. 10.1016/j.ad.2023.11.021. 2023
Dermatological toxicities of talquetamab, a new bispecific antibody: case series and literature review.
Mansilla-Polo M; (...); Botella-Estrada R
Letter. 10.1111/ddg.15502. 2024
Dermatological toxicities of talquetamab, a new bispecificantibody: case series and literature review
Mansilla-Polo, Miguel; (...); Botella-Estrada, Rafael
Letter. 10.1111/ddg.15502_g. 2024
Determining value in the treatment of activated PI3Kdelta syndrome in Spain: a multicriteria decision analysis from the perspective of key stakeholders.
Abad, Maria Reyes; (...); Gil, Alicia
Article. 10.33393/grhta.2024.3041. 2024
Determining what represents value in the treatment of prurigo nodularis and its key unmet needs in Spain through Multi-Criteria Decision Analysis
Silvestre, Juan Francisco; (...); Serra-Baldrich, Esther
Article. 10.1002/jvc2.275. 2024
Development and validation of a model to predict complex Mohs Micrographic Surgery in clinical practice: REGESMOSH scale.
Montero-Vilchez, Trinidad R.; (...); Sanmartin-Jimenez, Onofre
Article. 10.1111/jdv.19056. 2023
Dose tapering of dupilumab in patients with persistently controlled atopic dermatitis: a Spanish multicenter cohort study
Lasheras-Pérez MA; (...); Rodríguez-Serna M
Article. 10.1111/ijd.17030. 2024
Drug Survival in Cyclosporine Treatment for Moderate to Severe Atopic Dermatitis: Analysis of the Spanish Atopic Dermatitis Registry (BIOBADATOP).
Rodriguez, C Couselo; (...); Florez, A.
Article. 10.1016/j.ad.2023.07.014. 2023
Effectiveness and safety of brodalumab in the treatment of plaque, scalp and palmoplantar psoriasis: A multicentre retrospective study in a Spanish population.
Sahuquillo-Torralba, A; (...); Botella-Estrada, R
Article. 10.1111/ajd.14130. 2023
Effectiveness, safety and satisfaction of 1% tirbanibulin ointment in the treatment of actinic keratoses: A prospective study in real clinical practice.
Mansilla-Polo M; (...); Botella-Estrada R
Letter. 10.1111/ajd.14151. 2023
Erythema Elevatum Diutinum.
Mansilla-Polo M, Botella-Estrada R
Article. 10.1016/j.ad.2023.10.042. 2024
Fatal outcome in classic Kaposi's sarcoma.
Mansilla-Polo M, Botella-Estrada R
Article. 10.1016/j.ad.2023.03.013. 2024
Genetic Variants Associated with Biological Treatment Response in Inflammatory Bowel Disease: A Systematic Review.
Plaza J; (...); Moret-Tatay I
Article. 10.3390/ijms25073717. 2024
Guselkumab, Risankizumab, and Tildrakizumab demonstrate parallel effectiveness and safety in psoriasis treatment: a head-to-head comparative study in real clinical practice.
Mansilla-Polo M; (...); Botella-Estrada R
Article. 10.1016/j.abd.2024.04.004. 2024
Hemihypoatrophy as an extraordinary manifestation of linear morphoea.
Mansilla-Polo, Miguel, Navarro-Mira, Miguel A., Botella-Estrada, Rafael
Article. 10.1093/rap/rkac104. 2022
Histological deep margins in cutaneous squamous cell carcinoma of the scalp and risk of recurrence.
Verdaguer-Faja, Julia; (...); Jaka, Ane
Article. 10.1111/jdv.20250. 2024
How can artificial intelligence optimize value-based contracting?
Poveda, Jose Luis; (...); Medrano, Ignacio H.
Letter. 10.1186/s40545-022-00475-3. 2022
Identification of c.104T>G, p.Met35Arg (NM_00314.8) variant in heterozygosity in exon 2 of the PTEN gene as the Causative Factor for Cowden Syndrome: A Medical Case Study.
Mansilla-Polo, Miguel; (...); Botella-Estrada, Rafael
Article. 10.1093/ced/llad344. 2023
Interim analysis of the multinational, post-authorization safety study (NISSO) to assess the long-term safety of sonidegib in patients with locally advanced basal cell carcinoma
Gutzmer, Ralf; (...); Hauschild, Axel
Article. 10.1186/s12885-024-13101-z. 2024
Interparietal nodule in a 49-year-old woman.
Mansilla-Polo, Miguel; (...); Botella-Estrada, Rafael
Case Reports. 10.1111/ddg.15398. 2024
Interparietaler Knoten bei einer 49-jährigen Frau
Mansilla-Polo, Miguel; (...); Botella-Estrada, Rafael
Article. 10.1111/ddg.15398_g. 2024
Is erenumab an efficient alternative for the prevention of episodic and chronic migraine in Spain? Results of a cost-effectiveness analysis.
Pozo-Rosich P; (...); Irimia P
Article. 10.1186/s10194-024-01747-w. 2024
Isavuconazole Pharmacokinetics in Critically Ill Patients: Relationship with Clinical Effectiveness and Patient Safety.
Martin-Cerezuela, Maria; (...); Ramirez Galleymore, Paula
Article. 10.3390/antibiotics13080706. 2024
Klinisch-pathologische Eigenschaften kutaner und mukokutaner Leishmaniose bei mit TNF-a-Inhibitoren behandelten Patienten.
Palacios-Diaz, Rodolfo David; (...); Botella-Estrada, Rafael
Article. 10.1111/ddg.15007_g. 2023
'Lesion on the back of the hand in a hematopoietic stem cell transplant recipient'.
Mansilla-Polo M; (...); Botella-Estrada R
Article. 10.1007/s15010-024-02214-z. 2024
Manipulación de fármacos para su administración por gastrostomía endoscópica percutánea en pacientes con esclerosis lateral amiotrófica y nutrición enteral.
Vázquez Polo A; (...); Vázquez Costa JF
Article. 10.20960/nh.03946. 2022
Melanoma and LEOPARD Syndrome: Understanding the Role of PTPN11 Mutations in Melanomagenesis.
Palacios-Diaz, Rodolfo David; (...); Botella-Estrada, Rafael
Article. 10.2340/actadv.v104.14720. 2024
Mohs micrographic surgery in immunosuppressed vs immunocompetent patients: Results of a prospective nationwide cohort study (REGESMOHS, Spanish registry of Mohs surgery).
Abril-Pérez C; (...); Botella-Estrada R
Article. 10.1111/jdv.20103. 2024
Narrative Review and Update on Biologic and Small Molecule Drugs for Hidradenitis Suppurativa: An Entity With a Promising Future.
Mansilla-Polo M, Escutia-Muñoz B, Botella-Estrada R
Article. 10.1016/j.ad.2023.08.001. 2023
Narrative Review and Update on Biologic and Small Molecule Drugs for Hidradenitis Suppurativa: An Entity With a Promising Future.
Mansilla-Polo, M., Escutia-Munoz, B., Botella-Estrada, R.
Article. 10.1016/j.ad.2023.05.015. 2023
National Survey on the Use of Mobile Applications in Patients with Hemophilia and Other Coagulopathies
Eduardo Megias, Juan; (...); Poveda Andres, Jose Luis
Meeting Abstract. 10.1182/blood-2022-169938. 2022
New challenges of advanced therapies.
Megías-Vericat JE; (...); Poveda Andrés JL
Article. 10.1016/j.farma.2023.11.008. 2024
Nodular hidradenoma: Case report and brief literature review.
Mansilla-Polo, Miguel; (...); Botella-Estrada, Rafael
Article. 10.1016/j.patol.2025.100801. 2025
Observational study to evaluate discontinuation of monotherapy with cobicistat-boosted darunavir in patients with human immunodeficiency virus
Solana-Altabella, Antonio; (...); Poveda-Andres, Jose Luis
Article. 10.1097/MD.0000000000032208. 2022
ODs with a positive TPR conclusion, not subject to a conditional approval, and approved without requering a pass would be more likely to be reimbursed in Spain.
Poveda JL; (...); Badia X
Article. 10.1186/s13023-022-02610-4. 2023
Omics-Based Approaches for the Characterization of Pompe Disease Metabolic Phenotypes
Gomez-Cebrian, Nuria; (...); Puchades-Carrasco, Leonor
Review. 10.3390/biology12091159. 2023
OPTIMIZING MANAGEMENT AND OUTCOMES OF ACTIVATED PHOSPHOINOSITIDE 3-KINASE DELTA SYNDROME (APDS) IN SPAIN: BEWAYAPDS PROJECT
Flores-Moreno, S.; (...); Gil, A.
Meeting Abstract. 2024
Oral Ruxolitinib could Increase the Aggressiveness of Cutaneous Squamous Cell Carcinomas: A 6-Patient Series
Lasheras-Perez, M. A.; (...); Botella-Estrada, R.
Letter. 10.1016/j.ad.2023.07.035. 2025
Papulonecrotic tuberculides as a key to the diagnosis of tuberculosis: a case report.
Mansilla-Polo M; (...); Botella-Estrada R
Letter. 10.1111/ijd.16940. 2024
Paraoxonase I Activity and Its Relationship with Nutrition in Amyotrophic Lateral Sclerosis.
Proaño B; (...); de la Rubia Ortí JE
Article. 10.3390/antiox13081021. 2024
Pharmacogenetics in Response to Biological Agents in Inflammatory Bowel Disease: A Systematic Review.
Ballesta-Lopez, Octavio; (...); Poveda-Andres, Jose Luis
Article. 10.3390/ijms26041760. 2025
Podoconiosis.
Mansilla-Polo, Miguel, Lopez-Leon, Paula Teresa, Botella-Estrada, Rafael
Article. 10.1001/jamadermatol.2023.4143. 2023
Presence of good humanization practices in the healthcare of patients with rare diseases in Pharmacy Services
Company Albir MJ, Poveda Andrés JL, Edo Solsona MD
Article. 10.1016/j.farma.2023.06.0131130. 2024
Primary Cutaneous Lymphoma Registry of the Spanish Academy of Dermatology and Venereology (AEDV): Data for the First 5 Years.
Falkenhain-Lopez, D; (...); Ortiz-Romero, P L
Article. 10.1016/j.ad.2022.11.010. 2023
Prognostic factors for satellitosis or in-transit metastasis in cutaneous squamous cell carcinoma: A multicentric cohort study.
Marti-Marti I; (...); Toll A
Article. 10.1016/j.jaad.2023.02.048. 2023
Raccoon eyes as a diagnostic key for suspected amyloidosis
Mansilla-Polo, Miguel, Botella-Estrada, Rafael
Editorial Material. 10.1093/rap/rkad105. 2023
Rationale and study design for an Individualized PeriopeRative Open lung VEntilatory approach in Emergency Abdominal Laparotomy/scopy: study protocol for a prospective international randomized controlled trial.
Laguna G; (...); Ferrando C
Article. 10.1016/j.redare.2024.04.007. 2024
Reactive arthritis.
Mansilla-Polo M; (...); Botella-Estrada R
Article. 10.1016/j.medcli.2023.08.017. 2023
Real-world effectiveness and safety of bimekizumab for hidradenitis suppurativa: An ambispective observational study.
Mansilla-Polo, Miguel; (...); Botella-Estrada, Rafael
Article. 10.1111/ajd.14339. 2024
Recalcitrant Hailey-Hailey Disease With Satisfactory Response to Apremilast
Mansilla-Polo, M.; (...); Botella-Estrada, R.
Letter. 10.1016/j.ad.2024.10.025. 2024
Recalcitrant Hailey-Hailey Disease With Satisfactory Response to Apremilast.
Mansilla-Polo, M; (...); Botella-Estrada, R
Case Reports. 10.1016/j.ad.2023.05.022. 2023
Recalcitrant lichen planopilaris treated with upadacitinib: a case series
Lasheras-Perez, Miguel A.; (...); Botella-Estrada, Rafael
Article. 10.1111/ijd.17339. 2024
Refractory cutaneous lupus erythematosus successfully treated with anifrolumab: a case series.
Martin-Torregrosa, Daniel; (...); Torres-Navarro, Ignacio
Letter. 10.1111/ijd.17022. 2024
Requirements for Accessing New Dermatology Drugs in Spain: Results of the EQUIDAD Study.
Sanchez-Diaz, M.; (...); Carrascosa-Carrillo, J. M.
Article. 10.1016/j.ad.2023.10.016. 2023
Ruxolitinib for foreign body reaction to silicone in a patient with chronic graft-versus-host disease.
Palacios-Diaz, Rodolfo David; (...); Botella-Estrada, Rafael
Letter. 10.1111/ijd.17365. 2024
Ruxolitinib oral puede aumentar la agresividad de los carcinomas escamosos cutáneos: serie de 6 pacientes.
Lasheras-Perez MA; (...); Botella-Estrada R
Article. 10.1016/j.ad.2024.10.003. 2025
Sarcoidosis cutánea tras inyecciones de plasma rico en plaquetas y maquillaje permanente de cejas.
Martín-Torregrosa D; (...); Botella-Estrada R
Article. 10.1016/j.ad.2024.10.043. 2024
Scaling and periorificial crusts in a pediatric patient.
Fayos-Gregori, Rafael; (...); Botella-Estrada, Rafael
Article. 10.1007/s15010-024-02309-7. 2024
Scalp Melanoma: A High-Risk Subset of Cutaneous Head and Neck Melanomas with Distinctive Clinicopathological Features.
Palacios-Diaz RD; (...); Botella-Estrada R
Article. 10.3390/jcm12247643. 2023
Single Digital Metastasis of Rectal Adenocarcinoma
Mansilla-Polo, Miguel; (...); Botella-Estrada, Rafael
Letter. 10.1097/DAD.0000000000002529. 2023
Skin cancer risk after hematopoietic stem cell transplantation: a systematic review and meta-analysis.
Mansilla-Polo M; (...); Botella-Estrada R
Article. 10.1111/ijd.17371. 2024
Skin lesions in a lung transplant recipient
Mansilla-Polo, Miguel; (...); Botella-Estrada, Rafael
Editorial Material. 10.1016/j.eimc.2023.09.005. 2024
Skin lesions in a lung transplant recipient.
Mansilla-Polo M; (...); Botella-Estrada R
Case Reports. 10.1016/j.eimce.2023.09.005. 2024
Study of Microsatellite Instability by Immunohistochemistry in a Cohort of Patients With Melanoma
Diaz, Rodolfo David Palacios; (...); Estrada, Rafael Botella
Article. 10.1111/cup.14758. 2025
Successful treatment of erythema nodosum leprosum with upadacitinib and roflumilast.
Mansilla-Polo, Miguel; (...); Torres-Navarro, Ignacio
Letter. 10.1111/ijd.17293. 2024
Successful treatment of field of cancerization in the dorsum of the hands with 1% tirbanibulin ointment.
Abril-Perez, Carlos; (...); Botella-Estrada, Rafael
Article. 10.1093/ced/llad171. 2023
Successful Treatment of Mogamulizumab-Associated Rash With Upadacitinib: Evidence From 2 Cases.
Martin-Torregrosa, Daniel; (...); Botella-Estrada, Rafael
Article. 10.1001/jamadermatol.2024.4582. 2024
Successful Treatment of Stimulator of Interferon Genes-Associated Vasculopathy of Infantile Onset SAVI Syndrome With Anifrolumab.
Mansilla-Polo M; (...); Botella-Estrada R
Article. 10.1001/jamadermatol.2024.2160. 2024
Switching from dupilumab to tralokinumab in patients with atopic dermatitis due to inefficacy or side effects.
Lasheras-Pérez MA; (...); Rodriguez-Serna M
Article. 10.1111/ijd.16926. 2024
Tattoo-Associated Common Wart
Mansilla-Polo, M., Llavador-Ros, M., Botella-Estrada, R.
Editorial Material. 10.1016/j.ad.2024.05.001. 2024
Tattoo-Associated Common Wart.
Mansilla-Polo, M, Llavador-Ros, M, Botella-Estrada, R
Article. 10.1016/j.ad.2023.04.037. 2023
The association of salivary caffeine levels with serum concentrations in premature infants with apnea of prematurity
Garcia-Robles, Ana; (...); Saenz Gonzalez, Pilar
Article. 10.1007/s00431-022-04628-z. 2022
The value of the reflective discussion in decision-making using multi-criteria decision analysis (MCDA): an example of determining the value contribution of tabelecleucel for the treatment of the Epstein Barr virus-positive post-transplant lymphoproliferative disease (EBV+ PTLD).
Badia, Xavier; (...); Valles, Joan-Antoni
Article. 10.1186/s13023-024-03324-5. 2024
Toxic-metabolic encephalopathy induced by metronidazole and disulfiram: classics never die.
Chovi-Trull, Maria; (...); Poveda-Andres, Jose Luis
Article. 10.1136/ejhpharm-2024-004184. 2024
Treatment of palmoplantar psoriasis with oral roflumilast: a case series.
Lasheras-Perez, Miguel Antonio; (...); Botella-Estrada, Rafael
Article. 10.1093/ced/llae229. 2024
Use of an electrospun bioveil is safe and does not decrease skin graft take on burn wounds: A randomised, controlled clinical trial.
Perez-Del-Caz, Maria Dolores; (...); Perez-Plaza, Aranzazu
Article. 10.1016/j.burns.2025.107427. 2025
VALUE CRITERIA FOR OUTCOMES BASED MANAGED ENTRY AGREEMENT OF CAR-T IN RELAPSED OR REFRACTORY MULTIPLE MYELOMA (RRMM) THROUGH MCDA
Poveda, J. L.; (...); Lizan, L.
Meeting Abstract. 2023