Portal de investigación
Estudio en fase IIb, multicéntrico, de ampliación a largo plazo y de determinación de la dosis para evaluar la eficacia y la seguridad de JNJ-77242113 para el tratamiento de la psoriasis en placas de moderada a grave.
Datos básicos
- Código:
- 77242113PSO2002
- Protocolo:
- 77242113PSO2002
- EUDRACT:
- 2021-004320-16
- NCT:
- Centro:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Dotación:
- Año de incio:
- 2022
- Año de finalización:
- 2023
Objetivos del proyecto
Objetivo Principal: Evaluar la respuesta clínica a largo plazo del tratamiento con JNJ-77242113 en pacientes con psoriasis en placas de moderada a grave Objetivos Secundarios: - Evaluar la respuesta clínica a largo plazo del tratamiento con JNJ-77242113 en pacientes con psoriasis en placas de moderada a grave - Evaluar el efecto del tratamiento con JNJ-77242113 sobre la gravedad de la psoriasis notificada por el paciente en pacientes con psoriasis en placas de moderada a grave - Evaluar la seguridad y la tolerabilidad de JNJ-77242113 en pacientes con psoriasis en placas de moderada a grave
Documentos
- No hay documentos
Grupos
Financiadores - Promotores
Resultados del Ensayo Clínico
"Phytophotodermatitis as a clinical problem and as a therapeutic option: case report and review of the literature".
Mansilla-Polo, Miguel; (...); Botella-Estrada, Rafael
Article. 10.1016/j.pdpdt.2023.103304. 2023
[[Tranaslated article]]Primary Cutaneous Lymphoma Registry of the Spanish Academy of Dermatology and Venereology (AEDV): Data for the First 5 Years.
López DF; (...); Ortiz-Romero, P. L.
Article. 10.1016/j.ad.2022.11.013. 2023
[Translated article] BIOBADATOP Spanish Atopic Dermatitis Registry: Description and Early Findings.
Munera-Campos M; (...); Carrascosa JM
Article. 10.1016/j.ad.2023.05.010. 2023
[Translated article] Risk of a Second Skin Cancer in a Cohort of Patients With Nonmelanoma Skin Cancer - Basal Cell Carcinoma or Squamous Cell Carcinoma - Treated With Mohs Micrographic Surgery: A National Prospective Cohort Study.
Minano Medrano, R.; (...); Garcia-Doval, I
Article. 10.1016/j.ad.2022.01.035. 2022
A multi-criteria decision analysis on the value of nintedanib for interstitial lung diseases.
Zozaya, Neboa; (...); Verde, Luis
Article. 10.1017/S0266462322000459. 2022
Alpha-cardiac Actin Serum Expression Levels Detect Acute Cellular Rejection in Heart Transplant Patients.
Perez-Carrillo, Lorena; (...); Rosello-Lleti, Esther
Article. 10.1097/TP.0000000000004273. 2022
Altered MicroRNA Maturation in Ischemic Hearts: Implication of Hypoxia on XPO5 and DICER1 Dysregulation and RedoximiR State.
Perez-Carrillo, Lorena; (...); Rosello-Lleti, Esther
Article. 10.3390/antiox12071337. 2023
Analysis of Heart Transplant Survival According to Difference in Age Between Donor and Recipient.
Lopez-Vilella, Raquel; (...); Almenar-Bonet, Luis
Article. 10.1016/j.transproceed.2022.10.014. 2022
Analysis of heart transplantation survival according to difference in age between donor and recipient
Donoso Trenado, V.; (...); Almenar Bonet, L.
Meeting Abstract. 2022
Assessing the value of moderate-to-severe atopic dermatitis treatment using multi-criteria decision analysis (MCDA).
Pereyra-Rodríguez JJ; (...); Ortiz de Frutos FJ
Letter. 10.1111/jdv.19432. 2023
BIOBADATOP Spanish Atopic Dermatitis Registry: Description and Early Findings.
Munera-Campos M; (...); Carrascosa JM
Article. 10.1016/j.ad.2023.03.001. 2023
CA125: a new biomarker in patients with Fontan circulation (vol 76, pg 112, 2023)
Fuentes, Francisco Buendia; (...); Soriano, Joaquin Rueda
Correction. 10.1016/j.rec.2023.03.018. 2023
CA125: a new biomarker in patients with Fontan circulation.
Fuentes, Francisco Buendia; (...); Soriano, Joaquin Rueda
Article. 10.1016/j.rec.2022.05.029. 2022
Cardiac Allograft Rejection Induces Changes in Nucleocytoplasmic Transport: RANGAP1 as a Potential Non-Invasive Biomarker.
Lozano-Edo, Silvia; (...); Martinez-Dolz, Luis
Article. 10.3390/jpm12060913. 2022
Cardiac sodium/hydrogen exchanger (NHE11) as a novel potential target for SGLT2i in heart failure
Perez-Carrillo, L.; (...); Rosello-Lleti, E.
Meeting Abstract. 2022
Casal necklace.
Mansilla-Polo, Miguel, Martin-Torregrosa, Daniel, Botella-Estrada, Rafael
Article. 10.1016/j.medcli.2023.03.035. 2023
Clinical phenotypes according to diuretic combination in acute heart failure.
Lopez-Vilella, Raquel; (...); Bonet, Luis Almenar
Article. 10.1016/j.hjc.2023.03.009. 2023
Clinicopathological characteristics of cutaneous and mucocutaneous leishmaniasis in patients treated with TNF-alpha inhibitors.
Palacios-Diaz, Rodolfo David; (...); Botella-Estrada, Rafael
Article. 10.1111/ddg.15007. 2023
Combining Serum miR-144-3p and miR-652-3p as Potential Biomarkers for the Early Diagnosis and Stratification of Acute Cellular Rejection in Heart Transplantation Patients.
Pérez-Carrillo L; (...); Roselló-Lletí E
Article. 10.1097/TP.0000000000004622. 2023
Combining serum miR-144-3p and miR-652-3p as potential biomarkers for the early diagnosis and stratification of acute cellular rejection in heart transplantation patients
Perez-Carrillo, L.; (...); Rosello-Lleti, E.
Meeting Abstract. 2022
Conduction System Pacing for Cardiac Resynchronization Therapy
Cano, Oscar; (...); Martinez-Dolz, Luis
Review. 10.3390/jcdd10110448. 2023
Consensus recommendations for the improvement of inter- and intra-centre care coordination in the management of hemophilia.
Montoro-Ronsano JB; (...); Soto-Ortega I
Article. 10.1016/j.farma.2023.01.003. 2023
Consensus recommendations for the improvement of inter- and intra-centre care coordination in the management of hemophilia.
Montoro-Ronsano, Jose Bruno; (...); Soto-Ortega, Inmaculada
Article. 10.1016/j.farma.2023.04.002. 2023
Contact dermatitis by face mask.
Mansilla-Polo M, Navarro-Mira MÁ, Botella-Estrada R
Article. 10.1016/j.medcli.2023.01.004. 2023
COVID-19 infection in heart transplants in pre- and post-vaccination periods
Donoso Trenado, V.; (...); Almenar Bonet, L.
Meeting Abstract. 2022
COVID-19 Infection in Heart Transplants in Pre- and Postvaccination Periods.
Donoso Trenado, Victor; (...); Almenar-Bonet, Luis
Article. 10.1016/j.transproceed.2022.10.005. 2022
Cutaneous larva migrans.
Mansilla-Polo, Miguel; (...); Botella-Estrada, Rafael
Article. 10.1016/j.medcli.2023.03.037. 2023
Changes in the Treatment of Decompensated Advanced Heart Failure During Hospitalization and at Discharge.
Lopez-Vilella, Raquel; (...); Almenar Bonet, Luis
Article. 10.1016/j.transproceed.2022.10.002. 2022
Determining what represents value in the treatment of prurigo nodularis and its key unmet needs in Spain through Multi-Criteria Decision Analysis
Silvestre, Juan Francisco; (...); Serra-Baldrich, Esther
Article. 10.1002/jvc2.275. 2024
Development and validation of a model to predict complex Mohs Micrographic Surgery in clinical practice: REGESMOSH scale.
Montero-Vilchez, Trinidad R.; (...); Sanmartin-Jimenez, Onofre
Article. 10.1111/jdv.19056. 2023
Differences in epidemiology, comorbidities and treatment choice between plaque psoriasis and pustular psoriasis: results from the Biobadaderm registry.
Ruiz Genao, Diana P.; (...); Garcia-Doval, Ignacio
Letter. 10.1111/bjd.21763. 2022
Does hyaluronidase injected in periocular area change skin ultrastructure?: Standardized in vitro analysis
Aguilar-González M; (...); Pérez-López M
Article. 10.1111/jocd.15014. 2022
Drug survival and safety of biosimilars and originator adalimumab in the treatment of psoriasis: a multinational cohort study.
Phan, Duc Binh; (...); Yiu ZZN
Article. 10.1136/bmjopen-2023-075197. 2023
Drug Survival in Cyclosporine Treatment for Moderate to Severe Atopic Dermatitis: Analysis of the Spanish Atopic Dermatitis Registry (BIOBADATOP).
Rodriguez, C Couselo; (...); Florez, A.
Article. 10.1016/j.ad.2023.07.014. 2023
Drug survival of adalimumab biosimilars in real-world treatment of psoriasis: A Spanish multicenter study
Lopez-Ferrer, Anna; (...); Puig, Lluis
Article. 10.1111/dth.15831. 2022
Dystrophinopathy Phenotypes and Modifying Factors in DMD Exon 45-55 Deletion
Poyatos-Garcia, Javier; (...); Jesus Vilchez, Juan
Article. 10.1002/ana.26461. 2022
Effectiveness and safety of brodalumab in the treatment of plaque, scalp and palmoplantar psoriasis: A multicentre retrospective study in a Spanish population.
Sahuquillo-Torralba, A; (...); Botella-Estrada, R
Article. 10.1111/ajd.14130. 2023
Effectiveness of Secukinumab for the treatment of erythrodermic psoriasis. Multicenter study in daily practice.
Reymundo, A; (...); Dauden, E
Letter. 10.1111/jdv.19371. 2023
Effectiveness, safety and satisfaction of 1% tirbanibulin ointment in the treatment of actinic keratoses: A prospective study in real clinical practice.
Mansilla-Polo M; (...); Botella-Estrada R
Letter. 10.1111/ajd.14151. 2023
Evolutionary description of heart transplantation and heart-lung transplantation in congenital heart disease
Donoso Trenado, V.; (...); Almenar Bonet, L.
Meeting Abstract. 2022
Evolutionary Description of Heart Transplantation and Heart-Lung Transplantation in Congenital Heart Disease.
Donoso Trenado, Victor; (...); Almenar-Bonet, Luis
Article. 10.1016/j.transproceed.2022.10.006. 2022
Evolving Indications for Heart-Lung Transplant in Spain.
Lopez-Vilella, Raquel; (...); Almenar Bonet, Luis
Article. 10.1016/j.transproceed.2022.10.003. 2022
Fast and sustained improvement of patient-reported outcomes in psoriatic patients treated with secukinumab in a daily practice setting
Chicharro, Pablo; (...); Dauden, Esteban
Article. 10.1111/dth.15653. 2022
Golgi Apparatus fragmentation in dilated cardiomyopathy and its relationship with the alteration of vesicular transport
Gimenez-Escamilla, I.; (...); Rosello-Lleti, E.
Meeting Abstract. 2022
Healthcare Resource Utilization among Patients between 60-75 Years with Secondary Acute Myeloid Leukemia Receiving Intensive Chemotherapy Induction: A Spanish Retrospective Observational Study
Solana-Altabella, Antonio; (...); Martinez-Cuadron, David
Article. 10.3390/cancers14081921. 2022
Hemihypoatrophy as an extraordinary manifestation of linear morphoea.
Mansilla-Polo, Miguel, Navarro-Mira, Miguel A., Botella-Estrada, Rafael
Article. 10.1093/rap/rkac104. 2022
High adherence to secukinumab in patients with moderate to severe psoriasis: a long-term multicenter study in a daily practice setting
Martos-Cabrera, Luisa; (...); Dauden, Esteban
Letter. 10.1111/ijd.16365. 2022
Hospital pharmacy initiatives for improving the management of patients with congenital coagulopathies
Bruno Montoro-Ronsano, Jose; (...); Alberto Vella, Vincenzo
Article. 10.7399/fh.11729. 2022
How can artificial intelligence optimize value-based contracting?
Poveda, Jose Luis; (...); Medrano, Ignacio H.
Letter. 10.1186/s40545-022-00475-3. 2022
Identification of c.104T>G, p.Met35Arg (NM_00314.8) variant in heterozygosity in exon 2 of the PTEN gene as the Causative Factor for Cowden Syndrome: A Medical Case Study.
Mansilla-Polo, Miguel; (...); Botella-Estrada, Rafael
Article. 10.1093/ced/llad344. 2023
IgG antibody response to pneumococcal-conjugated vaccine (Prevenar®13) in children with immunodeficiency disorders.
Garrido-Jareño M; (...); Pemán-García J
Article. 10.1007/s00430-022-00759-0. 2023
Impact of Advanced Age on the Incidence of Major Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stable Coronary Artery Disease in a Real-World Setting in Spain.
González-Juanatey C; (...); Savana Research Group
Article. 10.3390/jcm12165218. 2023
Impact of Long-COVID on Health Care Burden: A Case Control Study
Valdivieso-Martinez, Bernardo; (...); Redon, Josep
Article. 10.3390/jcm12185768. 2023
Is the Benefit of Treating Iron Deficiency Greater in Acute Heart Failure with Renal Dysfunction?
Lopez-Vilella, Raquel; (...); Almenar Bonet L
Article. 10.3390/life13040915. 2023
Klinisch-pathologische Eigenschaften kutaner und mukokutaner Leishmaniose bei mit TNF-a-Inhibitoren behandelten Patienten.
Palacios-Diaz, Rodolfo David; (...); Botella-Estrada, Rafael
Article. 10.1111/ddg.15007_g. 2023
Left bundle branch pacing versus left ventricular septal pacing as a primary procedural endpoint during left bundle branch area pacing: Evaluation of two different implant strategies.
Cano, Oscar; (...); Martinez-Dolz, Luis
Article. 10.1111/jce.16128. 2023
Long-term outcomes of extended DAPT in a real-life cohort of consecutive STEMI patients.
Tizón-Marcos H; (...); Marrugat J
Article. 10.1016/j.rec.2022.12.003. 2023
Long-term study of prevalence and evolution of tricuspid regurgitation after orthotopic heart transplantation
Lopez Vilella, R.; (...); Almenar Bonet, L.
Meeting Abstract. 2022
Manipulación de fármacos para su administración por gastrostomía endoscópica percutánea en pacientes con esclerosis lateral amiotrófica y nutrición enteral.
Vázquez Polo A; (...); Vázquez Costa JF
Article. 10.20960/nh.03946. 2022
Mortality after the first hospital admission for acute heart failure de novo vs. acutely decompensated heart failure with reduced ejection fraction
Lopez Vilella, R. Raquel; (...); Almenar Bonet, L.
Meeting Abstract. 2023
Mortality After the First Hospital Admission for Acute Heart Failure, De Novo Versus Acutely Decompensated Heart Failure With Reduced Ejection Fraction.
Lopez-Vilella, Raquel; (...); Almenar Bonet, Luis
Article. 10.1016/j.amjcard.2023.03.008. 2023
Multiple Primary Melanomas: Retrospective Review in a Tertiary Care Hospital
Palacios-Diaz RD; (...); Botella-Estrada R
Article. 10.3390/jcm11092355. 2022
Narrative Review and Update on Biologic and Small Molecule Drugs for Hidradenitis Suppurativa: An Entity With a Promising Future.
Mansilla-Polo M, Escutia-Muñoz B, Botella-Estrada R
Article. 10.1016/j.ad.2023.08.001. 2023
Narrative Review and Update on Biologic and Small Molecule Drugs for Hidradenitis Suppurativa: An Entity With a Promising Future.
Mansilla-Polo, M., Escutia-Munoz, B., Botella-Estrada, R.
Article. 10.1016/j.ad.2023.05.015. 2023
National Survey on the Use of Mobile Applications in Patients with Hemophilia and Other Coagulopathies
Eduardo Megias, Juan; (...); Poveda Andres, Jose Luis
Meeting Abstract. 10.1182/blood-2022-169938. 2022
Non-invasive diagnosis of cardiac rejection using small non-coding RNAs
Gimenez-Escamilla, I.; (...); Rosello-Lleti, E.
Meeting Abstract. 2022
Non-traumatic spontaneous abdominal haemorrhage
Ballesta, M.; (...); Lerga, P. Estelles
Article. 10.1016/j.rx.2022.11.003. 2023
Non-traumatic spontaneous abdominal haemorrhage.
Ballesta M; (...); Estellés Lerga P
Article. 10.1016/j.rxeng.2022.11.004. 2023
Observational study to evaluate discontinuation of monotherapy with cobicistat-boosted darunavir in patients with human immunodeficiency virus
Solana-Altabella, Antonio; (...); Poveda-Andres, Jose Luis
Article. 10.1097/MD.0000000000032208. 2022
ODs with a positive TPR conclusion, not subject to a conditional approval, and approved without requering a pass would be more likely to be reimbursed in Spain.
Poveda JL; (...); Badia X
Article. 10.1186/s13023-022-02610-4. 2023
Omics-Based Approaches for the Characterization of Pompe Disease Metabolic Phenotypes
Gomez-Cebrian, Nuria; (...); Puchades-Carrasco, Leonor
Review. 10.3390/biology12091159. 2023
Papulonecrotic tuberculides as a key to the diagnosis of tuberculosis: a case report.
Mansilla-Polo M; (...); Botella-Estrada R
Letter. 10.1111/ijd.16940. 2024
Podoconiosis.
Mansilla-Polo, Miguel, Lopez-Leon, Paula Teresa, Botella-Estrada, Rafael
Article. 10.1001/jamadermatol.2023.4143. 2023
Population-based sequencing of Mycobacterium tuberculosis reveals how current population dynamics are shaped by past epidemics.
Cancino-Munoz, Irving; (...); Comas, Inaki
Article. 10.7554/eLife.76605. 2022
Presence of good humanization practices in the healthcare of patients with rare diseases in Pharmacy Services
Company Albir MJ, Poveda Andrés JL, Edo Solsona MD
Article. 10.1016/j.farma.2023.06.0131130. 2024
Prevalence of Tricuspid Regurgitation After Orthotopic Heart Transplantation and Its Evolution in the Follow-up Period: A Long-Term Study.
Lopez-Vilella, Raquel; (...); Almenar-Bonet, Luis
Article. 10.1016/j.transproceed.2022.09.009. 2022
Primary Cutaneous Lymphoma Registry of the Spanish Academy of Dermatology and Venereology (AEDV): Data for the First 5 Years.
Falkenhain-Lopez, D; (...); Ortiz-Romero, P L
Article. 10.1016/j.ad.2022.11.010. 2023
Prognostic factors for satellitosis or in-transit metastasis in cutaneous squamous cell carcinoma: A multicentric cohort study.
Marti-Marti I; (...); Toll A
Article. 10.1016/j.jaad.2023.02.048. 2023
Psoriasis onset over a fresh tattoo.
Abril-Perez, Carlos; (...); Botella-Estrada, Rafael
Article. 10.1016/j.medcli.2022.01.014. 2022
Raccoon eyes as a diagnostic key for suspected amyloidosis
Mansilla-Polo, Miguel, Botella-Estrada, Rafael
Editorial Material. 10.1093/rap/rkad105. 2023
Recalcitrant Hailey-Hailey Disease With Satisfactory Response to Apremilast.
Mansilla-Polo, M; (...); Botella-Estrada, R
Case Reports. 10.1016/j.ad.2023.05.022. 2023
Requirements for Accessing New Dermatology Drugs in Spain: Results of the EQUIDAD Study.
Sanchez-Diaz, M.; (...); Carrascosa-Carrillo, J. M.
Article. 10.1016/j.ad.2023.10.016. 2023
Safety of biologic therapy in combination with methotrexate in moderate to severe psoriasis: a cohort study from the BIOBADADERM registry.
Lluch-Galcera, Juan Jose; (...); Garcia-Doval, Ignacio
Article. 10.1093/bjd/ljad382. 2023
Secukinumab is effective and safe in the treatment of recalcitrant palmoplantar psoriasis and palmoplantar pustular psoriasis in a daily practice setting.
Reolid, Alejandra; (...); Dauden, Esteban
Article. 10.1016/j.jaad.2022.05.047. 2022
Single Digital Metastasis of Rectal Adenocarcinoma
Mansilla-Polo, Miguel; (...); Botella-Estrada, Rafael
Letter. 10.1097/DAD.0000000000002529. 2023
SMPTall man lettering application in medication information systems as a quality and safety strategy in hospital organization
Iglesias Gomez, Ruben; (...); Poveda Andres, Jose Luis
Article. 10.1111/jcpt.13703. 2022
Starkeya nomas sp. nov., a prosthecate and budding bacterium isolated from an immunocompromized patient.
Sahuquillo-Arce JM; (...); López-Hontangas JL
Article. 10.1099/ijsem.0.005805. 2023
Successful treatment of field of cancerization in the dorsum of the hands with 1% tirbanibulin ointment.
Abril-Perez, Carlos; (...); Botella-Estrada, Rafael
Article. 10.1093/ced/llad171. 2023
Switching from dupilumab to tralokinumab in patients with atopic dermatitis due to inefficacy or side effects.
Lasheras-Pérez MA; (...); Rodriguez-Serna M
Article. 10.1111/ijd.16926. 2024
Systematic Review of Pharmacogenetics of ABC and SLC Transporter Genes in Acute Myeloid Leukemia
Megías-Vericat JE; (...); Montesinos P
Review. 10.3390/pharmaceutics14040878. 2022
The association of salivary caffeine levels with serum concentrations in premature infants with apnea of prematurity
Garcia-Robles, Ana; (...); Saenz Gonzalez, Pilar
Article. 10.1007/s00431-022-04628-z. 2022
The contribution of fenfluramine to the treatment of Dravet syndrome in Spain through Multi-Criteria Decision Analysis.
Gil-Nagel A; (...); Gil A
Article. 10.1016/j.yebeh.2022.108711. 2022
Therapeutic approach in heart failure with poor diuretic response. Peripheral ultrafiltration vs. conventional treatment
Lopez-Vilella, R.; (...); Almenar Bonet, L.
Meeting Abstract. 2023
Therapeutic approach in heart failure with poor diuretic response: peripheral ultrafiltration vs. conventional treatment.
López-Vilella R; (...); Almenar Bonet L
Article. 10.1002/ehf2.14386. 2023
Uncontrolled asistole donation. Impact on primary graft failure and heart transplantation survival
Donoso Trenado, V.; (...); Almenar Bonet, L.
Meeting Abstract. 2022
Variation in diuretic requirement after peripheral ultrafiltration in heart failure with diuretic resistance
Lopez Vilella, R.; (...); Almenar Bonet, L.
Meeting Abstract. 2022
Variations in the medical treatment of heart failure during admission for decompensation
Lopez Vilella, R.; (...); Almenar Bonet, L.
Meeting Abstract. 2022
Why Iron Deficiency in Acute Heart Failure Should Be Treated: A Real-World Clinical Practice Study.
Lopez-Vilella, Raquel; (...); Almenar Bonet, Luis
Article. 10.3390/life12111828. 2022