Nefroblastoma. Experiencia a largo plazo en el abordaje multidisciplinario.

Autores de IIS La Fe

• Beatriz Rodriguez Iglesias

  Autor

• Agustin Serrano Durba

  Autor

• Maria Posadas Caraballo

  Autor

• Julia Balaguer Guill

  Autor

• Ivan Povo Martin

  Autor

• Carlos Dominguez Hinarejos

  Autor

• Francisco Boronat Tormo

  Autor

Grupos

• Investigación Clínica y Traslacional en Cáncer

  

  Leader

  José Gómez Codina

• Urología

  Leader

  Francisco Boronat Tormo

Abstract

OBJECTIVES: Main objective: to perform a descriptive study of patients with nephroblastoma, diagnostic tests, medical and surgical treatment. Secondary objective: to evaluate the rate of relapse and 5-year survival and risk factors for relapse and death. MATERIALS AND METHODS: Retrospective study of patients with nephroblastoma treated according to the protocol of the SIOP-2001. Demographic variables, comorbidities and associated syndromes were collected. Other data were tumor location, size, extent and stage. The relapse rate and the development of other secondary tumors as well as the long-term survival were also studied. RESULTS: We collected 33 patients with nephroblastoma. A biopsy was performed in 7 patients (21.2%). The Kaplan-Meir curve for event-free survival (tumor recurrence) was 84% with a 95% CI = [0.73-0.98] and the Kaplan-Meier overall survival curve was 0.93 95% CI [0.85-1]. Recurrence occurred in all patients before the first year. CONCLUSIONS: Nephroblastoma is a tumor with a favorable prognosis. The unfavorable histology as well as advanced stages are factors of a poor prognosis. The follow-up must be exhaustive during the first year after the diagnosis.

Keywords

• Anaplasia; Lymphadenectomy; Partial nephrectomy; Radical nephrectomy; Renal tumors; Risk; Staging; Wilms tumor